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https://www.readbyqxmd.com/read/29279923/evidence-required-for-drugs-granted-accelerated-approval-reply
#1
LETTER
Huseyin Naci, Aaron S Kesselheim
No abstract text is available yet for this article.
December 26, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29228534/a-case-with-short-stature-growth-hormone-deficiency-and-46-xx-xq27-qter-deletion
#2
Şule Yıldırım, Naci Topaloğlu, Mustafa Tekin, Fatma Sılan
We report a case of 11-year-old girl with growth retardation and 46, XX, Xq27-qter deletion. The endocrinologic evaluation revealed growth hormone deficiency. In karyotype analysis  46, XX, Xq27-qter deletion was determined. The deletion of terminal region of chromosome 27 is most commonly being detected during the evaluation of infertility, premature ovarian insufficiency or in screening for fragile X carrier status. To our knowledge, this is the first reported case with 46, XX, Xq27-qter deletion and growth hormone deficiency...
October 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29223517/combined-spinal-arteriovenous-malformation-and-spinal-dysraphism
#3
Civan Islak, Sedat Giray Kandemirli, Osman Kizilkilic, Naci Kocer, Saffet Tuzgen, Mehmet Murat Hanci
BACKGROUND: Spinal vascular malformations as a group are rare entities and coexistence of spinal arteriovenous malformation in or around the spinal dysraphism is extremely rare. CASE DESCRIPTION: Herein, we report two cases of combined spinal dysraphism and vascular malformations of the spinal cord. The first case is an arteriovenous malformation located in a filum terminale lipoma fed by the artery of filum terminale. This case was managed by multiple endovascular embolizations followed by surgery...
December 6, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29208168/biochemical-evaluation-of-hydroxyurea-derivative-schiff-bases-in-liver-of-rats
#4
Akif Evren Parlak, Yusuf Karagozoglu, Naci O Alayunt, Semra Turkoglu, Isil Yildirim, Mustafa Karatepe, Metin Koparir
In this study, it was aimed to examine the antioxidant and antihepatotoxic effects of hydroxyurea derivative Schiff bases on serum biochemical parameters (AST, ALT, LDH, urea, creatinine and total bilirubin) and antioxidant parameters (SOD, CAT, GPx, MDA). In this study, a total of 49 adult male Wistar rats was examined and they were divided into 7 equal groups. DMSO, which is diluted only with corn oil, was administered to control group. 25 mg / kg ligand, 25 mg / kg Schiff base - manganese, 25 mg / kg Schiff base-copper, 25 mg / kg Schiff base - zinc, 25 mg / kg Schiff base - nickel, 25 mg / kg Schiff base - cobalt complexes were administered to rats of experimental group subcutaneously for 15 days with three-day intervals throughout the test process...
November 30, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29206965/training-the-next-generation-of-cardiovascular-leaders-in-health-policy-and-economics
#5
Huseyin Naci, Paulus Kirchhof, Alec Vahanian, Jan Steffel, Isabel Bardinet, Elias Mossialos
No abstract text is available yet for this article.
December 1, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29172096/serum-agouti-related-protein-agrp-levels-in-bipolar-disorder-could-agrp-be-a-state-marker-for-mania
#6
Naci Parlak, Yasemin Görgülü, Rugül Köse Çinar, Mehmet Bülent Sönmez, Ebru Parlak
Orexigenic and anorexigenic peptides, especially agouti-related protein (AgRP) and leptin, play important roles in the regulation of energy homeostasis in bipolar disorder. AgRP regulates energy metabolism by increasing appetite and decreasing energy expenditure. The resting energy expenditures of patients with manic bipolar disorder are higher than those of controls. Due to the effects of AgRP on energy expenditure and the increased physical activity of manic patients, we hypothesised that serum AgRP levels may be lower in manic patients than in euthymic patients and controls...
November 6, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29167710/influence-of-nicotine-on-machined-and-anodized-surface-implants-histometric-analysis
#7
Maria-Salete-Sandini Linden, Luiz-Renato Paranhos, João-Paulo De Carli, Micheline-Sandini Trentin, Marcos-Eugênio de Bittencourt, Pâmela-Letícia Santos, Francisco-Carlos Groppo, Juliana-Camma Ramacciato
Background: The nicotine may generate a influence on bone repair and longevity of dental implants. This fact makes studies to improve the surface of the implants are constantly conducted. This study aimed to evaluate the influence of subcutaneous nicotine injection in the osseointegration process on different implant surfaces, through histomorphometric analysis. Material and Methods: Therefore, twenty-two male rabbits were randomly distributed into two groups according to the subcutaneous injections: (1) nicotine, 3 mg/day/kg and (2) 0...
October 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29167095/accelerated-access-to-new-drugs-and-technologies
#8
EDITORIAL
Huseyin Naci, Elias Mossialos
No abstract text is available yet for this article.
