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https://www.readbyqxmd.com/read/28904578/rosette-forming-glioneuronal-tumor-a-rare-posterior-fossa-tumor-in-an-adolescent
#1
Goutam Bera, Amitabha Das, Sandip Chatterjee, Uttara Chatterjee
Rosette-forming glioneuronal tumor (RGNT) is a rare variety of slow growing mixed glioneuronal tumor involving primarily fourth ventricular region and occurring predominantly in young adults. We present a case of a 16-year-old boy who presented with dizziness and occipital headache. On radiological evaluation, a fairly large hypodense posterior fossa mass lesion in relation to the left side of the vermis, with a large cystic component was found. Surgical resection of the tumor was performed. Histopathological examination showed a biphasic tumor composed of bland neurocytic cells, arranged in the form of neurocytic rosettes along with glial areas resembling low-grade glioma...
April 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/28836232/diencephalic-pediatric-low-grade-glioma-harboring-the-braf-v600e-mutation-presenting-with-various-morphologies-in-sequential-biopsy-specimens
#2
Yukitomo Ishi, Kanako C Hatanaka, Shigeru Yamaguchi, Hiromi Fujita, Hiroaki Motegi, Hiroyuki Kobayashi, Shunsuke Terasaka, Kiyohiro Houkin
A 5-year-old boy underwent biopsy of an intra-axial calcified tumor in the hypothalamus, which was incidentally found. Based on the presence of ganglion-like cells combined with glial cell element, the pathological diagnosis was ganglioglioma. Because the tumor grew gradually in size over the next 2 years, he underwent chemotherapy with temozolomide. However, at 8 years of age, the boy developed hydrocephalus and the cystic lesion had re-grown. Endoscopic cyst fenestration and tumor biopsy was performed, and pathological diagnosis was tentatively oligodendroglioma based on the presence of tumor cells with a perinuclear halo...
August 23, 2017: Brain Tumor Pathology
https://www.readbyqxmd.com/read/28686124/influence-of-an-intratumoral-cyst-on-drug-distribution-by-convection-enhanced-delivery-case-report
#3
Iryna Ivasyk, Peter F Morgenstern, Eva Wembacher-Schroeder, Mark M Souweidane
Convection-enhanced delivery (CED) uses positive pressure to induce convective flow of molecules and maximize drug distribution. Concerns have been raised about the effect of cystic structures on uniform drug distribution with CED. The authors describe the case of a patient with a diffuse intrinsic pontine glioma (DIPG) with a large cyst and examine its effect on drug distribution after CED with a radiolabeled antibody. The patient was treated according to protocol with CED of (124)I-8H9 to the pons for nonprogressive DIPG after radiation therapy as part of a Phase I trial (clinical trial registration no...
September 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28685138/immunophenotypic-signature-of-primary-glioblastoma-multiforme-a-case-of-extended-progression-free-survival
#4
Puneet Gandhi, Richa Khare, Nitin Garg, Sandeep Sorte
Glioblastoma-multiforme (GBM), the most aggressive glial tumor, has a worldwide age-adjusted incidence ranging from 0.59-3.69/100000 persons. Despite current multimodal-treatment approach, median-survival time and progression-free survival (PFS) remains short. Glioblastomas display a variety of molecular alterations, which necessitates determining which of these have a prognostic significance. This is a case of a 45-year-old patient who presented with progressive slurring of speech and features of raised intracranial pressure...
