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Cong Liu, Jinshui Yang, Liang Liu, Baozhen Li, Hongli Yuan, Weijie Liu
The capability of biofilm formation has a major impact on the industrial and biotechnological applications of Shewanella putrefaciens CN32. However, the detailed regulatory mechanisms underlying biofilm formation in S. putrefaciens CN32 remain largely unknown. In the present study, we describe a three-component regulatory system which negatively regulates the biofilm formation of S. putrefaciens CN32. The three-component regulatory system consists of a histidine kinase LrbS (Sputcn32_0303) and two cognate response regulators including a transcription factor LrbA (Sputcn32_0304) and a phosphodiesterase LrbR (Sputcn32_0305)...
May 12, 2017: Applied and Environmental Microbiology
Angelo Santana Del Pino, Nathan Medina-Rodríguez, Marta Hernández-García, Francisco J Nóvoa-Mogollón, Ana M Wägner
INTRODUCTION: Incidence of childhood-onset type 1 diabetes mellitus in the Canary Islands is the highest reported so far in Spain, and among the highest worldwide. The HLA region accounts for approximately half the genetic risk of type 1 diabetes. Our aim was to assess distribution of high-risk and protective HLA haplotypes in the Canarian families included in the T1DGC, as compared to the rest of Spain. METHODS: The T1DGC study, an international project to study the genetics and pathogenesis of type 1 diabetes, enrolled more than 3000 families with type 1 diabetes worldwide...
March 2017: Endocrinol Diabetes Nutr
N N Yin, S M Luo, J Lin, Z G Xie, G Huang, X Li, P L Zheng, J P Wang, Z G Zhou
Objective: To identify human leukocyte antigen (HLA)-DRB1, DQA1 and DQB1 susceptible alleles and genotypes in latent autoimmune diabetes in adults (LADA) patients of Chinese Han nationality. Methods: All subjects including 652 LADA patients and 1 181 healthy controls from 1999 to 2015 in Han nationality region of Hunan province were genotyped with high resolution at HLA-DRB1, DQA1 and DQB1 locus by PCR-sequence based typing (PCR-SBT). Frequencies of genotypes between patients and controls were compared by chi square test...
February 28, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Kevin Li-Chun Hsieh, Cheng-Yu Chen, Chung-Ming Lo
BACKGROUND: A computer-aided diagnosis (CAD) system based on intensity-invariant magnetic resonance (MR) imaging features was proposed to grade gliomas for general application to various scanning systems and settings. METHOD: In total, 34 glioblastomas and 73 lower-grade gliomas comprised the image database to evaluate the proposed CAD system. For each case, the local texture on MR images was transformed into a local binary pattern (LBP) which was intensity-invariant...
February 27, 2017: Computers in Biology and Medicine
Raj Packianathan, Andrew Hodge, Natalie Bruellke, Kylie Davis, Steven Maeder
BACKGROUND: The Australian paralysis tick, Ixodes holocyclus, causes paralysis predominantly in dogs and cats in the Eastern coastal regions of Australia. Rapid onset of effect of a parasiticide is critical to minimize the deleterious effects of these tick infestations, especially tick paralysis caused by the salivary neurotoxin. The speed of kill of a novel orally administered isoxazoline parasiticide, sarolaner chewable tablets (Simparica(®)), against I. holocyclus on dogs was evaluated and compared with afoxolaner (NexGard(®)) for 5 weeks after a single oral dose...
February 21, 2017: Parasites & Vectors
Marc B I Lobbes, Ingeborg J H Vriens, Annelotte C M van Bommel, Grard A P Nieuwenhuijzen, Marjolein L Smidt, Liesbeth J Boersma, Thijs van Dalen, Carolien Smorenburg, Henk Struikmans, Sabine Siesling, Adri C Voogd, Vivianne C G Tjan-Heijnen
PURPOSE: In this retrospective population-based cohort study, we analyzed breast MRI use and its impact on type of surgery, surgical margin involvement, and the diagnosis of contralateral breast cancer. METHODS: All Dutch patients with cT1-4N0-3M0 breast cancer diagnosed in 2011-2013 and treated with primary surgery were eligible for inclusion. Using multivariable analyses, we analyzed in different categories whether MRI use was related to surgery type, margin involvement, and diagnosis of contralateral breast cancer (CBC)...
April 2017: Breast Cancer Research and Treatment
Mohammed E Sayed, Idris A Busaily, Rana J Nahari, Ruaa O Hakami, Sami M Maashi, Naveen R Ramireddy
PURPOSE: To survey different educational levels (i.e., students, interns, technicians, and prosthodontic faculty) with regard to their opinions, attitudes, and adoption of three selected tripod techniques. The study will also investigate the accuracy of these techniques to reposition casts on the dental surveyor in anterio-posterior (AP) and lateral directions at both technique and educational levels. MATERIALS AND METHODS: Tripod points, scored lines, and cemented post tripod techniques were used in this study...
