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https://www.readbyqxmd.com/read/29129763/mammillothalamic-and-mammillotegmental-tracts-as-new-targets-for-dementia-and-epilepsy-treatment
#1
REVIEW
Naci Balak, Ece Balkuv, Ali Karadag, Recep Basaran, Huseyin Biceroglu, Buruç Erkan, Necmettin Tanriover
Very recently, neuromodulation through deep brain stimulation (DBS) has appeared as a new surgical procedure in the treatment of some types of dementia and epilepsy. The mammillothalamic and the mammillotegmental tracts are involved among the new targets. To our knowledge, a review article focused specifically on these mammillary body efferents is lacking in the medical literature. Their contribution to memory is, regrettably, often overlooked. There is evidence that mammillary bodies can contribute to memory independently from hippocampal formation, but the mechanism is not yet known...
November 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29091313/exenatide-upregulates-gene-expression-of-glucagon-like-peptide-1-receptor-and-nerve-growth-factor-in-streptozotocin-nicotinamide-induced-diabetic-mice
#2
Esen Gumuslu, Naci Cine, Merve Ertan, Oguz Mutlu, Ipek Komsuoglu Celikyurt, Guner Ulak
Glucagon like peptide-1 (GLP-1) is an incretine hormon that has modulating effects on insulin release. GLP-1 and receptors for GLP-1 are widely expressed throughout the body including brain.The expression of GLP-1 receptors is very specific to large neurons in hippocampus, neocortex and cerebellum. GLP-1 receptor stimulation enhances glucose-dependent insulin secretion and lowers blood glucose in type 2 diabetes mellitus. Studies on adipobiology of neurotrophins have focused on nerve growth factor (NGF) as an example of adipose-derived neurotrophins...
November 1, 2017: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/29081710/complications-and-midterm-outcomes-of-hemiarthroplasty-in-hemodialysis-patients
#3
Ahmet Salduz, Gökhan Polat, Turgut Akgül, Omer Naci Ergin, Koray Şahin, Önder Yazicioğlu
OBJECTIVE: The aim of this study was to evaluate the functional results, complications, and morbidity and mortality rates in patients with end-stage chronic renal failure (ESCRF) with collum femoris fractures who were treated with hemiarthroplasty. METHODS: From 2005 to 2013, patients with ESCRF admitted to our hospital with collum femoris fracture and treated with hemiarthroplasty were retrospectively evaluated, and 44 hips in 42 patients were included in the study...
September 2017: Acta Ortopedica Brasileira
https://www.readbyqxmd.com/read/29077212/genetic-variability-human-respiratory-syncytial-virus-subgroups-a-and-b-in-turkey-during-six-successive-epidemic-seasons-2009-2015
#4
Fatma Bayrakdar, Can Naci Kocabaş, Ayşe Başak Altaş, H Gökhan Kavuncuoğlu, Yasemin Coşgun, Emine Dibek Mısırlıoğlu Shahbazi, İhsan Durmaz, Gülay Korukluoğlu, Aykut Özkul
Human respiratory syncytial virus (HRSV) is most important viral respiratory pathogen of acute lower respiratory tract infections in infants and young children worldwide. The circulating pattern and genetic characteristics in the HRSV attachment glycoprotein gene was investigated in Turkey during 6 consecutive seasons from 2009 to 2015. HRSVA was dominant in the all epidemic seasons except 2011-2012 season. Partial sequences of the HVR2 region of the G gene of 479 HRSVA and 135 HRSVB were obtained. Most Turkish strains belonged to NA1, ON1 and BA9, which were the predominant genotypes circulating worldwide...
October 27, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/29051880/an-exceptional-case-of-suture-granuloma-30-years-following-an-open-repair-of-achilles-tendon-rupture-a-case-report
#5
Ömer Naci Ergin, Mehmet Demirel, Emre Özmen
INTRODUCTION: Rupture of the Achilles' tendon is a common injury occurring particularly in middle-aged men due to sports trauma. Operative treatment is preferred generally due to lower risk of re-rupture. Possible complications of the operation include suture granulomas. Suture granulomas might represent a foreign body reaction, which itself is the end-stage response of the inflammatory wound-healing process to biomaterials. It may occur with both absorbable and non-absorbable suture materials such as silk in our case...
May 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29027499/non-infectious-fever-after-acute-spinal-cord-injury-in-the-intensive-care-unit
#6
Fatma Ülger, Mehtap Pehlivanlar Küçük, Çağatay Erman Öztürk, İskender Aksoy, Ahmet Oğuzhan Küçük, Naci Murat
Objective The aim of the present study is to evaluate the frequency, etiology, risk factors and clinical outcomes in acute traumatic SCI patients who develop fever and to evaluate the relationship between fever and mortality. Design Retrospective data were collected between January 2007 and August 2016 from patients diagnosed with persistent fever from SCI cases observed in the ICU. Participants Among 5370 intensive care patients, 435 SCI patients were evaluated for the presence of fever. A total of 52 patients meeting the criteria were evaluated...
