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https://www.readbyqxmd.com/read/28212351/black-box%C3%A2-gastrointestinal%C3%A2-tract-needs%C3%A2-and%C3%A2-prospects%C3%A2-of%C3%A2-gaining%C3%A2-insights%C3%A2-of%C3%A2-fate%C3%A2-of%C3%A2-fat-%C3%A2-protein-%C3%A2-and%C3%A2-starch%C3%A2-in%C3%A2-case%C3%A2-of%C3%A2-exocrine%C3%A2-pancreatic%C3%A2-insufficiency%C3%A2-by%C3%A2-using%C3%A2-fistulated%C3%A2-pigs
#1
REVIEW
Anne Mößeler, Josef Kamphues
Exocrine pancreatic insufficiency (EPI) results in the maldigestion and malabsorption of nutrients. The digestive processes in humans and other monogastric species like rat and pig are characterized by a predominantly enzymatic digestion within the small intestine and microbial fermentation located in the hindgut. For protein, it is doctrine that only prececally absorbed amino acids can be transferred to the amino acid pool of the host, while postileal absorption of nitrogen-containing compounds occurs mainly in the form of ammonia, being a burden rather than a benefit for the organism...
February 16, 2017: Nutrients
https://www.readbyqxmd.com/read/28207296/gambit-a-parameterless-model-based-evolutionary-algorithm-for-mixed-integer-problems
#2
Krzysztof L Sadowski, Dirk Thierens, Peter A N Bosman
Learning and exploiting problem structure is one of the key challenges in optimization. This is especially important for black-box optimization (BBO) where prior structural knowledge of a problem is not available. Existing model-based Evolutionary Algorithms (EAs) are very efficient at learning structure in both the discrete, and in the continuous domain. In this paper, discrete and continuous model-building mechanisms are integrated for the Mixed-Integer (MI) domain, comprising discrete and continuous variables...
February 16, 2017: Evolutionary Computation
https://www.readbyqxmd.com/read/28194562/the-iboga-alkaloids
#3
Catherine Lavaud, Georges Massiot
Iboga alkaloids are a particular class of indolomonoterpenes most often characterized by an isoquinuclidine nucleus. Their first occurrence was detected in the roots of Tabernanthe iboga, a sacred plant to the people of Gabon, which made it cult object. Ibogaine is the main representative of this class of alkaloids and its psychoactive properties are well documented. It has been proposed as a drug cessation treatment and has a wide range of activities in targeting opioids, cocaine, and alcohol. The purpose of this chapter is to provide a background on this molecule and related compounds and to update knowledge on the most recent advances made...
2017: Progress in the Chemistry of Organic Natural Products
https://www.readbyqxmd.com/read/28193401/multiresponse-optimization-of-a-uplc-method-for-the-simultaneous-determination-of-tryptophan-and-15-tryptophan-derived-compounds-using-a-box-behnken-design-with-a-desirability-function
#4
Widiastuti Setyaningsih, Irfan E Saputro, Ceferino A Carrera, Miguel Palma, Carmelo G Barroso
A Box-Behnken design was used in conjunction with multiresponse optimization based on the desirability function to carry out the simultaneous separation of tryptophan and 15 derivatives by Ultra Performance Liquid Chromatography. The gradient composition of the mobile phase and the flow rate were optimized with respect to the resolution of severely overlapping chromatographic peaks and the total run time. Two different stationary phases were evaluated (hybrid silica and a solid-core-based C18 column). The methods were validated and a suitable sensitivity was found for all compounds in the concentration range 1-100μgL(-1) (R(2)>0...
