keyword
https://read.qxmd.com/read/38533323/equity-in-the-developmental-dysplasia-of-the-hip-ddh-diagnosis-and-treatment-a-retrospective-cohort-study-to-unravel-the-effect-of-area-deprivation-and-the-insurance-type
#1
JOURNAL ARTICLE
Samantha L Ferraro, Sarah Dance, Delara Rajabi, Ahmed Elabd, Sean Tabaie
Background Timely diagnosis of developmental dysplasia of the hip (DDH) is crucial for implementing less invasive treatment. However, socioeconomic barriers may lead to late diagnoses. The Area Deprivation Index (ADI) is an indicator of the socioeconomic challenges experienced by patients and their families. The primary objective is to investigate if the age at which DDH is diagnosed and the treatment protocol are influenced by the ADI or the insurance type. Materials and methods Using International Classification of Diseases-Tenth Edition (ICD-10) codes, newly diagnosed DDH patients (age under 10 years) from 2020 to 2023 were retrospectively identified at our pediatric tertiary center...
March 2024: Curēus
https://read.qxmd.com/read/38531826/epidemiology-of-spondylolisthesis-a-nationwide-study-from-2001-to-2016-in-the-italian-population
#2
JOURNAL ARTICLE
Umile Giuseppe Longo, Sergio De Salvatore, Luca Denaro, Alessandro Mazzola, Ilaria Piergentili, Vincenzo Denaro
STUDY DESIGN: Epidemiological study. OBJECTIVE: This study aimed to evaluate the annual incidence of spondylolisthesis requiring surgery in Italy and the epidemiological characteristics of the patients. BACKGROUND: The health care system continues to incur considerable costs as a result of low-back pain. Segmental instability of the lumbar spine has attracted significant interest from researchers as a potential mechanism leading to mechanical low back pain...
March 27, 2024: Clinical Spine Surgery
https://read.qxmd.com/read/38521289/predictors-of-mortality-and-burden-of-arrhythmias-in-endstage-heart-failure
#3
REVIEW
Endurance Evbayekha, Akanimo Antia, Brittany Dixon, Craig K Reiss, Shane Larue
BACKGROUND: Heart failure (HF) is a significant cause of morbidity and mortality in the United States, contributing to approximately 1 in 8 deaths. Individuals with end-stage HF (eHF) experience debilitating symptoms leading to poor quality of life (QoL). METHODS: We used the ICD-10 code for eHF (I5084) from the National Inpatient Sample (NIS) (2016-2020) to identify all patients with eHF. We used a multivariable logistic regression model to adjust for confounders and estimate the mortality probability in each arrhythmia cohort...
March 21, 2024: Current Problems in Cardiology
https://read.qxmd.com/read/38521146/outcomes-of-acute-ischemic-stroke-among-patients-with-renal-cell-carcinoma-a-nationwide-analysis
#4
JOURNAL ARTICLE
Galadu Subah, Sabrina Zeller, Aarti Jain, Emma Bloom, Saya Mieth, Nimrod Gozum, Austin Li, Fangyi Lin, Anaz Uddin, Stuart Brill, Tarik Al-Bermani, Gurmeen Kaur, Chirag D Gandhi, Fawaz Al-Mufti
INTRODUCTION: Renal cell carcinoma (RCC) has been associated with an increased risk for acute ischemic stroke (AIS). As individuals with cancer who experience AIS tend to face higher mortality rates compared to AIS patients without cancer, recognizing the implications of RCC in AIS is crucial for identifying high-risk patients for major complications and directing management strategies. OBJECTIVE: To examine risk factors, interventions, and outcomes for patients with AIS stratified by their RCC diagnosis...
March 21, 2024: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://read.qxmd.com/read/38519415/an-all-in-one-immunomodulator-engineered-clinical-translatable-immunotherapy-of-advanced-hepatocellular-carcinoma
#5
JOURNAL ARTICLE
Ting Xie, Cong Huang, Yuqing Wang, Haitao Zhang, Pei Guo, Thuy Thu Phann, Yao Cheng, Longtianyang Lei, Zhenghao Tao, Qing Gao, Hua Wei, Cui-Yun Yu
Clinical treatment of advanced hepatocellular carcinoma (HCC) remains a significant challenge. The use of RRx-001 with the function of downregulating the expression of innate immune checkpoint molecule CD47 provides a powerful means for treating advanced HCC containing a substantial proportion of immunosuppressive macrophages. We reported herein engineering of a previously optimized DOX-delivery nanoplatform based on sodium alginate to further co-deliver RRx-001 (BEA-D@R) for efficient immunotherapy of advanced HCC...
