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Vogt Koyanagi Harada

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https://www.readbyqxmd.com/read/29666121/clinical-features-and-visual-outcomes-of-111-patients-with-new-onset-acute-vogt-koyanagi-harada-disease-treated-with-pulse-intravenous-corticosteroids
#1
Makiko Nakayama, Hiroshi Keino, Takayo Watanabe, Annabelle A Okada
PURPOSE: To describe the clinical features, treatment and visual outcomes of Japanese patients with new-onset acute Vogt-Koyanagi-Harada (VKH) disease. METHODS: Clinical records of 111 patients who presented between 1999 and 2015 to the Ocular Inflammation Service of the Kyorin Eye Center, Tokyo, were reviewed. RESULTS: Of the 111 patients (68 women, 43 men), 16 had complete, 90 had incomplete and 5 had probable VKH disease. The median follow-up period was 36 months (4-175 months)...
April 17, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29615180/a-case-of-vogt-koyanagi-harada-syndrome-mimicking-optic-neuritis
#2
Muhammad Mateen Amir, Atif Masood, Zarmina Khan
Vogt-Koyanagi-Harada syndrome is a rare disease that occurs commonly in pigmented individuals of Asian origin. A 25-year female presented in medical outpatient department (OPD) of Al-Khidmat Teaching Hospital, Mansoora, Lahore with headache and neck stiffness. She was referred to eye OPD for the complaint of decreased vision. On examination, there was 6/24 vision, sluggish pupillary reaction and disc hyperemia in both eyes. She was treated as a case of optic neuritis. Few days later, she developed bilateral panuveitis, shallow exudative detachments and alopecia...
April 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29600191/late-onset-acute-vogt-koyanagi-harada-syndrome-challenges-on-the-way
#3
Sandra Rodrigues-Barros, Jacqueline Martins Sousa, Bruno Carvalho, Gabriel Andrade, Heloísa Nascimento
No abstract text is available yet for this article.
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29519769/rare-association-between-vogt-koyanagi-harada-disease-and-rheumatoid-arthritis-report-of-a-clinical-case-from-the-unit-of-multidisciplinary-uveitis
#4
Juan Alberto Paz-Solarte, Marisa Hernández-Garfella, Amalia Rueda-Cid, Cristina Campos-Fernández, Javier Calvo-Catala
No abstract text is available yet for this article.
March 5, 2018: Reumatología Clinica
https://www.readbyqxmd.com/read/29513616/retinal-pigment-epithelium-detachment-in-acute-vogt-koyanagi-harada-disease-an-unusual-finding-at-presentation
#5
Sana Khochtali, Imen Ksiaa, Kenza Megzari, Moncef Khairallah
PURPOSE: To report the cases of two patients who presented with acute Vogt-Koyanagi-Harada (VKH) disease and associated retinal pigment epithelium detachment (PED). METHODS: 2 case reports. Case 1: A 22-year-old male patient complained of acute bilateral decrease in vision. Initial best corrected visual acuity (BCVA) was 20/63, OU. There was 1+ vitreous cells, OU, exudative retinal detachment (ERD) in the right eye (RE), and a macular deep yellow lesion suggestive of PED in the left eye (LE)...
March 7, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29498905/decreased-interleukin-il-35-expression-is-associated-with-active-intraocular-inflammation-in-vogt-koyanagi-harada-vkh-disease
#6
Jianping Hu, Yirong Qin, Shenglan Yi, Chaokui Wang, Jinglu Yang, Lu Yang, Luoziyi Wang, Aize Kijlstra, Peizeng Yang, Hong Li
PURPOSE: Recent studies have reported that IL-35 has a protective effect in autoimmune disease. In this study, we explored the role of IL-35 in the pathogenesis of Vogt-Koyanagi-Harada (VKH) disease. METHODS: The IL-35/EBI3 and IL-35/P35 mRNA level was assayed by Real-Time PCR. The level of IL-35 in serum was detected by ELISA. PBMCs and monocyte-derived DCs were cultured with or without IL-35 and the concentration of IL-17, IL-10, IFN-γ, IL-6, TNF-α, and IL-1β in supernatants was tested by ELISA...
