keyword
MENU ▼
Read by QxMD icon Read
search

Black box

keyword
https://www.readbyqxmd.com/read/28735497/conceptual-dft-analysis-of-the-regioselectivity-of-1-3-dipolar-cycloadditions-nitrones-as-a-case-of-study
#1
Ramón Alain Miranda-Quintana, Marco Martínez González, David Hernández-Castillo, Luis A Montero-Cabrera, Paul W Ayers, Christophe Morell
The regioselectivity of the 1,3-dipolar cycloaddition of a model nitrone with a set of dipolarophiles, presenting diverse electronic effects, is analyzed using conceptual density functional theory (DFT) methods. We deviate from standard approaches based on frontier molecular orbitals and formulations of the local hard/soft acid/base principle and use instead the dual descriptor. A detailed analysis is carried out to determine the influence of the way to calculate the dual descriptor, the computational procedure, basis set and choice of method to condensate the values of this descriptor...
August 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28732056/inferring-microbial-interactions-in-thermophilic-and-mesophilic-anaerobic-digestion-of-hog-waste
#2
Grace Tzun-Wen Shaw, An-Chi Liu, Chieh-Yin Weng, Chu-Yang Chou, Daryi Wang
Anaerobic digestion (AnD) is a microbiological process that converts organic waste materials into biogas. Because of its high methane content, biogas is a combustible energy source and serves as an important environmental technology commonly used in the management of animal waste generated on large animal farms. Much work has been done on hardware design and process engineering for the generation of biogas. However, little is known about the complexity of the microbiology in this process. In particular, how microbes interact in the digester and eventually breakdown and convert organic matter into biogas is still regarded as a "black box...
2017: PloS One
https://www.readbyqxmd.com/read/28727866/pediatric-posttonsillectomy-analgesia-before-and-after-the-black-box-warning-against-codeine-use
#3
William C Van Cleve
No abstract text is available yet for this article.
July 20, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28722254/determination-of-irritant-threshold-concentrations-of-multiple-tree-grass-weed-and-mould-allergens-for-intradermal-testing-of-horses-residing-in-the-southern-usa
#4
Martha J Lane, Cherie M Pucheu-Haston, Michael T Kearney, Michelle Woodward
BACKGROUND: Appropriate allergen threshold concentrations (TCs) for intradermal testing (IDT) have not been established in horses for many pollen and mould allergens. OBJECTIVES: To determine the TCs in non-allergic horses and describe the frequency of late phase reactions for 26 allergens, including trees, grasses, weeds and moulds in horses residing in the southern Unites States. ANIMALS: Twenty four clinically normal horses in the southern United States...
July 18, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28720440/first-report-of-two-complete-clostridium-chauvoei-genome-sequences-and-detailed-in-silico-genome-analysis
#5
Prasad Thomas, Torsten Semmler, Inga Eichhorn, Antina Lübke-Becker, Christiane Werckenthin, Mostafa Y Abdel-Glil, Lothar H Wieler, Heinrich Neubauer, Christian Seyboldt
Clostridium (C.) chauvoei is a Gram-positive, spore forming, anaerobic bacterium. It causes black leg in ruminants, a typically fatal histotoxic myonecrosis. High quality circular genome sequences were generated for the C. chauvoei type strain DSM 7528(T) (ATCC 10092(T)) and a field strain 12S0467 isolated in Germany. The origin of replication (oriC) was comparable to that of Bacillus subtilis in structure with two regions containing DnaA boxes. Similar prophages were identified in the genomes of both C. chauvoei strains which also harbored hemolysin and bacterial spore formation genes...
July 15, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28715978/the-role-of-efflux-pumps-in-tuberculosis-treatment-and-their-promise-as-a-target-in-drug-development-unraveling-the-black-box
#6
Lindsey H M Te Brake, Gerjo J de Knegt, Jurriaan E de Steenwinkel, Teunis J P van Dam, David M Burger, Frans G M Russel, Reinout van Crevel, Jan B Koenderink, Rob E Aarnoutse
Insight into drug transport mechanisms is highly relevant to the efficacious treatment of tuberculosis (TB). Major problems in TB treatment are related to the transport of antituberculosis (anti-TB) drugs across human and mycobacterial membranes, affecting the concentrations of these drugs systemically and locally. Firstly, transporters located in the intestines, liver, and kidneys all determine the pharmacokinetics and pharmacodynamics of anti-TB drugs, with a high risk of drug-drug interactions in the setting of concurrent use of antimycobacterial, antiretroviral, and antidiabetic agents...
