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Aquagenic pruritus

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https://www.readbyqxmd.com/read/25814730/aquagenic-keratoderma-treated-with-tap-water-iontophoresis
#1
Enzo Errichetti, Angelo Piccirillo
Aquagenic keratoderma (AK) is a rare acquired skin condition characterized by recurrent and transient white papules and plaques associated with a burning sensation, pain, pruritus and/or hyperhidrosis on the palms and more rarely, soles triggered by sweat or contact with water. Often AK cause significant discomfort, thus requiring an appropriate therapy. Topical aluminum-based products are the most commonly used medications, but they are not always effective. We report a case of AK unresponsive to topical 20% of aluminum chloride successfully treated with tap water iontophoresis...
March 2015: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/25681269/hypo-osmotic-shock-induced-subclinical-inflammation-of-skin-in-a-rat-model-of-disrupted-skin-barrier-function
#2
Chihiro Kishi, Takeo Minematsu, Lijuan Huang, Yuko Mugita, Aya Kitamura, Gojiro Nakagami, Takumi Yamane, Mikako Yoshida, Hiroshi Noguchi, Megumi Funakubo, Taketoshi Mori, Hiromi Sanada
Aging disrupts skin barrier function and induces xerosis accompanied by pruritus. In many cases, elderly patients complain of pruritus during skin hygiene care, a condition called aquagenic pruritus of the elderly (APE). To date, the pathophysiology and mechanism of action of APE have not been elucidated. We conducted the present study to test the hypothesis that hypo-osmotic shock of epidermal cells induces skin inflammation and elongation of C-fibers by nerve growth factor β (NGFβ) as a basic mechanism of APE...
March 2015: Biological Research for Nursing
https://www.readbyqxmd.com/read/25640024/idiopathic-aquagenic-pruritus-pathogenesis-and-effective-treatment-with-atenolol
#3
Taige Cao, Angeline Anning Yong, Kong Bing Tan, Hong Liang Tey
Aquagenic pruritus (AP) is a rare condition with unknown pathogenesis. We explored its pathogenesis through investigations of a patient and report the first case to be effectively treated with atenolol. A 36-year-old Indian female presented with idiopathic AP. Small-fiber neuropathy involving itch/pain-transmitting C-fibers appears to be pathogenetically important: compared with matched controls, our patient had increased intra-epidermal nerve fibers, raised warmth detection threshold, and marked hyperknesis to electrical stimulation...
May 2015: Dermatologic Therapy
https://www.readbyqxmd.com/read/25184867/images-in-clinical-medicine-aquagenic-keratoderma
#4
Eduardo David Poletti, Rocío Muñoz-Sandoval
A 44-year-old otherwise healthy man presented with thickening of his palms after their immersion in water, accompanied by burning pain, pruritus, and edema. Onset was at 37 years of age. The patient had no family history of similar skin findings and said that he did not have a history of..
September 4, 2014: New England Journal of Medicine
https://www.readbyqxmd.com/read/24941674/the-role-of-capsaicin-in-dermatology
#5
REVIEW
Katherine Boyd, Sofia M Shea, James W Patterson
Neurogenic pain and pruritus are the common chief complaints at dermatology office visits. Unfortunately, they are also notoriously difficult conditions to treat. Topical capsaicin used as a single therapy or as an adjuvant offers a low-risk option for patients who do not achieve control on other therapies. This chapter presents the evidence behind topical capsaicin use in dermatologic conditions characterized by neurogenic pain or pruritus, including postherpetic neuralgia, notalgia paresthetica, brachioradial pruritus, lichen simplex chronicus, prurigo nodularis, pruritus ani, pruritus of hemodialysis, aquagenic pruritus, apocrine chromhidrosis, lipodermatosclerosis, alopecia areata, and psoriasis...
2014: Progress in Drug Research. Fortschritte der Arzneimittelforschung. Progrès des Recherches Pharmaceutiques
https://www.readbyqxmd.com/read/24141429/-aquagenic-urticaria-a-case-report
#6
B Kreft, J Wohlrab, W C Marsch
A 38-year-old woman presented with recurrent episodes of urticaria after contact with water affecting the upper part of the body. We confirmed the diagnosis of aquagenic urticaria. Aquagenic urticaria is a rare form of contact urticaria with small wheals generally affecting the upper part of the body. It has to be distinguished from aquagenic pruritus. The pathogenetic mechanisms are not known in detail. Treatment with antihistamines, ultraviolet therapy or application of protective hydrophobic barrier creams could be effective...
February 2014: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/24000512/postcoital-generalised-pruritus-as-a-first-symptom-of-polycythaemia-vera
#7
O P Patidar, Rekha Patidar, R P Patidar
Ploycythaemia vera (PV) is most common of chronic myeloproliferative disorder that involves the multipotent haemaotopoietic progenitor cells. PV has indolent course and recognised either by incidental discovery of high haemoglobin or haemtocrit. PV may present with aquagenic pruritus (AP) for years together without any other sign and symptoms. So advice of simple complete bood count as a routine in every case of pruritus can be helpful to diagnose it timely thereby dreaded complications of PV, related to hyperviscosity of blood like thrombosis both arterial and venous can be managed antecedently...
