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Punctate Inner Choroidopathy

Ali Tavallali, Lawrence A Yannuzzi
Idiopathic multifocal choroiditis (MFC) and/or punctate inner choroidopathy (PIC) describe a chronic progressive bilateral inflammatory chorioretinopathy that predominantly affect healthy myopic white women with no known associated systemic or ocular diseases. The principal sites of involvement are the retinal pigment epithelium (RPE) and outer retinal spaces; the choroid is not affected during the active phase of the disease. Idiopathic MFC with atrophy is a recently described variant. Although there is no generally accepted standard treatment, anti-inflammatory and anti-VEGF (vascular endothelial growth factor) agents are necessary in the acute stage to control the inflammation and choroidal neovascularization (CNV)...
October 2016: Journal of Ophthalmic & Vision Research
Shintaro Nakao, Yoshihiro Kaizu, Yuji Oshima, Taiji Sakamoto, Tatsuro Ishibashi, Koh-Hei Sonoda
Punctate inner choroidopathy (PIC) is a relatively uncommon inflammatory multifocal chorioretinopathy that predominantly affects young, myopic women. Subfoveal choroidal neovascularization (CNV) often leads to rapid loss of sight. Fluorescein angiography (FA) and indocyanine green angiography (ICGA) remain the existing gold standards for CNV diagnosis. However, these methods are invasive and time-consuming. Recently, optical coherence tomography angiography (OCTA) has been used more frequently as an adjunct to FA/ICGA...
December 1, 2016: Ophthalmic Surgery, Lasers & Imaging Retina
Dana Ahnood, Savitha Madhusudhan, Marie D Tsaloumas, Nadia K Waheed, Pearse A Keane, Alastair K Denniston
Punctate Inner Choroidopathy (PIC), an idiopathic inflammatory multifocal chorioretinopathy that predominantly affects young myopic women, appears to be relatively rare, but there is limited data to support accurate estimates of prevalence, and it is likely that the condition is under-diagnosed. The etiological relationship between PIC and other conditions within the 'white dot syndromes' group remains uncertain. We, like others, would suggest that PIC and multifocal choroiditis with panuveitis (MCP) represent a single disease process that is modified by host factors (including host immunoregulation) to cause the range of clinical phenotypes seen...
October 14, 2016: Survey of Ophthalmology
Barbara Terelak-Borys, Katarzyna Zagajewska, Irmina Jankowska-Lech, Piotr Tesla, Iwona Grabska-Liberek
PURPOSE: The purpose of this study was to describe a combination treatment for choroidal neovascular (CNV) membrane, secondary to punctate inner choroidopathy (PIC). PATIENT AND METHODS: A 44-year-old female patient was diagnosed with PIC complicated by the development of recurrent juxtafoveal neovascular membrane. The treatment included a sequence of monotherapy regimens: systemic steroid therapy, photodynamic therapy, and intravitreal injections of vascular endothelial growth factor (VEGF) inhibitor (anti-VEGF)...
2016: Therapeutics and Clinical Risk Management
M Roca, M Menezo, J M Ronchera, J M Esteban, B Roca
CASE REPORT: Punctate inner choroidopathy (PIC) is a variant of multifocal choroiditis that principally affects young and healthy women. A case of this condition is described in a woman who presented with a scotoma as the main complaint. Four months after the diagnosis of PIC, she developed an exudative neurosensory detachment associated with an active focus of juxtafoveal choroiditis. Finally, with systemic corticosteroids and intravitreal ranibizumab, she made excellent progress. DISCUSSION: Intravitreal ranibizumab, associated with systemic corticosteroids, may be an effective treatment for exudative neurosensory detachment complicating PIC...
August 20, 2016: Archivos de la Sociedad Española de Oftalmología
Ashleigh L Levison, Kimberly M Baynes, Careen Y Lowder, Peter K Kaiser, Sunil K Srivastava
PURPOSE: To describe the findings seen on optical coherence tomography angiography (OCTA) in patients with punctate inner choroidopathy (PIC) and multifocal choroiditis and panuveitis (MCP) complicated by choroidal neovascular membranes. METHODS: This was an Institutional Review Board-approved prospective, descriptive case series. 12 patients with PIC and MCP complicated by choroidal neovascularisation (CNV) were included. Each patient underwent slit-lamp examination by a uveitis specialist followed by conventional spectral domain OCT imaging of the macula...