June 16, 2017: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/28644110/detailed-magnetic-resonance-imaging-features-of-a-case-series-of-primary-gliosarcoma
#5
Luísa Sampaio, Paulo Linhares, José Fonseca
Objective We aimed to characterise the magnetic resonance imaging (MRI) features of a case series of primary gliosarcoma, with the inclusion of diffusion-weighted imaging and perfusion imaging with dynamic susceptibility contrast MRI. Materials and methods We conducted a retrospective study of cases of primary gliosarcoma from the Pathology Department database from January 2006 to December 2014. Clinical and demographic data were obtained. Two neuroradiologists, blinded to diagnosis, assessed tumour location, signal intensity in T1 and T2-weighted images, pattern of enhancement, diffusion-weighted imaging and dynamic susceptibility contrast MRI studies on preoperative MRI...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28631560/mithramycin-inhibits-epithelial-to-mesenchymal-transition-and-invasion-by-downregulating-sp1-and-snai1-in-salivary-adenoid-cystic-carcinoma
#6
Jiasu Li, Hongmei Gao, Lingxu Meng, Lin Yin
Mithramycin exhibits certain anticancer effects in glioma, metastatic cerebral carcinoma, malignant lymphoma, chorionic carcinoma and breast cancer. However, its effects on salivary adenoid cystic carcinoma remain unclear. Here, we report that mithramycin significantly inhibited epithelial-to-mesenchymal transition and invasion in human salivary adenoid cystic carcinoma cell lines. The underlying mechanism for this activity was further demonstrated to involve decreasing the expression of the transcription factors specificity protein 1 and SNAI1...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28629576/differentiation-of-brain-tumor-related-edema-based-on-3d-t1rho-imaging
#7
J E Villanueva-Meyer, R F Barajas, M C Mabray, W Chen, A Shankaranarayanan, P Koon, I J Barani, T Tihan, S Cha
BACKGROUND AND PURPOSE: Cerebral edema associated with brain tumors is an important source of morbidity. Its type depends largely on the capillary ultra-structures of the histopathologic subtype of underlying brain tumor. The purpose of our study was to differentiate vasogenic edema associated with brain metastases and infiltrative edema related to diffuse gliomas using quantitative 3D T1 rho (T1ρ) imaging. MATERIALS AND METHODS: Preoperative MR examination including whole brain 3D T1ρ imaging was performed in 23 patients with newly diagnosed brain tumors (9 with metastasis, 8 with lower grade glioma, LGG, 6 with glioblastoma, GBM)...
June 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28567590/evaluation-of-outcomes-after-stereotactic-radiosurgery-for-pilocytic-astrocytoma
#8
Daniel M Trifiletti, M Sean Peach, Zhiyuan Xu, Ronald Kersh, Timothy N Showalter, Jason P Sheehan
Pilocytic astrocytomas are rare intracranial gliomas that are typically treated with surgical extirpation. Our aim was to report the radiologic and clinical outcomes of patients treated with stereotactic radiosurgery (SRS) for pilocytic astrocytoma in the primary and salvage setting. Patients with pilocytic astrocytoma treated at a single institution with SRS from 1990 to 2015 were reviewed. Patient, disease, and treatment characteristics were collected and overall survival, local control, and toxicity were evaluated...
May 31, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28547652/histone-h3-k27m-mutations-in-adult-cerebellar-high-grade-gliomas
#9
Satoshi Nakata, Sumihito Nobusawa, Tatsuya Yamazaki, Tadashi Osawa, Keishi Horiguchi, Yasuhiro Hashiba, Hiroyuki Yaoita, Nozomi Matsumura, Hayato Ikota, Junko Hirato, Yuhei Yoshimoto, Hideaki Yokoo
Adult cerebellar high-grade gliomas (HGG) are rare and their molecular basis has not been fully elucidated. Although a diffuse midline glioma H3 K27M-mutant, a recently characterized variant of HGG, was reported to occasionally occur in the cerebellum, adult cases were rarely tested for this mutation; only five mutant cases have been reported to date. It currently remains unknown whether H3 K27M-mutant cerebellar gliomas share common histological features or have a uniformly dismal prognosis. In the present study, we assessed the prevalence of histone H3 K27M mutations in ten adult cerebellar HGG, identifying two H3F3A-mutant cases...
July 2017: Brain Tumor Pathology
https://www.readbyqxmd.com/read/28524459/prognostic-role-of-conventional-and-dynamic-contrast-enhanced-mri-in-optic-pathway-gliomas
#10
Nutchawan Jittapiromsak, Ping Hou, Ho-Ling Liu, Jia Sun, John M Slopis, T Linda Chi
BACKGROUND AND PURPOSE: The natural history of optic pathway glioma (OPG) is highly variable and unpredictable. We present a pilot study of the prognostic role of conventional and dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) in the evaluation of OPG. METHODS: We retrospectively reviewed 17 patients with 20 pretreatment OPG lesions who underwent conventional and DCE MRI between January 2010 and December 2016. Conventional MRI was evaluated for enhancement pattern, cystic component, optic nerve tortuosity, optic nerve dural ectasia, and optic nerve perineural thickening...