March 22, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38516172/mn-phenolic-networks-as-synergistic-carrier-for-sting-agonists-in-tumor-immunotherapy
#6
JOURNAL ARTICLE
Yingcai Meng, Jiaxin Huang, Jinsong Ding, Haiyan Zhou, Yong Li, Wenhu Zhou
The cGAS-STING pathway holds tremendous potential as a regulator of immune responses, offering a means to reshape the tumor microenvironment and enhance tumor immunotherapy. Despite the emergence of STING agonists, their clinical viability is hampered by stability and delivery challenges, as well as variations in STING expression within tumors. In this study, we present Mn-phenolic networks as a novel carrier for ADU-S100, a hydrophilic STING agonist, aimed at bolstering immunotherapy. These nanoparticles, termed TMA NMs, are synthesized through the coordination of tannic acid and manganese ions, with surface modification involving bovine serum albumin to enhance their colloidal stability...
June 2024: Materials today. Bio
https://read.qxmd.com/read/38511676/lambda-double-fixation-for-medial-epicanthoplasty-in-blepharophimosis-ptosis-epicanthus-inversus-syndrome
#7
JOURNAL ARTICLE
Ramón Medel, Elena Scherrer, Lucía Castaño Fernández-Vega, Juan Ignacio Racana, Claudia Cordero, María Inmaculada Paños Palacios, Luz Maria Vasquez
PURPOSE: This study aims to describe a novel approach to medial epicanthoplasty in patients with blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) and evaluate the surgical outcome of this technique. METHODS: A retrospective, noncomparative, interventional case series involving 22 BPES patients who underwent medial epicanthoplasty using the Lambda-Double-Fixation technique (LDFT) performed by a single surgeon. Pre- and postoperative measurements of inner intercanthal distance (DIC) and horizontal palpebral fissure (HPFL) were recorded...
March 21, 2024: Orbit
https://read.qxmd.com/read/38511183/a-comprehensive-analysis-of-cardiovascular-mortality-trends-in-peru-from-2017-to-2022-insights-from-183-386-deaths-of-the-national-death-registry
#8
JOURNAL ARTICLE
Hugo G Quezada-Pinedo, Noushin Sadat Ahanchi, Kim N Cajachagua-Torres, Jordan A Obeso-Manrique, Luis Huicho, Christoph Gräni, Taulant Muka
BACKGROUND/OBJECTIVES: Cardiovascular diseases are the leading cause of global mortality. Systematic studies on cardiovascular-related mortality at national and subnational levels in Peru are lacking. We aimed to describe the trends in cardiovascular-related mortality between 2017 and 2022 in Peru at national and subnational levels and by socioeconomic indicators. SUBJECTS/METHODS: We used data from the Peruvian death registry 2017-2022. Using ICD-10 codes, mortality was categorized into: hypertensive-, coronary-, and cerebrovascular- related deaths...
November 2023: American heart journal plus: cardiology research and practice
https://read.qxmd.com/read/38510954/trends-in-the-incidence-and-in-patient-outcomes-of-acute-myocardial-infarction-in-pregnancy-insights-from-the-national-inpatient-sample
#9
JOURNAL ARTICLE
Favour Markson, Rimaskep Garba Shamaki, Akanimo Antia, Anita Osabutey, Modele O Ogunniyi
STUDY OBJECTIVE: Pregnancy-related morbidity and mortality rates in the United States are rising despite advances in knowledge, technology, and healthcare delivery. Cardiovascular disease is the leading cause of adverse pregnancy outcomes, with acute myocardial infarction (AMI) being a potential contributor to the worse outcomes in pregnancy. DESIGN/SETTING: We analyzed data from the national inpatient sample database to examine trends in the incidence and in-hospital outcomes of myocardial infarction in pregnancy from 2016 to 2020...
October 2023: American heart journal plus: cardiology research and practice
https://read.qxmd.com/read/38510636/term-and-definition-of-a-deformity-after-a-spine-trauma-results-of-an-international-delphi-study
#10
JOURNAL ARTICLE
E E A De Gendt, S P J Muijs, L M Benneker, F C Oner
INTRODUCTION: Deformity of the spinal column after trauma could lead to pain, impaired function, and may sometimes necessitate extensive and high-risk surgery. This 'condition' has multiple terms and definitions that are used in research and clinics. A specific term and definition of this condition however is still lacking. A uniform and internationally accepted term and definition are necessary to compare cases and treatments in the future. RESEARCH QUESTION: Reach consensus on the term and definition of this deformity after spine trauma using a Delphi approach...