June 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28191447/reexamining-chronic-toxoplasma-gondii-infection-surprising-activity-for-a-dormant-parasite
#5
Anthony P Sinai, Elizabeth A Watts, Animesh Dhara, Robert D Murphy, Matthew S Gentry, Abhijit Patwardhan
PURPOSE OF REVIEW: Despite over a third of the world's population being chronically infected with Toxoplasma gondii, little is known about this largely asymptomatic phase of infection. This stage is mediated in vivo by bradyzoites within tissue cysts. The absence of overt symptoms has been attributed to the dormancy of bradyzoites. In this review, we reexamine the conventional view of chronic toxoplasmosis in light of emerging evidence challenging both the nature of dormancy and the consequences of infection in the CNS...
December 2016: Current Clinical Microbiology Reports
https://www.readbyqxmd.com/read/28188470/modeling-the-effect-of-tilting-passive-leg-exercise-and-functional-electrical-stimulation-on-the-human-cardiovascular-system
#6
Amirehsan Sarabadani Tafreshi, Jan Okle, Verena Klamroth-Marganska, Robert Riener
Long periods of bed rest negatively affect the human body organs, notably the cardiovascular system. To avert these negative effects and promote functional recovery in patients dealing with prolonged bed rest, the goal is to mobilize them as early as possible while controlling and stabilizing their cardiovascular system. A robotic tilt table allows early mobilization by modulating body inclination, automated passive leg exercise, and the intensity of functional electrical stimulation applied to leg muscles (inputs)...
February 10, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28187216/the-lexicocalorimeter-gauging-public-health-through-caloric-input-and-output-on-social-media
#7
Sharon E Alajajian, Jake Ryland Williams, Andrew J Reagan, Stephen C Alajajian, Morgan R Frank, Lewis Mitchell, Jacob Lahne, Christopher M Danforth, Peter Sheridan Dodds
We propose and develop a Lexicocalorimeter: an online, interactive instrument for measuring the "caloric content" of social media and other large-scale texts. We do so by constructing extensive yet improvable tables of food and activity related phrases, and respectively assigning them with sourced estimates of caloric intake and expenditure. We show that for Twitter, our naive measures of "caloric input", "caloric output", and the ratio of these measures are all strong correlates with health and well-being measures for the contiguous United States...
2017: PloS One
https://www.readbyqxmd.com/read/28186918/benchmarking-stochastic-algorithms-for-global-optimization-problems-by-visualizing-confidence-intervals
#8
Qunfeng Liu, Wei-Neng Chen, Jeremiah D Deng, Tianlong Gu, Huaxiang Zhang, Zhengtao Yu, Jun Zhang
The popular performance profiles and data profiles for benchmarking deterministic optimization algorithms are extended to benchmark stochastic algorithms for global optimization problems. A general confidence interval is employed to replace the significance test, which is popular in traditional benchmarking methods but suffering more and more criticisms. Through computing confidence bounds of the general confidence interval and visualizing them with performance profiles and (or) data profiles, our benchmarking method can be used to compare stochastic optimization algorithms by graphs...
February 7, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28185075/paediatric-patient-safety-and-the-need-for-aviation-black-box-thinking-to-learn-from-and-prevent-medication-errors
#9
Chi Huynh, Ian C K Wong, Jo Correa-West, David Terry, Suzanne McCarthy
Since the publication of To Err Is Human: Building a Safer Health System in 1999, there has been much research conducted into the epidemiology, nature and causes of medication errors in children, from prescribing and supply to administration. It is reassuring to see growing evidence of improving medication safety in children; however, based on media reports, it can be seen that serious and fatal medication errors still occur. This critical opinion article examines the problem of medication errors in children and provides recommendations for research, training of healthcare professionals and a culture shift towards dealing with medication errors...
February 10, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/28183327/characteristics-of-sirnas-derived-from-southern-rice-black-streaked-dwarf-virus-in-infected-rice-and-their-potential-role-in-host-gene-regulation
#10
Donglin Xu, Guohui Zhou
BACKGROUND: Virus-derived siRNAs (vsiRNAs)-mediated RNA silencing plays important roles in interaction between plant viruses and their hosts. Southern rice black-streaked dwarf virus (SRBSDV) is a newly emerged devastating rice reovirus with ten dsRNA genomic segments. The characteristics of SRBSDV-derived siRNAs and their biological implications in SRBSDV-rice interaction remain unexplored. METHODS: VsiRNAs profiling from SRBSDV-infected rice samples was done via small RNA deep sequencing...
