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https://www.readbyqxmd.com/read/28645980/association-between-human-herpesvirus-infections-and-dementia-or-mild-cognitive-impairment-a-systematic-review-protocol
#1
Charlotte Warren-Gash, Harriet Forbes, Judith Breuer, Andrew C Hayward, Angelique Mavrodaris, Basil H Ridha, Martin Rossor, Sara L Thomas, Liam Smeeth
INTRODUCTION: Persisting neurotropic viruses are proposed to increase the risk of dementia, but evidence of association from robust, adequately powered population studies is lacking. This is essential to inform clinical trials of targeted preventive interventions. METHODS AND ANALYSIS: We will carry out a comprehensive systematic review of published and grey literature of the association between infection with, reactivation of, vaccination against or treatment of any of the eight human herpesviruses and dementia or mild cognitive impairment...
June 23, 2017: BMJ Open
https://www.readbyqxmd.com/read/28645616/epidemiological-and-sociodemographic-factors-associated-with-complicated-alcohol-withdrawal-syndrome
#2
R Monte-Secades, M Blanco-Soto, J A Díaz-Peromingo, A Sanvisens-Bergé, M C Martín-González, A Barbosa, B Rosón-Hernández, M A Tejero-Delgado, R Puerta-Louro, R Rabuñal-Rey
OBJECTIVES: To analyse the influence of epidemiological and sociodemographic factors in complicated alcohol withdrawal syndrome (AWS). MATERIAL AND METHODS: A multicentre, observational prospective study was conducted on consecutively added patients with AWS hospitalised in internal medicine departments. We recorded sociodemographic, epidemiological, clinical and progression data. Complicated AWS was defined as that which progressed with seizures or delirium tremens...
June 20, 2017: Revista Clínica Española
https://www.readbyqxmd.com/read/28619299/comparative-cost-analysis-of-inpatient-integrative-medicine-results-of-a-pilot-study
#3
Thomas Ostermann, Romy Lauche, Holger Cramer, Gustav Dobos
BACKGROUND: Costs of integrative treatment alone and in comparison with other treatment approaches have scarcely been reported in the past. This study presents results of a comparative cost analysis of an inpatient integrative medicine treatment costs. METHODS: Data from 2006 for inpatients referred to a Department of Integrative Medicine in Germany were used. Case-related treatment costs were calculated, and transformed into Casemix-Indices and revenues per DRG...
June 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28614452/-profile-of-clinical-trials-enrolling-brazilian-children
#4
Jean Mendes de Lucena Vieira, Elisangela da Costa Lima, Marcelo Gerardin Poirot Land, Miriam Ventura, Helena Lutescia Luna Coelho
This study aimed to characterize the clinical trials with medicines enrolling Brazilian children and adolescents, registered in the databases of Clinical Trials and the Brazilian Clinical Trials Network (ReBEC) from 1994 to 2014. Only 462 clinical trials enrolled Brazilian children and adolescents. There was an increase in registrations beginning in 2003, with an important drop in 2011. Among these trials, 35.5% were hosted in Brazil. The international clinical trials were mostly conducted by North American companies...
June 12, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28602566/dis-integration-of-communication-in-healthcare-education-workplace-learning-challenges-and-opportunities
#5
Marcy E Rosenbaum
The purpose of this paper, based on a 2016 Heidelberg International Conference on Communication in Healthcare (ICCH) plenary presentation, is to examine a key problem in communication skills training for health professional learners. Studies have pointed to a decline in medical students' communication skills and attitudes as they proceed through their education, particularly during their clinical workplace training experiences. This paper explores some of the key factors in this disintegration, drawing on selected literature and highlighting some curriculum efforts and research conducted at the University of Iowa Carver College of Medicine as a case study of these issues...
