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Posterior uveitis

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https://www.readbyqxmd.com/read/28429127/uveitis-in-siriraj-hospital-pattern-differences-between-immune-related-uveitis-and-infectious-uveitis-in-a-university-based-tertiary-care-hospital
#1
Nattaporn Tesavibul, Sutasinee Boonsopon, Pitipol Choopong, Sujintana Tanterdtham
PURPOSE: To describe a proportion of uveitis and to analyse differences between immune-related uveitis and infectious uveitis groups. METHODS: A retrospective study of 458 uveitis patients were categorized into immune-related uveitis, infectious uveitis, masquerade, and undetermined groups. The pattern of inflammation was described. Subgroup analysis was performed to compare pattern differences between immune-related uveitis and infectious uveitis groups. RESULTS: The most common location of inflammation was the anterior eye segment...
April 20, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28426849/effect-of-adalimumab-on-visual-functioning-in-patients-with-noninfectious-intermediate-uveitis-posterior-uveitis-and-panuveitis-in-the-visual-1-and-visual-2-trials
#2
John Sheppard, Avani Joshi, Keith A Betts, Stacie Hudgens, Samir Tari, Naijun Chen, Martha Skup, Andrew D Dick
Importance: Adalimumab was recently approved for the treatment of noninfectious intermediate uveitis, posterior uveitis, and panuveitis. Objective: To assess the effect of adalimumab on the visual functioning and quality of life in patients with corticosteroid-dependent noninfectious intermediate uveitis, posterior uveitis, and panuveitis. Design: A post hoc analysis of clinical trials of adults with active (VISUAL-1) and inactive (VISUAL-2) noninfectious intermediate uveitis, posterior uveitis, and panuveitis was conducted in the United States, Canada, Europe, Israel, Australia, Latin America, and Japan...
April 20, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28414665/a-case-of-early-neurosyphilis
#3
M Walker, R Wisler, J Simmons, A Johnson
INTRODUCTION: Neurosyphilis is an infection of the central nervous system by Treponema pallidum, which can occur after the initial syphilis infection. Although commonly associated with late stage disease, patients with early neurosyphilis may present with acute syphilitic meningitis, meningovascular syphilis, or uveitis. CASE: A 28 year old man with a past medical history of HIV (CD4 364);, and recent diagnosis of uveitis presented to the Emergency Department with a positive RPR result...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28414043/quality-of-life-outcomes-from-a-randomized-clinical-trial-comparing-antimetabolites-for-intermediate-posterior-and-panuveitis
#4
Katherine M Niemeyer, John A Gonzales, Sivakumar R Rathinam, Manohar Babu, Radhika Thundikandy, Anuradha Kanakath, Travis C Porco, Erica N Browne, Maya M Rao, Nisha R Acharya
PURPOSE: To evaluate the changes in quality of life in noninfectious uveitis patients treated with two of the most commonly prescribed antimetabolite treatments. DESIGN: Secondary analysis of a multicenter, block-randomized, clinical trial (ClinicalTrials.gov NCT01232920). METHODS: Eighty patients at Aravind Eye Hospitals in Madurai and Coimbatore, India, with noninfectious intermediate, posterior, or panuveitis were randomized to receive oral methotrexate, 25 mg weekly, or oral mycophenolate mofetil, 1 g twice daily, and were followed up monthly for 6 months...
April 13, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28408754/lack-of-association-of-c3-gene-with-uveitis-additional-insights-into-the-genetic-profile-of-uveitis-regarding-complement-pathway-genes
#5
Ming Ming Yang, Jun Wang, Li Dong, De Ju Kong, Yan Teng, Ping Liu, Jiao Jie Fan, Xu Hui Yu
Uveitis is a devastating ocular disease that causes blindness. Our previous studies have achieved great advancements in depicting the genetic profiles of uveitis regarding complement pathway genes. This study aimed to provide additional insights into this interest by testing the "central" factor of the complement system, C3 gene variants, in two uveitis entities. Eight haplotype-tagging SNPs of C3 gene were genotyped in 141 anterior uveitis (AU), 158 non-infectious intermediate and posterior uveitis (NIPU) and 293 controls...