November 22, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29129763/mammillothalamic-and-mammillotegmental-tracts-as-new-targets-for-dementia-and-epilepsy-treatment
#9
REVIEW
Naci Balak, Ece Balkuv, Ali Karadag, Recep Basaran, Huseyin Biceroglu, Buruç Erkan, Necmettin Tanriover
Very recently, neuromodulation through deep brain stimulation (DBS) has appeared as a new surgical procedure in the treatment of some types of dementia and epilepsy. The mammillothalamic and the mammillotegmental tracts are involved among the new targets. To our knowledge, a review article focused specifically on these mammillary body efferents is lacking in the medical literature. Their contribution to memory is, regrettably, often overlooked. There is evidence that mammillary bodies can contribute to memory independently from hippocampal formation, but the mechanism is not yet known...
November 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29091313/exenatide-upregulates-gene-expression-of-glucagon-like-peptide-1-receptor-and-nerve-growth-factor-in-streptozotocin-nicotinamide-induced-diabetic-mice
#10
Esen Gumuslu, Naci Cine, Merve Ertan, Oguz Mutlu, Ipek Komsuoglu Celikyurt, Guner Ulak
Glucagon like peptide-1 (GLP-1) is an incretine hormon that has modulating effects on insulin release. GLP-1 and receptors for GLP-1 are widely expressed throughout the body including brain.The expression of GLP-1 receptors is very specific to large neurons in hippocampus, neocortex and cerebellum. GLP-1 receptor stimulation enhances glucose-dependent insulin secretion and lowers blood glucose in type 2 diabetes mellitus. Studies on adipobiology of neurotrophins have focused on nerve growth factor (NGF) as an example of adipose-derived neurotrophins...
November 1, 2017: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/29081710/complications-and-midterm-outcomes-of-hemiarthroplasty-in-hemodialysis-patients
#11
Ahmet Salduz, Gökhan Polat, Turgut Akgül, Omer Naci Ergin, Koray Şahin, Önder Yazicioğlu
OBJECTIVE: The aim of this study was to evaluate the functional results, complications, and morbidity and mortality rates in patients with end-stage chronic renal failure (ESCRF) with collum femoris fractures who were treated with hemiarthroplasty. METHODS: From 2005 to 2013, patients with ESCRF admitted to our hospital with collum femoris fracture and treated with hemiarthroplasty were retrospectively evaluated, and 44 hips in 42 patients were included in the study...
September 2017: Acta Ortopedica Brasileira
https://www.readbyqxmd.com/read/29077212/genetic-variability-human-respiratory-syncytial-virus-subgroups-a-and-b-in-turkey-during-six-successive-epidemic-seasons-2009-2015
#12
Fatma Bayrakdar, Can Naci Kocabaş, Ayşe Başak Altaş, H Gökhan Kavuncuoğlu, Yasemin Coşgun, Emine Dibek Mısırlıoğlu Shahbazi, İhsan Durmaz, Gülay Korukluoğlu, Aykut Özkul
Human respiratory syncytial virus (HRSV) is most important viral respiratory pathogen of acute lower respiratory tract infections in infants and young children worldwide. The circulating pattern and genetic characteristics in the HRSV attachment glycoprotein gene was investigated in Turkey during 6 consecutive seasons from 2009 to 2015. HRSVA was dominant in the all epidemic seasons except 2011-2012 season. Partial sequences of the HVR2 region of the G gene of 479 HRSVA and 135 HRSVB were obtained. Most Turkish strains belonged to NA1, ON1 and BA9, which were the predominant genotypes circulating worldwide...
October 27, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/29051880/an-exceptional-case-of-suture-granuloma-30-years-following-an-open-repair-of-achilles-tendon-rupture-a-case-report
#13
Ömer Naci Ergin, Mehmet Demirel, Emre Özmen
INTRODUCTION: Rupture of the Achilles' tendon is a common injury occurring particularly in middle-aged men due to sports trauma. Operative treatment is preferred generally due to lower risk of re-rupture. Possible complications of the operation include suture granulomas. Suture granulomas might represent a foreign body reaction, which itself is the end-stage response of the inflammatory wound-healing process to biomaterials. It may occur with both absorbable and non-absorbable suture materials such as silk in our case...
May 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29027499/non-infectious-fever-after-acute-spinal-cord-injury-in-the-intensive-care-unit
#14
Fatma Ülger, Mehtap Pehlivanlar Küçük, Çağatay Erman Öztürk, İskender Aksoy, Ahmet Oğuzhan Küçük, Naci Murat
Objective The aim of the present study is to evaluate the frequency, etiology, risk factors and clinical outcomes in acute traumatic SCI patients who develop fever and to evaluate the relationship between fever and mortality. Design Retrospective data were collected between January 2007 and August 2016 from patients diagnosed with persistent fever from SCI cases observed in the ICU. Participants Among 5370 intensive care patients, 435 SCI patients were evaluated for the presence of fever. A total of 52 patients meeting the criteria were evaluated...
