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Tito Fiore, Barbara Iaccheri, Alessio Cerquaglia, Marco Lupidi, Giovanni Torroni, Daniela Fruttini, Carlo Cagini
PURPOSE: To perform an analysis of optical coherence tomography (OCT) abnormalities in patients with MEWDS, during the acute and recovery stages, using enhanced depth imaging-OCT (EDI-OCT). METHODS: A retrospective case series of five patients with MEWDS was included. EDI-OCT imaging was evaluated to detect retinal and choroidal features. RESULTS: In the acute phase, focal impairment of the ellipsoid zone and external limiting membrane, hyperreflective dots in the inner choroid, and full-thickness increase of the choroidal profile were observed in the affected eye; disappearance of these findings and restoration of the choroidal thickness (p = 0...
October 11, 2016: Ocular Immunology and Inflammation
Alfredo Pece, Davide Allegrini, Stelios Kontadakis, Giuseppe Querques, Luca Rossetti
BACKGROUND: To report a patient with angioid streaks (ASs) and coincident multiple evanescent white dot syndrome (MEWDS) who developed choroidal neovascularization (CNV). CASE PRESENTATION: A 20-year-old woman presented with reduced vision (20/100) in her left eye (LE). Based on a complete ophthalmologic examination the patient was diagnosed with ASs and coincident MEWDS. Two weeks later best-corrected visual acuity (BCVA) improved up to 20/25 and the MEWDS findings almost disappeared...
2016: BMC Ophthalmology
Miho Nozaki, Satoshi Hamada, Masayo Kimura, Munenori Yoshida, Yuichiro Ogura
This report describes a 19-year-old patient with the rare association of multiple evanescent white dot syndrome (MEWDS) and choroidal neovascularization (CNV). Despite the initial diagnosis of MEWDS, her vision significantly decreased. Fluorescein angiography showed dye leakage and pooling at the macula, whereas optical coherence tomography (OCT) showed cystoid macular edema and serous neuroepithelial elevation. The dye leakage and pooling made it impossible to diagnose CNV. However, OCT angiography (OCTA) revealed a vascular structure in the outer retina, thereby leading to the CNV diagnosis...
June 1, 2016: Ophthalmic Surgery, Lasers & Imaging Retina
Kazuki Kuniyoshi, Hiroyuki Sakuramoto, Koji Sugioka, Chota Matsumoto, Shunji Kusaka, Yoshikazu Shimomura
To report the light- and dark-adapted perimetric findings in a patient with multiple evanescent white dot syndrome (MEWDS). The patient was a 25-year-old Japanese woman who underwent comprehensive ophthalmological examinations including measurements of the visual acuity, dilated ophthalmoscopy, Goldmann kinetic perimetry, electroretinography (ERG), indocyanine green fundus angiography (ICGA), and optical coherence tomography (OCT). Kinetic perimetry was performed under light- and dark-adapted conditions. The patient was diagnosed with MEWDS by the fundus and visual field findings, and the ICGA abnormalities...
August 2016: International Ophthalmology
Akihiro Takahashi, Wataru Saito, Yuki Hashimoto, Susumu Ishida
PURPOSE: A recent study revealed thickening of the inner retinal layers in acute stage of multiple evanescent white dot syndrome (MEWDS); however, the pathogenesis is still unknown. We report two cases with MEWDS whose funduscopy showed obvious retinal vasculitis. METHODS: Case reports. RESULTS: Healthy myopic 16- and 27-year-old women were the cases under study. In both cases, funduscopic examination revealed multiple, faint, small, subretinal white dots at the posterior pole to the midperiphery and macular granularity oculus dexter...
2015: International Medical Case Reports Journal
Lillian Abreu Dias, Eduardo H Morizot
PURPOSE: To characterize multiple evanescent white dot syndrome (MEWDS)-like lesions as diagnosed by clinical exam and fluorescein angiography (FA) to build an epidemiological profile of this disease and highlight the most common angiographical aspects. It is important to emphasize the existence of this syndrome and improve patients' information about the natural good course of this disease. METHODS: A cross-sectional study including all FA performed from July 2006 to October 2012 (6,111 exams analyzed) in patients at our ophthalmic emergency department, with analysis of the different angiographic aspects of the MEWDS-diagnosed cases...