October 13, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28990886/-assessing-the-knowledge-in-primary-health-care-following-an-educational-course-structured-in-the-context-of-gard-chronic-airway-diseases-national-control-program
#7
Ferda Öner Erkekol, Nurdan Köktürk, Dilşad Mungan, Cansın Saçkesen, Zeynep Pınar Önen, Seçil Özkan, Arzu Balkan, Pınar Ergün, Can Naci Kocabaş, Nur Baran Aksakal, Banu Ekici, Zübeyde Özkan Altunay, Bilun Gemicioğlu, Arzu Yorgancıoğlu
Introduction: Chronic obstructive pulmonary diseases are common causes of disease in the community and account for considerable percent of the caseload in primary health care facilities. For this reason, it is important to question and improve the knowledge of primary health care physicians. This study is designed to assess the level of knowledge for bronchial asthma and COPD of the primary healthcare physicians, both before and immediately after an educational course structured in the context of GARD Chronic Airway Diseases National Control Program...
June 2017: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/28978555/availability-of-evidence-of-benefits-on-overall-survival-and-quality-of-life-of-cancer-drugs-approved-by-european-medicines-agency-retrospective-cohort-study-of-drug-approvals-2009-13
#8
Courtney Davis, Huseyin Naci, Evrim Gurpinar, Elita Poplavska, Ashlyn Pinto, Ajay Aggarwal
Objective To determine the availability of data on overall survival and quality of life benefits of cancer drugs approved in Europe.Design Retrospective cohort study.Setting Publicly accessible regulatory and scientific reports on cancer approvals by the European Medicines Agency (EMA) from 2009 to 2013.Main outcome measures Pivotal and postmarketing trials of cancer drugs according to their design features (randomisation, crossover, blinding), comparators, and endpoints. Availability and magnitude of benefit on overall survival or quality of life determined at time of approval and after market entry...
October 4, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28922237/minimizing-the-harm-of-accidental-awareness-under-general-anesthesia-new-perspectives-from-patients-misdiagnosed-as-being-in-a-vegetative-state
#9
Mackenzie Graham, Adrian M Owen, Kaman Çipi, Charles Weijer, Lorina Naci
No abstract text is available yet for this article.
September 14, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28875355/is-there-an-association-between-flow-diverter-fish-mouthing-and-delayed-type-hypersensitivity-to-metals-a-case-control-study
#10
Naci Kocer, Prabath Kumar Mondel, Elif Yamac, Ayse Kavak, Osman Kizilkilic, Civan Islak
PURPOSE: Flow diverters are increasingly used in the treatment of complex and giant intracranial aneurysms. However, they are associated with complications like late aneurysmal rupture. Additionally, flow diverters show focal structural decrease in luminal diameter without any intimal hyperplasia. This resembles a "fish mouth" when viewed en face. In this pilot study, we tested the hypothesis of a possible association between flow diverter fish-mouthing and delayed-type hypersensitivity to its metal constituents...
November 2017: Neuroradiology
https://www.readbyqxmd.com/read/28874370/n-acetylglucosamine-1-phosphate-transferase-weca-as-a-validated-drug-target-in-mycobacterium-tuberculosis
#11
Stanislav Huszár, Vinayak Singh, Alica Polčicová, Peter Baráth, María Belén Barrio, Sophie Lagrange, Véronique Leblanc, Carol A Nacy, Valerie Mizrahi, Katarína Mikušová
The mycobacterial phosphoglycosyltransferase WecA, which initiates arabinogalactan biosynthesis in Mycobacterium tuberculosis, has been proposed as a target of the caprazamycin derivative CPZEN-45, a preclinical drug candidate for the treatment of tuberculosis. In this report, we describe the functional characterization of mycobacterial WecA and confirm the essentiality of its encoding gene in M. tuberculosis by demonstrating that the transcriptional silencing of wecA is bactericidal in vitro and in macrophages...
November 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28828208/protein-microarray-analysis-identifies-key-cytokines-associated-with-malignant-middle-cerebral-artery-infarction
#12
Zhonghe Zhou, Jinghua Zhang, Xiaoqiu Li, Cheng Xia, Yaling Han, Huisheng Chen
INTRODUCTION: We aimed to explore potential cytokines involved in the malignant middle cerebral artery infarction (MMI) and elucidate their underlying regulatory mechanisms. METHODS: We first developed a cytokine profile by Quantibody(®) Human Cytokine Antibody Array7000 using serum samples from eight patients with MMI and eight patients with non-acute cerebral infarction (NACI). The differentially expressed cytokines were then identified in patients with MMI using two-tailed Student's t-test and Fisher's Exact Test compared with patients with NACI...
