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Vogt Koyanagi Harada

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https://www.readbyqxmd.com/read/29220112/multispectral-image-analysis-in-vogt-koyanagi-harada-disease
#1
Guo Huang, Junchao Peng, Zi Ye, Aize Kijlstra, Donglei Zhang, Peizeng Yang
PURPOSE: To investigate fundus abnormalities in Vogt-Koyanagi-Harada (VKH) disease by a noninvasive tool, multispectral imaging (MSI). METHODS: A total of 77 patients with VKH and 163 healthy controls were enrolled between January and April 2015. The MSI findings were evaluated in combination with fundus fluorescein angiography (FFA), optical coherent tomography (OCT) and fundus photography (FP). Additionally, we compared extent of exposure of choroidal blood vessels between patients with VKH and healthy controls to evaluate retinal transmission function...
December 8, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29171577/a-case-of-vogt-koyanagi-harada-disease-in-a-16-year-old-girl
#2
Fahimullah Khan, Salman Zahid, Syed Shahmeer Raza, Mustafa Iqbal
Vogt Koyanagi Harada (VKH) is an autoimmune disease with widespread systemic manifestations. It typically presents with bilateral sudden painless loss of vision. It is mainly characterized by serous retinal detachment, iridocyclitis and choroidal swelling. The disease is more common in females and maximus incidence occurs in the age group of 30 to 40 years. We present a case of a 16-year-old girl who presented with sudden bilateral painless loss of vision. Fundus examination and OCT scanning confirmed bilateral serous retinal detachment...
November 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/29148525/differences-in-photoreceptor-recovery-among-patients-and-between-different-parts-of-the-posterior-pole-in-vogt-koyanagi-harada-disease
#3
M Zhou, R P Gu, Z Sun, C H Jiang, Q Chang, G Z Xu
PurposeTo investigate the recovery of photoreceptors following the treatment in Vogt-Koyanagi-Harada (VKH) disease.Patients and methodsThis was a retrospective study. We enrolled 28 patients with VKH (56 eyes). The clinical and optical coherence tomography (OCT) findings were recorded for 12 months after treatment. The patterns of photoreceptor recovery on OCT were defined: pattern F group=Foveal photoreceptor recovery visible first; pattern E group=Extrafoveal photoreceptor recovery visible first; and pattern S group=Simultaneous foveal and extrafoveal photoreceptor recovery...
November 17, 2017: Eye
https://www.readbyqxmd.com/read/29138505/increased-complement-3a-receptor-is-associated-with-behcet-s-disease-and-vogt-koyanagi-harada-disease
#4
Chaokui Wang, Shuang Cao, Dike Zhang, Hong Li, Aize Kijlstra, Peizeng Yang
Behcet's disease (BD) and Vogt-Koyanagi-Harada disease (VKH) are systemic and recurrent autoimmune diseases associated with abnormal T cell immune response. Complement 3a receptor (C3aR) and complement 5a receptor (C5aR) have been reported to be involved in T cell mediated autoimmune disease. This study aimed to investigate the role of C3aR and C5aR in these two diseases. The C3aR expression in PBMCs was increased in patients with active BD (aBD) and active VKH (aVKH). No statistical difference was found concerning the expression of C5aR in PBMCs between patients with aBD or aVKH and normal controls...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29121363/treatment-of-ipilimumab-induced-vogt-koyanagi-harada-syndrome-with-oral-dexamethasone
#5
Matthew T Witmer
The author presents a retrospective case report of a 54-year-old male with ipilimumab (Yervoy; Bristol-Myers Squibb, New York City, NY)-induced Vogt-Koyanagi-Harada Disease (VKH), which consisted of uveitis, optic neuritis, and choroiditis that was successfully treated with oral dexamethasone. The patient demonstrated resolution of uveitis, optic neuritis, and choroiditis 1 month following initiation of oral dexamethasone. Ipilimumab is a recently approved therapy for malignant melanoma. Reports have identified that VKH disease is a potential side effect of the medication...
