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https://www.readbyqxmd.com/read/28718514/aldehyde-dehydrogenase-1-a1-regulates-energy-metabolism-in-adipocytes-from-different-species
#1
Kefeng Yang, Christopher Adin, Qiwen Shen, Ly James Lee, Lianbo Yu, Paolo Fadda, Arpad Samogyi, Kathleen Ham, Lu Xu, Chen Gilor, Ouliana Ziouzenkova
BACKGROUND: Survival and longevity of xenotransplants depend on immune function and ability to integrate energy metabolism between cells from different species. However, mechanisms for interspecies cross talk in energy metabolism are not well understood. White adipose tissue stores energy and is capable of mobilization and dissipation of energy as heat (thermogenesis) by adipocytes expressing uncoupling protein 1 (Ucp1). Both pathways are under the control of vitamin A metabolizing enzymes...
July 17, 2017: Xenotransplantation
https://www.readbyqxmd.com/read/28713075/association-of-parental-obesity-and-diabetes-mellitus-with-circulating-adipokines-in-nonobese-nondiabetic-offspring
#2
Justin P Zachariah, Rene Quiroz, Danielle Enserro, Charlotte Andersson, John F Keaney, Lisa M Sullivan, Ramachandran S Vasan
BACKGROUND: Adipokines are implicated in the development of obesity-related traits. We hypothesized that nonobese participants without diabetes mellitus (DM) whose parents were obese or had DM would have altered circulating adipokines compared with those without parental history of these conditions. METHODS AND RESULTS: Participants in the community-based Framingham Third Generation cohort who were not obese (body mass index <30) and not diabetic with both parents in the Framingham Offspring cohort were included in this analysis (n=2034, mean age 40 years, 54% women)...
July 16, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28701570/adipose-derived-fatty-acid-binding-proteins-plasma-concentrations-are-increased-in-breast-cancer-patients
#3
Sandra Guaita-Esteruelas, Paula Saavedra-García, Alba Bosquet, Joan Borràs, Josefa Girona, Kepa Amiliano, Marta Rodríguez-Balada, Mercedes Heras, Luís Masana, Josep Gumà
BACKGROUND: Adipose tissue is an endocrine organ that could play a role in tumor progression via its secreted adipokines. The role of adipose-derived fatty acid-binding protein (FABP) 4 and FABP5 in breast cancer is presently under study, but their circulating levels in this pathology are poorly known. We analyzed the blood concentrations of FABP4 and FABP5 in breast cancer patients to determine whether there is an association between them and breast cancer. MATERIALS AND METHODS: We studied 294 women in the oncology department with a family history of breast cancer; 198 of the women had breast cancer, and 96 were healthy controls...
July 12, 2017: Oncologist
https://www.readbyqxmd.com/read/28701079/mir-185-inhibits-3t3-l1-cell-differentiation-by-targeting-srebp-1
#4
Chunyou Ning, Guilin Li, Lu You, Yao Ma, Long Jin, Jideng Ma, Xuewei Li, Mingzhou Li, Haifeng Liu
Adipogenesis involves a highly orchestrated series of complex events in which microRNAs (miRNAs) may play an essential role. In this study, we found that the miR-185 expression increased gradually during 3T3-L1 cells differentiation. To explore the role of miR-185 in adipogenesis, miRNA agomirs and antagomirs were used to perform miR-185 overexpression and knockdown, respectively. Overexpression of miR-185 dramatically reduced the mRNA expression of the adipogenic markers, PPARγ, FABP4, FAS, and LPL, and the protein level of PPARγ and FAS...
July 13, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28691342/dual-function-of-lactobacillus-kefiri-dh5-in-preventing-high-fat-diet-induced-obesity-direct-reduction-of-cholesterol-and-upregulation-of-ppar%C3%AE-in-adipose-tissue
#5
Dong-Hyeon Kim, Dana Jeong, Il-Byeong Kang, Hyunsook Kim, Kwang-Young Song, Kun-Ho Seo
SCOPE: Kefir consumption inhibits the development of obesity and non-alcoholic fatty liver disease in mice fed 60% high-fat diet (HFD). To identify the key contributor of this effect, we isolated lactic acid bacteria (LAB) from kefir and examined their anti-obesity properties from in vitro screening and in vivo validation. METHODS AND RESULTS: Thirteen kefir LAB isolates were subjected to survivability test using artificial gastrointestinal environment and cholesterol-reducing assay...