August 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28814358/frequency-of-selective-immediate-responders-to-aminopenicillins-and-cephalosporins-in-turkish-children
#13
Emine Dibek Misirlioglu, Hakan Guvenir, Muge Toyran, Emine Vezir, Murat Capanoglu, Ersoy Civelek, Betul Buyuktiryaki, Tayfur Ginis, Can Naci Kocabas
BACKGROUND: Beta-lactam antibiotics (BLA) are the most commonly prescribed antibiotics and are responsible for the majority of immediate hypersensitivity reactions to drugs in children. Cross-reactivity is important in hypersensitivity to BLAs because these drugs all share a common beta-lactam structure and some share similar side chains. OBJECTIVE: The aim of this study was to evaluate the clinical characteristics of patients who are diagnosed with immediate-type BLA hypersensitivity and frequency of patients with side chain hypersensitivity, "selective responders...
September 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28810023/characteristics-of-preapproval-and-postapproval-studies-for-drugs-granted-accelerated-approval-by-the-us-food-and-drug-administration
#14
Huseyin Naci, Katelyn R Smalley, Aaron S Kesselheim
Importance: Drugs treating serious or life-threatening conditions can receive US Food and Drug Administration (FDA) accelerated approval based on showing an effect in surrogate measures that are only reasonably likely to predict clinical benefit. Confirmatory trials are then required to determine whether these effects translate to clinical improvements. Objective: To characterize preapproval and confirmatory clinical trials of drugs granted accelerated approval...
August 15, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28803706/health-policy-in-times-of-austerity-a-conceptual-framework-for-evaluating-effects-of-policy-on-efficiency-and-equity-illustrated-with-examples-from-europe-since-2008
#15
Martin Wenzl, Huseyin Naci, Elias Mossialos
The objective of this paper is to provide a framework for evaluation of changes in health policy against overarching health system goals. We propose a categorisation of policies into seven distinct health system domains. We then develop existing analytical concepts of insurance coverage and cost-effectiveness further to evaluate the effects of policies in each domain on equity and efficiency. The framework is illustrated with likely effects of policy changes implemented in a sample of European countries since 2008...
September 2017: Health Policy
https://www.readbyqxmd.com/read/28756119/what-to-do-or-not-to-do-when-randomization-is-not-possible
#16
EDITORIAL
Huseyin Naci
No abstract text is available yet for this article.
November 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28749553/myelopathy-in-beh%C3%A3-et-s-disease-the-bagel-sign
#17
Ugur Uygunoglu, Burcu Zeydan, Yesim Ozguler, Serdal Ugurlu, Emire Seyahi, Naci Kocer, Civan Islak, Kejal Kantarci, Sabahattin Saip, Aksel Siva, Orhun H Kantarci
OBJECTIVE: To describe the clinical and distinctive imaging features of myelopathy associated with Behçet's disease (BD). METHODS: We evaluated the records of patients meeting the following criteria: (1) fulfillment of the International Study Group criteria for BD; (2) clinically suggestive of myelopathy; (3) simultaneous spinal cord and brain magnetic resonance images (MRIs) within 1 month of acute worsening of myelopathy; and (4) follow-up duration ≥ 1 year after initial MRI evaluation...
August 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28736662/can-time-resolved-nirs-provide-the-sensitivity-to-detect-brain-activity-during-motor-imagery-consistently
#18
Androu Abdalmalak, Daniel Milej, Mamadou Diop, Mahsa Shokouhi, Lorina Naci, Adrian M Owen, Keith St Lawrence
Previous functional magnetic resonance imaging (fMRI) studies have shown that a subgroup of patients diagnosed as being in a vegetative state are aware and able to communicate by performing a motor imagery task in response to commands. Due to the fMRI's cost and accessibility, there is a need for exploring different imaging modalities that can be used at the bedside. A promising technique is functional near infrared spectroscopy (fNIRS) that has been successfully applied to measure brain oxygenation in humans...
April 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28689831/successful-desensitization-of-elosulfase-alfa-induced-anaphylaxis-in-a-pediatric-patient-with-morquio-syndrome
#19
Hakan Guvenir, Emine Dibek Misirlioglu, Murat Capanoglu, Betul Buyuktiryaki, Ozlem Unal, Muge Toyran, Can Naci Kocabas
No abstract text is available yet for this article.
July 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28599141/chinese-yellow-dust-and-korean-infant-health
#20
Duha T Altindag, Deokrye Baek, Naci Mocan
Naturally-occurring Yellow Dust outbreaks, which are produced by winds flowing to Korea from China and Mongolia, create air pollution. Although there is a seasonal pattern of this phenomenon, there exists substantial variation in its timing, strength, and location from year to year. To warn residents about air pollution in general, and about these dust storms in particular, Korean authorities issue different types of public alerts. Using birth certificate data on more than 1.5 million babies born between 2003 and 2011, we investigate the impact of air pollution, and the avoidance behavior triggered by pollution alerts on various birth outcomes...
August 2017: Social Science & Medicine
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