Xingran Li, Guoqing Wang, Xiaotang Wang, Wanqian Li, Na Li, Xianyang Liu, Wei Fan, Siyuan He, Yue Han, Guannan Su, Qingfeng Cao, Peizeng Yang, Shengping Hou
Vogt-Koyanagi-Harada (VKH) disease is a severe autoimmune disease. Herein, whole-exome sequencing (WES) study are performed on 2,573 controls and 229 VKH patients with follow-up next-generation sequencing (NGS) in a collection of 2,380 controls and 2,278 VKH patients. A rare c.188T>C (p Val63Ala) variant in the olfactory receptor 11H1 (OR11H1) gene is found to be significantly associated with VKH disease (rs71235604, Pcombined = 7.83 × 10-30 , odds ratio = 3.12). Functional study showes that OR11H1-A63 significantly increased inflammatory factors production and exacerbated barrier function damage...
January 2, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)