March 2, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29490353/association-of-long-noncoding-rnas-polymorphisms-with-ankylosing-spondylitis-vogt-koyanagi-harada-disease-and-behcet-s-disease
#7
Yingying Yue, Jun Zhang, Lu Yang, Shengyun Liu, Jian Qi, Qingfeng Cao, Chunjiang Zhou, Yao Wang, Aize Kijlstra, Peizeng Yang, Shengping Hou
Purpose: Long noncoding RNAs (lncRNAs) are emerging as important regulators of inflammatory immune responses, whereby genetic variants may affect this biologic function. This study aimed to investigate the association of 110 single nucleotide polymorphisms (SNPs) of lncRNAs, known to be associated with autoimmune disease, in patients with ocular Vogt-Koyanagi-Harada (VKH) disease, Behcet's disease (BD), and acute anterior uveitis (AAU) with or without ankylosing spondylitis (AS). Methods: A two-stage case-control study was performed on 1626 VKH patients, 384 BD patients, 624 AAU with AS, 751 AAU without AS, 720 AS without AAU, and 3305 healthy subjects...
February 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29489658/positron-emission-tomography-computed-tomography-scan-of-vogt-koyanagi-harada-syndrome-with-associated-autoimmune-thyroid-disease-a-case-report-and-literature-review
#8
Ke-Hao Huang, Ming-Cheng Tai, Lung-Chi Lee, Tzu-Heng Weng, Yi-Hao Chen, Li-Fan Lin, Jiann-Torng Chen, Da-Wen Lu, Ching-Long Chen
RATIONALE: Vogt-Koyanagi-Harada (VKH) syndrome is a rare disease and could be associated with autoimmune thyroid disease (AITD). This report was aimed to investigate the utility of F-fludeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) for the diagnosis of VKH syndrome with AITD and to perform a literature review on the association between the 2 diseases. PATIENT CONCERNS: A 55-year-old woman without the history of ocular trauma suffered from chronic headache...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29488243/hla-drb1-04-05-in-two-cases-of-vogt-koyanagi-harada-disease-like-uveitis-developing-from-an-advanced-melanoma-patient-treated-by-sequential-administration-of-nivolumab-and-dabrafenib-trametinib-therapy
#9
Taku Fujimura, Yumi Kambayashi, Kayo Tanita, Yota Sato, Takanori Hidaka, Astushi Otsuka, Hidenori Tanaka, Sadanori Furudate, Akira Hashimoto, Setsuya Aiba
Although uveitis is reported as a rare adverse event (AE) associated with dabrafenib/trametinib therapy or nivolumab, the occurrence of severe uveitis is extremely rare. We describe two cases of Vogt-Koyanagi-Harada (VKH)-like uveitis developing after the sequential administration of nivolumab and dabrafenib/trametinib therapy. Interestingly, both cases had HLA-DRB1*04:05, which is strongly associated with VKH disease, and achieved biologically complete remission after the treatment for uveitis. Our cases suggest a possible correlation between VKH-like uveitis as an AE and the clinical outcomes of sequential administration of nivolumab and dabrafenib/trametinib therapy for the treatment of advanced melanoma...
February 27, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29476208/mr-findings-of-the-orbit-in-patients-with-vogt-koyanagi-harada-disease
#10
Tomohiro Ando, Hiroki Kato, Kiyofumi Mochizuki, Kenji Ozawa, Satoshi Goshima, Masayuki Matsuo
PURPOSE: We aimed to evaluate the MR findings of the orbit in patients with Vogt-Koyanagi-Harada disease (VKHD). METHODS: We included 14 patients with clinically diagnosed VKHD, who underwent orbital MR imaging before treatment between May 2011 and August 2017. The mean duration from initial symptom onset to MR imaging was 16 days (range, 2-36 days). Fat-suppressed gadolinium-enhanced T1-weighted images were obtained in six patients. We retrospectively assessed the choroids and Tenon's capsules for the presence of thickening on unenhanced images and abnormal enhancement on contrast-enhanced images...
