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Hussein Algahtani, Ashjan Alkhotani, Bader Shirah
BACKGROUND AND PURPOSE: Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is an immune-mediated chorioretinal disease that causes acute visual symptoms with characteristic ophthalmoscopic findings. Neurological complications are rarely reported in the literature. Here we report two new cases of APMPPE that presented with neurological manifestations, one of which was associated with peripheral neuropathy, which has not been described before. METHODS: A retrospective database review of all patients with a diagnosis of APMPPE was performed...
October 2016: Journal of Clinical Neurology
Bo Li, Ricarda J Bentham, John R Gonder
INTRODUCTION: VKH disease is a chronic, bilateral, granulomatous panuveitis with potential involvement of neurological, auditory and integumentary systems. On the other hand, APMPPE is believed to be an immune-driven chorioretinal vascular disease characterized by multifocal, flat, grey-white placoid lesions at the level of the RPE. We describe a case with overlapping figures of both conditions. CASE DESCRIPTION: A 19-year-old female presented with unilateral blurry vision and was found to have clinical and IVFA findings consistent with APMPPE...
2016: SpringerPlus
Fabio Scarinci, Amani A Fawzi, Amr Shaarawy, Joseph M Simonett, Lee M Jampol
PURPOSE: To quantify the external limiting membrane (ELM) disruption and photoreceptor volume changes in eyes with acute posterior multifocal placoid pigment epitheliopathy (APMPPE) using Spectral Domain Optical Coherence Tomography (SD-OCT) at the acute and resolution phases. METHODS: Retrospective study of 10 eyes of 5 patients with APMPPE. Intact ELM and the Bruch's membrane were manually traced using ImageJ software and their lengths from each scan of the Spectral Domain Optical Coherence Tomography macular volume were summed...
August 23, 2016: Retina
Reiko Kinouchi, Noriko Nishikawa, Akihiro Ishibazawa, Akitoshi Yoshida
Few cases have been reported describing choroidal vasculature in acute posterior multifocal placoid pigment epitheliopathy (APMPPE) using optical coherence tomography (OCT) angiography. We report choroidal vasculature changes in an APMPPE patient with the clinical course characterized by OCT angiography. A 39-year-old female was referred to us for bilateral multiple white spots in bilateral fundus. The best-corrected visual acuity was 20/20 in the right eye and 20/50 in the left eye. Multiple yellowish-white placoid lesions were observed in bilateral fundus, and fluorescein angiography showed a "block early, stain late" pattern at the placoid lesions characteristic of APMPPE...
July 28, 2016: International Ophthalmology
Serena Salvatore, Laura R Steeples, Adam H Ross, Clare Bailey, Richard W J Lee, Ester Carreño
Optical coherence tomography angiography (OCTA) provides noninvasive in vivo vascular imaging of the retina and choriocapillaris. To highlight OCTA utility, the authors align structural changes and their resolution with functional outcome. The authors present a case of acute posterior multifocal placoid pigment epitheliopathy (APMPPE) and sequential changes during transition to inactive disease. In the acute phase, altered flow and nonperfusion were seen in defined islands of choriocapillaris. Over time, progressive reperfusion was observed and accompanied clinical resolution and functional visual restoration...
July 1, 2016: Ophthalmic Surgery, Lasers & Imaging Retina
M Maier, K Wehrmann, C P Lohmann, N Feucht
This article reports the case of a 32-year-old female patient who presented with severe spasmodically occurring retrobulbar pain, headaches and light sensitivity. The neurological examination confirmed cephalalgia but no evidence of other neurological symptoms was found. Ophthalmoscopy revealed yellowish patchy lightened spots in the middle periphery. Fluorescein angiography (FLA) and indocyanine green angiography (ICGA) revealed findings typical for acute posterior multifocal placoid pigment epitheliopathy (APMPPE)...
May 9, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
Kiriko Hirooka, Wataru Saito, Michiyuki Saito, Yuki Hashimoto, Shohei Mori, Kousuke Noda, Susumu Ishida
PURPOSE: To quantitatively examine changes in choroidal circulation hemodynamics in patients with acute posterior multifocal placoid pigment epitheliopathy (APMPPE). METHODS: Retrospective observational case series. Five eyes of 3 APMPPE patients were included. In all APMPPE eyes, laser speckle flowgraphy was conducted to evaluate the mean blur rate (MBR), a quantitative index of relative blood flow velocity. The changes in MBR at the initial visit and after 3 and 6 months were statistically analyzed...