January 2013: Journal of the Indian Medical Association
https://www.readbyqxmd.com/read/23790517/follow-up-of-patients-with-systemic-lupus-erythematosus-what-is-not-found-in-the-guidelines
#8
J Jiménez-Alonso, J A Vargas-Hitos, N Navarrete-Navarrete, M Zamora-Pasadas, S Aguilar-Huergo, L Jáimez, J M Sabio
A series of measures in the management of patients with systemic lupus erythematosus (SLE) which usually are not found in the lupus guidelines are discussed. In the lupus patient who has been well-controlled in the long term, the dose of hydroxychloroquine should be progressively reduced, without decreasing more than approximately 600 mg per week. We recommend taking this drug in the morning in patients with insomnia, at night in those with dyspepsia and to separate the intake of the drug from the shower (and the water should be as cool as possible) in those patients with aquagenic pruritus...
December 2013: Revista Clínica Espanõla
https://www.readbyqxmd.com/read/23657863/aquagenic-pruritus-in-polycythemia-vera-characteristics-and-influence-on-quality-of-life-in-441-patients
#9
Fabian P Siegel, Jan Tauscher, Petro E Petrides
Aquagenic pruritus (AP) is a symptom typical for polycythemia vera, but very little is known about its exact frequency, characteristics, influence on quality of life, and proper treatment. Therefore, we investigated these aspects in a large cohort of German patients with polycythemia vera using a patient directed questionnaire. Our analysis revealed that 301 of 441 analyzed patients suffered from AP. In 64.8%, AP occurred on average 2.9 years prior to diagnosis of polycythemia vera. Only in 15.4% did this lead to a hematological investigation...
August 2013: American Journal of Hematology
https://www.readbyqxmd.com/read/23602165/aquagenic-keratoderma-associated-with-a-mutation-of-the-cystic-fibrosis-gene
#10
V Coelho-Macias, S Fernandes, P Lamarão, F Assis-Pacheco, J Cardoso
Reported for the first time in 1996, aquagenic keratoderma is a rare condition which is characterized by edematous flat-topped papules appearing on palmar skin after water immersion. Multiple anecdotal associations have been described but, recently, the association with cystic fibrosis gene mutations (CFTR) has been highlighted. The authors describe an 18 year-old female, with one-month complaints of pruritus and swelling of palmar skin after water immersion. On examination, palmar skin was unremarkable but, 5 minutes after water immersion, multiple whitish papules became apparent...
May 2013: Revista Portuguesa de Pneumologia
https://www.readbyqxmd.com/read/23477795/aquagenic-pruritus-induced-by-clomipramine
#11
Mauro Vitor Mendlowicz, João Luiz Lopes Lima, Leonardo Franklin Fontenelle
OBJECTIVE: Aquagenic pruritus is the development of severe, prickling-like skin discomfort without observable skin lesions that is evoked by contact with water at any temperature. METHOD: This is a case report of a man presenting with aquagenic pruritus after starting clomipramine treatment for anxiety and depression. RESULTS: The patient's aquagenic pruritus resolved after discontinuing the clomipramine but reemerged when treatment was restarted...
September 2013: General Hospital Psychiatry
https://www.readbyqxmd.com/read/22813714/dermatoscopy-as-an-adjunctive-diagnostic-tool-in-aquagenic-syringeal-acrokeratoderma
#12
Engin Sezer, Emel Erkek, Deniz Duman, Sedef Sahin, Emel Cetin
Aquagenic syringeal acrokeratoderma (ASA) is a rare skin disorder of the palms and/or soles, characterized by whitish papules with occasional pruritus or pain sensation. Herein we report a 27-year-old man with a diagnosis of ASA based on clinical and histopathological features, and describe the dermatoscopic features consistent with threefold enlarged sweat duct pores compared with a normal-looking palmar skin area. As far as we are aware, dermatoscopic features of ASA have not been reported so far.
2012: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/22044449/aquagenic-wrinkling-of-the-palms-and-the-potential-role-for-genetic-testing
#13
REVIEW
Ligaya Park, Cherise Khani, Joan Tamburro
Aquagenic wrinkling of the palms (AWP) is a condition characterized by excessive wrinkling, palmar edema, and whitish papules accompanied by pain, pruritus, or discomfort after brief immersion of the hands in water. It is well documented to be associated with cystic fibrosis (CF), with several theories regarding the pathogenesis having been proposed. We report a case of two sisters with AWP in whom CF has not been diagnosed and review the literature on AWP and its association with CF and CF carrier status. Because diagnosis of mild forms CF or knowledge of an underlying CF genetic mutation is frequently unknown, identification of AWP may represent the only sign of such mutations...
May 2012: Pediatric Dermatology
https://www.readbyqxmd.com/read/21965864/aquagenic-pruritus-beneath-water-lies
#14
C Shanmuga Sekar, C R Srinivas, Sheja Jacob
No abstract text is available yet for this article.