November 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29111815/novel-treatment-regimen-of-vogt-koyanagi-harada-disease-with-a-reduced-dose-of-corticosteroids-combined-with-immunosuppressive-agents
#6
Peizeng Yang, Zi Ye, Liping Du, Qingyun Zhou, Jian Qi, Liang Liang, Lili Wu, Chaokui Wang, Aize Kijlstra
PURPOSE: To investigate the effectiveness, visual outcome, and prognostic factors of Vogt-Koyanagi-Harada (VKH) disease treatment with a reduced dose of corticosteroids combined with immunosuppressive agents. METHODS: The clinical characteristics, auxiliary examinations, treatment result, visual outcome, and prognostic factors in VKH patients were analyzed. RESULTS: A total of 998 VKH patients were divided into posterior uveitis group (Group1), anterior uveal involvement group (Group 2), and recurrent granulomatous anterior uveitis group (Group 3)...
November 7, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29083984/review-of-epidemiology-of-uveitis-in-asia-pattern-of-uveitis-in-a-tertiary-hospital-in-the-philippines
#7
Jessica Marie Abaño, Pia Regina Galvante, Paul Siopongco, Kunny Dans, Juan Lopez
PURPOSE: To describe the pattern of uveitis in patients seen at the uveitis clinic of the East Avenue Medical Center, Philippines. METHODS: Clinical records of patients seen from January 2010 to June 2015 were reviewed. Data collected included demographics, clinical presentation, associated systemic disease, work-up, and diagnosis. RESULTS: A total of 595 records were reviewed. The mean age at presentation was 38 ± 18.4 years. The majority of the cases were unilateral and chronic...
2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29080887/evaluation-of-vestibular-functions-in-patients-with-vogt-koyanagi-harada-disease
#8
Keishi Fujiwara, Shinya Morita, Kimiko Hoshino, Atsushi Fukuda, Yuji Nakamaru, Akihiro Homma
Vogt-Koyanagi-Harada (VKH) disease is an idiopathic, multisystem autoimmune disorder characterized by bilateral, diffuse granulomatous uveitis associated with neurological, audiovestibular, and dermatological manifestations. The purpose of this study is to investigate vestibular functions in patients with VKH disease. A total of 43 patients with VKH disease in Hokkaido University Hospital were enrolled in this study. Subjective symptoms such as dizziness or vertigo and the results of various vestibular examinations including nystagmus testing, caloric testing, and vestibular-evoked myogenic potential (VEMP) testing were investigated...
2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/29050185/-optical-coherence-tomography-angiography-of-acute-vogt-koyanagi-harada-disease
#9
S S Jia, C Zhao, D Gong, Z Chen, M F Zhang
Objective: To measure vascular density in retinal and choroidal capillary layers by optical coherence tomography angiography (OCTA) and to explore their potential clinical values in Vogt-Koyanagi-Harada disease (VKH). Methods: This is a cross-sectional case-control study. Twenty-one acute VKH cases presented to Peking Union Medical College Hospital between April 2015 and July 2015 and 49 healthy controls were enrolled in this study. OCTA was performed with a split-spectrum amplitude-decorrelation angiography-optical coherence tomography (SSADA-OCT) system borrowed from Optovue Inc...
October 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29023176/induction-of-vogt-koyanagi-harada-disease-by-interferon-alpha-and-ribavirin-treatment-in-patients-with-hepatitis-c-a-case-report-and-review-of-the-literature
#10
Jialiang Duan, Yang Wang, Danyan Liu, Jingxue Ma
PURPOSE: To describe a case of Vogt-Koyanagi-Harada disease (VKH) presenting in a hepatitis C patient after interferon-alpha (IFN-α) and ribavirin treatment. METHODS: A retrospective review of our patient and a review of the published literature. RESULTS: A 59 year-old man developed VKH after the four months of IFN-α and ribavirin therapy for hepatitis C. The patient's VKH was controlled by systemic corticosteroids. The relationship between VKH and IFN-α is discussed based on the published literature...
