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https://www.readbyqxmd.com/read/28922237/minimizing-the-harm-of-accidental-awareness-under-general-anesthesia-new-perspectives-from-patients-misdiagnosed-as-being-in-a-vegetative-state
#1
Mackenzie Graham, Adrian M Owen, Kaman Çipi, Charles Weijer, Lorina Naci
No abstract text is available yet for this article.
September 14, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28875355/is-there-an-association-between-flow-diverter-fish-mouthing-and-delayed-type-hypersensitivity-to-metals-a-case-control-study
#2
Naci Kocer, Prabath Kumar Mondel, Elif Yamac, Ayse Kavak, Osman Kizilkilic, Civan Islak
PURPOSE: Flow diverters are increasingly used in the treatment of complex and giant intracranial aneurysms. However, they are associated with complications like late aneurysmal rupture. Additionally, flow diverters show focal structural decrease in luminal diameter without any intimal hyperplasia. This resembles a "fish mouth" when viewed en face. In this pilot study, we tested the hypothesis of a possible association between flow diverter fish-mouthing and delayed-type hypersensitivity to its metal constituents...
September 5, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28874370/n-acetylglucosamine-1-phosphate-transferase-weca-as-a-validated-drug-target-in-mycobacterium-tuberculosis
#3
Stanislav Huszár, Vinayak Singh, Alica Polčicová, Peter Baráth, María Belén Barrio, Sophie Lagrange, Véronique Leblanc, Carol A Nacy, Valerie Mizrahi, Katarína Mikušová
The mycobacterial phosphoglycosyltransferase, WecA, which initiates arabinogalactan biosynthesis in Mycobacterium tuberculosis, has been proposed as a target of the caprazamycin derivative, CPZEN-45, a preclinical drug candidate for treatment of tuberculosis. In this report, we describe the functional characterization of mycobacterial WecA and confirm the essentiality of its encoding gene in M. tuberculosis by demonstrating that transcriptional silencing of wecA is bactericidal in vitro and in macrophages. Silencing of wecA also conferred hypersensitivity of M...
September 5, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28828208/protein-microarray-analysis-identifies-key-cytokines-associated-with-malignant-middle-cerebral-artery-infarction
#4
Zhonghe Zhou, Jinghua Zhang, Xiaoqiu Li, Cheng Xia, Yaling Han, Huisheng Chen
INTRODUCTION: We aimed to explore potential cytokines involved in the malignant middle cerebral artery infarction (MMI) and elucidate their underlying regulatory mechanisms. METHODS: We first developed a cytokine profile by Quantibody(®) Human Cytokine Antibody Array7000 using serum samples from eight patients with MMI and eight patients with non-acute cerebral infarction (NACI). The differentially expressed cytokines were then identified in patients with MMI using two-tailed Student's t-test and Fisher's Exact Test compared with patients with NACI...
August 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28814358/frequency-of-selective-immediate-responders-to-aminopenicillins-and-cephalosporins-in-turkish-children
#5
Emine Dibek Misirlioglu, Hakan Guvenir, Muge Toyran, Emine Vezir, Murat Capanoglu, Ersoy Civelek, Betul Buyuktiryaki, Tayfur Ginis, Can Naci Kocabas
BACKGROUND: Beta-lactam antibiotics (BLA) are the most commonly prescribed antibiotics and are responsible for the majority of immediate hypersensitivity reactions to drugs in children. Cross-reactivity is important in hypersensitivity to BLAs because these drugs all share a common beta-lactam structure and some share similar side chains. OBJECTIVE: The aim of this study was to evaluate the clinical characteristics of patients who are diagnosed with immediate-type BLA hypersensitivity and frequency of patients with side chain hypersensitivity, "selective responders...
September 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28810023/characteristics-of-preapproval-and-postapproval-studies-for-drugs-granted-accelerated-approval-by-the-us-food-and-drug-administration
#6
Huseyin Naci, Katelyn R Smalley, Aaron S Kesselheim
Importance: Drugs treating serious or life-threatening conditions can receive US Food and Drug Administration (FDA) accelerated approval based on showing an effect in surrogate measures that are only reasonably likely to predict clinical benefit. Confirmatory trials are then required to determine whether these effects translate to clinical improvements. Objective: To characterize preapproval and confirmatory clinical trials of drugs granted accelerated approval...
