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https://www.readbyqxmd.com/read/28276432/tuberculosis-drugs-in-the-2016-development-pipeline
#1
Barbara E Laughon, Carol A Nacy
No abstract text is available yet for this article.
March 9, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28259211/cholesterol-levels-in-patients-with-chronic-lymphocytic-leukemia
#2
Irfan Yavasoglu, Gokhan Sargin, Fergun Yilmaz, Sermin Altındag, Gulsum Akgun, Anil Tombak, Bila Toka, Sinan Dal, Hasan Ozbas, Guven Cetin, Ayhan Donmez, Zeynep Arzu Yegin, Oktay Bilgir, Naci Tiftik, Sehmus Ertop, Orhan Ayyildiz, Mehmet Sonmez, Gokhan Pektas, Gurhan Kadıkoylu, Murat Tombuloglu, Zahit Bolaman
Low cholesterol levels may be accompanied by solid tumors or hematological malignancies such as multiple myeloma. Decreased cholesterol levels have been reported in some experimental studies about chronic lymphocytic leukemia (CLL). It may be associated with tumoral cell metabolism. Herein, we examine blood lipid profiles of patients with newly diagnosed CLL (284 male, 276 female, mean age 64 ± 11 years) as defined by National Cancer Institute criteria. The control group consisted of 71 healthy subjects with mean age 55 ± 9 years (28 male, 43 females)...
April 2017: Journal of the National Medical Association
https://www.readbyqxmd.com/read/28229254/the-impact-of-post-procedural-complications-on-reimbursement-length-of-stay-and-mechanical-ventilation-among-patients-undergoing-transcatheter-aortic-valve-implantation-in-germany
#3
Klaus Kaier, Holger Reinecke, Huseyin Naci, Lutz Frankenstein, Martin Bode, Werner Vach, Philip Hehn, Andreas Zirlik, Manfred Zehender, Jochen Reinöhl
BACKGROUND: The impact of various post-procedural complications after transcatheter aortic valve implantation (TAVI) on resource use and their consequences in the German reimbursement system has still not been properly quantified. METHODS: In a retrospective observational study, we use data from the German DRG statistic on patient characteristics and in-hospital outcomes of all isolated TAVI procedures in 2013 (N = 9147). The impact of post-procedural complications on reimbursement, length of stay and mechanical ventilation was analyzed using both unadjusted and risk-adjusted linear and logistic regression analyses...
February 22, 2017: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/28194064/therapeutic-plasma-exchange-in-patients-with-neurologic-disorders-review-of-63-cases
#4
Anil Tombak, Mehmet Ali Uçar, Aydan Akdeniz, Arda Yilmaz, Hakan Kaleagası, Mehmet Ali Sungur, Eyup Naci Tiftik
Therapeutic plasma exchange (TPE) is a procedure that reduces circulating autoantibodies of the patients. TPE is commonly used in neurological disorders where autoimmunity plays a major role. We report our experience with regard to the indications, adverse events and outcomes of plasma exchange in neurological disorders. Sixty-three patients were included to this retrospective study. Median age was 48 years (range 1-85), there was a predominance of males. Neurological indications included Guillain-Barrè syndrome (n = 22), myasthenia gravis (n = 21), chronic inflammatory demyelinating polyneuropathy (n = 7), polymyositis (n = 3), multifocal motor neuropathy (n = 2), acute disseminated encephalomyelitis (n = 2), neuromyelitis optica (n = 2), multiple sclerosis (n = 2), limbic encephalitis (n = 1) and transverse myelitis (n = 1)...