June 3, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28589536/distinguishing-pathogenic-mutations-from-background-genetic-noise-in-cardiology-the-use-of-large-genome-databases-for-genetic-interpretation
#6
REVIEW
Jonas Ghouse, Morten W Skov, Robert S Bigseth, Gustav Ahlberg, Jørgen K Kanters, Morten S Olesen
Advances in clinical genetic testing has led to increased insight into the human genome, including how challenging it is to interpret rare genetic variation. In some cases, the ability to detect genetic mutations exceeds the ability to understand their clinical impact, limiting the advantage of these technologies. Obstacles in genomic medicine are many and include: understanding the level of certainty/uncertainty behind pathogenicity determination, the numerous different variant interpretation-guidelines used by clinical laboratories, delivering the certain or uncertain result to the patient, helping patients evaluate medical decisions in light of uncertainty regarding the consequence of the findings...
June 6, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28585846/-czech-linguistic-validation-of-the-pelvic-organ-prolapse-urinary-incontinence-sexual-questionnaire-iuga-revised
#7
Z Rušavý, P Nečesalová, E Rinnová, M Smažinka, M Havíř, V Kališ
OBJECTIVE: To produce a Czech version of a validated tool for sexual quality of life assessment among women with pelvic floor disorders; PISQ-IR (Pelvic organ prolapse/Incontinence Sexual Questionnaire - Internationally Revised). DESIGN: Original study. SETTING: Department of Obstetrics and Gynecology, University Hospital and Faculty of Medicine, Charles University in Pilsen. METHODS: The whole process of translation and linguistic validation of the questionnaire followed the protocol of the International Urogynecology Association developed for this purpose...
2017: Ceská Gynekologie
https://www.readbyqxmd.com/read/28583115/tuberculosis-arthritis-of-the-sternoclavicular-joint-after-uncomplicated-falciparum-malaria-a-case-report
#8
Boundia Djiba, Baidy Sy Kane, Mamadou Alpha Diallo, Khadim Diongue, Ngoné Diaba Diack, Hamidou Deme, Mouhamed Dieng, Maimouna Sow, Daouda Ndiaye, Abdoulaye Pouye
BACKGROUND: Malaria and tuberculosis are co-endemic in many developing countries. However their associations are rarely reported. Yet, it has been suggested that a pathological process may link the two diseases. CASE PRESENTATION: A 20-year-old female patient was admitted in the internal medicine service of Aristide Le Dantec Hospital for uncomplicated malaria. She was previously treated for autoimmune hemolytic anaemia using prednisone at 5 mg per day. Clinical examination showed swelling in front of the sternoclavicular joint...
June 5, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28579421/an-interactive-ambulatory-nephrology-curriculum-for-internal%C3%A2-medicine-interns-design-implementation-and-participant%C3%A2-feedback
#9
Alexis C Gomez, Karen M Warburton, Rachel K Miller, Dan Negoianu, Jordana B Cohen
While diminishing nephrology fellow recruitment is a known issue, more work is needed to evaluate possible interventions to reverse this trend. We designed and implemented a curriculum to increase exposure to ambulatory nephrology among internal medicine interns. The curriculum focused on key aspects of outpatient nephrology practice, including supervised clinic visits, formal themed didactic content, and an online interactive forum with assigned evidence-based readings and small-group responses to relevant cases...
June 2, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28571585/number-needed-to-treat-nnt-in-clinical-literature-an-appraisal
#10
Diogo Mendes, Carlos Alves, Francisco Batel-Marques
BACKGROUND: The number needed to treat (NNT) is an absolute effect measure that has been used to assess beneficial and harmful effects of medical interventions. Several methods can be used to calculate NNTs, and they should be applied depending on the different study characteristics, such as the design and type of variable used to measure outcomes. Whether or not the most recommended methods have been applied to calculate NNTs in studies published in the medical literature is yet to be determined...