April 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28406760/adherence-to-guidelines-for-the-treatment-of-beh%C3%A3-et-s-syndrome-in-new-york-and-amsterdam
#6
Floor G Kerstens, Franktien Turkstra, Selma Atalay, Richard M van Vugt, Christopher J Swearingen, Yusuf Yazici
OBJECTIVES: To assess adherence to published guidelines for the treatment of Behçet's syndrome (BS) in two geographic areas. METHODS: We extracted guideline statements from the 2008 EULAR recommendations. Adherence to these statements was evaluated retrospectively in both New York (USA) and Amsterdam (The Netherlands), by reviewing records from patients fulfilling the ISG criteria. We analysed data per statement and event, and divided data according to the year in which an event occurred...
April 13, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28399985/immunosuppressive-treatment-of-non-infectious-uveitis-history-and-current-choices
#7
Zhao Chan, Zhang Meifen
Non-infectious uveitis is one of the leading causes of preventable blindness worldwide. Long-term immunosuppressive treatment is generally required to achieve durable control of inflammation in posterior and panuveitis. Although systemic corticosteroids have been the gold standard of immunosup- pressive treatment for uveitis since first introduced in 1950s, its side effects of long-term use often warrant an adjuvant treatment to reduce the dosage/duration of corticosteroids needed to maintain disease control...
April 10, 2017: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/28396946/pattern-and-causes-of-visual-loss-in-beh%C3%A3-et-s-uveitis-short-term-and-long-term-outcomes
#8
Radgonde Amer, Walaa Alsughayyar, Diego Almeida
BACKGROUND: To analyze the pattern and causes of visual loss in patients with Behçet's uveitis and to report on the short-term outcome at 6 months and at last follow-up visit. Also, to analyze the pattern of visual acuity changes in eyes with and without macular involvement at the specified time points. METHODS: This is a retrospective cohort study of a single-center in an academic practice. Fifty-three patients with Behçet's uveitis evaluated between 2004 and 2014 were included...
April 10, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28394239/management-of-uveitis-and-scleritis-in-necrobiotic-xanthogranuloma
#9
John A Gonzales, Anna Haemel, Andrew J Gross, Nisha R Acharya
Necrobiotic xanthogranuloma (NXG) is a chronic, progressive non-Langerhans histiocytic granulomatous disease. While case reports describing periorbital involvement of NXG are frequent, only a few case reports describing ocular involvement, such as scleritis and uveitis, exist. Herein, we present a case presenting initially as bilateral anterior and posterior scleritis, as well as a chronic bilateral granulomatous panuveitis, and discuss the immunosuppressant options that should be considered for this disease with protean manifestations...
April 10, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28389634/tuberculous-posterior-sclero-uveitis-with-features-of-vogt-koyanagi-harada-uveitis-an-unusual-case
#10
Dimitrios Kalogeropoulos, George Kitsos, Athanasios Konstantinidis, Constantina Gartzonika, Evgenia Svarna, Konstantinos Malamos, Emmanouil Katsanevakis, Chris Kalogeropoulos
BACKGROUND Ocular tuberculosis (TB) is a clinical entity that presents with a wide range of clinical manifestations. It is regarded as an extremely challenging condition from the point of view of diagnostic approach and calls for early diagnosis and prompt treatment, as it can potentially lead to blindness. CASE REPORT This is a case report of a 32-year-old male from southern India who has been living and working in Greece over the last 10 years and presented with 2-week history of pain and progressive visual impairment of his left eye...