May 2016: Japanese Journal of Ophthalmology
Raquel Goldhardt, Heena Patel, Janet L Davis
PURPOSE: An association between antecedent viral illness and acute posterior multifocal placoid pigment epitheliopathy (APMPPE) has long been suspected. The authors propose dengue fever as a possible cause of APMPPE, based on three patients who travelled to or lived in endemic areas and had serologic evidence of prior exposure. METHODS: Review of case records of two patients. RESULTS: The index patient presented with APMPPE after her second confirmed dengue infection...
December 2016: Ocular Immunology and Inflammation
Hashim Ali Khan, Muhammad Aamir Shahzad
PURPOSE: To report a case of acute posterior multifocal placoid pigment epitheliopathy (APMPPE) with atypical features. CASE REPORT: A 30-year-old otherwise healthy woman presented with a 7-day history of visual disturbance in her left eye. The best corrected visual acuity in her left eye was 6/36. Funduscopy revealed multiple cream-colored placoid lesions, serous macular elevation, and papillitis. Fundus fluorescein angiography revealed early hypofluorescence and late hyperfluorescence...
January 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
David Case, Joshua Seinfeld, David Kumpe, Zach Folzenlogen, William Jones, Jennifer Simpson, Richard Hughes
BACKGROUND: Present a case report of acute posterior multifocal placoid pigment epitheliopathy (APMPPE) associated with stroke along with the serologic findings, diagnostic findings, and treatment in addition to presenting a review of other case reports to date in literature. With this information, we are attempting to identify key diagnostic features and appropriate treatment options for patients with this disease. METHODS: Presentation of case report, background on APMPPE, review of the literature and previous case reports, and discussion of diagnostic workup and treatment options for these patients...
October 2015: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Panagiotis Malamos, Panos Masaoutis, Ilias Georgalas, Stelios Maselos, Konstantinos Andrianopoulos, Chryssanthi Koutsandrea, Nikos N Markomichelakis
BACKGROUND: To evaluate the correlation of fundus autofluorescence (FAF) with indocyanine green angiography (ICGA) in patients with various posterior uveitis disorders. METHODS: Interventional case series including 23 eyes of 15 patients with diagnosis of a specific type of retinochoroiditis, such as acute posterior multifocal placoid pigment epitheliopathy (APMPPE), serpiginous-like choroiditis, multifocal choroiditis (MFC), Harada disease, and syphilitic retinochoroiditis...
2015: BioMed Research International
Annie Chan, Mark S Blumenkranz, Steven R Sanislo
PURPOSE: To report a case of extensive acute posterior multifocal placoid pigment epitheliopathy (APMPPE). METHODS: Case report. RESULTS: An 18-year-old girl was admitted and treated with intravenous acyclovir and intravitreal gancyclovir for presumed acute retinal necrosis. As the lesions faded and vision improved, the findings became more consistent with an extensive form of APMPPE. CONCLUSION: Acute posterior multifocal placoid pigment epitheliopathy can present very aggressively early in its course...
2010: Retinal Cases & Brief Reports
Sanjeewa Wickremasinghe, Lyndell Lim
PURPOSE: To report the occurrence and optical coherence tomography characteristics of serous retinal detachments in a patient with acute posterior multifocal placoid pigment epitheliopathy (APMPPE). METHODS: A patient with APMPPE presented with a dramatic reduction in vision associated with bilateral serous retinal detachments. RESULTS: After systemic steroid treatment, the serous detachments resolved leaving pigmentary changes typical of resolved APMPPE...
2010: Retinal Cases & Brief Reports
Lilian K Julián, Mauricio D Martínez-Cartier
PURPOSE: To report the occurrence of acute posterior multifocal placoid pigment epitheliopathy (APMPPE)-like posterior uveitis as part of the ocular manifestation of tubulointerstitial nephritis and uveitis (TINU) syndrome. METHODS: A 54-year-old previously healthy woman received oral ibuprofen and dipirone because of high fever and malaise. Three days after being started on this treatment, she developed bilateral posterior uveitis resembling APMPPE accompanied by anterior segment inflammation in the context of acute renal nephritis and maculopapular skin rash probably related to drug exposure...