March 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/28097840/assessment-of-lipid-profile-and-some-risk-factors-of-atherosclerosis-in-children-whose-parents-had-early-onset-coronary-artery-disease
#5
Helen Bornaun, Naci Öner, Kemal Nişli, Kazım Öztarhan, Taner Yavuz, Ümit Türkoğlu, Aygün Dindar, Rukiye Eker Ömeroglu
BACKGROUND/AIM: The objective of our study was to analyze the lipid profile and some risk factors of atherosclerosis such as oxidized-low density lipoprotein (ox-LDL), small dense LDL (sd LDL) in the offspring of patients with premature coronary heart disease (CHD). POPULATION AND METHODS: Children whose parents had early onset CHD were matched with age and sex pairs. Study and controls were analyzed for lipid levels, apolipoproteins (Apo- A,B,E), ox-LDL, sd LDL and lipoprotein (a) [Lp(a)]...
February 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28078316/covert-narrative-capacity-mental-life-in-patients-thought-to-lack-consciousness
#6
Lorina Naci, Mackenzie Graham, Adrian M Owen, Charles Weijer
Despite the apparent absence of external signs of consciousness, a significant proportion of behaviorally nonresponsive patients can respond to commands by willfully modulating their brain activity. However, little is known about the mental life of these patients. We discuss a recent innovative approach, which sheds light on the preserved cognitive capacities of these patients, including executive function, theory of mind, and the experience of affective states. This research represents a fundamental shift in our understanding of these patients, and has important implications for both their continued treatment and care...
January 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/28060556/the-frequency-of-sleep-disordered-breathing-in-children-with-asthma-and-its-effects-on-asthma-control
#7
Tayfur Ginis, Fatih Alper Akcan, Murat Capanoglu, Muge Toyran, Refika Ersu, Can Naci Kocabas, Ersoy Civelek
BACKGROUND: The presence of sleep-disordered breathing (SDB) in children with asthma may cause difficult to control asthma. OBJECTIVES: The aim of this study was to determine the frequency of SDB in children with asthma, to evaluate its effects on asthma control and to assess the risk factors associated with the presence of SDB. METHODS: Parents of children who Sleep Questionnaire (PSQ) and the Childhood Asthma Control Test (C-ACT). Asthma control level was assessed according to Global Initiative for Asthma (GINA)...
January 6, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28052800/clinical-diagnosis-and-management-of-anaphylaxis-in-infancy
#8
Emine Dibek Misirlioglu, Emine Vezir, Müge Toyran, Murat Capanoglu, Hakan Guvenir, Ersoy Civelek, Can Naci Kocabas
BACKGROUND: Anaphylaxis is increasingly reported in infancy. Diagnosis and management of anaphylaxis is difficult, and data are limited in infants. The aim of the present study was to determine the clinical course and management strategies used for anaphylaxis in infancy. METHODS: Patients attending to our clinic and who had anaphylaxis under 2 years old were evaluated. Sixty-three patients were enrolled for the study. The mean ± standard deviation age was 10.6 ± 6...
January 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28024099/serum-vaspin-levels-and-carotid-intima-media-thickness-in-pre-dialysis-patients
#9
Aytac Akyol, Davut Demirkıran, Serkan Akdag, Mehmet Naci Aldemir, Hakkı Simsek, Hasan Ali Gumrukcuoglu, Musa Sahin, Habib Emre
BACKGROUND AND OBJECTIVE: Vaspin is a molecule belonging to adipokine family which is associated with insulin resistance and obesity in humans. Several studies have evaluated the serum levels of vaspin in various conditions including coronary artery disease and chronic hemodialysis patients. To our best knowledge, serum vaspin levels have not yet been studied in pre dialysis patients. Carotid intima-media thickness (CIMT) is a noninvasive procedure used to diagnose the extent of carotid atherosclerotic vascular disease...
December 26, 2016: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28008357/bicuspid-aortic-valve-disease-systematic-review-and-meta-analysis-of-surgical-aortic-valve-repair
#10
Maximilian Salcher, Huseyin Naci, Sarah Pender, Titus Kuehne, Marcus Kelm
Aortic valve repair is still emerging, and its role in the treatment of bicuspid aortic valve disease (BAVD) is not yet fully understood. Our objective is to synthesise available evidence on outcomes after surgical aortic valve repair in patients with BAVD. We conducted a systematic review of clinical studies using prespecified methods for searching, identifying and selecting eligible studies in 4 databases, and synthesising results (PROSPERO 2014:CRD42014014415). 2 researchers independently reviewed full-text articles and extracted data...