2024: Brain Spine
https://read.qxmd.com/read/38506890/risk-of-infections-related-to-endovascular-catheters-and-cardiac-implantable-devices-in-hemodialysis-patients
#11
REVIEW
Gaetano Alfano, Niccolò Morisi, Silvia Giovanella, Monica Frisina, Alessio Amurri, Lorenzo Tei, Maria Ferri, Giulia Ligabue, Gabriele Donati
Patients requiring dialysis are extremely vulnerable to infectious diseases. The high burden of comorbidities and weakened immune system due to uremia and previous immunosuppressive therapy expose the patient on dialysis to more infectious events than the general population. The infectious risk is further increased by the presence of endovascular catheters and implantable cardiologic devices. The former is generally placed as urgent vascular access for dialysis and in subjects requiring hemodialysis treatments without autogenous arteriovenous fistula...
March 20, 2024: Journal of Vascular Access
https://read.qxmd.com/read/38501328/implantable-cardioverter-defibrillator-lead-failure-and-revision-following-transcutaneous-bicaval-valve-tricvalve%C3%A2-implantation
#12
Allan Plant, Fergus Stewart, Darren Hooks
INTRODUCTION: Tricuspid regurgitation is associated with significant morbidity and mortality, and occurs at a higher rate in patients with cardiovascular implantable electronic devices. Percutaneous strategies for managing tricuspid regurgitation are evolving, including the development of bicaval valve implantation which has been successfully used in patients with pacing leads. METHODS AND RESULTS: We present the first documented case of lead failure following TricValve® implantation, a dedicated self-expanding system for bicaval valve implantation, and the first successful lead revision procedure in this setting...
March 19, 2024: Journal of Cardiovascular Electrophysiology
https://read.qxmd.com/read/38498970/ligand-regulation-strategy-to-modulate-ros-nature-in-a-rhodamine-iridium-iii-hybrid-system-for-phototherapy
#13
JOURNAL ARTICLE
Fangfang Wei, Feng Chen, Siye Wu, Menglei Zha, Jiqiang Liu, Ka-Leung Wong, Kai Li, Keith Man-Chung Wong
The efficacy of photodynamic therapy (PDT) is highly dependent on the photosensitizer features. The reactive oxygen species (ROS) generated by photosensitizers is proven to be associated with immunotherapy by triggering immunogenic cell death (ICD) as well. In this work, we establish a rhodamine-iridium(III) hybrid model functioning as a photosensitizer to comprehensively understand its performance and potential applications in photodynamic immunotherapy. Especially, the correlation between the ROS generation efficiency and the energy level of the Ir(III)-based excited state (T1 '), modulated by the cyclometalating (C∧ N) ligand, is systematically investigated and correlated...
March 18, 2024: Inorganic Chemistry
https://read.qxmd.com/read/38496106/a-case-series-of-paederus-dermatitis-understanding-its-varied-and-diverse-clinical-presentations
#14
JOURNAL ARTICLE
Bhanupriya Tamilselvan, Srikanth Shanmugam, Pragasam Shakthi
Introduction  Paederus dermatitis arises from inadvertent skin contact with insects of the genus Paederus , leading to irritant contact dermatitis. This study aims to highlight the diverse clinical presentations and the remarkable ability of the disease to mimic various dermatological conditions.  Methodology  A total of 15 patients diagnosed with Paederus dermatitis in a period of four months from August 2023 to November 2023 were included in this retrospective study. The demographic profile, detailed history, clinical presentation, and site of lesion distribution were documented...
February 2024: Curēus
https://read.qxmd.com/read/38495409/the-role-of-early-cardiac-resynchronization-therapy-implantation-in-dilated-cardiomyopathy-patients-with-narrow-qrs-carrying-lamin-a-c-mutation
#15
JOURNAL ARTICLE
Miry Blich, Wisam Darawsha, Allon Eyal, Faheem Shehadeh, Monther Boulous, Lior Gepstein, Mahmoud Suleiman
BACKGROUND: Dilated cardiomyopathy (DCM) caused by Lamin A/C gene (LMNA) mutation is complicated with atrioventricular conduction disturbances, malignant ventricular arrhythmias and progressive severe heart failure. OBJECTIVE: We hypothesized that early cardiac resynchronization therapy (CRT) implantation in LMNA mutation carriers with an established indication for pacemaker or implantable cardioverter defibrillator (ICD), may preserve ejection fraction, and delay disease progression to end stage heart failure...