July 10, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28686516/standardized-cirsium-setidens-nakai-ethanolic-extract-suppresses-adipogenesis-and-regulates-lipid-metabolisms-in-3t3-l1-adipocytes-and-c57bl-6j-mice-fed-high-fat-diets
#6
Bong-Yeon Cho, Mi-Ryeong Park, Jin-Ha Lee, Moon-Jin Ra, Kyoung Chan Han, Il-Jun Kang, Ok-Hwan Lee
Cirsium setidens Nakai, a wild perennial herb, grows mainly in Gangwon province, Korea, and has been reported to contain bioactive ingredients with various medicinal activities, including the treatment of edema, bleeding, and hemoptysis. However, the potential antiobesity effects of C. setidens Nakai have not been fully investigated. This study evaluated the antiobesity effect of standardized C. setidens Nakai ethanolic extract (CNE) in 3T3-L1 adipocytes and in obese C57BL/6J mice fed a high-fat diet. CNE suppressed the expression of lipogenic genes and increased the expression of lipolytic genes...
July 7, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28684700/proteomics-analysis-reveals-an-important-role-for-the-ppar-signaling-pathway-in-dbdct-induced-hepatotoxicity-mechanisms
#7
Yunlan Li, Xinxin Liu, Lin Niu, Qingshan Li
A patented organotin di-n-butyl-di-(4-chlorobenzohydroxamato)tin (DBDCT) with high a antitumor activity was designed, however, its antitumor and toxic mechanisms have not yet been clearly illustrated. Hepatic proteins of DBDCT-treated rats were identified and analyzed using LC-MS/MS with label-free quantitative technology. In total, 149 differentially expressed proteins were successfully identified. Five protein and mRNA expressions were involved in the peroxisome proliferator-activated receptor (PPAR) signaling pathway, including a scavenger receptor (CD36), adipocyte fatty acid binding protein 4 (FABP4), enoyl-CoA hydratase (EHHADH), acetyl-CoA acyltransferase 1 (ACAA1), and phosphoenolpyruvate carboxykinase (PEPCK) in DBDCT-treated Rat Liver (BRL) cells...
July 6, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28666109/subspecies-and-diet-affect-the-expression-of-genes-involved-in-lipid-metabolism-and-chemical-composition-of-muscle-in-beef-cattle
#8
Priscilla D Teixeira, Dalton M Oliveira, Mario L Chizzotti, Antonio Chalfun-Junior, Tamara C Coelho, MateusP Gionbelli, Luciano V Paiva, José Roberto R Carvalho, Marcio M Ladeira
Fourteen Nellore and 14 Angus young bulls with BW of 381±11.8kg were randomly assigned into 2 feeding groups (whole shelled corn without forage (WSC) or corn silage and ground corn (GC)) to evaluate chemical composition and expression of genes involved in lipid metabolism in the longissimus thoracis (LT). We hypothesized that bulls fed the WSC diet have greater amounts of intramuscular fat and Angus have higher expression levels of PPAR and SREBF. Meat from Angus bulls had greater ether extract compared to Nellore (P<0...
June 17, 2017: Meat Science
https://www.readbyqxmd.com/read/28665940/adiposity-and-adipogenic-gene-expression-in-four-different-muscles-in-beef-cattle
#9
Lara Martínez Del Pino, Ana Arana, Leopoldo Alfonso, José Antonio Mendizábal, Beatriz Soret
Anatomical site and divergent functionalities of muscles can be related to differences in IMF content, metabolism and adipogenic gene expression. Then, potential differences in different muscles in beef cattle were studied. As a second objective, the main sources of experimental variability associated to RT-qPCR results were analyzed following a nested design in order to implement appropriate experimental designs minimizing gene expression variability. To perform the study Longissimus thoracis (LT), Semitendinosus (SM), Masseter (MS), Sternomandibularis (ST) and subcutaneous adipose tissue (SAT) samples of Pirenaica young bulls (n = 4) were collected for IMF, collagen and protein quantification, analysis of adipocyte size distribution and gene expression (PPARG, CEBPA, FAPB4 and WNT10B)...
2017: PloS One
https://www.readbyqxmd.com/read/28665611/comprehensive-myocardial-proteogenomics-profiling-reveals-c-ebp%C3%AE-as-the-key-factor-in-the-lipid-storage-of-arvc
#10
Liang Chen, Fan Yang, Xiao Chen, Man Rao, Ning-Ning Zhang, Kai Chen, HaiTeng Deng, Jiang-Ping Song, Sheng-Shou Hu
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is hereditary cardiomyopathy characterized by the fibro-fatty replacement of the myocardium. A small number of noncomprehensive profiling studies based on human cardiac tissues have been conducted and reported; consequently, ARVC's gene expression pattern characteristics remain largely undocumented. Our study applies large-scaled, quantitative proteomics based on TMT-labeled LC-MS/MS to analyze the left and right ventricular myocardium of four ARVC and four DCM explanted hearts to compare them with normal hearts...