August 18, 2016: British Journal of Ophthalmology
Teresa Barth, Florian Zeman, Horst Helbig, Isabel Oberacher-Velten
PURPOSE: To assess the etiology, clinical features, and outcome of choroidal neovascularization (CNV) in children. METHODS: We retrospectively assessed 10 eyes of 8 patients younger than 18 years diagnosed with CNV. The main clinical parameters included predisposing ocular pathologies, best-corrected visual acuity before and after treatment, characteristics of CNV, and treatment modalities. RESULTS: Two boys and 6 girls with CNV and a mean age of 13...
August 4, 2016: European Journal of Ophthalmology
A Stepanov, J Studnička, L Hejsek, J Dusová, N Jirásková
UNLABELLED: Punctate Inner Choroidopathy (PIC) is a rare idiopathic ocular inflammatory disease. It occurs mostly in young, myopic, otherwise healthy women. Symptoms of the disease include acute vision decrease associated with central and paracentral scotoma. In 80% of cases PIC occur bilaterally. We report the case of a woman at the age of twenty-five, who was treated for PIC. Due to the finding of active inflammatory deposit in the retina of the left eye and low visual acuity was recommended corticosteroid therapy with a good therapeutic effect...
2016: Ceská a Slovenská Oftalmologie
Bettina Hohberger, Michael Rudolph, Antonio Bergua
PURPOSE: Choroidal neovascularization (CNV) associated with punctate inner choroidopathy (PIC) is a rare clinical entity, yet still a challenge for medical treatment. A case of a young myopic woman developing CNV secondary to unilateral PIC is presented. Clinical morphology, diagnostic procedure and follow-up are reported. CASE REPORT: A 29-year-old woman presented with multiple yellowish dots at the posterior pole. No other signs of inflammation could be seen. Angiography with fluorescein yielded hyperfluorescent signals in the affected areas with a diffuse leak, and SD-OCT showed a slightly elevated retinal pigment epithelial layer, consistent with the diagnosis of PIC...
September 2015: Case Reports in Ophthalmology
Michael A Klufas, Thomas OʼHearn, David Sarraf
PURPOSE: To present the optical coherence tomography angiography and widefield fundus autofluorescence (FAF) imaging findings of a 34-year-old woman with punctate inner choroidopathy and Type 2 neovascularization. METHODS: In the retrospective case report, optical coherence tomography angiography imaging was performed with the RTVue XR Avanti (Optovue Inc, Fremont, CA) platform, which uses split spectrum amplitude decorrelation angiography to detect flow. PATIENTS: Single patient with the diagnosis of punctate inner choroidopathy...
2015: Retinal Cases & Brief Reports
Miaoling Li, Xiongze Zhang, Feng Wen
Purpose. To investigate the fundus autofluorescence (FAF) spectrum of punctate inner choroidopathy (PIC). Methods. This is a retrospective observational case series of 27 consecutive patients with PIC admitted from October 2013 to March 2015, who underwent short-wavelength- (SW-) and near-infrared- (NIR-) FAF imaging, spectral domain optical coherence tomography (SD-OCT), fluorescein angiography (FA), and indocyanine green angiography (ICGA). Results. There were three primary findings on the FAF imaging of patients with PIC...
2015: Journal of Ophthalmology
Kunfang Wu, Xiongze Zhang, Yu Su, Yuying Ji, Chengguo Zuo, Meng Li, Feng Wen
PURPOSE: To describe demographic features and clinical and imaging characteristics of inflammatory choroidal neovascularization (CNV) in a Chinese population. METHODS: A retrospective case review of patients with CNV secondary to uveitis from 2002 to 2013. RESULTS: A total of 125 patients (150 eyes, 166 CNVs; bifocal CNVs in 16 eyes), 64% of whom were women, were reviewed. The mean age was 35.86 years. The proportions of patients with punctate inner choroidopathy (PIC), multifocal choroiditis (MFC), and Vogt-Koyanagi-Harada (VKH) were 50...
