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Acute Posterior Multifocal Placoid Pigment Epitheliopathy

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https://www.readbyqxmd.com/read/29554890/untreated-acute-posterior-multifocal-placoid-pigment-epitheliopathy-apmppe-a-case-series
#1
Olivia Xerri, Sawsen Salah, Dominique Monnet, Antoine P Brézin
BACKGROUND: Acute Posterior Multifocal Placoid Pigment Epitheliopathy (APMPPE) is a rare inflammatory eye disease that affects the Retinal Pigment Epithelium and outer retina. The purpose of this study was to describe its presentations, as well as its prognosis in a series of untreated patients. METHODS: Records of patients seen in the department of Ophthalmology at Cochin University Hospital, Paris, between April 2002 and June 2015 were retrospectively studied...
March 20, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29420099/ocular-complications-in-influenza-virus-infection
#2
Joanna Brydak-Godowska, Monika Turczyńska, Mariusz Przybyś, Lidia B Brydak, Dariusz Kęcik
PURPOSE: To describe a case series of ocular complications associated with upper respiratory tract infections. METHODS: Four patients aged 21-61 years (three females, one male) had confirmed ocular complications connected with a general upper respiratory tract infection with myalgia and fever. Ophthalmological examination, including a visual acuity test, a slit-lamp exam, intraocular pressure measurements, fluorescein and indocyanine green angiography, optical coherence tomography (OCT), and diagnostic tests for influenza were performed in the patients (RT-PCR, HAI)...
February 8, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29344060/neuro-ophthalmic-presentation-of-neuro-sweet-disease
#3
Padmaja Sudhakar, Stuart Tobin, William O Connor, Sachin Kedar
Acute febrile neutrophilic dermatosis (Sweet syndrome) is a systemic inflammatory condition usually associated with autoimmune or neoplastic processes and characterised by inflammatory dermatologic lesions such as erythematous plaques and papules associated with fever and leukocytosis. Neurological and ophthalmological involvement is rare. The authors describe an unusual case of Sweet syndrome associated with microscopic polyangiitis presenting with papilloedema, anterior uveitis, and skin rash. Years later, he developed acute posterior multifocal placoid pigment epitheliopathy...
August 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29117661/a-rare-case-of-infectious-multifocal-serpiginoid-choroiditis
#4
Miloš Mitrašević, Svetlana Jovanović, Filip Radotić, Snežana Pešić, Zorica Jovanović
Multifocal serpiginoid choroiditis is an infectious variety of serpiginous choroiditis. The disease is characterized by infectious etiology and overlapping clinical features in an intermediary form of acute posterior multifocal placoid pigment epitheliopathy and serpiginous choroiditis. In a 33-year-old patient, bilateral multiple placoid partially confluent chorioretinal lesions were diagnosed after a febrile flu-like episode. On the right eye, there was a progressive decrease in visual acuity. Later, the lesions had a prolonged progressive devastating clinical course and widespread distribution of placoid lesions, and took the form of serpiginoid choroiditis...
December 2016: Acta Clinica Croatica
https://www.readbyqxmd.com/read/28983094/application-of-oct-angiography-to-characterise-the-evolution-of-chorioretinal-lesions-in-acute-posterior-multifocal-placoid-pigment-epitheliopathy
#5
T R Burke, C J Chu, S Salvatore, C Bailey, A D Dick, R W J Lee, A H Ross, E Carreño
PurposeThe aim of this study was to determine a sequence of structural changes in acute posterior multifocal placoid pigment epitheliopathy (APMPPE) using optical coherence tomography-angiography (OCT-A) and comparing with other imaging modalities.Patients and methodsPatients with a new diagnosis of acute-onset APMPPE referred to a regional specialist centre from October 2015 to October 2016 were included. Multimodal imaging employed on all patients from diagnosis included the following: fundus fluorescein angiography, indocyanine green angiography, fundus autofluorescence, spectral domain-OCT (SD-OCT), and OCT-A...
October 2017: Eye
https://www.readbyqxmd.com/read/28960121/multimodal-evaluation-of-patients-with-acute-posterior-multifocal-placoid-pigment-epitheliopathy-and-serpiginous-choroiditis
#6
Monique Mangeon, Claudio Zett, Camila Amaral, Eduardo Novais, Cristina Muccioli, Gabriel Andrade, Heloisa Nascimento, Rubens Belfort
PURPOSE: To evaluate retinal and choroidal changes in patients with non-granulomatous choroiditis using the multimodality imaging (MMI). METHODS: Eight eyes of four patients were analyzed. Three patients (six eyes) were diagnosed with serpiginous choroiditis (SC) and one patient (two eyes) with acute posterior multifocal placoid pigment epitheliopathy (APMPPE). The patients were imaged on the same day using the RTVue Avanti XR instrument OCT/OCTA (Optovue Inc, Fremont, CA), Heidelberg Retina Angiograph 2 FAF and FA (Heidelberg Engineering, Germany), and TRC50DXi Topcon FP (Topcon Medical Systems, Oakland, NJ)...
September 29, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28902333/multi-modal-imaging-including-optical-coherence-tomography-angiography-in-patients-with-posterior-multifocal-placoid-pigment-epitheliopathy
#7
Jens Ulrich Werner, Christian Enders, Gerhard Klaus Lang, Gabriele Elisabeth Lang
BACKGROUND AND OBJECTIVE: New imaging methods provide novel insights into the pathogenesis of acute posterior multifocal placoid pigment epitheliopathy (APMPPE). PATIENTS AND METHODS: Four patients (eight eyes) in acute, subacute, and late phases of the disease were analyzed with multi-modal imaging methods including optical coherence tomography angiography (OCTA), structural OCT, fundus photography, and fundus autofluorescence. One patient was observed during the entire disease course...