January 18, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
Tomohiro Iguchi, Toru Ikegami, Tetsuhiro Fujiyoshi, Tomoharu Yoshizumi, Ken Shirabe, Yoshihiko Maehara
BACKGROUND/AIMS: Despite the development of strategies to minimize blood loss during hepatectomy challenges remain. Our aim was to determine whether low positive airway pressure (PAP) without positive end-expiratory pressure (PEEP) could minimize blood loss during hepatectomy. METHODS: Forty-one living liver donors who underwent extended left lobectomy or right lobectomy between December 2012 and November 2013 were retrospectively analyzed. In the standard PAP group (n = 18), tidal volume was 8-10 ml/kg, respiratory rate was 10-12/min and PEEP was maintained at 5 cm H2O...
2017: Digestive Surgery
M Delhaye, F Orts, F Bury, G Loas
OBJECTIVE: The 20-item Toronto Alexithymia Scale (TAS-20) is the most widely used measure of alexithymia in non-clinical or clinical populations. The TAS-20 evaluates three dimensions of the alexithymia construct: the difficulty identifying feelings (DIF), the difficulty describing feelings (DDF) and externally oriented thinking (EOT). The TAS-20 is also used in adolescents or children, and the psychometric properties of the scale have not been systematically evaluated in these populations...
October 10, 2016: L'Encéphale
Ali Mohammad Varzi, Farhad Shahsavar, Mohammad Javad Tarrahi
Human leukocyte antigen (HLA) genes are the most polymorphic loci in the human genome and encode the highly polymorphic molecules critically involved in immune responses. Anthropological studies based on highly polymorphic HLA genes provide useful information for bone marrow donor registry, forensic medicine, disease association studies, as well as designing peptide vaccines against tumors, and infectious or autoimmune diseases. The aim of this study was to determine the HLA-DRB1 and HLA-DQB1 allele frequencies in 100 unrelated Lak individuals from Lorestan province of Iran...
July 2016: Human Immunology
S Mohammadi, S Abbasi, M G Scanlon
In the present study, the influence of octenyle succinic anhydride (OSA),gum concentration, pH, temperature and reaction time on esterification of Persian gum (PG), and its soluble (SFPG) and insoluble (IFPG) fractions, were investigated by response surface methodology (RSM) in order to optimize the reaction conditions based on the degree of substitution (DS). The individual effect of all independent variables as well as the interactive effects of temperature-OSA concentration, and OSA-PG concentrations on DS was significant...
August 2016: International Journal of Biological Macromolecules
Jinmei Huang, Liangshi Xiong, Jin Wang, Yongfang Liu, Qirong Zhu, Jun Lei, Zhonghui Zhou
Single-nucleotide polymorphisms in the human leukocyte antigen (HLA)-DQB1 gene are associated with chronic inflammatory and immunological diseases. Host genetic factors have a key role in the development of chronic hepatitis B (CHB). The aim of the present study was to investigate the association between the HLA-DQB1 polymorphisms and the susceptibility to CHB. PubMed, Embase, CNKI and Wanfang databases were searched for the studies that reported the association of the HLA-DQB1 polymorphisms with CHB between January 1, 1966 and July 30, 2015...
May 2016: Biomedical Reports
Jing Yan, Danfeng Peng, Feng Jiang, Rong Zhang, Miao Chen, Tao Wang, Dandan Yan, Shiyun Wang, Xuhong Hou, Yuqian Bao, Cheng Hu, Weiping Jia
AIMS/HYPOTHESIS: We aimed to evaluate the combined effects of type 2 diabetes risk variants on predicting deterioration of blood glucose and progression of beta cell function and insulin sensitivity in a 9 year prospective cohort from the Chinese population. METHODS: We constructed a weighted genetic risk score (GRS) model based on 40 variants associated with type 2 diabetes validated in an established cross-sectional Chinese population (n = 6,822). The weighted scores were categorised into tertiles to assess the predictive capacity for incidence of type 2 diabetes and impaired glucose regulation (IGR), as well as for changes in Stumvoll first- and second-phase insulin secretion indices and Gutt's insulin sensitivity index (ISI) in a community-based 9 year prospective cohort (n = 2,495), including 2,192 individuals with normal glucose tolerance and 303 with IGR at baseline, through logistic, Cox and multiple linear regression tests...