July 2011: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/20597963/polycythemia-vera-associated-pruritus-and-its-management
#15
REVIEW
Kamal S Saini, Mrinal M Patnaik, Ayalew Tefferi
BACKGROUND: Pruritus is a defining feature of polycythemia vera (PV) and is seen in approximately 40% of patients. In most cases, the pruritus is characteristically triggered by contact with water (aquagenic) at any temperature. MATERIALS AND METHODS: A detailed MEDLINE search for all English language articles related to PV, PV-associated pruritus and aquagenic pruritus that were published from 1965 till date was carried out. RESULTS: Many different treatment options have been tried over the past several decades, including antihistamines, antidepressants, interferon alpha, phlebotomy, phototherapy, iron supplements and myelosuppressive medications, all demonstrating mixed results...
September 2010: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/20546386/aquagenic-pruritus-associated-diseases-and-clinical-pruritus-characteristics
#16
Tina Heitkemper, Tanja Hofmann, Ngoc Quan Phan, Sonja Ständer
BACKGROUND: Aquagenic pruritus (AP) can be induced by systemic diseases. The distribution of underlying diseases in a representative patient collective has not been investigated. This retrospective study aimed to determine the frequency and pruritus-specific parameter of systemic diseases in a series of patients. PATIENTS AND METHODS: Data of 39 patients with AP (24 f, 15 m; mean age: f: 51.3 ± 20.1, m: 57.2 ± 15.0 years) were obtained and statistically evaluated as follows: demographic data, pruritus characteristics, underlying diseases, family history...
October 2010: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/20462660/antipruritic-treatment-with-systemic-%C3%AE-opioid-receptor-antagonists-a-review
#17
REVIEW
Ngoc Quan Phan, Jeffrey D Bernhard, Thomas A Luger, Sonja Ständer
During the past two decades, systemic μ-opioid receptor antagonists (MORA) have been used in the treatment of various forms of chronic pruritus. In a number of case reports, case series, and controlled trials, treatment with MORA has demonstrated considerable antipruritic effects. In double-blind controlled studies, significant antipruritic relief has been achieved by MORA in cholestatic pruritus, chronic urticaria, and atopic dermatitis. In case reports and case series, antipruritic efficacy of MORA has been reported in prurigo nodularis, mycosis fungoides, postburn pruritus, aquagenic pruritus, hydroxyethyl starch-induced pruritus, and pruritus of unknown origin...
October 2010: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/20302572/frequency-of-aquagenic-palmoplantar-keratoderma-in-cystic-fibrosis-a-new-sign-of-cystic-fibrosis
#18
N Garçon-Michel, A-M Roguedas-Contios, G Rault, J Le Bihan, S Ramel, K Revert, A Dirou, L Misery
BACKGROUND: Aquagenic palmoplantar keratoderma (APPK), also known as aquagenic wrinkling of the palms, is characterized by oedema of palms and/or soles, whitish papules, hyperwrinkling and sometimes pruritus or pain after water immersion. Its frequency in the general population is unknown. About 40 cases have been reported to date, including some among patients with cystic fibrosis (CF) or CF heterozygotes. OBJECTIVES: To determine the frequency of APPK among patients with CF...
July 2010: British Journal of Dermatology
https://www.readbyqxmd.com/read/19608683/the-jak2v617-mutation-induces-constitutive-activation-and-agonist-hypersensitivity-in-basophils-from-patients-with-polycythemia-vera
#19
Lisa Pieri, Costanza Bogani, Paola Guglielmelli, Maria Zingariello, Rosa Alba Rana, Niccolò Bartalucci, Alberto Bosi, Alessandro M Vannucchi
BACKGROUND: The JAK2V617F mutation has been associated with constitutive and enhanced activation of neutrophils, while no information is available concerning other leukocyte subtypes. DESIGN AND METHODS: We evaluated correlations between JAK2V617F mutation and the count of circulating basophils, the number of activated CD63(+) basophils, their response in vitro to agonists as well as the effects of a JAK2 inhibitor. RESULTS: We found that basophil count was increased in patients with JAK2V617F -positive myeloproliferative neoplasms, particularly in those with polycythemia vera, and was correlated with the V617F burden...
November 2009: Haematologica
https://www.readbyqxmd.com/read/19374742/prevalence-and-characteristics-of-aquagenic-pruritus-in-a-young-african-population
#20
T A Salami, S O Samuel, K C Eze, E Irekpita, E Oziegbe, M O Momoh
BACKGROUND: Aquagenic pruritus (AP) occurs during or after contact of the skin with water such as occurs in bathing. METHODS: This study aims to describe the prevalence of aquagenic pruritus in a young adult population and describe the circumstances of bathing.A Population-based cross sectional study involving administration of Questionnaires to young adult Nigerians on the occurrence of pruritus associated with bathing. RESULTS: The prevalence of bathing pruritus among respondents in this study was 23...
2009: BMC Dermatology
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