October 12, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29020488/unilateral-ocular-manifestations-of-vogt-koyanagi-harada-disease
#11
Edmund Tsui, Alexander Bottini, Quraish Ghadiali, Chandrakumar Balaratnasingam, Irene Barbazetto
PURPOSE: To describe a case of unilateral Vogt-Koyanagi-Harada (VKH) disease and associated multimodal imaging. METHODS: Retrospective case report. RESULTS: A 50-year-old Hispanic male presented with three days of painless decreased vision in his left eye, headache, and decreased hearing. His visual acuity was 20/20 in the right eye and counting fingers in the left eye. Examination of his right eye was unremarkable. Funduscopic examination of his left eye revealed multiple serous retinal detachments...
October 11, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28984712/acute-angle-closure-secondary-to-tubercular-choroidal-granuloma
#12
Sushmita Kaushik, Ramandeep Singh, Atul Arora, Gunjan Joshi, Kusum Sharma, Basavraj Tigari
Acute angle closure is usually thought to be secondary to pupillary block which is relieved by laser iridotomy. Anterior rotation of the ciliary body at the scleral spur following development of an inflammatory cilio-choroidal detachment may result in a presentation of acute angle closure. It is imperative to recognize this condition correctly, because the management is with cycloplegics and anti-inflammatory drugs, which is diametrically opposite to the treatment of primary angle closure. More importantly, it has been reported as a consequence of serious systemic disease such as HIV infection and Vogt Koyanagi Harada(VKH) syndrome...
September 3, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28983414/anti-tnf%C3%AE-therapy-and-switching-in-severe-uveitis-related-to-vogt-koyanagi-harada-syndrome
#13
Bryan Josue Flores Robles, Juan Blanco-Madrigal, Abel Alejandro Sanabria Sanchinel, Dixie Huntley Pascual, Rosario Demetrio-Pablo, Ricardo Blanco
The study aimed to describe the effectiveness of switching the anti-TNFα agent when an acceptable clinical response has not been obtained with the first anti-TNFα agent in patients with uveitis in VKH syndrome. Patients diagnosed with VKH syndrome being evaluated from the uveitis unit of a single tertiary hospital from January 1, 2000, to October 30, 2015. Patients who presented uveitis with an inadequate response to a first anti-TNFα and required switching to a second anti-TNFα were selected. Complete clinical response was assumed in patients whose visual acuity was normal and those who showed absence of inflammatory findings (inflammatory cells in the anterior chamber and vitritis) or absence of macular thickening in upon OCT...
September 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28979622/-vitiligo-revealing-vogt-koyanagi-harada-disease
#14
Mohamed El Amraoui, Youssef Zemmez, Ahmed Bouhamidi, Rachid Frikh, Naoufal Hjira, Mohammed Boui
Vitiligo is a chronic auto-immune skin disease, often associated or discovers other autoimmune pathologies. His association with Ophthalmological type pan uveitis and/or neurological type of meningitis and/or inner ear type of hearing loss determines the disease or Vogt -Koyanagi-Harada syndrome (VKH). We related the case of a young woman who consulted for recurrent uveitis for a year, and it was only with the onset of vitiligo lesions that VKH disease diagnosis was discussed and confirmed.
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28972425/lord-nelson-s-1758-1805-left-eye
#15
William Pryse-Phillips
Following the loss of his right eye at Calvi in 1794, Lord Nelson suffered increasing left-sided visual loss, here considered most likely to have been due to the ocular inflammatory condition 'sympathetic ophthalmia'. It is also argued that his succeeding episodes of violent headaches with nausea and prostration, and possible depigmentation of hair, reflected the development of an uveomeningoencephalitic syndrome akin to that of Vogt-Koyanagi-Harada disease, which is best regarded as the same condition with a different aetiology...
