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https://www.readbyqxmd.com/read/27904945/-sarcoidosis-and-uveitis-an-update
#1
REVIEW
J G Garweg
Ocular involvement in sarcoidosis is present in up to one third of patients and is frequently manifested before the underlying systemic disease has been diagnosed. With a view to the therapeutic consequences an early diagnosis of the underlying disease is advantageous. In cases of visual loss early diagnostic measures include invasive procedures, such as ultrasound-guided bronchoalveolar lavage and transbronchial biopsy, if nodular conjunctival or cutaneous manifestations which would confirm the diagnosis are not present...
November 30, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/27901620/etiology-and-clinical-features-of-ocular-inflammatory-diseases-in-a-tertiary-referral-centre-in-sydney-australia
#2
Sophia L Zagora, Richard Symes, Aaron Yeung, Will Yates, Denis Wakefield, Peter J McCluskey
PURPOSE: To report the pattern of uveitis in patients attending a tertiary uveitis service in Sydney, Australia. METHODS: The charts of patients seen between January 2009 and December 2015 were retrospectively reviewed. Data pertaining to patient demographics, eye examination on presentation, work-up and final diagnoses were collected. RESULTS: The total number of patients with uveitis seen over this period was 1165. There were 650 males (56%) and 515 females (44%)...
November 30, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27896896/presumed-tuberculous-uveitis-in-non-endemic-country-for-tuberculosis-case-series-from-a-new-zealand-tertiary-uveitis-clinic
#3
Ken K Ng, Mitzi Nisbet, Erika M Damato, Joanne L Sims
BACKGROUND: To describe the clinical spectrum of presumed tuberculous (TB) uveitis in a developed, non-endemic country of high immigrant population. DESIGN: Retrospective review of a consecutive case series. PARTICIPANTS: All 39 patients diagnosed with presumed TB uveitis at the tertiary uveitis service in Auckland from 2007 to 2014. METHODS: Clinical chart review. MAIN OUTCOME MEASURES: Patient demographics, risk factors, ophthalmic manifestations, management and outcome...
November 28, 2016: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/27886802/advancements-in-the-management-of-uveitis
#4
REVIEW
Sergio Schwartzman
Uveitis may exist as a clinical manifestation of an underlying systemic disease or may represent an idiopathic entity, sometimes with a very characteristic pattern. Different forms of uveitis have been defined on the basis of three important variables: chronicity, anatomic location, and underlying etiology. The evolving understanding of the immune system has resulted in a more targeted approach to manage patients with different forms of uveitis, although clearly this approach is at a very early stage. Altered patterns of cellular processing and different cytokine expression, including TNF, IL-1, IL-2, IL-6, and IL17, have been defined in uveitis, and this has laid the pathway for targeted therapy...
April 2016: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/27871762/clinical-and-histopathologic-ocular-findings-in-disseminated-mycobacterium-chimaera-infection-after-cardiothoracic-surgery
#5
Sandrine A Zweifel, Daniela Mihic-Probst, Christine A Curcio, Daniel Barthelmes, Andrea Thielken, Peter M Keller, Barbara Hasse, Christian Böni
PURPOSE: To investigate and characterize clinical and histopathologic ocular findings in patients with disseminated infection with Mycobacterium chimaera, a slow-growing nontuberculous mycobacterium (NTM), subsequent to cardiothoracic surgery. DESIGN: Observational case series. PARTICIPANTS: Five white patients (10 eyes). METHODS: Analysis of clinical ocular findings, including visual acuity, slit-lamp biomicroscopy, spectral-domain optical coherence tomography (SD OCT), fundus autofluorescence (FAF), and fluorescein angiography/indocyanine green (ICG) angiography findings, of patients with a disseminated M...
November 18, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27849408/ocular-siderosis-subsequent-to-a-missed-pars-plana-metallic-foreign-body-that-masqueraded-as-refractory-intermediate-uveitis
#6
Michael Politis, Boris Rosin, Radgonde Amer
No abstract text is available yet for this article.
November 16, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27800257/peripheral-vasculitis-intermediate-uveitis-and-interferon-use-in-multiple-sclerosis
#7
Şeref Kinyas, Haluk Esgin
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. A 40-year-old female patient with a 12-year history of MS was admitted to our clinic with blurred vision and floaters in her right eye for about 1 month. Here, we share the findings and the management of intermediate uveitis and retinal periphlebitis in an MS case being treated with interferon beta-1a for 7 years.