2010: Retinal Cases & Brief Reports
Jacob J Yunker, Edgar L Ready, Charles L Tucker, Robert E Morris, C Douglas Witherspoon
OBJECTIVES: To report a patient with acute posterior multifocal placoid pigment epitheliopathy (APMPPE) who developed a thalamic infarction and to discuss this unusual presentation. DESIGN: Interventional case report and literature review. METHODS: A 23-year-old man with APMPPE presented with acute confusion and memory loss. He underwent complete ophthalmologic and neurologic examination, with neuroimaging including magnetic resonance angiography (MRA)...
2008: Retinal Cases & Brief Reports
M Mafrici, M Salomone, S Valente, E Gerace, P Trabucco, S Navarre, M Villain, E M Vingolo
We report a rare case of acute posterior multifocal placoid pigment epitheliopathy (APMPPE) in an elderly patient and a review of the recent scientific literature. A 65-year-old Caucasian man, forty-five days after return from tropical travel he developed right-sided facial palsy with right hemiplegia, dysarthria and a positive Babinski sign. He started prednisone 90 mg/day. Clinical, laboratory and imaging examinations were reported. Five months later there was a complete neurological and ophthalmological recovery...
2014: La Clinica Terapeutica
A Stepanov, A Feuermannová, J Studnička, L Hejsek, M Burova, N Jirásková, P Rozsíval
Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) affects individuals between 20 to 30 years of age and ocular manifestations are often preceded by flu-like illness. Symptoms of the disease include acute vision decrease associated with central and paracentral scotoma. Impairment of vision is usually bilateral, but may be asymmetric. We report the case of a man at the age of twenty-one, who was treated for APMPPE. Due to the involvement of the macula, low visual acuity and related immunogenetic predisposition (HLA-B27 positivity) was recommended corticosteroid therapy with a good therapeutic effect...
April 2014: Ceská a Slovenská Oftalmologie
Minoru Tanigawa, Yoko Tsukahara, Hiromitsu Yamanaka
PURPOSE: We report a case of acute posterior multifocal placoid pigment epitheliopathy (APMPPE), which was difficult to differentiate from posterior pole-type Vogt-Koyanagi-Harada (VKH) disease because the lesions were mainly located in the macula bilaterally. CASE REPORT: A 33-year-old man presented with rapid bilateral loss of vision. Fundoscopy revealed yellow-white subretinal lesions in the posterior pole of both eyes. Optical coherence tomography (OCT) revealed the presence of subretinal fluid with a subretinal septum...
2013: Case Reports in Ophthalmology
Mohamed G Gendy, Amani A Fawzi, Robert T Wendel, Dante J Pieramici, Joel A Miller, Lee M Jampol
IMPORTANCE: Persistent placoid maculopathy (PPM) is a rare clinical entity with features that superficially resemble acute posterior multifocal placoid pigment epitheliopathy (APMPPE) and macular serpiginous choroidopathy. It is important to differentiate PPM from APMPPE because both conditions may appear similar at presentation. OBJECTIVE: To investigate the short-term and long-term retinal changes in patients with PPM using spectral domain optical coherence tomography (SD-OCT), indocyanine green angiography (ICG-A), fluorescein angiography (FA), and fundus autofluorescence (FAF)...
January 2014: JAMA Ophthalmology
Gilda Cennamo, Giuseppe Nicoletti, Francesca Amoroso, Nunzio Velotti, Mauro Soda, Giuseppe De Crecchio
PURPOSE: To report the functional and anatomic features of a case of acute posterior multifocal placoid pigment epitheliopathy (APMPPE). METHODS: Case report. RESULTS: A 30-year-old man presented with a decrease of visual acuity that started a few days earlier. Fundus examination showed multiple, subretinal, white-yellowish lesions at the posterior pole in both eyes, suggesting APMPPE. Symptoms and clinical signs resolved within a few weeks, leaving well-defined areas of atrophy of the retinal pigment epithelium (RPE)...
March 2014: European Journal of Ophthalmology
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