August 15, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28803706/health-policy-in-times-of-austerity-a-conceptual-framework-for-evaluating-effects-of-policy-on-efficiency-and-equity-illustrated-with-examples-from-europe-since-2008
#7
Martin Wenzl, Huseyin Naci, Elias Mossialos
The objective of this paper is to provide a framework for evaluation of changes in health policy against overarching health system goals. We propose a categorisation of policies into seven distinct health system domains. We then develop existing analytical concepts of insurance coverage and cost-effectiveness further to evaluate the effects of policies in each domain on equity and efficiency. The framework is illustrated with likely effects of policy changes implemented in a sample of European countries since 2008...
September 2017: Health Policy
https://www.readbyqxmd.com/read/28756119/what-to-do-or-not-to-do-when-randomization-is-not-possible
#8
EDITORIAL
Huseyin Naci
No abstract text is available yet for this article.
July 17, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28749553/myelopathy-in-beh%C3%A3-et-s-disease-the-bagel-sign
#9
Ugur Uygunoglu, Burcu Zeydan, Yesim Ozguler, Serdal Ugurlu, Emire Seyahi, Naci Kocer, Civan Islak, Kejal Kantarci, Sabahattin Saip, Aksel Siva, Orhun H Kantarci
OBJECTIVE: To describe the clinical and distinctive imaging features of myelopathy associated with Behçet's disease (BD). METHODS: We evaluated the records of patients meeting the following criteria: (1) fulfillment of the International Study Group criteria for BD; (2) clinically suggestive of myelopathy; (3) simultaneous spinal cord and brain magnetic resonance images (MRIs) within 1 month of acute worsening of myelopathy; and (4) follow-up duration ≥ 1 year after initial MRI evaluation...
August 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28736662/can-time-resolved-nirs-provide-the-sensitivity-to-detect-brain-activity-during-motor-imagery-consistently
#10
Androu Abdalmalak, Daniel Milej, Mamadou Diop, Mahsa Shokouhi, Lorina Naci, Adrian M Owen, Keith St Lawrence
Previous functional magnetic resonance imaging (fMRI) studies have shown that a subgroup of patients diagnosed as being in a vegetative state are aware and able to communicate by performing a motor imagery task in response to commands. Due to the fMRI's cost and accessibility, there is a need for exploring different imaging modalities that can be used at the bedside. A promising technique is functional near infrared spectroscopy (fNIRS) that has been successfully applied to measure brain oxygenation in humans...
April 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28689831/successful-desensitization-of-elosulfase-alfa-induced-anaphylaxis-in-a-pediatric-patient-with-morquio-syndrome
#11
Hakan Guvenir, Emine Dibek Misirlioglu, Murat Capanoglu, Betul Buyuktiryaki, Ozlem Unal, Muge Toyran, Can Naci Kocabas
No abstract text is available yet for this article.
July 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28599141/chinese-yellow-dust-and-korean-infant-health
#12
Duha T Altindag, Deokrye Baek, Naci Mocan
Naturally-occurring Yellow Dust outbreaks, which are produced by winds flowing to Korea from China and Mongolia, create air pollution. Although there is a seasonal pattern of this phenomenon, there exists substantial variation in its timing, strength, and location from year to year. To warn residents about air pollution in general, and about these dust storms in particular, Korean authorities issue different types of public alerts. Using birth certificate data on more than 1.5 million babies born between 2003 and 2011, we investigate the impact of air pollution, and the avoidance behavior triggered by pollution alerts on various birth outcomes...
August 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28589600/timing-and-characteristics-of-cumulative-evidence-available-on-novel-therapeutic-agents-receiving-food-and-drug-administration-accelerated-approval
#13
Huseyin Naci, Olivier J Wouters, Radhika Gupta, John P A Ioannidis
Policy Points: Randomized trials-the gold standard of evaluating effectiveness-constitute a small minority of existing evidence on agents given accelerated approval. One-third of randomized trials are in therapeutic areas outside of FDA approval and less than half evaluate the therapeutic benefits of these agents but use them instead as common backbone treatments. Agents receiving accelerated approval are often tested concurrently in several therapeutic areas. For most agents, no substantial time lag is apparent between the average start dates of randomized trials evaluating their effectiveness and those using them as part of background therapies...