January 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/27789936/management-of-noninfectious-posterior-uveitis-with-intravitreal-drug-therapy
#8
REVIEW
Hui Yi Tan, Aniruddha Agarwal, Cecilia S Lee, Jay Chhablani, Vishali Gupta, Manoj Khatri, Jayabalan Nirmal, Carlos Pavesio, Rupesh Agrawal
Uveitis is an important cause of vision loss worldwide due to its sight-threatening complications, especially cystoid macular edema, as well as choroidal neovascularization, macular ischemia, cataract, and glaucoma. Systemic corticosteroids are the mainstay of therapy for noninfectious posterior uveitis; however, various systemic side effects can occur. Intravitreal medication achieves a therapeutic level in the vitreous while minimizing systemic complications and is thus used as an exciting alternative. Corticosteroids, antivascular endothelial growth factors, immunomodulators such as methotrexate and sirolimus, and nonsteroidal anti-inflammatory drugs are currently available for intravitreal therapy...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27782772/clinical-patterns-and-causes-of-intraocular-inflammation-in-a-uveitis-patient-cohort-from-egypt
#9
Rowayda M Amin, Mohamed Gowieda, Ahmed Bedda, Ahmed Kamel, Alaa Radwan
PURPOSE: To analyze the patterns and causes of intraocular inflammation in patients attending uveitis referral clinics in Egypt. METHODS: The study included 454 patients with uveitis examined both at the Department of Ophthalmology, Alexandria Faculty of Medicine, and tertiary uveitis referral clinics in Cairo and the International Eye Clinic in Upper Egypt, between August 2013 and March 2016. All patients had a comprehensive ocular examination and systemic work-up...
October 26, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27782762/epidemiology-and-clinical-features-of-uveitis-from-urban-populations-in-south-india
#10
Swapnali Sabhapandit, Somasheila I Murthy, Vivek M Singh, Ketaki Gaitonde, Madhumita Gopal, Kerul Marsonia, Shajeera Sajid, Kalpana Babu
PURPOSE: To report the epidemiology of uveitis in two urban centers in South India. METHODS: Case records seen between January 2014 and December 2014 at two tertiary eye centers in South India were retrospectively reviewed. RESULTS: A total of 1123 patients in the study population had uveitis. Anterior uveitis was seen in 48.9%, posterior in 20.5%, intermediate in 17.3%, and panuveitis in 13.3%. Of these cases, 68.4% were acute uveitis. Pediatric uveitis constituted 6...
October 26, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27765666/safety-efficacy-and-pharmacokinetics-of-a-single-tablet-regimen-containing-elvitegravir-cobicistat-emtricitabine-and-tenofovir-alafenamide-in-treatment-naive-hiv-infected-adolescents-a-single-arm-open-label-trial
#11
Aditya H Gaur, Hilda Kizito, Wasana Prasitsueubsai, Natella Rakhmanina, Mohammed Rassool, Rana Chakraborty, Jagmohan Batra, Pope Kosalaraksa, Wicharn Luesomboon, Danielle Porter, Yongwu Shao, Michael Myers, Lillian Ting, Devi SenGupta, Erin Quirk, Martin S Rhee
BACKGROUND: The prodrug tenofovir alafenamide is associated with improved renal and bone safety compared with tenofovir disoproxil fumarate. We aimed to assess safety, pharmacokinetics, and efficacy of this single-tablet, fixed-dose combination of elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide in HIV-infected, treatment-naive adolescents. METHODS: We did a 48 week, single-arm, open-label trial in treatment-naive adolescents with HIV from ten hospital clinics in South Africa, Thailand, Uganda, and the USA...
December 2016: Lancet HIV
https://www.readbyqxmd.com/read/27758984/clinical-features-of-sarcoidosis-in-oman-a-report-from-the-middle-east-region
#12
B Jayakrishnan, Nasser Al-Busaidi, Ahsan Al-Lawati, Jojy George, Omar A Al-Rawas, Yaqoub Al-Mahrouqi, Nabil Al-Lawati
BACKGROUND: Though clinical features of sarcoidosis follow a similar pattern, some heterogeneity is seen in different ethnic and racial groups. OBJECTIVES: To describe for the first time the clinical characteristics of sarcoidosis patients in the Sultanate of Oman. METHODS: The data on all cases of sarcoidosis followed up in the two tertiary hospitals in Oman were retrieved retrospectively. RESULTS: Of the 92 patients, for representing the ethnic data only Omani patients (n=83) were included...
October 7, 2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
https://www.readbyqxmd.com/read/27730316/alemtuzumab-induced-remission-of-multiple-sclerosis-associated-uveitis
#13
Mark D Willis, Trevor P Pickersgill, Neil P Robertson, Richard W J Lee, Andrew D Dick, Ester Carreño
PURPOSE: The purpose of the study was to report a case of multiple sclerosis (MS)-associated uveitis refractory to conventional immunosuppressants, with subsequent remission following treatment with alemtuzumab. METHODS: Case report Patient was treated with intravenous alemtuzumab, a lymphocyte depleting anti-CD52 monoclonal antibody that has recently been approved for use in relapsing MS. RESULTS: A 17-year-old female presented with bilateral optic neuritis and subsequently bilateral intermediate uveitis and secondary macular oedema...
October 11, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/27729756/non-human-immunodeficiency-virus-related-ocular-syphilis-in-a-korean-population-clinical-manifestations-and-treatment-outcomes
#14
Yonguk Kim, Seung-Young Yu, Hyung Woo Kwak
PURPOSE: To describe the clinical manifestations and treatment outcomes of ocular syphilis in patients without human immunodeficiency virus (HIV) infection. METHODS: A total of 45 eyes from 39 patients with ocular syphilis confirmed by serologic tests were reviewed retrospectively. The included cases were all non-HIV-infected patients presenting with intraocular inflammation from 2002 to 2014 at Kyung Hee University Hospital. Medical records of 45 eyes were analyzed and included best-corrected visual acuity and ophthalmologic examination findings of the anterior and posterior segments to determine the focus of inflammation...
