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Posterior uveitis

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https://www.readbyqxmd.com/read/29872258/visual-outcome-and-complications-of-cataract-extraction-after-pars-plana-vitrectomy
#1
Amanda Rey, Ignasi Jürgens, Xavier Maseras, Agnieszka Dyrda, Patricia Pera, Antonio Morilla
Purpose: To evaluate the visual outcomes and complications of phacoemulsification in previously vitrectomized eyes. Patients and methods: A retrospective analysis of 87 consecutive vitrectomized eyes (87 patients) which had undergone phacoemulsification with intraocular lens implantation between 2013 and 2016. Results: The mean interval from pars plana vitrectomy (PPV) to cataract surgery (CS) was 18.8 months. Mean age at CS was 61.5 years...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29869018/early-treatment-of-tuberculous-uveitis-improves-visual-outcome-a-10-year-cohort-study
#2
Luis Anibarro, Eliana Cortés, Ana Chouza, Alberto Parafita-Fernández, Juan Carlos García, Alberto Pena, Carlos Fernández-Cid, África González-Fernández
PURPOSE: Diagnosis of tuberculous uveitis (TBU) is often challenging and is usually made after excluding other causes of uveitis. We analysed the characteristics of TBU and variables associated with visual outcome. METHODS: A retrospective, observational analysis was performed in patients with presumptive TBU who were started on specific TB treatment between January 2006 and June 2016. Demographic, clinical, radiological, analytical and ophthalmic examination variables were studied...
June 4, 2018: Infection
https://www.readbyqxmd.com/read/29804464/diffuse-subretinal-fibrosis-syndrome-a-rare-entity
#3
Natacha D Stolowy, Benjamin P Donnadieu, Alban Cm Comet, Sébastien Nadeau, Marie A-S Beylerian, Danièle Denis, Frédéric J Matonti
Background/ purpose: Diffuse subretinal fibrosis and uveitis syndrome is an inflammatory disease rarely reported. The purpose of this article is to describe a rare case of diffuse subretinal fibrosis syndrome in an 8-year-old child. METHODS AND RESULTS: The patient initially presented with a loss of vision in his right eye, with a visual acuity of 20/200. The visual acuity of the left eye was normal. Clinical examination showed bilateral anterior and posterior inflammation while the fundus revealed on the right eye an inter maculopapillar fibrosed lesion with a discrete retinal hemorrhage and a similar but smaller lesion on the left eye...
May 1, 2018: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29802245/zika-virus-infection-causes-persistent-chorioretinal-lesions
#4
Mohanraj Manangeeswaran, Jennifer L Kielczewski, H Nida Sen, Biying C Xu, Derek D C Ireland, Ian L McWilliams, Chi-Chao Chan, Rachel R Caspi, Daniela Verthelyi
Zika-infected patients can have eye involvement ranging from mild conjunctivitis to severe chorioretinal lesions, however the possible long-term sequelae of infection and timeline to recovery remain unknown. Here we describe the partial recovery of chorioretinal lesions in an immunocompetent patient diagnosed with bilateral posterior uveitis associated with Zika infection and show that some lesions resolved with focal atrophy evident as pigmentary changes on funduscopy. To better understand the progression of the lesions and correlate the changes in fundus imaging with local viral load, immune responses, and retinal damage, we developed a symptomatic mouse model of ocular Zika virus infection...
