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Intermediate uveitis

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https://www.readbyqxmd.com/read/29907630/clinical-features-of-paediatric-uveitis-at-a-tertiary-referral-centre-in-s%C3%A3-o-paulo-sp-brazil
#1
Fernanda Maria Silveira Souto, Bárbara Vilela Giampietro, Julia Thiemi Takiuti, Lucia Maria Arruda Campos, Carlos Eduardo Hirata, Joyce Hisae Yamamoto
AIMS: To analyse the clinical features, systemic associations, treatment and visual outcomes of uveitis in children from a referral centre in São Paulo, Brazil. METHODS: Clinical records of patients under 16 years old who attended the Uveitis Service, Hospital das Clinicas, Faculdadede Medicina, Universidade de São PauloFMUSP, between April and September 2017, were reviewed retrospectively. Patients with incomplete medical records, previous ocular trauma, or less than six6 months of follow-up were excluded...
June 15, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29774027/clinical-remission-of-sight-threatening-non-infectious-uveitis-is-characterized-by-an-upregulation-of-peripheral-t-regulatory-cell-polarized-towards-t-bet-and-tigit
#2
Rose M Gilbert, Xiaozhe Zhang, Robert D Sampson, Michael R Ehrenstein, Dao X Nguyen, Mahid Chaudhry, Charles Mein, Nadiya Mahmud, Grazyna Galatowicz, Oren Tomkins-Netzer, Virginia L Calder, Sue Lightman
Background: Non-infectious uveitis can cause chronic relapsing and remitting ocular inflammation, which may require high dose systemic immunosuppression to prevent severe sight loss. It has been classically described as an autoimmune disease, mediated by pro-inflammatory Th1 and Th17 T-cell subsets. Studies suggest that natural immunosuppressive CD4+ CD25+ FoxP3+ T-regulatory cells (Tregs) are involved in resolution of inflammation and may be involved in the maintenance of clinical remission...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29767349/-primary-ophthalmological-diagnosis-of-treponema-pallidum-infection-a-case-series
#3
D Grassl, V Brandi Falcone, K Gorte, G Sauder
This report is on five patients (four men and one woman) between the age of 24 and 66 years old who presented with unclear visual impairment in our clinic between 2009 and 2016 for co-evaluation. The clinical picture included intermediate uveitis, chorioretinitis, panuveitis and bilateral spontaneous cystoid macular edema. None of the patients reported systemic or dermatological symptoms. In all five patients, serological testing revealed a Treponema pallidum infection as the reason for ocular inflammation...
May 16, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29719641/patterns-of-uveitis-at-a-tertiary-referral-center-in-northeastern-iran
#4
Seyedeh Maryam Hosseini, Nasser Shoeibi, Raheleh Ebrahimi, Mehdi Ghasemi
Purpose: To describe the demographic and clinical patterns of patients with uveitis referred to a tertiary center in northeastern Iran. Methods: This cross-sectional retrospective study included 235 patients with uveitis who had been referred to the uveitis clinic of Khatam-Al-Anbia eye hospital, affiliated to Mashhad University of Medical Sciences, from February 2013 to March 2014. Data regarding patient age, sex, anatomical location of the disease, and etiologic and clinical features were analyzed...
April 2018: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/29713256/primary-glomerulonephritis-with-unique-c4d-deposition-and-concurrent-non-infectious-intermediate-uveitis-a-case-report-and-literature-review
#5
Jong Man Park, Harin Lee, Sangheon Song, Eun Young Seong, Ihm Soo Kwak, Sung Who Park, Young-Keum Kim, Nari Shin, Mee Young Sol
C4 glomerulopathy is a recently introduced entity that presents with bright C4d staining and minimal or absent immunoglobulin and C3 staining. We report a case of a 62-year-old man with C4 glomerulonephritis (GN) and uveitis. He presented to the nephrology department with proteinuria and hematuria. The patient also had intermediate uveitis along with proteinuria and hematuria. A kidney biopsy that was performed in light of continuing proteinuria and hematuria showed a focal proliferative, focal sclerotic glomerulopathy pattern on light microscopy, absent staining for immunoglobulin or C3 by immunofluorescence microscopy, with bright staining for C4d on immunohistochemistry, and electron-dense deposits on electron microscopy...