July 2016: Diabetologia
Mark K Friedberg, Renee Margossian, Minmin Lu, Laura Mercer-Rosa, Heather T Henderson, Arni Nutting, Kevin Friedman, Kimberly M Molina, Karen Altmann, Charles Canter, Lynn A Sleeper, Steven D Colan
Systolic and diastolic function affect dilated cardiomyopathy (DCM) outcomes. However, systolic-diastolic coupling, as a distinct characteristic, may itself affect function but is poorly characterized. We hypothesized that echocardiographic left ventricular (LV) longitudinal systolic tissue velocities (S') correlate with diastolic longitudinal velocities (E') and that their relationship is associated with ventricular function and that this relationship is impaired in pediatric DCM. We analyzed data from the Pediatric Heart Network Ventricular Volume Variability study, using linear regression and generalized additive modeling to assess relationships between S' and E' at the lateral and septal mitral annulus...
June 1, 2016: Journal of Applied Physiology
Shuoming Luo, Jian Lin, Zhiguo Xie, Yufei Xiang, Peilin Zheng, Gan Huang, Xia Li, Yu Liao, William A Hagopian, Cong-Yi Wang, Zhiguang Zhou
The focus of current study is to address HLA-conferred risks to T1D and LADA susceptibility, and determine their discrepancies for the HLA-conferred risks. The risks for Chinese T1D and LADA patients conferred by HLA genes significantly differ from those patients with Caucasian origin.
April 2016: Journal of Clinical Endocrinology and Metabolism
Kristina M Sefc, Stephan Koblmüller
A recent study of North American canids by Rutledge et al. (Biol. Lett. 11, 20150303 (doi:10.1098/rsbl.2015.0303)) refutes the hypothesized hybrid origin of the eastern wolf (EW) based on genomic evidence against very recent hybridization. However, the analyses do not rule out the possibility of more ancient hybridization. Claims to have resolved the evolutionary origin of the EW are therefore inappropriate. Importantly, though, we plead that uncertainty about the ancient history of the taxon should not affect current conservation policy...
February 2016: Biology Letters
Clivia Hejny, Volker Kahlenberg, Daniela Schmidmair, Predrag Dabić
Single-crystal X-ray diffraction of Cs3ScSi6O15 shows the presence of main reflections and satellite reflections up to the fourth order along the c* direction. The (3+1)-dimensional incommensurately modulated structure was solved in superspace group X3m1(00gamma)0s0 [a = 13.861 (1), c = 6.992 (1) Å, V = 1163.4 (2) Å(3)] with a modulation wavevector q = 0.14153 (2)c*. Refinement of three modulation waves for positional and anisotropic displacement parameter values for all atoms converged to R(obs) values for all, main and satellite reflections of first, second and third order of 0...
February 2016: Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials
Luiza F Rocha, Ana Paula Luppino Assad, Roberta G Marangoni, Ana Paula Toledo Del Rio, João Francisco Marques-Neto, Percival D Sampaio-Barros
The objective of this study is to describe the characteristics of patients with Erasmus syndrome (ES) in a large SSc Brazilian cohort. Nine hundred and forty-seven SSc patients attended at the Scleroderma Outpatient Clinic at two academic medical centers in Brazil and classified as SSc according to the ACR/EULAR criteria were retrospectively studied. Information on demographics, clinical, and laboratory features was obtained by chart review. ES patients had their HLA class II characterized by PCR-SSO method as available...
May 2016: Rheumatology International
Wen-Hui Lei, Jun Xin, Xue-Ping Yu, Jie Li, Ming-Feng Mao, Jian-Song Ji, Chui-Fen Wu, Chao-Yong Zhu, Lie Jin
Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare disease of unknown etiology defined by the combination of tubulointerstitial nephritis, uveitis, and biochemical abnormalities. It has been reported that TINU mainly affects adolescents and young women. Here we reported a special case regarding a 60-year-old man with acute renal failure due to TINU syndrome documented by renal biopsy.We present a rare case of an elderly patient, who had been suffering from a fever for 2 weeks, characterized by sudden onset and resolving spontaneously, and accompanied by extreme fatigue, loss of appetite, and shivering...
November 2015: Medicine (Baltimore)
Dorottya Csuka, Nóra Veszeli, Éva Imreh, Zsuzsanna Zotter, Judit Skopál, Zoltán Prohászka, Lilian Varga, Henriette Farkas
BACKGROUND: The activation of plasma enzyme systems contributes to hereditary angioedema attacks. We aimed to study the activation markers of the fibrinolytic, coagulation, and contact systems in a larger number of paired samples obtained from the same C1-INH-HAE patients in symptom-free periods and during attacks. METHODS: Eleven parameters (Factors XI, XII, and C1-inhibitor activity; the concentrations of the D-dimer, prothrombin fragments 1 + 2, plasminogen, plasminogen activator inhibitor-1 [PAI-1], thrombin-anti-thrombin III [TAT] complex, fibrinogen) were measured along with prothrombin time and activated partial thromboplastin time (aPTT), using commercial kits...
2015: Orphanet Journal of Rare Diseases
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