May 25, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29780935/two-cases-of-cytomegalovirus-panuveitis-in-immunocompetent-patients
#5
Masato Sakai, Hiroshi Takase, Kenichi Namba, Kazuomi Mizuuchi, Daiju Iwata, Susumu Ishida
Purpose: To report two cases of panuveitis in immunocompetent patients in which cytomegalovirus was involved. Observation: Case 1 was a 46-year-old man who had a history of recurrent anterior chamber inflammations in his left eye. After Nd:YAG laser posterior capsulotomy, he developed panuveitis with vitreous haze and periphlebitis. Polymerase chain reaction (PCR) examination revealed the presence of cytomegalovirus (CMV) DNA in the anterior chamber (AC). He responded well to a series of intravitreal injections of ganciclovir (GCV)...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29780926/macular-edema-associated-with-intraocular-ointment-after-cataract-surgery
#6
Asaka Kudo, Takashi Kudo, Daisuke Takahashi, Tomomi Metoki, Yukihiko Suzuki, Mitsuru Nakazawa
Purpose: To report a case with macular edema associated with uveitis, a decreased corneal endothelial cell density, and vitreous opacity caused by migrated intraocular antibiotic ointment after uneventful cataract surgery. Observations: A 63-year-old man underwent uneventful sutureless superior clear corneal phacoemulsification and implantation of an intraocular lens in his right eye. Eleven months later, he complained of blurred vision when he gazed downward. Three months later, uveitis, vitreous opacity, and retinal hemorrhage were noted...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29774027/clinical-remission-of-sight-threatening-non-infectious-uveitis-is-characterized-by-an-upregulation-of-peripheral-t-regulatory-cell-polarized-towards-t-bet-and-tigit
#7
Rose M Gilbert, Xiaozhe Zhang, Robert D Sampson, Michael R Ehrenstein, Dao X Nguyen, Mahid Chaudhry, Charles Mein, Nadiya Mahmud, Grazyna Galatowicz, Oren Tomkins-Netzer, Virginia L Calder, Sue Lightman
Background: Non-infectious uveitis can cause chronic relapsing and remitting ocular inflammation, which may require high dose systemic immunosuppression to prevent severe sight loss. It has been classically described as an autoimmune disease, mediated by pro-inflammatory Th1 and Th17 T-cell subsets. Studies suggest that natural immunosuppressive CD4+ CD25+ FoxP3+ T-regulatory cells (Tregs) are involved in resolution of inflammation and may be involved in the maintenance of clinical remission...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29752046/long-term-outcomes-for-pediatric-patients-having-transscleral-fixation-of-the-capsular-bag-with-intraocular-lens-for-ectopia-lentis
#8
Julia M Byrd, Marielle P Young, Wei Liu, Yue Zhang, David B Tate, Alan S Crandall, Leah A Owen
PURPOSE: To report the long-term outcomes of transscleral fixation of capsular tension rings (CTR) with intraocular lens (IOL) placement in pediatric patients with ectopia lentis. SETTING: John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. DESIGN: Retrospective case series. METHODS: Pediatric patients requiring lens extraction with transscleral capsular bag fixation with a CTR and IOL for ectopia lentis between January 2006 and January 2016 were analyzed...
May 8, 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29719641/patterns-of-uveitis-at-a-tertiary-referral-center-in-northeastern-iran
#9
Seyedeh Maryam Hosseini, Nasser Shoeibi, Raheleh Ebrahimi, Mehdi Ghasemi
Purpose: To describe the demographic and clinical patterns of patients with uveitis referred to a tertiary center in northeastern Iran. Methods: This cross-sectional retrospective study included 235 patients with uveitis who had been referred to the uveitis clinic of Khatam-Al-Anbia eye hospital, affiliated to Mashhad University of Medical Sciences, from February 2013 to March 2014. Data regarding patient age, sex, anatomical location of the disease, and etiologic and clinical features were analyzed...
April 2018: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/29715058/corneal-endothelial-changes-in-beh%C3%A3-et-s-patients-with-inactive-ocular-involvement
#10
Cem Cankaya, Tongabay Cumurcu, Abuzer Gunduz, Ilknur Fırat
PURPOSE: The purpose of this article is to evaluate alterations in the corneal endothelial layer in Behçet's disease (BD) with inactive ocular involvement using specular microscopy. MATERIALS AND METHODS: Thirty-three eyes of 33 BD patients who had at least one anterior segment involvement and no active inflammation in the last 3 months were included in the study (group 1). Twenty-seven of the 33 BD patients had an anterior uveitis attack and six of them had a panuveitis (both anterior and posterior involvement) attack...