October 13, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28990886/-assessing-the-knowledge-in-primary-health-care-following-an-educational-course-structured-in-the-context-of-gard-chronic-airway-diseases-national-control-program
#15
Ferda Öner Erkekol, Nurdan Köktürk, Dilşad Mungan, Cansın Saçkesen, Zeynep Pınar Önen, Seçil Özkan, Arzu Balkan, Pınar Ergün, Can Naci Kocabaş, Nur Baran Aksakal, Banu Ekici, Zübeyde Özkan Altunay, Bilun Gemicioğlu, Arzu Yorgancıoğlu
Introduction: Chronic obstructive pulmonary diseases are common causes of disease in the community and account for considerable percent of the caseload in primary health care facilities. For this reason, it is important to question and improve the knowledge of primary health care physicians. This study is designed to assess the level of knowledge for bronchial asthma and COPD of the primary healthcare physicians, both before and immediately after an educational course structured in the context of GARD Chronic Airway Diseases National Control Program...
June 2017: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/28978555/availability-of-evidence-of-benefits-on-overall-survival-and-quality-of-life-of-cancer-drugs-approved-by-european-medicines-agency-retrospective-cohort-study-of-drug-approvals-2009-13
#16
Courtney Davis, Huseyin Naci, Evrim Gurpinar, Elita Poplavska, Ashlyn Pinto, Ajay Aggarwal
Objective To determine the availability of data on overall survival and quality of life benefits of cancer drugs approved in Europe.Design Retrospective cohort study.Setting Publicly accessible regulatory and scientific reports on cancer approvals by the European Medicines Agency (EMA) from 2009 to 2013.Main outcome measures Pivotal and postmarketing trials of cancer drugs according to their design features (randomisation, crossover, blinding), comparators, and endpoints. Availability and magnitude of benefit on overall survival or quality of life determined at time of approval and after market entry...
October 4, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28922237/minimizing-the-harm-of-accidental-awareness-under-general-anesthesia-new-perspectives-from-patients-misdiagnosed-as-being-in-a-vegetative-state
#17
Mackenzie Graham, Adrian M Owen, Kaman Çipi, Charles Weijer, Lorina Naci
No abstract text is available yet for this article.
September 14, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28875355/is-there-an-association-between-flow-diverter-fish-mouthing-and-delayed-type-hypersensitivity-to-metals-a-case-control-study
#18
Naci Kocer, Prabath Kumar Mondel, Elif Yamac, Ayse Kavak, Osman Kizilkilic, Civan Islak
PURPOSE: Flow diverters are increasingly used in the treatment of complex and giant intracranial aneurysms. However, they are associated with complications like late aneurysmal rupture. Additionally, flow diverters show focal structural decrease in luminal diameter without any intimal hyperplasia. This resembles a "fish mouth" when viewed en face. In this pilot study, we tested the hypothesis of a possible association between flow diverter fish-mouthing and delayed-type hypersensitivity to its metal constituents...
November 2017: Neuroradiology
https://www.readbyqxmd.com/read/28874370/n-acetylglucosamine-1-phosphate-transferase-weca-as-a-validated-drug-target-in-mycobacterium-tuberculosis
#19
Stanislav Huszár, Vinayak Singh, Alica Polčicová, Peter Baráth, María Belén Barrio, Sophie Lagrange, Véronique Leblanc, Carol A Nacy, Valerie Mizrahi, Katarína Mikušová
The mycobacterial phosphoglycosyltransferase WecA, which initiates arabinogalactan biosynthesis in Mycobacterium tuberculosis, has been proposed as a target of the caprazamycin derivative CPZEN-45, a preclinical drug candidate for the treatment of tuberculosis. In this report, we describe the functional characterization of mycobacterial WecA and confirm the essentiality of its encoding gene in M. tuberculosis by demonstrating that the transcriptional silencing of wecA is bactericidal in vitro and in macrophages...
November 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28828208/protein-microarray-analysis-identifies-key-cytokines-associated-with-malignant-middle-cerebral-artery-infarction
#20
Zhonghe Zhou, Jinghua Zhang, Xiaoqiu Li, Cheng Xia, Yaling Han, Huisheng Chen
INTRODUCTION: We aimed to explore potential cytokines involved in the malignant middle cerebral artery infarction (MMI) and elucidate their underlying regulatory mechanisms. METHODS: We first developed a cytokine profile by Quantibody(®) Human Cytokine Antibody Array7000 using serum samples from eight patients with MMI and eight patients with non-acute cerebral infarction (NACI). The differentially expressed cytokines were then identified in patients with MMI using two-tailed Student's t-test and Fisher's Exact Test compared with patients with NACI...
August 2017: Brain and Behavior
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