October 2016: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/27726522/the-spectrum-of-uveitis-in-southern-vietnam
#15
Myhanh Nguyen, Jay Siak, Soon-Phaik Chee, Vo Quang Hong Diem
PURPOSE: To describe the pattern of uveitis among Vietnamese at two eye hospitals in Southern Vietnam. METHODS: We retrospectively reviewed the charts of 212 consecutive uveitis cases that presented to two eye hospitals in Ho Chi Minh City, Vietnam, from July 2011 to February 2015. The patients were identified from a database maintained by the hospitals. Patients with keratitis, episcleritis, orbital inflammation, post-surgical endophthalmitis, traumatic iritis, and corneal graft rejection were excluded...
October 11, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27692526/intravitreal-sirolimus-for-noninfectious-uveitis-a-phase-iii-sirolimus-study-assessing-double-masked-uveitis-treatment-sakura
#16
Quan Dong Nguyen, Pauline T Merrill, W Lloyd Clark, Alay S Banker, Christine Fardeau, Pablo Franco, Phuc LeHoang, Shigeaki Ohno, Sivakumar R Rathinam, Stephan Thurau, Abu Abraham, Laura Wilson, Yang Yang, Naveed Shams
PURPOSE: To evaluate the efficacy and safety of intravitreal sirolimus in the treatment of noninfectious uveitis (NIU) of the posterior segment (i.e., posterior, intermediate, or panuveitis). DESIGN: Phase III, randomized, double-masked, active-controlled, 6-month study with intravitreal sirolimus. PARTICIPANTS: Adults with active NIU of the posterior segment (intermediate, posterior, or panuveitis), defined as a vitreous haze (VH) score >1+...
November 2016: Ophthalmology
https://www.readbyqxmd.com/read/27690673/systemic-inflammatory-immune-signatures-in-a-patient-with-crb1-linked-retinal-dystrophy
#17
Fleurieke Verhagen, Jonas Kuiper, Stefan Nierkens, S M Imhof, Timothy Radstake, Joke de Boer
OBJECTIVE: In this report we describe, for the first time, the activation of the peripheral immune compartment in a patient with a CRB1 linked retinal degenerative disease, masquerading as intermediate uveitis. METHODS: To monitor the immune system during systemic immunosuppressive treatment, given for the initial diagnosis of intermediate uveitis, blood samples were taken before and during therapy, for analysis of peripheral blood mononuclear cell-subsets and circulating immune mediators...
October 3, 2016: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/27687961/assessment-of-vitreous-haze-using-ultra-wide-field-retinal-imaging
#18
Drew Dickson, Aniruddha Agarwal, Mohammad Ali Sadiq, Muhammad Hassan, Robin High, Quan Dong Nguyen, Yasir J Sepah
BACKGROUND: Conventional fundus imaging has been used to assess vitreous haze (VH) in patients with uveitis. Ultra-wide field (UWF) retinal imaging that uses scanning laser technology has not been evaluated for the detection of VH. This pilot study evaluates the ability of UWF imaging in detecting VH. Patients with intermediate, posterior, or panuveitis were examined to assess the level of VH using slit-lamp biomicroscopy. Colored fundus images were acquired using a Carl Zeiss FF450 camera...
December 2016: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/27682154/analysis-of-the-impact-of-allergy-and-atopy-on-new-onset-of-uveitis
#19
Rafael S Grajewski, Niusha Barahmand Pour, Katja Burian, Albert Caramoy, Bernd Kirchhof, Claus Cursiefen, Ludwig M Heindl
PURPOSE: The inappropriate immune response to harmless foreign and self-antigens is a common feature of allergy, atopy and autoimmune disease. The influence of environmental factors in the initiation of autoimmunity is not well understood. It is conceivable that immune responses to allergens may also serve as a trigger of bystander immune reactions, including autoimmunity such as uveitis. Therefore, we wanted to investigate the prevalence of allergies and atopy in patients with different types of uveitis in comparison to a control cohort...
September 29, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27681002/infliximab-therapy-in-patients-with-noninfectious-intermediate-uveitis-resistant-to-conventional-immunomodulatory-therapy
#20
Arash Maleki, Haitham F Sahawneh, Lina Ma, Halea Meese, Yuchen He, C Stephen Foster
PURPOSE: To examine the efficacy and safety of infliximab therapy in the treatment for noninfectious intermediate uveitis resistant to conventional immunomodulatory therapy. METHODS: Forty-four eyes of 23 patients with resistant noninfectious intermediate uveitis who were treated with infliximab infusions for a minimum period of 3 months were included. Demographic data, clinical data, and fluorescein angiography and optical coherence tomography findings were collected from the Massachusetts Eye Research and Surgery Institution database between August 2005 and February 2014...
September 27, 2016: Retina
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