May 1, 2018: Current Eye Research
https://www.readbyqxmd.com/read/29705838/potential-predictors-for-frequent-relapse-in-human-leukocyte-antigen-b27-associated-uveitis
#11
Mirinae Kim, Yoon Seob Sim, Seung Yong Choi, Young-Hoon Park
PURPOSE: To identify potential predictors for frequent relapse in a cohort of patients with human leukocyte antigen (HLA)-B27-associated uveitis in a tertiary referral center at the initial visit. METHODS: This retrospective cohort study comprised 130 patients diagnosed with HLA-B27-associated uveitis. Subjects were divided into two groups according to the frequency of uveitis attacks (number/year): frequent relapse (FR) (who relapsed more than twice a year, 38) and infrequent relapse (IR) group (who relapsed twice or less than twice a year, 92)...
April 29, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29704469/current-treatment-of-ocular-toxoplasmosis-in-immunocompetent-patients-a-network-meta-analysis
#12
REVIEW
Yanxia Zhang, Xiao Lin, Fangli Lu
Ocular toxoplasmosis (OT) is the most frequent form of infectious posterior uveitis caused by the protozoan parasite Toxoplasma gondii. To evaluate the available evidence in peer-reviewed publications about the most effective therapy for OT in immunocompetent patients, herein a systematic literature search was conducted using Embase, PubMed, Google Scholar, and the Cochrane Central Register of Controlled Trials (CENTRAL) database from January 1987 to October 2017, with search terms "OT", "retinochoroiditis", "treatment", and "immunocompetent"; search filters "controlled clinical trial", "randomized clinical trial", and "clinical trial"...
April 25, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29697588/the-collaborative-ocular-tuberculosis-study-cots-1-a-multinational-review-of-251-patients-with-tubercular-retinal-vasculitis
#13
Dinesh V Gunasekeran, Rupesh Agrawal, Aniruddha Agarwal, Ester Carreño, Dhananjay Raje, Kanika Aggarwal, Onn M Kon, Quan Dong Nguyen, Carlos Pavesio, Vishali Gupta
PURPOSE: Tubercular retinal vasculitis (TRV) is a heterogeneous disease that can be difficult to manage because of nonspecific presentation and limitations of confirmatory tests for tuberculosis. This is a big data analysis on phenotypes and treatment outcomes for TRV. METHODS: Multicentre retrospective study of patients with TRV between January 2004 and December 2014 and a minimum follow-up of 1 year. RESULTS: Two hundred and fifty-one patients with TRV with a mean age of 38...
April 24, 2018: Retina
https://www.readbyqxmd.com/read/29689028/detection-of-type-1-choroidal-neovascular-membranes-using-optical-coherence-tomography-angiography-in-tubercular-posterior-uveitis
#14
Kanika Aggarwal, Aniruddha Agarwal, Aman Sharma, Kusum Sharma, Vishali Gupta
PURPOSE: To study optical coherence tomography angiography (OCTA) and multimodal imaging features of Type 1 inflammatory choroidal neovascularization (CNV) in tubercular serpiginous-like choroiditis and response to anti-vascular endothelial growth factor therapy. METHODS: In this study, multimodal imaging was performed using OCTA, enhanced-depth imaging optical coherence tomography, fluorescein angiography, and indocyanine green angiography. Correlation of OCTA with other imaging modalities in the detection of CNV was performed...
April 23, 2018: Retina
https://www.readbyqxmd.com/read/29686615/theissenolactone-c-exhibited-ocular-protection-of-endotoxin-induced-uveitis-by-attenuating-ocular-inflammatory-responses-and-glial-activation
#15
Fan-Li Lin, Jau-Der Ho, Yu-Wen Cheng, George C Y Chiou, Jing-Lun Yen, Hung-Ming Chang, Tzong-Huei Lee, George Hsiao
The aim of this study was to investigate the effects of a natural component, theissenolactone C (LC53), on the ocular inflammation of experimental endotoxin-induced uveitis (EIU) and its related mechanisms in microglia. Evaluation of the severity of anterior uveitis indicated that LC53 treatment significantly decreased iridal hyperemia and restored the clinical scores. Additionally, the deficient retina functions of electroretinography were improved by LC53. LC53 significantly reduced levels of tumor necrosis factor (TNF)-α, monocyte chemoattractant protein-1, protein leakage and activation of matrix metalloproteinases in the anterior section during EIU...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29682916/pediatric-uveitis
#16
Nicole Shu-Wen Chan, Jessy Choi, Chui Ming Gemmy Cheung
Pediatric uveitis differs from adult-onset uveitis and is a topic of special interest because of its diagnostic and therapeutic challenges. Children with uveitis are often asymptomatic and the uveitis is often chronic, persistent, recurrent, and resistant to conventional treatment. Anterior uveitis is the most common type of uveitis in children; the prevalence of intermediate, posterior, and panuveitis varies geographically and among ethnic groups. Regarding etiology, most cases of pediatric uveitis are idiopathic but can be due to systemic inflammatory disorders, infections, or a manifestation of masquerade syndrome...