April 30, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29682916/pediatric-uveitis
#6
Nicole Shu-Wen Chan, Jessy Choi, Chui Ming Gemmy Cheung
Pediatric uveitis differs from adult-onset uveitis and is a topic of special interest because of its diagnostic and therapeutic challenges. Children with uveitis are often asymptomatic and the uveitis is often chronic, persistent, recurrent, and resistant to conventional treatment. Anterior uveitis is the most common type of uveitis in children; the prevalence of intermediate, posterior, and panuveitis varies geographically and among ethnic groups. Regarding etiology, most cases of pediatric uveitis are idiopathic but can be due to systemic inflammatory disorders, infections, or a manifestation of masquerade syndrome...
May 2018: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29656829/-uveitis-treated-with-biotherapy-and-or-dmard-analysis-from-the-french-pharmacovigilance-study-base
#7
L Cabane, S Baillif, B Baldin, V Breuil, L Euller-Ziegler, N Tieulié
PURPOSE: To report the characteristics of uveitis cases occurring while on biologic therapy or disease-modifying antirheumatic drugs (DMARDs) reported to the French national pharmacovigilance database. METHODS: All the uveitis cases occurring in patients with chronic rheumatologic diseases, chronic inflammatory intestinal diseases or connective tissue diseases, while treated with DMARDs and/or biologic therapies between 2000 and 2015 and reported to the French National Pharmacovigilance Database were collected...
April 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29652198/efficacy-and-safety-of-mycophenolate-mofetil-in-the-treatment-of-recalcitrant-intermediate-uveitis
#8
Sowkath Ali, Ranju Kharel Sitaula, Jyotirmay Biswas
PURPOSE: To evaluate the efficacy and safety of mycophenolate mofetil (MMF) in the treatment of recalcitrant intermediate uveitis in a tertiary referral eye-care center over a 1-year period. METHODS: Patients with at least three recurrences of intermediate uveitis per year, defined as relapse of disease after quiescent phase for >3 months after discontinuing all treatments and those with a minimum follow-up of 1 year, were analyzed retrospectively. MMF was initiated with oral steroids and the Standardization of Uveitis Nomenclature guidelines were used to evaluate patients at every visit...
April 13, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29625716/-ocular-manifestations-in-beh%C3%A3-et-s-disease
#9
A-C Desbois, C Terrada, P Cacoub, B Bodaghi, D Saadoun
Ocular disease in Behçet's disease is frequent and may be associated with a poor functional prognosis. Uveitis is the most common ocular manifestation in Behçet's disease and represents a diagnostic criterion of the disease. The ocular involvement is inaugural of the disease in 20% of the cases or may develop 2 to 3 years after the beginning of the extraocular signs. The risk of blindness at 5 years is in the order of 15 to 25%, mainly due to macular involvement or retinal vasculitis. Uveitis may be anterior, intermediate, posterior or panuveitis...
April 3, 2018: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29611087/long-term-retention-rates-of-adalimumab-and-infliximab-in-non-infectious-intermediate-posterior-and-panuveitis
#10
Claudia Fabiani, Antonio Vitale, Giacomo Emmi, Alice Bitossi, Giuseppe Lopalco, Jurgen Sota, Silvana Guerriero, Ida Orlando, Marco Capozzoli, Fiorella Fusco, Francesco Rana, Florenzo Iannone, Bruno Frediani, Mauro Galeazzi, Lorenzo Vannozzi, Gian Marco Tosi, Luca Cantarini
The aim of the present study was to compare long-term adalimumab (ADA) and infliximab (IFX) retention rates in patients with intermediate, posterior, or panuveitis. Additional aims are as follows: (i) to identify any difference in the causes of treatment discontinuation between patients treated with ADA and IFX; (ii) to assess any impact of demographic features, concomitant treatments, and different lines of biologic therapy on ADA and IFX retention rates; and (iii) to identify any correlation between ADA and IFX treatment duration and the age at uveitis onset, the age at onset of the associated systemic diseases, and the age at the start of treatment...