2024: American Journal of Cardiovascular Disease
https://read.qxmd.com/read/38493795/global-regional-and-national-burden-of-disorders-affecting-the-nervous-system-1990-2021-a-systematic-analysis-for-the-global-burden-of-disease-study-2021
#16
JOURNAL ARTICLE
(no author information available yet)
BACKGROUND: Disorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not include neurodevelopmental disorders, as defined by the International Classification of Diseases (ICD)-11, or a subset of cases of congenital, neonatal, and infectious conditions that cause neurological damage...
March 5, 2024: Lancet Neurology
https://read.qxmd.com/read/38492178/pacing-and-defibrillation-consideration-in-the-era-of-transcatheter-tricuspid-valve-replacement
#17
REVIEW
Devinder S Dhindsa, Wissam Mekary, Mikhael F El-Chami
PURPOSE OF REVIEW: Tricuspid regurgitation is a commonly encountered valvular pathology in patients with trans-tricuspid pacing or implantable cardioverter-defibrillator leads. Transcatheter tricuspid valve interventions are increasingly performed in patients at high surgical risk. Implantation of these valves can lead to the "jailing" of a trans-tricuspid lead. This practice carries both short- and long-term risks of lead failure and subsequent infection without the ability to perform traditional transvenous lead extraction...
March 16, 2024: Current Cardiology Reports
https://read.qxmd.com/read/38491478/the-impact-of-multimorbidity-among-adults-with-cardiovascular-diseases-on-healthcare-costs-in-indonesia-a-multilevel-analysis
#18
JOURNAL ARTICLE
Royasia Viki Ramadani, Mikael Svensson, Sven Hassler, Budi Hidayat, Nawi Ng
BACKGROUND: Cardiovascular diseases (CVDs) are the leading cause of death in Indonesia, accounting for 38% of the total mortality in 2019. Moreover, healthcare spending on CVDs has been at the top of the spending under the National Health Insurance (NHI) implementation. This study analyzed the association between the presence of CVDs with or without other chronic disease comorbidities and healthcare costs among adults (> 30 years old) and if the association differed between NHI members in the subsidized group (poorer) and non-subsidized households group (better-off) in Indonesia...
March 15, 2024: BMC Public Health
https://read.qxmd.com/read/38490966/risk-factors-for-readmission-following-surgical-decompression-for-spinal-epidural-abscesses-an-analysis-of-4595-patients
#19
JOURNAL ARTICLE
Mitchell K Ng, Ariel Rodriguez, Aaron Lam, Ahmed Emara, Ian J Wellington, Nicholas U Ahn, Amrit S Khalsa, John K Houten, Ahmed Saleh, Afshin E Razi
STUDY DESIGN: Retrospective cohort study. OBJECTIVES: The study aimed to (1) compare baseline demographics of patients undergoing surgery for SEA who were/were not readmitted; (2) identify risk factors for 90-day readmissions; and (3) quantify 90-day episode-of-care health care costs. BACKGROUND: Spinal epidural abscess (SEA), while rare, occurring ~2.5-5.1/10,000 admissions, may lead to permanent neurologic deficits and mortality. Definitive treatment often involves surgical intervention via decompression...
March 12, 2024: Clinical Spine Surgery
https://read.qxmd.com/read/38489540/assessing-the-impact-of-transitioning-to-11th-revision-of-the-international-classification-of-diseases-icd-11-on-comorbidity-indices
#20
JOURNAL ARTICLE
Jean Noel Nikiema, Djeneba Thiam, Azadeh Bayani, Alexandre Ayotte, Nadia Sourial, Michèle Bally
OBJECTIVES: This study aimed to support the implementation of the 11th Revision of the International Classification of Diseases (ICD-11). We used common comorbidity indices as a case study for proactively assessing the impact of transitioning to ICD-11 for mortality and morbidity statistics (ICD-11-MMS) on real-world data analyses. MATERIALS AND METHODS: Using the MIMIC IV database and a table of mappings between the clinical modification of previous versions of ICD and ICD-11-MMS, we assembled a population whose diagnosis can be represented in ICD-11-MMS...
March 15, 2024: Journal of the American Medical Informatics Association: JAMIA
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