May 2018: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29669371/need-for-quantitative-measurement-methods-for-posterior-uveitis-comparison-of-dual-fa-icga-angiography-edi-oct-choroidal-thickness-and-sun-vitreous-haze-evaluation-in-stromal-choroiditis
#17
Filippo Fabro, Carl P Herbort
BACKGROUND/PURPOSE: Quantitative methods for posterior uveitis are necessary for precise appraisal and follow-up of inflammation in practice and in clinical trials. The aim of this study was to assess fluorescein angiography (FA), indocanine green angiography (ICGA), and enhanced depth imaging optical coherence tomography choroidal thickness (EDI-OCT CT) in two stromal choroiditis entities, birdshot retinochoroiditis (BRC), and Vogt-Koyanagi-Harada disease (VKH), as well as to determine (1) disease patterns, (2) respective response to therapy, and (3) their potential utility in clinical trials in comparison to vitreous haze, the present standard outcome used in clinical trials...
April 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29663152/a-glimpse-into-uveitis-in-the-aging-eye-pathophysiology-clinical-presentation-and-treatment-considerations
#18
REVIEW
Elizabeth Akinsoji, Raquel Goldhardt, Anat Galor
Uveitis describes a group of inflammatory conditions of the eye that have various underlying causes and clinical presentations. Susceptibilities to uveitis in the elderly may be attributed to age-related risk factors such as immunosenescence, increased immunological inflammatory mediators, and autoimmunity. Overall, anterior uveitis is more common than posterior and panuveitis in the general population and also in the elderly. Some causes of uveitis in the elderly are herpes simplex virus, ocular ischemic syndrome, sarcoidosis, and central nervous system lymphoma, and these will be discussed in detail herein...
May 2018: Drugs & Aging
https://www.readbyqxmd.com/read/29660509/glycosylation-enhanced-biocompatibility-of-the-supramolecular-hydrogel-of-an-anti-inflammatory-drug-for-topical-suppression-of-inflammation
#19
Taotao Xiong, Xianglian Li, Yanfang Zhou, Qianqian Song, Renshu Zhang, Lei Lei, Xingyi Li
Intravitreal/periocular injection of triamcinolone acetonide (TA) suspension is a common uveitis treatment, but it displays a high risk for serious side effects (e.g., high intraocular pressure, retinal toxicity). We report here an intravitreally injectable thermosensitive glycosylated TA (TA-SA-Glu) hydrogel, formed by covalently conjugating glucosamine (Glu) with succinate TA (TA-SA), for treating uveitis. The TA-SA-Glu hydrogelator forms a supramolecular hydrogel spontaneously in aqueous solution with a minimal gelation concentration of 0...
June 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29656829/-uveitis-treated-with-biotherapy-and-or-dmard-analysis-from-the-french-pharmacovigilance-study-base
#20
L Cabane, S Baillif, B Baldin, V Breuil, L Euller-Ziegler, N Tieulié
PURPOSE: To report the characteristics of uveitis cases occurring while on biologic therapy or disease-modifying antirheumatic drugs (DMARDs) reported to the French national pharmacovigilance database. METHODS: All the uveitis cases occurring in patients with chronic rheumatologic diseases, chronic inflammatory intestinal diseases or connective tissue diseases, while treated with DMARDs and/or biologic therapies between 2000 and 2015 and reported to the French National Pharmacovigilance Database were collected...
April 2018: Journal Français D'ophtalmologie
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