April 3, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29582812/changing-uveitis-patterns-in-south-india-comparison-between-two-decades
#11
Jyotirmay Biswas, Ranju Kharel Sitaula, Priyansha Multani
Purpose: Changing pattern of uveitis in a subset of a population is an important ocular health indicator. Methods: A comparative study was done between uveitis patients of 2013 and 1995 using two proportions Z-test. Results: In 2013, 352 new uveitis cases were examined. Males 56%, females 44%; unilateral 30.4%; bilateral in 69.6%. A specific diagnosis achieved in 66.2%. Anterior uveitis was seen in 35.22%, intermediate uveitis in 30.11%, posterior uveitis in 25%, and panuveitis in 9...
April 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29543632/perivascular-thickening-on-optical-coherence-tomography-as-a-marker-of-inflammation-in-birdshot-retinochoroiditis
#12
Akshay S Thomas, Angel L Hatef, Sandra S Stinnett, Robert T Keenan, Glenn J Jaffe
PURPOSE: In this study, we hypothesized that thickening along the major arcade vessels is a noninvasive marker of inflammation in eyes with birdshot retinochoroiditis (BRC). METHODS: In this single-center retrospective study, patients with BRC were identified. Perivascular thickening was categorized as mild, moderate, or severe, based on a set of standard reference retinal thickness maps derived from representative spectral domain optical coherence tomography volume scans...
March 14, 2018: Retina
https://www.readbyqxmd.com/read/29536169/-intraocular-inflammation-in-multiple-sclerosis
#13
N Stübiger, K Ruprecht, U Pleyer
Multiple sclerosis (MS) is a chronic inflammatory disorder of the brain and the spinal cord occurring mostly in young adults and is associated with temporary or permanent neurological deficits. An association between uveitis and MS has been recognized for a long time. Current data indicate an approximately 10 times higher prevalence of uveitis in patients with MS compared to the general population. In particular, MS is associated with intermediate uveitis and typically with concomitant retinal vasculitis...
March 13, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29480837/assessment-of-diagnostic-and-therapeutic-vitrectomy-for-vitreous-opacity-associated-with-uveitis-with-various-etiologies
#14
Tomohito Sato, Rina Kinoshita, Manzo Taguchi, Sunao Sugita, Toshikatsu Kaburaki, Yutaka Sakurai, Masaru Takeuchi
Vitreous opacity (VO) is a common feature of intermediate uveitis, posterior uveitis, and panuveitis. Fundus observation is critical for determining the etiology of uveitis, however, is often interfered with VO. In these clinical settings, vitrectomy contributes to a correct diagnosis and guides alternative management strategies. The purpose of this study was to evaluate the diagnostic yield and surgical outcome of vitrectomy in uveitic patients with VO and compare the visual outcome between infectious and noninfectious uveitis...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29455252/the-effect-of-anti-tumor-necrosis-factor-alpha-agents-on-the-outcome-in-pediatric-uveitis-of-diverse-etiologies
#15
Iris Deitch, Radgonde Amer, Oren Tomkins-Netzer, Zohar Habot-Wilner, Ronit Friling, Ron Neumann, Michal Kramer
PURPOSE: This study aimed to report the clinical outcome of children with uveitis treated with anti-tumor necrosis factor alpha (TNF-α) agents. METHODS: This included a retrospective cohort study. Children with uveitis treated with infliximab or adalimumab in 2008-2014 at five dedicated uveitis clinics were identified by database search. Their medical records were reviewed for demographic data, clinical presentation, ocular complications, and visual outcome. Systemic side effects and the steroid-sparing effect of treatment were documented...
April 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29452449/efficacy-of-natalizumab-in-intermediate-uveitis-related-to-multiple-sclerosis-a-case-report
#16
Ségolène Roemer, Alexandre Bissig, Alda Rocca, Renaud Du Pasquier, Yan Guex-Crosier
No abstract text is available yet for this article.