April 2018: Neuroradiology
https://www.readbyqxmd.com/read/29468405/efficacy-and-safety-of-ripasudil-a-rho-associated-kinase-inhibitor-in-eyes-with-uveitic-glaucoma
#11
Sentaro Kusuhara, Atsuko Katsuyama, Wataru Matsumiya, Makoto Nakamura
PURPOSE: The purpose of this study was to describe the initial experience, efficacy, and safety of ripasudil hydrochloride hydrate (ripasudil), a Rho-associated kinase inhibitor eye drop, for uveitic glaucoma. METHODS: In this retrospective case series, we retrieved the clinical data of 21 eyes from 19 patients with open-angle uveitic glaucoma who were treated with ripasudil at Kobe University Hospital. We analyzed the median intraocular pressure (IOP) reductions after ripasudil treatment and collected the information on the adverse events that were encountered during the course of this treatment period...
February 21, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29467803/vogt-koyanagi-harada-disease-presenting-as-unilateral-neuroretinits
#12
Francesco Pellegrini, Emanuela Interlandi, Giovanni Prosdocimo
A 42-year-old female presented with unilateral visual loss associated with systemic symptoms of fever and headache. Although initial ophthalmic examination revealed a unilateral neuroretinitis, investigation for infectious and non-infectious causes of neuroretinitis were negative. At our examination, retinal imaging (suggestive of bilateral involvement) along with the results of lumbar puncture (pleocytosis) and clinical findings was consistent with a diagnosis of Vogt-Koyanagi-Harada disease. The patient was treated with intravenous steroids with prompt resolution of her symptoms...
February 2018: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29443768/association-of-human-leukocyte-antigen-hla-dq-and-hla-dqa1-dqb1-alleles-with-vogt-koyanagi-harada-disease-a-systematic-review-and-meta-analysis
#13
Bing Liu, Tuo Deng, Linxin Zhu, Jingxiang Zhong
OBJECTIVE: The aim of this study was to evaluate the association of human leukocyte antigen (HLA)-DQ and HLA-DQA1/DQB1 alleles with Vogt-Koyanagi-Harada (VKH), providing further evidences on the genetic background of this disease. METHODS: A comprehensive literature search was conducted on the relationship of HLA-DQ and/or HLA-DQA1/DQB1 alleles with VKH through PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, VIP, and databases for grey literature...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29397539/acquired-myopia-in-vogt-koyanagi-harada-disease
#14
Hiroyuki Takahashi, Hiroshi Takase, Yukiko Terada, Manabu Mochizuki, Kyoko Ohno-Matsui
PURPOSE: To analyze the change in refractive error and the axial length of chronic Vogt-Koyanagi-Harada (VKH) disease. METHODS: Medical records of 106 eyes of 54 adult VKH patients were analyzed. The refractive error and the axial length were compared between the baseline (defined as the time point at least 2 weeks after acute stage of VKH) and the final visit. The rate of the eyes with significant myopia progression [defined as refraction change toward myopia > 1 diopter (D)] was examined...
February 3, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29396390/diagnostic-function-of-3d-optical-coherence-tomography-images-in-diagnosis-of-vogt-koyanagi-harada-disease-at-acute-uveitis-stage
#15
Gui-Ling Zhao, Rui-Zhuang Li, Yan-Hua Pang, Xiu-Qin Wang, Hong-Juan Peng, Jin-Fen Wei, Zhou Zhou
BACKGROUND This study analyzed the macular 3D-OCT images of Vogt-Koyanagi-Harada disease (VKH) in uveitis, explored the characteristics of 3D-OCT images of the macular region of VKH, and assessed which characteristics contribute most to VKH diagnosis. MATERIAL AND METHODS The 3D-OCT examination of 25 cases of VKH was performed on the macular area, and the image characteristics were analyzed. RESULTS Our study included a total of 50 eyes from 25 cases of VKH patients, 10 males and 15 females, aged 17 to 64 years, mean (39...