June 1, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28557000/clinical-trials-in-veterinary-medicine-a-new-era-brings-new-challenges
#11
M A Oyama, S S Ellenberg, P A Shaw
Randomized clinical trials (RCTs) are among the most rigorous ways to determine the causal relationship between an intervention and important clinical outcome. Their use in veterinary medicine has become increasingly common, and as is often the case, with progress comes new challenges. Randomized clinical trials yield important answers, but results from these studies can be unhelpful or even misleading unless the study design and reporting are carried out with care. Herein, we offer some perspective on several emerging challenges associated with RCTs, including use of composite endpoints, the reporting of different forms of risk, analysis in the presence of missing data, and issues of reporting and safety assessment...
May 30, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28553735/group-observed-structured-encounter-gosce-for-third-year-medical-students-improves-self-assessment-of-clinical-communication
#12
Allison B Ludwig, Amanda C Raff, Juan Lin, Ellie Schoenbaum
OBJECTIVES: This study assesses the effectiveness of a GOSCE in teaching medical students clinical communication, as well as group collaboration and peer feedback. METHODS: The GOSCE was administered during the Internal Medicine clerkship. Groups consisted of 4-6 students and one faculty member. Students completed pre- and post-GOSCE surveys to assess confidence in clinical communication and a GOSCE evaluation to rate the overall experience. Pre- and post-GOSCE program survey scores were compared, and the mean score and standard deviation of the GOSCE evaluation was calculated...
May 27, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28546866/a-diagnostic-protocol-designed-for-determining-allergic-causes-in-patients-with-blood-eosinophilia
#13
Jean-François Magnaval, Guy Laurent, Noémie Gaudré, Judith Fillaux, Antoine Berry
BACKGROUND: Blood eosinophilia is a common laboratory abnormality, and its characterization frequently represents a quandary for primary care physicians. Consequently, in France, specialists and particularly hematologists, often must investigate patients who present with blood eosinophilia that often, but not always, occurs because of allergic causes. Both the Departments of Hematology and Parasitology at Toulouse University Hospitals established a collaboration to rule out allergic causes of eosinophilia, particularly helminthiases, prior to initiating more sophisticated investigations...
2017: Military Medical Research
https://www.readbyqxmd.com/read/28541237/treatment-decision-making-capacity-in-hospitalized-patients-with-schizophrenia
#14
N Bilanakis, V K Peritogiannis, Aik Vratsista
In contemporary medical ethics and clinical practice the autonomy of patients and their right to accept or refuse an offered treatment is acknowledged and respected. Prerequisite for the right of a patient to consent to any medical act is the capacity to make valid decisions regarding his/ her treatment. The objective of our study was to assess -for the first time in our country- treatment decision-making capacity of hospitalized patients with schizophrenia; to explore any possible association with demographic and clinical variables; and to compare treatment decision-making capacity of patients with schizophrenia with medical patients' capacity...
January 2017: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/28537495/remotely-guided-breast-sonography-for-long-term-space-missions-a-case-report-and-discussion
#15
Jackelynne P Silva-Martinez, Andreia Sorice Genaro, Hui Annie Wen, Naama Glauber, Thais Russomano
BACKGROUND: Space radiation can cause different types of cancers in crewmembers, especially during long-term space missions. INTRODUCTION: To date, a complete bilateral breast ultrasound has not been performed at the International Space Station (ISS). A breast screening imaging technique could be a useful tool for early identification of breast cancer in astronauts. We hypothesized that breast ultrasound performed by a crewmember while being remotely guided by a specialist from the ground could be an essential tool for medical diagnosis in space...