July 13, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28665070/identification-of-downstream-genes-of-the-mtor-pathway-that-predict-recurrence-and-progression-in-non-muscle-invasive-high-grade-urothelial-carcinoma-of-the-bladder
#11
Subin Jin, In Ho Chang, Jin Wook Kim, Young Mi Whang, Ha Jeong Kim, Soon Auck Hong, Tae Jin Lee
Microarray analysis was used to investigate the lack of identified mammalian target of rapamycin (mTOR) pathway downstream genes to overcome cross-talk at non-muscle invasive high-grade (HG)-urothelial carcinoma (UC) of the bladder, gene expression patterns, gene ontology, and gene clustering by triple (p70S6K, S6K, and eIF4E) small interfering RNAs (siRNAs) or rapamycin in 5637 and T24 cell lines. We selected mTOR pathway downstream genes that were suppressed by siRNAs more than 2-fold, or were up-regulated or down-regulated by rapamycin more than 2-fold...
August 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28655922/direct-conversion-of-human-fibroblasts-to-brown-adipocytes-by-small-chemical-compounds
#12
Yukimasa Takeda, Yoshinori Harada, Toshikazu Yoshikawa, Ping Dai
Brown adipocytes play an important role in human energy metabolism and prevention of obesity and diabetes. Induced pluripotent stem cells (iPSCs) represent a promising source for brown adipocytes; however, exogenous gene induction is generally required for iPSCs generation, which might cause undesired effects particularly in long-term treatment after transplantation. We have previously reported a cocktail of six small chemical compounds that enables a conversion of human fibroblasts into chemical compound-induced neuronal cells (CiNCs)...
June 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28654680/serum-fatty-acid-binding-protein-4-fabp4-concentration-is-associated-with-insulin-resistance-in-peripheral-tissues-a-clinical-study
#13
Risa Nakamura, Tsuyoshi Okura, Yohei Fujioka, Keisuke Sumi, Kazuhiko Matsuzawa, Shoichiro Izawa, Etsuko Ueta, Masahiko Kato, Shin-Ichi Taniguchi, Kazuhiro Yamamoto
Type 2 diabetes mellitus (T2DM) is caused by insulin resistance and β cell dysfunction. In recent studies reported that several markers associated with insulin sensitivity in skeletal muscle, Adiponectin and other parameters, such as fatty acid-binding protein (FABP4), have been reported to regulate insulin resistance, but it remains unclear which factor mostly affects insulin resistance in T2DM. In this cross-sectional study, we evaluated the relationships between several kinds of biomarkers and insulin resistance, and insulin secretion in T2DM and healthy controls...
2017: PloS One
https://www.readbyqxmd.com/read/28625910/a-high-fat-diet-enhances-the-sensitivity-of-chick-adipose-tissue-to-the-effects-of-centrally-injected-neuropeptide-y-on-gene-expression-of-adipogenesis-associated-factors
#14
Guoqing Wang, Carli A Williams, Betty R McConn, Mark A Cline, Elizabeth R Gilbert
The purpose of this study was to determine how dietary macronutrient composition and exogenous neuropeptide Y (NPY) affect mRNA abundance of factors associated with lipid metabolism in chick adipose tissue. Chicks were fed one of three isocaloric (3000kcal metabolizable energy (ME)/kg) diets after hatch: high carbohydrate (HC; control), high fat (HF; 30% of ME from soybean oil) or high protein (HP; 25% crude protein). On day 4 post-hatch, vehicle or 0.2nmol of NPY was injected intracerebroventricularly and abdominal and subcutaneous fat depots collected 1h later...
June 16, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28620819/cellular-growth-and-tube-formation-of-htr8-svneo-trophoblast-effects-of-exogenously-added-fatty-acid-binding-protein-4-and-its-inhibitor
#15
Sanjay Basak, Arnab Sarkar, Santosh Mathapati, Asim K Duttaroy
Adequate placental angiogenesis is critical for the establishment of the placental circulation and thus for normal feto-placental growth and development. Fatty acid-binding protein-4 (FABP4) plays a pro-angiogenic role in endothelial cells; however, very little information is available in placental first trimester trophoblast cells. Here we report that exogenously added FABP4 (exo-FABP4) stimulated tube formation (as a measure of in vitro angiogenesis) in HTR8/SVneo trophoblastic cells. HTR-8/SVneo cells were incubated in the presence of exogenously added FABP4 at different concentrations and time points...