May 19, 2017: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/28378288/development-of-cystic-malacia-after-high-dose-cranial-irradiation-of-pediatric-cns-tumors-in-long-term-follow-up
#11
Fumiyuki Yamasaki, Takeshi Takayasu, Ryo Nosaka, Ikuno Nishibuchi, Hiroshi Kawaguchi, Manish Kolakshyapati, Shumpei Onishi, Taiichi Saito, Kazuhiko Sugiyama, Masao Kobayashi, Kaoru Kurisu
PURPOSE: The purpose of this study is to investigate the incidence of cystic malacia in long-term survivors of pediatric brain tumors treated with high-dose cranial irradiation. MATERIALS AND METHODS: Between 1997 and 2015, we treated 41 pediatric patients (26 males, 15 females; age ranging from 3.3 to 15.7 years, median 9-year-old) of pediatric brain tumors [17 medulloblastomas, 7 primitive neuroectodermal tumors (PNET), 3 pineoblastomas, 6 non-germinomatous germ cell tumors (NGGCT), 8 gliomas (including 4 ependymomas, 1 anaplastic astrocytoma, 1 oligodendroglioma, 1 pilocytic astrocytoma, 1 astroblastoma)] with high-dose craniospinal irradiation...
April 4, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28222441/unusual-occurrence-of-multifocal-desmoplastic-infantile-astrocytoma-a-case-report-and-review-of-the-literature
#12
Vinayak Narayan, Amey R Savardekar, Anita Mahadevan, A Arivazhagan, Lingegowda Appaji
Desmoplastic infantile gliomas are rare, benign tumors of the early infancy period. Two histological subtypes - desmoplastic infantile astrocytoma (DIA) and desmoplastic infantile ganglioglioma - have been described. The characteristic features of DIAs are lobar location, glial histology, and excellent prognosis after complete surgical excision. DIAs usually present as solitary, cortical-surfacing, solid-cystic neoplasms; however, atypical, aggressive, and multifocal variants of DIA have been reported in the literature...
2017: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28216397/gamma-knife-radiosurgery-for-low-grade-gliomas-clinical-results-at-long-term-follow-up-of-tumor-control-and-patients-quality-of-life
#13
Filippo Gagliardi, Michele Bailo, Alfio Spina, Carmine A Donofrio, Nicola Boari, Alberto Franzin, Arianna Fava, Antonella Del Vecchio, Angelo Bolognesi, Pietro Mortini
OBJECTIVE: First-line therapy for low-grade gliomas (LGGs) is surgery, in some cases followed by radiotherapy and chemotherapy. Gamma Knife radiosurgery (GKRS) has gained more relevance in the management of these tumors. The aim of this study was to assess efficacy and safety of GKRS for treatment of LGGs. METHODS: Between 2001 and 2014, 42 treatments were performed on 39 patients harboring LGGs; 48% of patients underwent previous surgery, and 20.5% underwent previous radiotherapy...
May 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28195245/ependymoma-with-diffuse-signet-ring-features-report-of-a-case-and-review-of-the-literature
#14
L Cima, S Beccari, C Ghimenton, G Pinna, A Beltramello, M Chilosi, M Brunelli, A Eccher
Signet-ring cell ependymoma is a rare variant of ependymoma with only seven cases described in literature. Biological behavior and prognosis of this entity are not well-known until now. We present a case of a 49-year-old female with a history of headache and gait instability. Magnetic resonance imaging showed an upper cervical tumor with cystic component and mural nodule. The patient underwent surgery. Microscopically some cells displayed an eccentric nucleus compressed to the periphery by vacuolated cytoplasm...
March 2016: Pathologica
https://www.readbyqxmd.com/read/28120058/endoscopic-reconstruction-of-csf-pathways-in-ventricular-tumors
#15
Piero Andrea Oppido
Neuroendoscopy is now considered to be a minimally invasive surgical approach for expanding lesions bulging into the ventricle, and it is also considered to be a relevant tool for performing biopsy procedures, fenestration of cystic walls, or for performing tumor removal in selected cases. Furthermore, the use of neuroimaging and the accurate follow-up of brain tumor patients have allowed the documentation of tumoral and pseudotumoral cystic areas that cause the obstruction of cerebrospinal fluid (CSF) pathways...