May 24, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/28536833/development-of-standardized-image-interpretation-for-68ga-psma-pet-ct-to-detect-prostate-cancer-recurrent-lesions
#16
Stefano Fanti, Silvia Minozzi, Joshua James Morigi, Frederik Giesel, Francesco Ceci, Christian Uprimny, Michael S Hofman, Matthias Eiber, Sarah Schwarzenbock, Paolo Castellucci, Cristina Bellisario, Stéphane Chauvie, Fabrizio Bergesio, Louise Emmett, Uwe Haberkorn, Irene Virgolini, Markus Schwaiger, Rodney J Hicks, Bernd J Krause, Arturo Chiti
METHODS: After primary treatment, biochemical relapse (BCR) occurs in a substantial number of patients with prostate cancer (PCa). PET/CT imaging with prostate-specific membrane antigen based tracers (68Ga-PSMA) has shown promising results for BCR patients. However, a standardized image interpretation methodology has yet to be properly agreed. The aim of this study, which was promoted and funded by European Association of Nuclear Medicine (EANM), is to define standardized image interpretation criteria for 68Ga-PSMA PET/CT to detect recurrent PCa lesions in patients treated with primary curative intent therapy (radical prostatectomy or radiotherapy) who presented a biochemical recurrence...
May 23, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28535618/granulomatosis-with-polyangiitis-in-tunisia
#17
I Ben Ghorbel, N Belfeki, N Baouendi, T Ben Salem, M H Houman
Granulomatosis with polyangiitis (GPA) is more frequent in Northern rather than Southern countries. Very few studies have been conducted in Africa. We have performed a retrospective descriptive study including clinical and laboratory profiles of 30 Tunisian GPA patients seen at the department of Internal Medicine of the University Hospital of la Rabta from 2000 to 2014. Mean age at initial GPA diagnosis was 46±12 years, and the average number of months between the onset of symptoms and diagnosis was 25. Seventeen (56%) were male, and 13 (44%) were female...
May 22, 2017: Reumatismo
https://www.readbyqxmd.com/read/28534685/biotin-interference-with-routine-clinical-immunoassays-understand-the-causes-and-mitigate-the-risks
#18
Shanika Samarasinghe, Farah Meah, Vinita Singh, Arshi Basit, Nicholas Emanuele, Mary Ann Emanuele, Alaleh Mazhari, Earle W Holmes
OBJECTIVES: The objectives of this report are to review the mechanisms of biotin interference with streptavidin/biotin-based immunoassays, identify automated immunoassay systems vulnerable to biotin interference, describe how to estimate and minimize the risk of biotin interference in vulnerable assays, and review the literature pertaining to biotin interference in endocrine function tests. METHODS: The data in the manufacturer's "Instructions for Use" for each of the methods utilized by seven immunoassay system were evaluated...
May 23, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28507284/melanoma-masquerading-as-a-zosteriform-rash
#19
Saif Ibrahim, Bashar Al-Turk, Ciel Harris, Farrah Al-Saffar, Sayf Said, Maheera Farsi, Jeffrey Winder, Christian Landa
BACKGROUND Primary care physicians and internal medicine specialists frequently encounter a variety of rashes. Many of these cases look and feel typical of common entities, resulting in the potential for misdiagnosis. CASE REPORT This is a case of a zosteriform rash where the surprising true diagnosis of metastatic melanoma was confirmed with bedside skin punch biopsy. Possible mechanisms involve direct cutaneous injury, neuronal, and dorsal root ganglia involvement in metastases. CONCLUSIONS Skin biopsy is indispensable especially when there is a lack of clinical response or deterioration in the clinical condition...
May 16, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28502910/balancing-volume-and-duration-of-information-consumption-by-physicians-the-case-of-health-information-exchange-in-critical-care
#20
Liran Politi, Shlomi Codish, Iftach Sagy, Lior Fink
BACKGROUND: The realization of the potential benefits of health information exchange systems (HIEs) for emergency departments (EDs) depends on the way these systems are actually used. The attributes of volume of information and duration of information processing are important for the study of HIE use patterns in the ED, as cognitive load and time constraints may result in a trade-off between these attributes. Experts and non-experts often use different problem-solving strategies, which may be consequential for their system use patterns...
May 11, 2017: Journal of Biomedical Informatics
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