July 2015: Arquivos Brasileiros de Oftalmologia
Miaoling Li, Xiongze Zhang, Feng Wen
Purpose. To investigate the fundus autofluorescence (FAF) spectrum of punctate inner choroidopathy (PIC). Methods. This is a retrospective observational case series of 27 consecutive patients with PIC admitted from October 2013 to March 2015, who underwent short-wavelength- (SW-) and near-infrared- (NIR-) FAF imaging, spectral domain optical coherence tomography (SD-OCT), fluorescein angiography (FA), and indocyanine green angiography (ICGA). Results. There were three primary findings on the FAF imaging of patients with PIC...
2015: Journal of Ophthalmology
Yuki Hashimoto, Wataru Saito, Kousuke Noda, Susumu Ishida
BACKGROUND: The mechanism underlying focal choroidal excavation (FCE) remains largely unknown. We evaluated the sequential progression of FCE generation using enhanced depth imaging optical coherence tomography (EDI-OCT) in a patient with multiple evanescent white dot syndrome (MEWDS). CASE PRESENTATION: A 37-year-old woman suffered MEWDS in the right eye. EDI-OCT showed the loss of photoreceptor inner segment/outer segment junction line, detachment between the retinal pigment epithelium (RPE) and Bruch's membrane, and dome-shaped, moderately reflective, focal photoreceptor-layer lesions corresponding to perifoveal white dots...
2014: BMC Ophthalmology
Hideo Akiyama, Hirotaka Itakura, Danjie Li, Tomoyuki Kashima, Keisuke Nitta, Yukitoshi Shimoda, Ryo Mukai, Shoji Kishi
BACKGROUND: Multiple evanescent white dot syndrome (MEWDS) is an acute and usually unilateral retinopathy that occurs predominantly in young adults. This report presents the outcomes of ganglion cell analysis (GCA) in MEWDS. CASE PRESENTATION: A 41-year-old woman was diagnosed as MEWDS in right eye. At her initial visit, the deviation map of the ganglion cell analysis showed there was a decrease of the ganglion cell layer (GCL) + inner plexiform layer (IPL) thickness in both eyes, even though her left eye was not affected...
2014: BMC Ophthalmology
Andrea Perdicchi, Fabio Guglielmelli, Antonella Leonardi, Santi M Recupero
No abstract text is available yet for this article.
2007: Retinal Cases & Brief Reports
Maurizio Battaglia Parodi, Pierluigi Iacono, Bruno Falcomatà, Gianluigi Bolognesi, Francesco Bandello
PURPOSE: To report the near-infrared fundus autofluorescence (NIR-FAF) pattern in 2 cases of multiple evanescent white-dot syndrome (MEWDS). METHODS: Three consecutive patients with MEWDS underwent a complete ophthalmologic examination, including color photograph, blue-light fundus autofluorescence, NIR-FAF, fluorescein angiography, and indocyanine green angiography (ICGA). Main outcome measure was the identification of NIR-FAF pattern. RESULTS: Fluorescein angiography showed patchy hyperfluorescence of the whitish dots...
January 2015: European Journal of Ophthalmology
Yuki Hashimoto, Wataru Saito, Michiyuki Saito, Kiriko Hirooka, Shohei Mori, Kousuke Noda, Susumu Ishida
PURPOSE: On the basis of angiographic features, it is suggested that choroidal circulation disturbance may be involved in the pathogenesis of multiple evanescent white dot syndrome (MEWDS). The aim of this study is to quantitatively evaluate changes in choroidal circulation hemodynamics using laser speckle flowgraphy (LSFG) in patients with MEWDS. METHODS: Twelve eyes of 12 patients with MEWDS and 12 unaffected fellow eyes as controls were included. The macular mean blur rate (MBR), a quantitative index of relative blood flow velocity in the choroid, was measured by LSFG...
September 2015: Graefe's Archive for Clinical and Experimental Ophthalmology
Luciana Castro Lavigne, David Leonardo Cruvinel Isaac, José Osório Duarte Júnior, Marcos Pereira de Avila
The purpose of this study was to describe a patient with multiple evanescent white dot syndrome (MEWDS) who presented with classic retinal findings and transient changes in outer retinal anatomy. A 20-year-old man presented with mild blurred vision in the left eye, reporting flu-like symptoms 1 week before the visual symptoms started. Fundus examination of the left eye revealed foveal granularity and multiple scattered spots deep to the retina in the posterior pole. Fluorescein angiography and indocyanine green angiography showed typical MEWDS findings...