June 15, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28606512/heme-oxygenase-1-mediates-anti-adipogenesis-effect-of-raspberry-ketone-in-3t3-l1-cells
#16
Yung-Chieh Tsai, Bo-Cheng Yang, Wen-Huang Peng, Yen-Mei Lee, Mao-Hsiung Yen, Pao-Yun Cheng
BACKGROUND: Obesity is caused by excessive accumulation of body fat and is closely related to complex metabolic diseases. Raspberry ketone (RK), a major aromatic compound in red raspberry, was recently reported to possess anti-obesity effects. However, its mechanisms are unclear. AIM: Adipogenesis plays a critical role in obesity and, therefore, this study aimed to investigate the effect and mechanisms of action of RK on adipogenesis in 3T3-L1 preadipocytes. MATERIALS AND METHODS: 3T3-L1 preadipocytes were differentiated in medium containing insulin, dexamethasone, and 1-methyl-3-isobutylxanthine...
July 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28583436/serum-levels-of-fatty-acid-binding-protein-4-and-fat-metabolic-markers-in-relation-to-catecholamines-following-exercise
#17
Tatsuya Iso, Hiroaki Sunaga, Hiroki Matsui, Shu Kasama, Naomi Oshima, Hikari Haruyama, Nozomi Furukawa, Kiyomi Nakajima, Tetsuo Machida, Masami Murakami, Tomoyuki Yokoyama, Masahiko Kurabayashi
BACKGROUND: Lipolysis is stimulated by activation of adrenergic inputs to adipose tissues. Our recent study showed that serum concentrations of fatty acid binding protein 4 (FABP4) are robustly elevated in patients with acute myocardial infarction and ventricular tachyarrhythmia, that display a marked activation of the sympathetic nervous system (SNS). However, it remains unknown whether circulating FABP4 concentrations are associated with exercise-induced SNS activation. METHODS: Thirty one healthy volunteers underwent cardiopulmonary exercise testing on a cycle ergometer up to the workload levels below and above anaerobic threshold, low- and high-intensity exercise, respectively...
June 2, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28582464/total-control-of-fat-cells-from-adipogenesis-to-apoptosis-using-a-xanthene-analog
#18
Ching-Hsuan Tung, Myung Shin Han, Jianjun Qi
Overcrowded adipocytes secrete excess adipokines and cytokines under stress, which results in a deregulated metabolism. This negative response to stress increases the possibility of obesity and several of its associated diseases, such as cancer and atherosclerosis. Therefore, a reduction in the number of adipocytes may be a rational strategy to relieve the undesired expansion of adipose tissue. A newly synthesized xanthene analog, MI-401, was found to have two distinct effects on the regulation of the adipocyte's life cycle...
2017: PloS One
https://www.readbyqxmd.com/read/28580407/mc3t3-osteoblast-like-cells-cultured-at-alkaline-ph-microarray-data-affymetrix-genechip-mouse-2-0-st
#19
Anne-Marie Galow, Alexander Rebl, Dirk Koczan, Jan Gimsa
It is well known that pH plays a pivotal role in the control of bone remodeling. However, no comprehensive gene expression data are available for the effects of alkaline pH on osteoblasts. We cultured differentiating MC3T3-E1 osteoblast-like cells at pH 7.4, 7.8, and 8.4 for 14 days. To identify differential gene expression, microarray data were collected with Affymetrix GeneChips. The data were validated by real-time PCRs for five genes that were found to be greatly regulated in the GeneChip-experiments (DMP1, FABP4, SFRP2 and TNFRSF19) or considered relevant for the terminal function of osteoblasts (DMP1 and ATF4)...
August 2017: Data in Brief
https://www.readbyqxmd.com/read/28579594/exploration-of-underlying-mechanism-of-anti-adipogenic-activity-of-sulfuretin
#20
Ramakanta Lamichhane, Se-Gun Kim, Sona Kang, Kyung-Hee Lee, Prakash Raj Pandeya, Hyun-Ju Jung
Sulfuretin is a natural flavonoid found in the plant Rhus verniciflua Stokes. The plant has been traditionally used as medicinal agent for antiviral, cathartic, diaphoretic, anti-rheumatic and sedative activities in East Asia. In this study we isolated and identified sulfuretin from R. verniciflua and investigated its anti-adipogenic activity against 3T3-L1 preadipocytes cells. We evaluated the effects of sulfuretin on the adipogenic transcription factors like PPARγ, C/EBPα, FAS, Fabp4, adiponectin and Zfp521 by gene expression (real-time QPCR) and Western blot analysis...
June 3, 2017: Biological & Pharmaceutical Bulletin
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