2016: Open Heart
https://www.readbyqxmd.com/read/28005816/microsurgical-replantation-of-two-consecutive-traumatic-total-scalp-avulsions
#11
Murat Livaoğlu, Muhammet Uraloglu, Yasemin Imamoğlu, Ersin M Ömür Altun, Naci Karaçal
Total scalp avulsion is a rare but severe injury frequently ending in hair loss, and one that can even be life-threatening. It frequently occurs in women and in men with long hair and as a result of injuries by industrial or agricultural equipment or of animal attacks. The first option in treatment is replantation of hairy skin with microsurgery.The authors report 2 consecutive patients with total scalp avulsion presenting to our clinic. Similar injury mechanisms and total scalp avulsions were present in both patients...
November 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27931300/clinical-and-etiologic-evaluation-of-the-children-with-chronic-urticaria
#12
Dilek Azkur, Ersoy Civelek, Mge Toyran, Emine Dibek Msrlolu, Mustafa Erkoolu, Ayenur Kaya, Emine Vezir, Tayfur Gini, Ayegl Akan, Can Naci Kocaba
BACKGROUND: Chronic urticaria (CU) is a skin disorder defined as daily or almost daily exhibition of pruritic and transient wheals that last for 6 weeks. CU is divided into two subtypes: chronic spontaneous urticaria (CSU) and chronic inducible urticaria (CIndU). OBJECTIVES: To evaluate the clinical features, possible causes, associated findings, and laboratory results of different subtypes of CU in children according to a new classification. METHODS: In this study, we evaluated the clinical features, laboratory investigations, and provocation tests of children with different subtypes of CU according to a new classification...
November 2016: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/27927932/ethical-clinical-translation-of-stem-cell-interventions-for-neurologic-disease
#13
David J Cote, Annelien L Bredenoord, Timothy R Smith, Mario Ammirati, Jannick Brennum, Ivar Mendez, Ahmed S Ammar, Naci Balak, Gene Bolles, Ignatius Ngene Esene, Tiit Mathiesen, Marike L Broekman
The application of stem cell transplants in clinical practice has increased in frequency in recent years. Many of the stem cell transplants in neurologic diseases, including stroke, Parkinson disease, spinal cord injury, and demyelinating diseases, are unproven-they have not been tested in prospective, controlled clinical trials and have not become accepted therapies. Stem cell transplant procedures currently being carried out have therapeutic aims, but are frequently experimental and unregulated, and could potentially put patients at risk...
January 17, 2017: Neurology
https://www.readbyqxmd.com/read/27879229/the-incidence-of-ototoxicity-in-patients-using-iron-chelators
#14
Serhan Derin, Fatih Mehmet Azık, Yaşar Topal, Hatice Topal, Volkan Karakuş, Petek Uzay Çetinkaya, Murat Şahan, Tansel Erdem Azık, Can Naci Kocabaş
OBJECTIVE: In this study, we aimed to detect the incidences of ototoxicity in patients with hemoglobinopathies taking deferoxamine (DFO), deferiprone, and deferasirox using the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) scale to obtain more objective data. MATERIALS AND METHODS: Fifty-five transfusion-dependent patients were evaluated in this study. The NCI CTCAE scale was used to assess ototoxicity levels. The average ferritin and hemoglobin levels, the type of iron chelator, and the duration of therapy of all the patients were recorded...