June 2016: Ocular Immunology and Inflammation
Mariana Sá-Cardoso, Arnaldo Dias-Santos, Natália Nogueira, Heloísa Nascimento, Rubens Belfort-Mattos
Purpose. To report a case of bilateral punctate inner choroidopathy (PIC). Case Report. A 26-year-old Caucasian woman presented with bilateral blurred vision with one year of evolution. There was no relevant systemic disease or family history. Best-corrected visual acuity in the right eye was 20/30 and in the left eye was 20/20; there was no clinically significant refractive error. Fundoscopy evidenced multiple, small, round, yellow-white lesions limited to the posterior pole of both eyes, with greater macular involvement in the RE...
2015: Case Reports in Ophthalmological Medicine
Joana Campos, António Campos, Sílvia Mendes, Arminda Neves, Diana Beselga, Jp Castro Sousa
This article reviews clinically relevant data regarding punctate inner choroidopathy, mainly the various treatment options. Punctate inner choroidopathy is an uncommon, inflammatory, multifocal chorioretinopathy affecting mostly young myopic women. It is characterized by the presence of multiple, small, well-defined, yellow-white fundus lesions, in the absence of intraocular inflammation. We describe etiology, clinical findings and ancillary tests that help in the diagnosis and detection of complications. Treatment options that have been used to manage patients with PIC and CNV include immunosuppressants, corticoids, laser photocoagulation, photodynamic therapy, intravitreal anti-VEGF agents and submacular surgery...
2014: Medical Hypothesis, Discovery and Innovation in Ophthalmology
Hyesun Kim, Se Joon Woo, Yong-Kyu Kim, Sung Chul Lee, Christopher Seungkyu Lee
No abstract text is available yet for this article.
July 2015: Ophthalmology
Radgonde Amer, Ethan Priel, Michal Kramer
PURPOSE: To describe the spectral-domain optical coherence tomographic (SD-OCT) features of inflammatory choroidal neovascular membranes (iCNV) in multifocal choroiditis and punctate inner choroidopathy, and to compare them to those of the acute inflammatory lesions in the same underlying diseases. This is a retrospective, consecutive, observational case series. METHODS: Each patient underwent a comprehensive eye examination, fundus photography, and fluorescein angiography (FA) on the initial visit...
June 2015: Graefe's Archive for Clinical and Experimental Ophthalmology
Yukari Jo, Fumi Gomi, Yasushi Ikuno
PURPOSE: To investigate the pathology of punctate inner choroidopathy (PIC) using spectral-domain optical coherence tomography. METHODS: We retrospectively reviewed spectral-domain optical coherence tomography findings of 14 cases with active PIC. We obtained specific appearance of the active PIC lesion that were characterized by yellowish/white round spots in fundus examination with fluorescein leakage. Fluorescein angiogram and confocal indocyanine green angiogram were also reviewed...
2012: Retinal Cases & Brief Reports
Eduardo C De Souza, Eduardo Raskin, Leonardo Castro, Lilia Muralha, Osias Souza, Rafael Pena
PURPOSE: To document the intraretinal migration of presumed toxocara larvae mimicking punctate inner choroidopathy, idiopathic choroidal neovascularization, and diffuse unilateral subacute neuroretinitis. METHODS: Sequential color photographs, fluorescein angiograms, and optical coherence tomography were performed in three unrelated adult patients with presumed ocular toxocariasis. RESULTS: Characteristic fundoscopic manifestations simulating punctate inner choroidopathy, idiopathic choroidal neovascularization, and diffuse unilateral subacute neuroretinitis were reported in these patients, respectively...
2012: Retinal Cases & Brief Reports
Jyotirmay Biswas, Rajiv Raman, Deepak Bhojwani
No abstract text is available yet for this article.
September 2014: Indian Journal of Ophthalmology
Marion R Munk, Jesse J Jung, Kristin Biggee, William R Tucker, H Nida Sen, Ursula Schmidt-Erfurth, Amani A Fawzi, Lee M Jampol
PURPOSE: To report acute/subacute vision loss and paracentral scotomata in patients with idiopathic multifocal choroiditis/punctate inner choroidopathy due to large zones of acute photoreceptor attenuation surrounding the chorioretinal lesions. METHODS: Multimodal imaging case series. RESULTS: Six women and 2 men were included (mean age, 31.5 ± 5.8 years). Vision ranged from 20/20-1 to hand motion (mean, 20/364). Spectral domain optical coherence tomography demonstrated extensive attenuation of the external limiting membrane, ellipsoid and interdigitation zones, adjacent to the visible multifocal choroiditis/punctate inner choroidopathy lesions...
February 2015: Retina
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