keyword
MENU ▼
Read by QxMD icon Read
search

Ccr4 fasl

keyword
https://www.readbyqxmd.com/read/24510967/negative-regulation-by-pd-l1-during-drug-specific-priming-of-il-22-secreting-t-cells-and-the-influence-of-pd-1-on-effector-t-cell-function
#1
Andrew Gibson, Monday Ogese, Andrew Sullivan, Eryi Wang, Katy Saide, Paul Whitaker, Daniel Peckham, Lee Faulkner, B Kevin Park, Dean J Naisbitt
Activation of PD-1 on T cells is thought to inhibit Ag-specific T cell priming and regulate T cell differentiation. Thus, we sought to measure the drug-specific activation of naive T cells after perturbation of PD-L1/2/PD-1 binding and investigate whether PD-1 signaling influences the differentiation of T cells. Priming of naive CD4(+) and CD8(+) T cells against drug Ags was found to be more effective when PD-L1 signaling was blocked. Upon restimulation, T cells proliferated more vigorously and secreted increased levels of IFN-γ, IL-13, and IL-22 but not IL-17...
March 15, 2014: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/23782916/characterization-of-circulating-cd8-t-cells-expressing-skin-homing-and-cytotoxic-molecules-in-active-non-segmental-vitiligo
#2
Bao-Xiang Zhang, Mao Lin, Xiao-Yi Qi, Ron-Xin Zhang, Zhen-Dong Wei, Jie Zhu, Mao-Qiang Man, Cai-Xia Tu
BACKGROUND: Vitiligo is caused by melanocyte depletion. Studies have suggested that skin-homing cytotoxic T lymphocytes that express cutaneous lymphocyte-associated antigen (CLA) are responsible for melanocyte depletion. The characteristics of these skin-homing cytotoxic T cells have not been well established yet. OBJECTIVES: To investigate the frequency of skin-homing CD8(+)T cells (CD8(+)CLA(+)T cells) and their expression of cytotoxic molecules, as well as migration-related molecules in CD8(+)T cell in non-segmental vitiligo patients...
May 2013: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/22987284/human-leukocyte-antigen-hla-b-57-01-restricted-activation-of-drug-specific-t-cells-provides-the-immunological-basis-for-flucloxacillin-induced-liver-injury
#3
Manal M Monshi, Lee Faulkner, Andrew Gibson, Rosalind E Jenkins, John Farrell, Caroline J Earnshaw, Ana Alfirevic, Karin Cederbrant, Ann K Daly, Neil French, Munir Pirmohamed, B Kevin Park, Dean J Naisbitt
UNLABELLED: The role of the adaptive immune system in adverse drug reactions that target the liver has not been defined. For flucloxacillin, a delay in the reaction onset and identification of human leukocyte antigen (HLA)-B*57:01 as a susceptibility factor are indicative of an immune pathogenesis. Thus, we characterize flucloxacillin-responsive CD4+ and CD8+ T cells from patients with liver injury and show that naive CD45RA+CD8+ T cells from volunteers expressing HLA-B*57:01 are activated with flucloxacillin when dendritic cells present the drug antigen...
February 2013: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/17404270/human-peripheral-blood-t-regulatory-cells-tregs-functionally-primed-ccr4-tregs-and-unprimed-ccr4-tregs-regulate-effector-t-cells-using-fasl
#4
Dolgor Baatar, Purevdorj Olkhanud, Kenya Sumitomo, Dennis Taub, Ronald Gress, Arya Biragyn
Regulatory CD25(+)CD4(+) T cells (Tregs) play an important role in the control of peripheral tolerance. In this study we demonstrate that human peripheral blood Tregs can be divided into two distinct populations based on the expression of CCR4. The majority ( approximately 75%) of freshly isolated Tregs express CCR4 and presumably represent memory-type Tregs. Interestingly, CCR4(-) Tregs require anti-CD3 Ab-mediated activation to acquire a regulatory activity, while CCR4(+) Tregs appear to be already primed to suppress the proliferation of CD8(+) T cells...
April 15, 2007: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/16937495/caffeic-acid-phenethyl-ester-modifies-the-th1-th2-balance-in-ileal-mucosa-after-gamma-irradiation-in-the-rat-by-modulating-the-cytokine-pattern
#5
Olivier Grémy, Marc Benderitter, Christine Linard
AIM: To pharmacologically modulate Th polarization in the ileum exposed to ionizing radiation by using the immuno-modulatory/apoptotic properties of Caffeic Acid Phenethyl Ester (CAPE). METHODS: Rats received CAPE (30 mg/kg) treatment ip 15 min prior to intestinal 10 Gy gamma-irradiation and once a day for a 6 d period after irradiation. Expression of genes implicated in Th differentiation in ileal mucosa (IL-23/IL-12Rbeta2), Th cytokine responses (IFN-gamma, IL-2, IL-4, IL-13), Th migratory behaviour (CXCR3, CCR5, CCR4), Th signalling suppressors (SOCS1, SOCS3), transcription factor (T-Bet, GATA-3) and apoptosis (FasL/Fas, TNF/TNFR, XIAP, Bax, caspase-3) was analyzed by RT-PCR 6 h and 7 d post-irradiation...
August 21, 2006: World Journal of Gastroenterology: WJG
1
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"