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https://www.readbyqxmd.com/read/27926652/hysteroscopic-sterilization-with-essure-summary-of-the-u-s-food-and-drug-administration-actions-and-policy-implications-for-postmarketing-surveillance
#1
Jessica R Walter, Comeron W Ghobadi, Emily Hayman, Shuai Xu
In September 2015, the U.S. Food and Drug Administration (FDA) convened a meeting of the Obstetrics and Gynecology Advisory Board Committee to address the sudden increase of patient-reported adverse events surrounding Essure, a Class III device offering a less invasive method for permanent female sterilization. After a review of the premarketing and postmarketing data and existing scientific literature, the FDA concluded there was insufficient evidence to remove the device from the market. However, the FDA did release a new guidance document requiring a black box warning for the device and ordered a new postmarketing study comparing Essure's safety and efficacy with laparoscopic tubal sterilization...
December 2, 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27919153/-nudge-strategies-at-a-glance-an-overview-more-freedom-or-new-paternalism
#2
Luca Leone
Under the theoretical assumptions of individual bounded rationality and of behavioural psychology about human actions and agency, nudge has been promoted as an alternative to traditional regulatory tools, characterized by being inexpensive, choice-preserving, and bound to promote legitimate goals and citizens' welfare within through specific choice architectures. Applicable to several domains, health included, the nudging approach runs in connection with requests and needs arising from marketing strategies, with the aim of maximizing economic rationality and efficiency...
November 2016: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/27911544/fermionic-orbital-optimization-in-tensor-network-states
#3
C Krumnow, L Veis, Ö Legeza, J Eisert
Tensor network states and specifically matrix-product states have proven to be a powerful tool for simulating ground states of strongly correlated spin models. Recently, they have also been applied to interacting fermionic problems, specifically in the context of quantum chemistry. A new freedom arising in such nonlocal fermionic systems is the choice of orbitals, it being far from clear what choice of fermionic orbitals to make. In this Letter, we propose a way to overcome this challenge. We suggest a method intertwining the optimization over matrix product states with suitable fermionic Gaussian mode transformations...
November 18, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27903591/platelet-rich-plasma-powder-a-new-preparation-method-for-the-standardization-of-growth-factor-concentrations
#4
Matthias Kieb, Frank Sander, Cornelia Prinz, Stefanie Adam, Anett Mau-Möller, Rainer Bader, Kirsten Peters, Thomas Tischer
BACKGROUND: Platelet-rich plasma (PRP) is widely used in sports medicine. Available PRP preparations differ in white blood cell, platelet, and growth factor concentrations, making standardized research and clinical application challenging. PURPOSE: To characterize a newly standardized procedure for pooled PRP that provides defined growth factor concentrations. STUDY DESIGN: Controlled laboratory study. METHODS: A standardized growth factor preparation (lyophilized PRP powder) was prepared using 12 pooled platelet concentrates (PCs) derived from different donors via apheresis...
November 30, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27900537/rnai-mediated-resistance-to-rice-black-streaked-dwarf-virus-in-transgenic-rice
#5
Mohamed M S Ahmed, Shiquan Bian, Muyue Wang, Jing Zhao, Bingwei Zhang, Qiaoquan Liu, Changquan Zhang, Shuzhu Tang, Minghong Gu, Hengxiu Yu
Rice black-streaked dwarf virus (RBSDV), a member of the genus Fijivirus in the family Reoviridae, causes significant economic losses in rice production in China and many other Asian countries. Development of resistant varieties by using conventional breeding methods is limited, as germplasm with high level of resistance to RBSDV have not yet been found. One of the most promising methods to confer resistance against RBSDV is the use of RNA interference (RNAi) technology. RBSDV non-structural protein P7-2, encoded by S7-2 gene, is a potential F-box protein and involved in the plant-virus interaction through the ubiquitination pathway...
November 30, 2016: Transgenic Research
https://www.readbyqxmd.com/read/27887032/provider-perception-of-pharmacy-services-in-the-patient-centered-medical-home
#6
Nicole P Albanese, Alyssa M Pignato, Scott V Monte
BACKGROUND: Despite the positive data on clinical outcomes, cost savings, and provider experience, no study has surveyed providers to evaluate what pharmacy services they find to be worthwhile. OBJECTIVE: To determine what clinical, cost/access, and educational pharmacy services providers in a patient-centered medical home (PCMH) consider worthwhile and the perceived barriers to successful pharmacist incorporation. METHODS: A cross-sectional online survey was distributed to primary care physicians, nurse practitioners, and physician assistants in a PCMH physician group...