November 23, 2016: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/27858509/review-of-seasonal-influenza-in-canada-burden-of-disease-and-the-cost-effectiveness-of-quadrivalent-inactivated-influenza-vaccines
#15
Edward W Thommes, Morgan Kruse, Michele Kohli, Rohita Sharma, Stephen G Noorduyn
In the 2015/16 influenza season, the Canadian National Advisory Committee on Immunization (NACI) recommended vaccination with quadrivalent inactivated influenza vaccine (QIV) for infants aged 6-23 months and trivalent inactivated influenza vaccines (TIVs) or QIVs in adults. The objective of this review (GSK study identifier: HO-13-14054) is to examine the epidemiology and disease burden of influenza in Canada and the economic benefits of vaccination. To inform this review, we performed a systematic literature search of relevant Canadian literature and National surveillance data...
November 18, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27857302/four-core-optical-fiber-as-a-calorimetric-gauge
#16
Sema Güvenç, Belkıs Gökbulut, Gülşen Kösoğlu, Heba Yüksel, Mehmet Naci Inci
A four-core optical fiber is demonstrated as a calorimetric gauge for investigation of one-dimensional heat transfer measurements. Transient heat pulses from a Nd:YAG laser of 600 ms duration with a repetition rate of the order of 10 s are delivered onto the cleaved distal end face of the four-core fiber, aiming at one of the single cores only, which cause an optical path length difference between four guiding cores due to the temperature-induced change in the index of refraction and physical length of the targeted fiber core of concern...
November 10, 2016: Applied Optics
https://www.readbyqxmd.com/read/27814648/mapping-preserved-real-world-cognition-in-severely-brain-injured-patients
#17
Leah Sinai, Adrian M Owen, Lorina Naci
Decoding the contents of consciousness from brain activity is one of most challenging frontiers of cognitive neuroscience. The ability to interpret mental content without recourse to behavior is most relevant for understanding patients who may be demonstrably conscious, but entirely unable to speak or move willfully in any way, precluding any systematic investigation of their conscious experience. Until recently, patient studies have used structured instructions to elicit willful modulation of brain activity according to command...
January 1, 2017: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/27774970/massive-pulmonary-embolism-and-a-cardiac-mass-thrombus-or-metastasis
#18
Murat Gül, Naci Babat, Fatih Mehmet Uçar, Mehmet Serdar Kuyumcu, Özcan Özeke
Cardiac mass can be described as an abnormal structure within or directly contiguous to the heart. Tumors and thrombi are the most common types of cardiac masses. Intracardiac thrombi have been encountered in various clinical settings and can result in severe morbidity and mortality due to embolic events. Cardiac neoplasms are extremely rare, and are usually metastatic tumors. The major primary malignancies associated with cardiac metastases include cancers of the lung, breast, stomach, and liver, and lymphoma, leukemia, and melanoma...
October 2016: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/27601459/communication-of-treatment-rankings-obtained-from-network-meta-analysis-using-data-visualization
#19
Huseyin Naci
No abstract text is available yet for this article.
September 2016: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/27543730/the-etiology-and-clinical-features-of-anaphylaxis-in-a-developing-country-a-nationwide-survey-in-turkey
#20
Ersoy Civelek, Mustafa Erkoçoğlu, Ayşegül Akan, Celal Özcan, Ayşenur Kaya, Emine Vezir, Tayfur Giniş, Dilek Azkur, Müge Toyran, Mahmut Tokaç, Can Naci Kocabaş
BACKGROUND: Despite the increasing frequency of anaphylaxis, there is inadequate information on the etiology and clinical features in various countries, regions and age groups, especially in developing countries. OBJECTIVE: Our aim is to assess the etiology and clinical findings of anaphylaxis in Turkey. Gathering reliable data about the etiology and clinical findings of anaphylaxis in the general population will decrease the related morbidity and mortality. METHOD: We obtained the names and phone numbers of individuals who had been prescribed an epinephrine auto-injector with a diagnosis of anaphylaxis from ministry of health...
August 16, 2016: Asian Pacific Journal of Allergy and Immunology
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