April 8, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28367531/bilateral-cytomegalovirus-retinitis-in-a-healthy-infant
#11
Seyedeh Maryam Hosseini, Mir-Naghi Moosavi, Naser Shoeibi, Mehdi Sakhaee, Hossein Ghavamsaeedi
PURPOSE: To report a case of bilateral cytomegalovirus (CMV) retinitis in an otherwise healthy infant. METHODS: A four-month-old, healthy, male infant was evaluated for visual inattention. RESULTS: This full-term infant with a normal birth weight and an uneventful gestational period was referred with symptoms of visual inattention, fever, and agitation one week prior to admission. Ocular involvements were detected in the form of bilateral pan uveitis with diffuse bilateral retinitis and vasculitis with hemorrhage in the peripheral retina and posterior pole...
March 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28366648/randomized-control-trial-evaluating-a-standardized-strategy-for-uveitis-etiological-diagnosis-ulisse
#12
Audrey de Parisot, Laurent Kodjikian, Marie-Hélène Errera, Neila Sedira, Emmanuel Heron, Laurent Pérard, Pierre-Loïc Cornut, Christelle Schneider, Sophie Rivière, Priscille Ollé, Grégory Pugnet, Pascal Cathébras, Pierre Manoli, Bahram Bodaghi, David Saadoun, Stéphanie Baillif, Nathalie Tieulie, Marc Andre, Frédéric Chiambaretta, Nicolas Bonin, Philip Bielefeld, Alain Bron, Frédéric Mouriaux, Boris Bienvenu, Stéphanie Vicente, Sylvie Bin, Christiane Broussolle, Evelyne Decullier, Pascal Sève
PURPOSE: To prospectively assess the efficiency of a standardized diagnostic approach, compared to an open strategy, for the etiological diagnosis of uveitis. DESIGN: Non-inferiority, prospective, multicenter, clustered randomized control trial. METHODS: Consecutive patients with uveitis, who visited one of the participating Departments of Ophthalmology, were included. In the standardized group, all patients had a minimal work-up regardless of the type of uveitis (complete blood count, erythrocyte sedimentation rate, C-reactive protein, tuberculin skin test, syphilis serology and chest X ray) followed by more complex investigations according to ophthalmological findings...
March 30, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28353369/cystoid-macular-edema-in-retinitis-pigmentosa-with-intermediate-uveitis-responded-well-to-oral-and-posterior-subtenon-steroid
#13
Koushik Tripathy
No abstract text is available yet for this article.
March 29, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/28345572/late-dislocation-of-in-the-bag-intraocular-lenses-in-uveitic-eyes-an-analysis-of-management-and-complications
#14
Sudha K Ganesh, Parveen Sen, Hitesh R Sharma
AIM: An analysis of late in-the-bag dislocation of intraocular lenses (IOL), in uveitic eyes. SETTING: Referral uveitis clinic. DESIGN: Retrospective case series. MATERIALS AND METHODS: All case records of eyes with chronic uveitis that had phacoemulsification with IOL implantation, at a referral uveitis clinic between February 1997 and January 2015 were retrieved and analyzed. Only those eyes with no documented intraoperative complication and no predisposing risks to IOL dislocation, such as pseudoexfoliation, high myopia, trauma, and prior VR surgery were included in this study...
February 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28331634/multi-modal-imaging-and-anatomic-classification-of-the-white-dot-syndromes
#15
REVIEW
Meisha L Raven, Alexander L Ringeisen, Yoshihiro Yonekawa, Maxwell S Stem, Lisa J Faia, Justin L Gottlieb
The white dot syndromes (WDS) are a diverse group of posterior uveitidies that share similar clinical findings but are unique from one another. Multimodal imaging has allowed us to better understand the morphology, the activity and age of lesions, and whether there is CNV associated with these different ocular pathologies. The "white dot syndromes" and their uveitic masqueraders can now be anatomically categorized based on lesion localization. The categories include local uveitic syndromes with choroidal pathology, systemic uveitic syndromes with choroidal pathology, and multifocal choroiditis with outer retinal/choriocapillaris pathology with uveitis and without uveitis...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28328621/ocular-involvement-in-children-with-inflammatory-bowel-disease
#16
Samuele Naviglio, Fulvio Parentin, Silvia Nider, Nicolò Rassu, Stefano Martelossi, Alessandro Ventura
BACKGROUND: Data on ocular manifestations of inflammatory bowel disease (IBD) in children are limited. Some authors have reported a high prevalence of asymptomatic uveitis, yet the significance of these observations is unknown and there are no recommendations on which ophthalmologic follow-up should be offered. METHODS: Children with IBD seen at a single referral center for pediatric gastroenterology were offered ophthalmologic evaluation as part of routine care for their disease...