May 2014: Arquivos Brasileiros de Oftalmologia
Rei Arai, Itaru Kimura, Yutaka Imamura, Kei Shinoda, Celso Soiti Matsumoto, Keisuke Seki, Masahiro Ishida, Akira Murakami, Atsushi Mizota
PURPOSE: To evaluate the photoreceptor inner and outer segment layer thickness in eyes with MEWDS. DESIGN: Prospective, non-comparative, observational case series. The follow-up duration was 4 months. METHODS: Four women were diagnosed with unilateral MEWDS. The ages of the patients were 25, 24, 35, and 40 years. The retinal microstructure was assessed by spectral-domain optical coherence tomography (SD-OCT). The thickness of the photoreceptor inner (IS) and outer (OS) segments and sum of them (IS + OS) at the fovea were analyzed...
October 2014: Graefe's Archive for Clinical and Experimental Ophthalmology
Flore De Bats, Benjamin Wolff, Vivien Vasseur, Aude Affortit, Laurent Kodjikian, José-Alain Sahel, Martine Mauget-Faÿsse
Purpose. The recent use of "en-face" enhanced-depth imaging spectral-domain optical coherence tomography (EDI SD-OCT) helps distinguish the retinal layers involved in the physiopathology of multiple evanescent white dot syndrome (MEWDS). Methods. Four patients presenting with MEWDS underwent a comprehensive ocular examination including C-scan ("en-face") EDI SD-OCT at the initial visit and during follow-up. Results. C-scans combined with the other multimodal imaging enabled the visualization of retinal damage...
2014: Journal of Ophthalmology
Min Kyu Shin, Ik Soo Byon, Sung Who Park, Ji Eun Lee
Macular serous retinal detachment (MSRD) is a rare complication in highly myopic patients with an inferior staphyloma, tilted disc, or dome-shaped macula. Multiple evanescent white dot syndrome (MEWDS) presents with sudden visual loss and multiple yellowish dots that resolve spontaneously within several weeks. The authors report the development and spontaneous resolution of subretinal fluid accompanied by MEWDS in a myopic patient with a dome-shaped macula. Dysfunction of the retinal pigment epithelium due to MEWDS likely induced temporary MSRD in this patient...
May 2014: Ophthalmic Surgery, Lasers & Imaging Retina
Ken Ogino, Shoji Kishi, Nagahisa Yoshimura
Although the cause of multiple evanescent white dot syndrome (MEWDS) has not been elucidated, 2 reports have described cases of MEWDS after vaccination. A 16-year-old girl presented with throat pain, headache, and photopsia in the left eye 2 weeks after receiving a human papillomavirus (HPV) vaccination. The clinical examination revealed numerous white dots on the fundus, visual field loss, and abnormal electroretinography results, which are concordant with a diagnosis of MEWDS. Although the white dots on the fundus disappeared within a few months, her visual field continued to deteriorate progressively over 1...
January 2014: Case Reports in Ophthalmology
Cai-xi Zhou, Li-min Liu, Ai-ling Mao, Wei Wei
OBJECTIVE: To observe the imaging features of fundus autofluorescence (FAF) in patients with multiple evanescent white dot syndrome (MEWDS). METHODS: Retrospective case-series study. Eight cases of MEWDS patients visited Xingtai eye hospital between January 2009 and December 2010 were included in this study. Three males and 5 females, aged from 19 to 48 years, mean age was 33 years old. The span between onset and visit to the hospital was between 2 to 12 days, the average time was 6...
December 2013: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
Anthony Joseph, Ehsan Rahimy, K Bailey Freund, John A Sorenson, David Sarraf
The authors present three cases of multiple evanescent white dot syndrome (MEWDS) with characteristic fundus autofluorescence (FAF) findings, including one patient without any visible white dots on funduscopic examination and another with many more hyperautofluorescent lesions than seen ophthalmoscopically. Additionally, the findings support an alternative mechanism for the hyperautofluorescent lesions in MEWDS, whereby photoreceptor loss causes unmasking of normal underlying retinal pigment epithelium autofluorescence...
November 1, 2013: Ophthalmic Surgery, Lasers & Imaging Retina
Benjamin J Thomas, Thomas A Albini, Harry W Flynn
The clinical presentation of multiple evanescent white dot syndrome (MEWDS) was described nearly 30 years ago; however, our understanding of its pathophysiology continues to change, evolving with our imaging modalities. Initially, electroretinography and fluorescein angiography indicated retinal pigment epithelium (RPE) and outer retinal damage. But with indocyanine green angiography, theories shifted to a primary choroidopathy. Only spectral-domain optical coherence tomography (SD-OCT) directly demonstrated the primary effect on RPE and outer retina, although enhanced depth-imaging OCT (EDI-OCT) may further modify our understanding...
November 1, 2013: Ophthalmic Surgery, Lasers & Imaging Retina
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