February 3, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29339644/changes-in-central-macular-thickness-and-retinal-nerve-fiber-layer-thickness-in-eyes-with-vogt-koyanagi-harada-disease-a-2-year-follow-up-study
#16
Yong-Seop Han, Kyung-Sup Shin, Woo-Hyuk Lee, Jung-Yeul Kim
PURPOSE: To investigate the central macular thickness (CMT) and retinal nerve fiber layer (RNFL) thickness in eyes with Vogt-Koyanagi-Harada (VKH) disease associated with optic disc swelling and serous retinal detachment through a 24-month follow-up period. METHODS: We prospectively investigated 28 eyes of 14 treatment-naïve patients with acute VKH disease associated with optic disc swelling and serous retinal detachment and 30 eyes of 15 normal individuals to compare changes in the CMT and average RNFL thickness...
2018: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/29334924/longitudinal-observation-of-subretinal-fibrosis-in-vogt-koyanagi-harada-disease
#17
Chan Zhao, Fangtian Dong, Fei Gao, Xinshu Liu, Minghang Pei, Shanshan Jia, Meifen Zhang
BACKGROUND: Subretinal fibrosis (SRF) is a vision-threatening complication of Vogt-Koyanagi-Harada disease (VKH). It has long been recognized as a sequela of chronic inflammation. The developmental process of SRF, however, has not been described. The purpose of this study is to provide longitudinal observations of SRF in VKH. METHODS: Retrospective chart review of 10 VKH patients referred to our group between January 2008 and September 2015 at acute uveitic stage with SRF at presentation or who developed SRF during follow up...
January 15, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29321438/vogt-koyanagi-harada-disease-associated-with-influenza-a-virus-infection-a-case-report
#18
Nozomu Yoshino, Ai Kawamura, Akira Ishii, Katsuyuki Yoshida, Tamami Watanabe, Takeshi Yamashita, Takahiko Fukuchi, Fumihiko Toyoda, Akihiko Kakehashi, Hitoshi Sugawara
We herein report a case of a 31-year-old Japanese man who simultaneously had a positive influenza A virus antigen test result and Vogt-Koyanagi-Harada disease (VKHD), demonstrated by both diffuse multiple early hyperfluorescent points on fluorescein fundus photography and serous retinal detachments on optical coherence tomography. He had meningitis. It was difficult to determine whether the main cause of meningitis was influenza A or VKHD. After initial treatment with peramivir for influenza A and then methylprednisolone pulse with subsequent corticosteroid therapy for VKHD, his symptoms improved gradually...
January 11, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29285231/associations-between-tnfsf4-tnfsf8-and-tnfsf15-and-beh%C3%A3-et-s-disease-but-not-vkh-syndrome-in-han-chinese
#19
Yan Jiang, Ling Cheng, Xin Li, Wenke Zhou, Li Zhang
The present study was designed to explore the interrelationship between single nucleotide polymorphisms (SNP) of the tumor necrosis factor superfamily (TNFSF) and its respective receptor superfamily (TNFRSF) genes and Behcet's disease (BD) and Vogt-Koyanagi-Harada syndrome (VKH) in Han Chinese. The study sample included 796 patients with BD, 792 patients with VKH syndrome, and 1604 healthy controls. The genotyping of 35 SNPs was performed by MassARRAY platform (Sequenom), iPLEX Gold Assay, PCR-restriction fragment length polymorphism assay and TaqMan SNP assay...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29258782/corticotherapy-vs-corticotherapy-plus-immunosuppressive-therapy-in-acute-vogt-koyanagi-harada-disease
#20
L E Concha-Del Río, L Gómez, L Arellanes-García
INTRODUCTION: Vogt-Koyanagi-Harada disease is a multisystem disorder characterized by a bilateral granulomatous panuveitis. Multiple therapeutic regimens have been used to control inflammation in acute uveitic stage to prevent irreversible visual loss. The purpose of this paper is to compare the effect, on functional and anatomic outcomes, of early treatment with standard corticotherapy vs. corticotherapy plus immunosuppressive (IMT) therapy in acute Vogt-Koyanagi-Harada disease (Group A vs Group B)...
December 16, 2017: Archivos de la Sociedad Española de Oftalmología
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