March 21, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28324879/quantitative-analysis-of-uveitis-macular-edema-in-multiple-sclerosis-patients-receiving-deep-posterior-sub-tenon-triamcinolone-acetonide-injection
#17
Svetlana Jovanović, Tatjana Šarenac Vulović, Filip Radotić, Zorica Tončić, Maja Živković, Nenad Petrović
AIM: We aimed to analyze the effects of adjunctive posterior sub-Tenon capsule triamcinolone acetonide injection in the treatment of intermediate uveitis macular edema in multiple sclerosis patients that could not be controlled by systemic corticosteroid medications and immunomodulators. METHODS: The study included 30 eyes of 25 patients with multiple sclerosis who received a posterior sub-Tenon injection of 40 mg/mL triamcinolone acetonide. Parameters monitored for therapy efficiency were best-corrected visual acuity, intraocular pressure, central foveal thickness (CFT), and fluorescein angiography (FA) scores...
March 22, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28323505/pattern-of-uveitis-in-a-referral-hospital-in-bangladesh
#18
Zahedur Rahman, Ziaul Ahsan, Niaz Abdur Rahman, Parthopratim Dutta Majumder
PURPOSE: To report the pattern of uveitis in a tertiary eye care center in Bangladesh. METHODS: Retrospective analysis of all uveitis cases visiting uveitis clinic of Bangladesh Eye Hospital between January, 2009 and April, 2015. RESULTS: In total, 652 patients (mean age 32.3 years, female 47.8%) were included in the study. Uveitis was bilateral in 42.6% of cases. Anterior uveitis was the most common (39.2%) case, closely followed by intermediate uveitis (22...
March 21, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28318350/clinical-course-and-outcomes-of-pediatric-tubercular-uveitis-in-north-india
#19
Savleen Kaur, Kanika Aggarwal, Aniruddha Agarwal, Deepti Suri, Anju Gupta, Ramandeep Singh, Reema Bansal, Surjit Singh, Nirbhai Singh, Amod Gupta, Vishali Gupta
PURPOSE: To analyze the clinical features, course, management, and outcomes of tubercular (TB) uveitis in the pediatric population and assess the response to anti-tubercular therapy (ATT). METHODS: Hospital records of children (≤16 years) from a large tertiary-care institute between January 2001 and December 2015 were reviewed. RESULTS: A total of 32 children (mean age: 10.7 ± 4.27 years; range 2-16) were diagnosed with TB-associated uveitis...
March 20, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28315319/interferon-alpha2a-and-systemic-corticosteroid-in-monotherapy-in-chronic-uveitis-results-of-the-randomised-controlled-birdferon-study
#20
Christine Fardeau, Anne Simon, Benoît Rodde, Fabiana Viscogliosi, Pierre Labalette, Vincent Looten, Sophie Tézenas du Montcel, Phuc LeHoang
PURPOSE: Macular edema is the leading cause of vision loss in bilateral chronic non-infectious posterior uveitis, and is used to being treated using corticosteroids, immunosuppressive agents and biotherapies. The aim of this trial was to assess and compare the efficacy and safety of corticosteroids and IFN-α in adults with such conditions. STUDY DESIGN: Randomized controlled trial SUBJECTS: Adult patients with bilateral posterior autoimmune non-infectious and non-tumoral uveitis complicated by macular edema in at least one eye, were recruited...
March 14, 2017: American Journal of Ophthalmology
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