January 1, 2017: Journal of Medical Biography
https://www.readbyqxmd.com/read/28972028/microrna-20a-5p-suppresses-il-17-production-by-targeting-osm-and-ccl1-in-patients-with-vogt-koyanagi-harada-disease
#16
Rui Chang, Shenglan Yi, Xiao Tan, Yang Huang, Qingfeng Wang, Guannan Su, Chunjiang Zhou, Qingfeng Cao, Gangxiang Yuan, Aize Kijlstra, Peizeng Yang
AIM: To elucidate the role of microRNA-20a-5p (miR-20a-5p) in the pathogenesis of Vogt-Koyanagi-Harada (VKH) disease. METHODS: Quantitative real-time PCR was used to quantify miR-20a-5p expression in CD4(+) T cells from patients with active VKH and normal controls. The promoter methylation status of miR-20a-5p was detected by bisulfite sequencing PCR. Targets were evaluated by a luciferase reporter assay. The functional effects of miR-20a-5p on CD4(+) T cells from patients with active VKH were assessed by upregulation or downregulation of its expression using liposomes...
September 28, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28914578/the-choroidal-vascularity-index-decreases-and-choroidal-thickness-increases-in-vogt-koyanagi-harada-disease-patients-during-a-recurrent-anterior-uveitis-attack
#17
Shulin Liu, Liping Du, Qingyun Zhou, Qi Zhang, Ke Hu, Jian Qi, Liang Liang, Chunjiang Zhou, Aize Kijlstra, Peizeng Yang
PURPOSE: To measure changes in the choroidal vascularity index (CVI) in chronic Vogt-Koyanagi-Harada (VKH) disease during a recurrent anterior uveitis attack. METHODS: Forty VKH patients and 40 normal controls were included in this study. Choroidal images were recorded before and during a recurrent anterior uveitis attack, as well as after appropriate treatment. CVI was measured by the binarization technique using ImageJ software (Bethesda, MD). RESULTS: The CVI was 0...
September 15, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28910557/vogt-koyanagi-harada-syndrome-in-a-group-of-patients-in-two-ophthalmology-referral-centers-in-bogot%C3%A3-colombia
#18
Carol L Guayacán, Brahyan Galindo-Mendez, Alejandra de-la-Torre
PURPOSE: To describe the clinical presentation of Vogt-Koyanagi-Harada (VKH) syndrome in a group of patients in Colombia. METHODS: Retrospective review of 2638 medical records of patients with uveitis in two centers during 17 years. RESULTS: A total of 25 patients with uveitis were diagnosed with VKH syndrome (0.95%), 23 patients were included in the data analysis (0.87%), 78.3% females, and mean age of diagnosis was 37 years (SD ± 29)...
September 14, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28905833/unusual-case-of-vitiligo-reversal-in-vogt-koyanagi-harada-syndrome
#19
Praveen Subudhi, Zahiruddin Khan, B Nageswar Rao Subudhi, Silla Sitaram
No abstract text is available yet for this article.
September 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28868031/optical-coherence-tomography-angiography-employing-a-novel-technique-for-investigation-in-vogt-koyanagi-harada-disease
#20
Panagiotis Giannakouras, Konstantinos Andreanos, Barbara Giavi, Andreas Diagourtas
PURPOSE: To report a case of Vogt-Koyanagi-Harada (VKH) disease and describe the imaging findings by means of optical coherence tomography angiography (OCTA). METHODS: Medical and ophthalmological history, ophthalmological examination, laboratory evaluation, B-scan ultrasonography, fluorescein and indocyanine angiography, and optical coherence tomography (OCT) were performed at baseline, as well as OCTA. RESULTS: A 50-year-old healthy female presented with decreased vision in both eyes...
May 2017: Case Reports in Ophthalmology
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