July 17, 2017: Annual Review of Pharmacology and Toxicology
https://www.readbyqxmd.com/read/28714920/the-role-of-perceived-social-norms-in-rural-sanitation-an-explorative-study-from-infrastructure-restricted-settings-of-south-ethiopia
#7
Josef Novotný, Jana Kolomazníková, Helena Humňalová
The perception of social sanitation norms (PSSNs) around unacceptability of open defecation has been a key aspect of recent sanitation interventions. However, underlying mechanisms through which "reconstructed" PSSNs affect sanitation outcomes have been a black box. This explorative cross-sectional study examines direct and indirect links between PSSNs and sanitation safety using data from structured interviews and observations in 368 households in rural South Ethiopia. In addition to a positive association between PSSNs and sanitation safety, we propose and examine the following two mechanisms: First, we confirm a potentially adverse feedback of PSSNs on future sanitation safety by enhancing the emotional satisfaction with current sanitation practice (satisfaction independent of the functionality of sanitation facilities)...
July 17, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28714785/effects-of-alcohol-on-inhibitory-avoidance-learning-in-zebrafish-danio-rerio
#8
Ricardo Rodrigues Amorim, Priscila Fernandes Silva, Ana Carolina Luchiari
The zebrafish (Danio rerio) can be used in studies addressing the effects of drugs on learning, memory, and anxiety. In the present study, we investigated the effect of different alcohol treatments (chronic and acute) on the learning and anxiety response of zebrafish in an inhibitory avoidance paradigm. Zebrafish were initially exposed to different alcohol treatments and submitted to an inhibitory avoidance protocol, where an electroshock was applied to the fish as they swam from the white to the black side of a shuttle box tank (naturally preferred environment of zebrafish)...
July 17, 2017: Zebrafish
https://www.readbyqxmd.com/read/28711053/representations-in-neural-network-based-empirical-potentials
#9
Ekin D Cubuk, Brad D Malone, Berk Onat, Amos Waterland, Efthimios Kaxiras
Many structural and mechanical properties of crystals, glasses, and biological macromolecules can be modeled from the local interactions between atoms. These interactions ultimately derive from the quantum nature of electrons, which can be prohibitively expensive to simulate. Machine learning has the potential to revolutionize materials modeling due to its ability to efficiently approximate complex functions. For example, neural networks can be trained to reproduce results of density functional theory calculations at a much lower cost...
July 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28694108/increased-blood-pressure-variability-upon-standing-up-improves-reproducibility-of-cerebral-autoregulation-indices
#10
Adam Mahdi, Dragana Nikolic, Anthony A Birch, Mette S Olufsen, Ronney B Panerai, David M Simpson, Stephen J Payne
Dynamic cerebral autoregulation, that is the transient response of cerebral blood flow to changes in arterial blood pressure, is currently assessed using a variety of different time series methods and data collection protocols. In the continuing absence of a gold standard for the study of cerebral autoregulation it is unclear to what extent does the assessment depend on the choice of a computational method and protocol. We use continuous measurements of blood pressure and cerebral blood flow velocity in the middle cerebral artery from the cohorts of 18 normotensive subjects performing sit-to-stand manoeuvre...
July 7, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28691274/commentary-on-holst-et-al-2017-the-relationship-between-alcohol-dependence-and-risk-of-somatic-diseases-and-mortality-the-black-box-strikes-back
#11
https://www.readbyqxmd.com/read/28690156/the-microbiome-as-engineering-tool-manufacturing-and-trading-between-microorganisms
#12
REVIEW
Jo De Vrieze, Marlies E R Christiaens, Willy Verstraete
The integration of microbial technologies within the framework of the water-energy nexus has been taking place for over a century, but these mixed microbial communities are considered hard to deal with 'black boxes'. Process steering is mainly based on avoiding process failure by monitoring conventional parameters, e.g., pH and temperature, which often leads to operation far below the intrinsic potential. Mixed microbial communities do not reflect a randomised individual mix, but an interacting microbiological entity...
July 6, 2017: New Biotechnology
https://www.readbyqxmd.com/read/28689019/common-versus-specific-factors-in-psychotherapy-opening-the-black-box
#13
REVIEW
Roger Mulder, Greg Murray, Julia Rucklidge
Do psychotherapies work primarily through the specific factors described in treatment manuals, or do they work through common factors? In attempting to unpack this ongoing debate between specific and common factors, we highlight limitations in the existing evidence base and the power battles and competing paradigms that influence the literature. The dichotomy is much less than it might first appear. Most specific factor theorists now concede that common factors have importance, whereas the common factor theorists produce increasingly tight definitions of bona fide therapy...
July 5, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28688344/finding-the-way-forward-for-forensic-science-in-the-us-a-commentary-on-the-pcast-report
#14
REVIEW
I W Evett, C E H Berger, J S Buckleton, C Champod, G Jackson
A recent report by the US President's Council of Advisors on Science and Technology (PCAST), (2016) has made a number of recommendations for the future development of forensic science. Whereas we all agree that there is much need for change, we find that the PCAST report recommendations are founded on serious misunderstandings. We explain the traditional forensic paradigms of match and identification and the more recent foundation of the logical approach to evidence evaluation. This forms the groundwork for exposing many sources of confusion in the PCAST report...