April 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29429764/safety-and-efficacy-of-adalimumab-in-patients-with-noninfectious-uveitis-in-an-ongoing-open-label-study-visual-iii
#17
Eric B Suhler, Alfredo Adán, Antoine P Brézin, Eric Fortin, Hiroshi Goto, Glenn J Jaffe, Toshikatsu Kaburaki, Michal Kramer, Lyndell L Lim, Cristina Muccioli, Quan Dong Nguyen, Joachim Van Calster, Luca Cimino, Martina Kron, Alexandra P Song, Jianzhong Liu, Sophia Pathai, Anne Camez, Ariel Schlaen, Mirjam E J van Velthoven, Albert T Vitale, Manfred Zierhut, Samir Tari, Andrew D Dick
PURPOSE: To evaluate safety and efficacy of adalimumab in patients with noninfectious intermediate, posterior, or panuveitis. DESIGN: Phase 3, open-label, multicenter clinical trial extension (VISUAL III). PARTICIPANTS: Adults meeting treatment failure (TF) criteria or who completed VISUAL I or II (phase 3, randomized, double-masked, placebo-controlled) without TF. METHODS: Patients received adalimumab 40 mg every other week...
February 8, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29420114/role-of-ct-chest-and-cytology-in-differentiating-tuberculosis-from-presumed-sarcoidosis-in-uveitis
#18
Reema Bansal, Amod Gupta, Ritesh Agarwal, Mohit Dogra, Garvit Bhutani, Vishali Gupta, M R Dogra, Deeksha Katoch, Ashutosh Nath Aggarwal, Aman Sharma, Raje Nijhawan, Ritambara Nada, Uma Nahar Saikia, Pranab Dey, Digambar Behera
PURPOSE: To report the role of CT chest and cytology in suspected tubercular and sarcoid uveitis. METHODS: This is a retrospective, interventional case series of 376 uveitis patients with suspected ocular tuberculosis (TB)/sarcoidosis seen between January 2010 and April 2015 at the Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh. All underwent CT chest, and had following inclusion criteria: (1) Presence of active granulomatous anterior/intermediate/posterior uveitis or panuveitis; (2) a documented tuberculin skin test/QuantiFERON-TB Gold test; (3) all other causes of infectious/non-infectious uveitis ruled out...
February 8, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29420111/increased-aqueous-humor-cd4-cd8-lymphocyte-ratio-in-sarcoid-uveitis
#19
Namita Dave, Priyanka Chevour, Padmamalini Mahendradas, Anitha Venkatesh, Ankush Kawali, Rohit Shetty, Arkasubhra Ghosh, Swaminathan Sethu
PURPOSE: To determine aqueous humor CD4+/CD8+ T-lymphocyte ratio changes in sarcoid and non-sarcoid uveitis with anterior chamber involvement. METHODS: The case-control study includes 61 patients with either anterior uveitis, intermediate uveitis with anterior spill, or panuveitis. A total of 21 of them were categorized as sarcoid uveitis and 40 as non-sarcoid uveitis according to diagnostic criteria. CD4+/CD8+ ratio in the aqueous humor was determined using flow cytometry...
February 8, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29394119/safety-and-efficacy-of-intravitreal-dexamethasone-implant-for-refractory-uveitic-macular-edema-in-adults-and-children
#20
Dhanashree Ratra, Atanu Barh, Manideepa Banerjee, Vineet Ratra, Jyotirmay Biswas
PURPOSE: To assess safety and efficacy of intravitreal dexamethasone (DEX) implant in refractory uveitic macular edema (ME). METHODS: We retrospectively analyzed medical records of patients with nonresponsive ME secondary to chronic, noninfectious intermediate or posterior uveitis, treated with intravitreal DEX implants. RESULTS: A total of 42 eyes of 34 patients (aged 6-67 years) received 56 implants. Mean follow-up was 19.2 ± 2.2 months after DEX implant...
February 2, 2018: Ocular Immunology and Inflammation
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