February 10, 2017: Virology Journal
https://www.readbyqxmd.com/read/28182601/erratum-vol-66-no-4
#11
(no author information available yet)
In the cover box "National Black HIV/AIDS Awareness Day - February 7, 2017," on page 97, the second sentence of the second paragraph should have read, "Among blacks living with diagnosed HIV infection in 2013, 54% were retained in care (two or more CD4 or viral load tests ≥3 months apart) and 49% had a suppressed viral load (<200 copies/mL at most recent test) (2)."
February 10, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28176768/soil-networks-become-more-connected-and-take-up-more-carbon-as-nature-restoration-progresses
#12
Elly Morriën, S Emilia Hannula, L Basten Snoek, Nico R Helmsing, Hans Zweers, Mattias de Hollander, Raquel Luján Soto, Marie-Lara Bouffaud, Marc Buée, Wim Dimmers, Henk Duyts, Stefan Geisen, Mariangela Girlanda, Rob I Griffiths, Helene-Bracht Jørgensen, John Jensen, Pierre Plassart, Dirk Redecker, Rűdiger M Schmelz, Olaf Schmidt, Bruce C Thomson, Emilie Tisserant, Stephane Uroz, Anne Winding, Mark J Bailey, Michael Bonkowski, Jack H Faber, Francis Martin, Philippe Lemanceau, Wietse de Boer, Johannes A van Veen, Wim H van der Putten
Soil organisms have an important role in aboveground community dynamics and ecosystem functioning in terrestrial ecosystems. However, most studies have considered soil biota as a black box or focussed on specific groups, whereas little is known about entire soil networks. Here we show that during the course of nature restoration on abandoned arable land a compositional shift in soil biota, preceded by tightening of the belowground networks, corresponds with enhanced efficiency of carbon uptake. In mid- and long-term abandoned field soil, carbon uptake by fungi increases without an increase in fungal biomass or shift in bacterial-to-fungal ratio...
February 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/28165731/a-novel-experimental-modeling-approach-to-characterize-perfluorinated-surfactants-in-soils
#13
Denis Courtier-Murias, Eric Michel, Stéphane Rodts, François Lafolie
Soil contamination is still poorly understood and modeled in part due to the difficulties of looking inside the "black box" constituted by soils. Here, we investigated the application of a recently developed 1H NMR technique to 19F NMR relaxometry experiments and utilized the results as inputs for an existing model. This novel approach yields 19F T2 NMR relaxation values of any fluorinated contaminant, which are among the most dangerous ones, allowing us to non-invasively and directly monitor their fate in soils...
February 6, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28160230/risk-evaluation-and-mitigation-strategies-remss-are-they-improving-drug-safety-a-critical-review-of-remss-requiring-elements-to-assure-safe-use-etasu
#14
REVIEW
Pol F Boudes
Risk Evaluation and Mitigation Strategies (REMSs) with Elements to Assure Safe Use (ETASU) are requested for drugs with significant safety risks. We reviewed REMS programs issued since 2011 to evaluate their rationales, characteristics, and consistencies, and evaluated their impact on improving drug safety. We conducted a literature search and a survey of relevant websites (FDA, manufacturers, and REMSs). ETASU characteristics were summarized. REMS risks were compared with labeled risks, including black box warnings...