June 26, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28686749/setting-research-priorities-for-maternal-newborn-child-health-and-nutrition-in-india-by-engaging-experts-from-256-indigenous-institutions-contributing-over-4000-research-ideas-a-chnri-exercise-by-icmr-and-inclen
#15
Narendra K Arora, Archisman Mohapatra, Hema S Gopalan, Kerri Wazny, Vasantha Thavaraj, Reeta Rasaily, Manoj K Das, Meenu Maheshwari, Rajiv Bahl, Shamim A Qazi, Robert E Black, Igor Rudan
BACKGROUND: Health research in low- and middle- income countries (LMICs) is often driven by donor priorities rather than by the needs of the countries where the research takes place. This lack of alignment of donor's priorities with local research need may be one of the reasons why countries fail to achieve set goals for population health and nutrition. India has a high burden of morbidity and mortality in women, children and infants. In order to look forward toward the Sustainable Development Goals, the Indian Council of Medical Research (ICMR) and the INCLEN Trust International (INCLEN) employed the Child Health and Nutrition Research Initiative's (CHNRI) research priority setting method for maternal, neonatal, child health and nutrition with the timeline of 2016-2025...
June 2017: Journal of Global Health
https://www.readbyqxmd.com/read/28681464/qualitative-exploration-of-relationships-between-peers-in-residential-addiction-treatment
#16
Joanne Neale, Charlotte N E Tompkins, John Strang
Relationships between peers are often considered central to the therapeutic process, yet there is relatively little empirical research either on the nature of peer-to-peer relationships within residential treatment or on how those relationships generate positive behaviour change or facilitate recovery. In this paper, we explore relationships between peers in residential addiction treatment, drawing upon the concept of social capital to frame our analyses. Our study was undertaken during 2015 and 2016 in two English residential treatment services using the same therapeutic community-informed model of treatment...
July 5, 2017: Health & Social Care in the Community
https://www.readbyqxmd.com/read/28673048/taming-the-beast-a-community-teaching-material-resource-for-beast-2
#17
Joëlle Barido-Sottani, Veronika Bošková, Louis du Plessis, Denise Kühnert, Carsten Magnus, Venelin Mitov, Nicola F Müller, Julija Pecerska, David A Rasmussen, Chi Zhang, Alexei J Drummond, Tracy A Heath, Oliver G Pybus, Timothy G Vaughan, Tanja Stadler
Phylogenetics and phylodynamics are central topics in modern evolutionary biology. Phylogenetic methods reconstruct the evolutionary relationships among organisms, whereas phylodynamic approaches reveal the underlying diversification processes that lead to the observed relationships. These two fields have many practical applications in disciplines as diverse as epidemiology, developmental biology, palaeontology, ecology, and linguistics. The combination of increasingly large genetic datasets and increases in computing power is facilitating the development of more sophisticated phylogenetic and phylodynamic methods...
June 29, 2017: Systematic Biology
https://www.readbyqxmd.com/read/28670083/olmesartan-associated-enteropathy
#18
Vivian S Ebrahim, Jason Martin, Stacey Murthy, Elizabeth Odstrcil, He Huang, Daniel Polter
Olmesartan, an angiotensin-receptor blocker frequently prescribed for hypertension, has been commercially available since 2002. In 2012, olmesartan-associated enteropathy was described, and the Food and Drug Administration now requires a black-box warning for olmesartan regarding severe diarrhea. The disorder can be life-threatening and often requires hospitalization. We present three cases that represent different aspects of this disorder, as well as some unusual features.
July 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28667939/validation-of-a-novel-nonlinear-black-box-wiener-system-model-for-arterial-pulse-transmission
#19
Amit M Patel, John K-J Li
Numerous linear dynamic models exist for describing the arterial pulse transmission phenomenon. We introduce a novel Wiener system based model in which a linear filter representing large arteries is coupled with a hysteresis-free nonlinear function representing complex wave transmission of branching arteries and the periphery. Experimental datasets (n = 7) are used to first estimate the Wiener model with linear, quadratic and cubic function for the aorta to radial artery pulse transmission and aorta to femoral artery pulse transmission...
June 23, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28651043/visualizing-the-contributions-of-virtual-states-to-two-photon-absorption-cross-sections-by-natural-transition-orbitals-of-response-transition-density-matrices
#20
Kaushik D Nanda, Anna I Krylov
Observables such as two-photon absorption cross sections cannot be computed from the wave functions of initial and final states alone because of their nonlinear nature. Rather, they depend on the entire manifold of the excited states, which follows from the familiar sum-over-states expressions of second- and higher-order properties. Consequently, the interpretation of the computed nonlinear optical properties in terms of molecular orbitals is not straightforward and usually relies on approximate few-states models...
July 5, 2017: Journal of Physical Chemistry Letters
keyword
keyword
79860
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"