November 24, 2016: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/27883984/car-speed-estimation-based-on-cross-ratio-using-video-data-of-car-mounted-camera-black-box
#7
Inhwan Han
This paper proposes several methods for using footages of car-mounted camera (car black box) to estimate the speed of the car with the camera, or the speed of other cars. This enables estimating car velocities directly from recorded footages without the need of specific physical locations of cars shown in the recorded material. To achieve this, this study collected 96 cases of black box footages and classified them for analysis based on various factors such as travel circumstances and directions. With these data, several case studies relating to speed estimation of camera-mounted car and other cars in recorded footage while the camera-mounted car is stationary, or moving, have been conducted...
December 2016: Forensic Science International
https://www.readbyqxmd.com/read/27882515/collaborative-care-for-anxiety-what-s-inside-the-black-box-and-how-can-it-be-improved
#8
EDITORIAL
Peter Roy-Byrne
No abstract text is available yet for this article.
November 23, 2016: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/27881149/antipsychotic-prescribing-patterns-during-and-after-critical-illness-a-prospective-cohort-study
#9
Jason E Tomichek, Joanna L Stollings, Pratik P Pandharipande, Rameela Chandrasekhar, E Wesley Ely, Timothy D Girard
BACKGROUND: Antipsychotics are used to treat delirium in the intensive care unit (ICU) despite unproven efficacy. We hypothesized that atypical antipsychotic treatment in the ICU is a risk factor for antipsychotic prescription at discharge, a practice that might increase risk since long-term use is associated with increased mortality. METHODS: After excluding patients on antipsychotics prior to admission, we examined antipsychotic use in a prospective cohort of ICU patients with acute respiratory failure and/or shock...
November 24, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27878470/%C3%AE-2-agonists
#10
Charlotte K Billington, Raymond B Penn, Ian P Hall
History suggests β agonists, the cognate ligand of the β2 adrenoceptor, have been used as bronchodilators for around 5,000 years, and β agonists remain today the frontline treatment for asthma and chronic obstructive pulmonary disease (COPD). The β agonists used clinically today are the products of significant expenditure and over 100 year's intensive research aimed at minimizing side effects and enhancing therapeutic usefulness. The respiratory physician now has a therapeutic toolbox of long acting β agonists to prophylactically manage bronchoconstriction, and short acting β agonists to relieve acute exacerbations...
November 23, 2016: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/27875140/vismatchmaker-cooperation-of-the-user-and-the-computer-in-centralized-matching-adjustment
#11
Po-Ming Law, Wenchao Wu, Yixian Zheng, Huamin Qu
Centralized matching is a ubiquitous resource allocation problem. In a centralized matching problem, each agent has a preference list ranking the other agents and a central planner is responsible for matching the agents manually or with an algorithm. While algorithms can find a matching which optimizes some performance metrics, they are used as a black box and preclude the central planner from applying his domain knowledge to find a matching which aligns better with the user tasks. Furthermore, the existing matching visualization techniques (i...
January 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/27875137/visualizing-the-hidden-activity-of-artificial-neural-networks
#12
Paulo E Rauber, Samuel G Fadel, Alexandre X Falcao, Alexandru C Telea
In machine learning, pattern classification assigns high-dimensional vectors (observations) to classes based on generalization from examples. Artificial neural networks currently achieve state-of-the-art results in this task. Although such networks are typically used as black-boxes, they are also widely believed to learn (high-dimensional) higher-level representations of the original observations. In this paper, we propose using dimensionality reduction for two tasks: visualizing the relationships between learned representations of observations, and visualizing the relationships between artificial neurons...
January 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/27871734/the-black-box-warning-on-philanthrocapitalism
#13
Jocalyn Clark, Linsey McGoey
No abstract text is available yet for this article.
November 19, 2016: Lancet
https://www.readbyqxmd.com/read/27852450/should-we-trust-build-up-wash-off-water-quality-models-at-the-scale-of-urban-catchments
#14
Céline Bonhomme, Guido Petrucci
Models of runoff water quality at the scale of an urban catchment usually rely on build-up/wash-off formulations obtained through small-scale experiments. Often, the physical interpretation of the model parameters, valid at the small-scale, is transposed to large-scale applications. Testing different levels of spatial variability, the parameter distributions of a water quality model are obtained in this paper through a Monte Carlo Markov Chain algorithm and analyzed. The simulated variable is the total suspended solid concentration at the outlet of a periurban catchment in the Paris region (2...