June 2017: Milbank Quarterly
https://www.readbyqxmd.com/read/28530778/a-comparison-of-the-treatment-results-of-dpen-reduction-internal-fixation-and-intramedullary-nailing-in-adult-forearm-diaphyseal-fractures
#14
Ahmet Köse, Ali Aydın, Naci Ezirmik, Ömer Selim Yıldırım
BACKGROUND: We compared the union and functional results of intramedullary nailing and open reduction internal fixation treatment applied to adults with a forearm diaphysis fracture (fracture of the radius and/or ulna). METHODS: We retrospectively examined 90 patients with completed skeletal maturation who were surgically treated for a forearm diaphyseal fracture. Patients with a Monteggia Galeazzi and ipsilateral upper extremity fracture and those with an open epiphyseal line, Type 3 open fracture, pathological fracture, or brain trauma were excluded from the study...
May 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/28521566/quality-of-life-in-turkish-infertile-couples-and-related-factors
#15
Asli Goker, Emre Yanikkerem, Ozer Birge, Naci Kemal Kuscu
Infertility is a major life crisis affecting couples' psychosocial and physical health. We aimed to assess the quality of life in Turkish infertile couples. This cross-sectional survey was carried out in 127 infertile couples admitted to a University Hospital. The quality of life was measured using the fertility quality of life tool (FertiQoL) scale. Women had lower overall quality of life than men. Women and men who were married for fewer than 10 years had a significantly lower emotional score. Women who had a history of infertility treatment, men who have lived in the town or village men with primary infertility and men who have had primary education or lower, had lower scores for mind/body subscale...
May 19, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28479100/corrigan-pulse-and-fullness-of-the-neck-vessels-in-a-neonate
#16
Mehmet Kenan Kanburoglu, Naci Öner
No abstract text is available yet for this article.
May 4, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28452297/clinical-and-etiologic-evaluation-of-the-children-with-chronic-urticaria
#17
Dilek Azkur, Ersoy Civelek, Müge Toyran, Emine Dibek Mısırlıoğlu, Mustafa Erkoçoğlu, Ayşenur Kaya, Emine Vezir, Tayfur Giniş, Ayşegül Akan, Can Naci Kocabaş
BACKGROUND: Chronic urticaria (CU) is a skin disorder defined as daily or almost daily exhibition of pruritic and transient wheals that last for >6 weeks. CU is divided into two subtypes: chronic spontaneous urticaria (CSU) and chronic inducible urticaria (CIndU). OBJECTIVES: To evaluate the clinical features, possible causes, associated findings, and laboratory results of different subtypes of CU in children according to a new classification. METHODS: In this study, we evaluated the clinical features, laboratory investigations, and provocation tests of children with different subtypes of CU according to a new classification...
November 1, 2016: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28447968/protective-effects-of-ursodeoxycholic-acid-in-experimental-corrosive-esophagitis-injury-in-rats
#18
Adem Ku Çu K, Naci Topaloglu, Sule Yildirim, Mustafa Tekin, Mesut Erbas, Hasan Ali Kiraz, Havva Erdem, Aybars Özkan
Accidental caustic ingestions are serious medical problems especially in childhood. Various treatment modalities are being used for the complications of caustic injuries such as stricture formation. The aim of this study is to establish whether ursodeoxycholic acid (UDCA) has protective effects on experimental corrosive esophagitis in rats. Twenty four Wistar-albino rats, weighing 220-240 g, were used in the study. Experimental animals were divided in three groups randomly: UDCA treatment group (Group T, n:8), control group (Group K, n: 8) and sham group (Group S, n: 8)...
2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28430037/ethical-difficulties-in-the-innovative-surgical-treatment-of-patients-with-recurrent-glioblastoma-multiforme
#19
David J Cote, Naci Balak, Jannick Brennum, Daniel T Holsgrove, Neil Kitchen, Herbert Kolenda, Wouter A Moojen, Karl Schaller, Pierre A Robe, Tiit Mathiesen, Marike L Broekman
No abstract text is available yet for this article.
April 21, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28425254/wheezing-asthma-and-atopy-in-premature-infants-at-2-years-of-age
#20
Sevim Ünal, Ayşenur Kaya, Leyla Bilgin, Emine Misirlioğlu, Can Naci Kocabaş
BACKGROUND/AIM: We aimed to evaluate wheezing, bronchial asthma (BA), and atopy in premature infants at 2 years of age via a cross-sectional study. MATERIALS AND METHODS: Premature infants at <37 weeks of gestational age (GA) were assessed for atopy by skin-prick test and serum immunoglobulin E level at 2 years of age. The family's and infant's histories of allergy, BA, atopy, and wheezing were obtained by questionnaire and from hospital records. RESULTS: There were 98 infants, with mean birth weight (BW) 1517...
April 18, 2017: Turkish Journal of Medical Sciences
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