2017: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/27843910/primary-orbital-cystic-pilocytic-astrocytoma
#16
Hardeep Singh Mudhar, Murtuza Nuruddin, Soma Roy
PURPOSE: To describe the clinical, radiological and histopathological features of a highly unusual primary orbital glioma. PROCEDURES: A 6-year-old female presented with right-sided proptosis that revealed a well-defined intraconal mass on CT imaging with intact orbital bony walls. During the removal of the lesion, it dissected away freely from the muscles and was separated from the optic nerve and globe. There was no communication with the brain. RESULTS: Histology showed histological features highly favouring a pilocytic astrocytoma enveloped by meninges...
October 2016: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/27764513/heterogeneity-of-histopathological-presentation-of-pilocytic-astrocytoma-diagnostic-pitfalls-a-review
#17
REVIEW
E Matyja, W Grajkowska, K Stępień, E Naganska
Pilocytic astrocytomas (PAs) are the most frequent primary astroglial tumours affecting children and adolescents. They occur sporadically or in association with a genetically determined syndrome - neurofibromatosis type 1. Classic PA usually manifests as a well-circumscribed, often cystic, slowly growing tumour, which corresponds to WHO grade I. The majority of pilocytic tumours arise along the neuraxis, predominantly in the cerebellum. They are associated with favourable long-term outcome or spontaneous regression, even after incomplete resection...
2016: Folia Neuropathologica
https://www.readbyqxmd.com/read/27698865/rapid-increase-in-cystic-volume-of-an-anaplastic-astrocytoma-misdiagnosed-as-neurocysticercosis-a-case-report
#18
Hong-Jiang Li, Hong-Xiu Han, Dong-Fu Feng
Reports describing a rapid increase in the cystic volume of anaplastic astrocytoma (AA) in a short time frame are rare. The present study reports the case of a 68-year-old male who was admitted to the No. 9 People's Hospital, Shanghai Jiaotong University School of Medicine (Shanghai, China), with a small cystic brain lesion and positive immunological testing for cysticercosis. Head magnetic resonance imaging (MRI) showed a cystic lesion, 6 mm in diameter, in the left frontal lobe. Neurocysticercosis was suspected and the patient was treated with a clinical trial of albendazole and steroids...
October 2016: Oncology Letters
https://www.readbyqxmd.com/read/27695569/nocardia-farcinica-abscess-of-the-cerebellum-in-an-immunocompetent-patient-a-case-report-and-review-of-the-literature
#19
María Pascual-Gallego, Pedro Alonso-Lera, Ana Arribi, Juan A Barcia, Javier Marco
Nocardial brain abscesses are uncommon and rarely occur in patients without predisposing factors. They may be mistaken for gliomas or necrotic metastases, and surgical intervention may be required to make the diagnosis. We report the first case of Nocardia farcinica cerebellar abscess in a patient without immunosuppression. He presented to us with headache and instability beginning a week before. Brain magnetic resonance imaging (MRI) revealed a cystic lesion located at the right cerebellar hemisphere, hypointense in T1 and hyperintense in T2, with a fine wall that enhanced after injection of gadolinium...
October 2016: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/27622554/prognostic-value-of-18-f-fet-pet-imaging-in-re-irradiation-of-high-grade-glioma-results-of-a-phase-i-clinical-trial
#20
Soren Moller, Ian Law, Per Munck Af Rosenschold, Junia Costa, Hans Skovgaard Poulsen, Svend Aage Engelholm, Silke Engelholm
BACKGROUND AND PURPOSE: Positron emission tomography (PET) provides quantitative metabolic information and potential biomarkers of treatment outcome. We aimed to determine the prognostic value of early (18)F-fluoroethyl-tyrosine ((18)F-FET) PET scans acquired during re-irradiation for recurrent high-grade glioma (HGG). MATERIAL AND METHODS: A phase I clinical trial of re-irradiation of HGG was carried out. MRI and (18)F-FET PET were used for target delineation and follow-up...
September 9, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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