February 3, 2017: Drugs in R&D
https://www.readbyqxmd.com/read/28144817/engagement-and-mentor-support-as-drivers-of-social-development-in-the-project-k-youth-development-program
#15
Cassandra M Chapman, Kelsey L Deane, Niki Harré, Matthew G R Courtney, Julie Moore
Youth development programs can achieve positive social outcomes, however studies comparing the influence of different program components are rare. Structural equation modeling of longitudinal, multilevel data (N = 327) from Project K, a multi-component youth development program, assessed how experiences of engagement or support in each component affected social outcomes. Participants reported significant gains in social self-efficacy and sense of community after the program. Engagement in the outdoor adventure and support during the mentoring partnership components significantly contributed to observed social gains, while engagement in the community service component did not...
January 31, 2017: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/28138223/computational-intelligence-models-to-predict-porosity-of-tablets-using-minimum-features
#16
Mohammad Hassan Khalid, Pezhman Kazemi, Lucia Perez-Gandarillas, Abderrahim Michrafy, Jakub Szlęk, Renata Jachowicz, Aleksander Mendyk
The effects of different formulations and manufacturing process conditions on the physical properties of a solid dosage form are of importance to the pharmaceutical industry. It is vital to have in-depth understanding of the material properties and governing parameters of its processes in response to different formulations. Understanding the mentioned aspects will allow tighter control of the process, leading to implementation of quality-by-design (QbD) practices. Computational intelligence (CI) offers an opportunity to create empirical models that can be used to describe the system and predict future outcomes in silico...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28129582/an-up-no-change-or-down-system-time-dependent-expression-of-mrnas-in-contused-skeletal-muscle-of-rats-used-for-wound-age-estimation
#17
Jun-Hong Sun, Xi-Yan Zhu, Ta-Na Dong, Xiao-Hong Zhang, Qi-Qing Liu, San-Qiang Li, Qiu-Xiang Du
The combined use of multiple markers is considered a promising strategy in estimating the age of wounds. We sought to develop an "up, no change, or down" system and to explore how to combine and use various parameters. In total, 78 Sprague Dawley rats were divided randomly into a control group and contusion groups of 4-, 8-, 12-, 16-, 20-, 24-, 28-, 32-, 36-, 40-, 44-, and 48-h post-injury (n=6 per group). A contusion was produced in the right limb of the rats under diethyl ether anesthesia by a drop-ball technique; the animals were sacrificed at certain time points thereafter, using a lethal dose of pentobarbital...
January 17, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28125487/new-black-box-warning-for-direct-acting-antivirals-for-hcv
#18
Diane S Aschenbrenner
No abstract text is available yet for this article.
February 2017: American Journal of Nursing
https://www.readbyqxmd.com/read/28123056/human-embryos-cultured-in-vitro-to-14-days
#19
REVIEW
Samantha A Morris
We know a great deal about the development of the mammalian embryo until the time that the blastocyst implants into the uterus. With model organisms such as the mouse, we have also developed a considerable understanding of development immediately around gastrulation as embryos can be recovered at this stage for short-term in vitro culture. However, the intervening period of development remained a 'black box' because it takes place as the blastocyst is implanting into the uterus. Over the past 6 years, techniques pioneered and developed in Magdalena Zernicka-Goetz's laboratory for the in vitro culture of embryos through these implantation stages have opened up this box, affording the first glimpse of embryonic development through these previously hidden stages...
January 2017: Open Biology
https://www.readbyqxmd.com/read/28122568/thermodynamic-considerations-in-renal-separation-processes
#20
Robert H Louw, David M Rubin, David Glasser, Robyn F R Letts, Diane Hildebrandt
BACKGROUND: Urine production in the kidney is generally thought to be an energy-intensive process requiring large amounts of metabolic activity to power active transport mechanisms. This study uses a thermodynamic analysis to evaluate the minimum work requirements for urine production in the human kidney and provide a new perspective on the energy costs of urine production. In this study, black-box models are used to compare the Gibbs energy inflow and outflow of the overall kidney and physiologically-based subsections in the kidney, to calculate the work of separation for urine production...
January 26, 2017: Theoretical Biology & Medical Modelling
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