January 1, 2017: Water Research
https://www.readbyqxmd.com/read/27833145/impacts-of-brown-carbon-from-biomass-burning-on-surface-uv-and-ozone-photochemistry-in-the-amazon-basin
#15
Jungbin Mok, Nickolay A Krotkov, Antti Arola, Omar Torres, Hiren Jethva, Marcos Andrade, Gordon Labow, Thomas F Eck, Zhanqing Li, Russell R Dickerson, Georgiy L Stenchikov, Sergey Osipov, Xinrong Ren
The spectral dependence of light absorption by atmospheric particulate matter has major implications for air quality and climate forcing, but remains uncertain especially in tropical areas with extensive biomass burning. In the September-October 2007 biomass-burning season in Santa Cruz, Bolivia, we studied light absorbing (chromophoric) organic or "brown" carbon (BrC) with surface and space-based remote sensing. We found that BrC has negligible absorption at visible wavelengths, but significant absorption and strong spectral dependence at UV wavelengths...
November 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27831805/opening-the-black-box-of-communication-and-decision-making-for-lung-cancer-screening-and-nodule-evaluation-implications-for-policy-and-practice
#16
Renda Soylemez Wiener
No abstract text is available yet for this article.
November 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27814325/fatal-cardiac-arrest-in-2-children-possible-role-of-ondansetron
#17
Scott M Brenner, Jenny Boucher
INTRODUCTION: Ondansetron is commonly used to treat vomiting in gastroenteritis, but has a United States Food and Drug Administration black box warning for risk of Q wave to T wave time interval (QT) prolongation. We report 2 pediatric cases of fatal refractory cardiac arrest after administration of ondansetron. CASES: A 10-year-old previously healthy boy presented to the emergency room with gastroenteritis symptoms. After intravenous fluids, morphine, antibiotics, and 2 doses of ondansetron, the patient became unresponsive with agonal respirations and a wide complex tachycardia consistent with ventricular tachycardia...
November 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27812336/piperine-suppresses-pyroptosis-and-interleukin-1%C3%AE-release-upon-atp-triggering-and-bacterial-infection
#18
Yi-Dan Liang, Wen-Jing Bai, Chen-Guang Li, Li-Hui Xu, Hong-Xia Wei, Hao Pan, Xian-Hui He, Dong-Yun Ouyang
Piperine is a phytochemical present in black pepper (Piper nigrum Linn) and other related herbs, possessing a wide array of pharmacological activities including anti-inflammatory effects. Previously, we demonstrated that piperine has therapeutic effects on bacterial sepsis in mice, but the underlying mechanism has not been fully elucidated. In this study, we aimed to investigate the influences of piperine on pyroptosis in murine macrophages. The results showed that piperine dose-dependently inhibited ATP-induced pyroptosis, thereby suppressing interleukin-1β (IL-1β) or high mobility group box-1 protein (HMGB1) release in LPS-primed bone marrow-derived macrophages and J774A...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27811595/objective-assessment-of-checklist-fidelity-using-digital-audio-recording-and-a-standardized-scoring-system-audit
#19
Douglas Salgado, Kimberly R Barber, Michael Danic
OBJECTIVES: The use of the World Health Organization Surgical Safety Checklist (SSC) has been reported to significantly reduce operative morbidity and mortality rates. Recent findings have cast doubt on the efficacy of such checklists in improving patient safety. The effectiveness of surgical safety checklists cannot be fully measured or understood without an accurate assessment of implementation fidelity, most effectively through direct observations of the checklist process. Here, we describe the use of a secure audio recording protocol in conjunction with a novel standardized scoring system to assess checklist compliance rates...
November 2, 2016: Journal of Patient Safety
https://www.readbyqxmd.com/read/27805829/2015-lush-science-prize
#20
REVIEW
Jenny McCann, Terry McCann
The Lush Prize supports animal-free testing by rewarding the most effective projects and individuals who have been working toward the goal of replacing animals in product or ingredient safety testing. Prizes are awarded for developments in five strategic areas: Science; Lobbying; Training; Public Awareness; and Young Researchers. Should there be a major breakthrough in 21st century toxicology, a Black Box Prize equivalent to the entire annual fund of £250,000 is awarded. A Background Paper is prepared each year, prior to the judging process, to provide the panel with a brief overview of current developments in the field of Replacement alternatives, particularly those relevant to the concept of toxicity pathways...
October 2016: Alternatives to Laboratory Animals: ATLA
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