September 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28810039/distinguishing-white-dot-syndromes-with-patterns-of-choroidal-hypoperfusion-on-optical-coherence-tomography-angiography
#8
Jay C Wang, Inês Laíns, Lucia Sobrin, John B Miller
BACKGROUND AND OBJECTIVE: To compare patterns of choroidal hypoperfusion in white dot syndromes (WDS) using optical coherence tomography angiography (OCTA). PATIENTS AND METHODS: Consecutive patients with WDS were imaged with either the Zeiss AngioPlex OCT Angiography (Carl Zeiss AG, Oberkochen, Germany) or the AngioVue OCT Angiography (Optovue, Fremont, CA) from February to November 2016. Four patients with acute posterior multifocal placoid pigment epitheliopathy (APMPPE), birdshot chorioretinopathy (BCR), presumed ocular histoplasmosis syndrome (POHS), and multiple evanescent white dot syndrome (MEWDS) were selected...
August 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28376557/-infection-associated-acute-posterior-multifocal-placoid-pigment-epitheliopathy
#9
F Jordan, U Voigt, J Dawczynski, R Augsten, D Meller
Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is a rare inflammatory chorioretinopathy, which mainly affects young light-skinned, myopic adults between 20 and 30 years of age. The exact aetiology of APMPPE is unknown. Some patients report a viral or flu-like illness preceding the onset of APMPPE symptoms. This condition is usually bilateral and self-limiting with a good overall prognosis. Visual loss is sudden, but usually temporary. Relapses are very rare. Foveal involvement may lead to a worse visual prognosis...
April 4, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28253223/observation-and-clinical-pattern-in-patients-with-white-dot-syndromes-the-role-of-color-photography-in-monitoring-ocular-changes-in-long-term-observation
#10
Joanna Brydak-Godowska, Joanna Gołębiewska, Monika Turczyńska, Joanna Moneta-Wielgoś, Agnieszka Samsel, Piotr K Borkowski, Michał Ciszek, Agnieszka Płonecka-Rodzoch, Aleksandra Kużnik-Borkowska, Joanna Ciszewska, Elżbieta Makomaska-Szaroszyk, Lidia B Brydak, Dariusz Kęcik
BACKGROUND The aim of this study was to assess the clinical course and distinctive features of different white dot syndromes (WDS) in patients attending the Ophthalmology Department, Medical University of Warsaw in the years 1995-2015. MATERIAL AND METHODS Sixty-two (62) patients (43 females and 19 males), aged 18 to 77 years, referred with a WDS were included in this prospective study, with observation period ranging from 5 months to 16 years. All patients underwent a complete ophthalmological examination and multimodal imaging studies...
March 2, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28166161/characterizing-photoreceptor-changes-in-acute-posterior-multifocal-placoid-pigment-epitheliopathy-using-adaptive-optics
#11
Philipp K Roberts, Peter L Nesper, Alex C Onishi, Dimitra Skondra, Lee M Jampol, Amani A Fawzi
PURPOSE: To characterize lesions of acute posterior multifocal placoid pigment epitheliopathy (APMPPE) by multimodal imaging including adaptive optics scanning laser ophthalmoscopy (AOSLO). METHODS: We included patients with APMPPE at different stages of evolution of the placoid lesions. Color fundus photography, spectral domain optical coherence tomography, infrared reflectance, fundus autofluorescence, and AOSLO images were obtained and registered to correlate microstructural changes...
January 2018: Retina
https://www.readbyqxmd.com/read/28151840/acute-posterior-multifocal-placoid-pigment-epitheliopathy-on-optical-coherence-tomography-angiography
#12
Michael J Heiferman, Safa Rahmani, Lee M Jampol, Peter L Nesper, Dimitra Skondra, Leo A Kim, Amani A Fawzi
PURPOSE: To investigate choroidal involvement in acute posterior multifocal placoid pigment epitheliopathy (APMPPE). METHODS: A retrospective observational case series using multimodal imaging including optical coherence tomography (OCT) angiography. RESULTS: Five patients with APMPPE were included. In most acute lesions, OCT angiography revealed outer retinal and retinal pigment epithelium (RPE) hyperreflective lesions with attenuated OCT signal in the underlying choroid, but careful examination allowed us to identify a single lesion with decreased choriocapillaris flow outside the signal attenuation...
November 2017: Retina
https://www.readbyqxmd.com/read/28099970/keeping-the-name-of-acute-posterior-multifocal-placoid-pigment-epitheliopathy
#13
Lee M Jampol, Debra A Goldstein, Amani A Fawzi
No abstract text is available yet for this article.
March 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28097335/renaming-of-acute-posterior-multifocal-placoid-pigment-epitheliopathy-apmppe-to-acute-multifocal-placoid-choroidopathy-amp-c
#14
Alice Yang Zhang, Ian C Han, Morton F Goldberg
No abstract text is available yet for this article.
March 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28056129/acute-posterior-multifocal-placoid-pigment-epitheliopathy-associated-with-drug-reaction-with-eosinophilia-and-systemic-symptoms-syndrome
#15
Alice Yang Zhang, Jithin Yohannan, Morton F Goldberg, Ian C Han
No abstract text is available yet for this article.
January 5, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27819416/neurological-manifestations-of-acute-posterior-multifocal-placoid-pigment-epitheliopathy
#16
Hussein Algahtani, Ashjan Alkhotani, Bader Shirah
BACKGROUND AND PURPOSE: Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is an immune-mediated chorioretinal disease that causes acute visual symptoms with characteristic ophthalmoscopic findings. Neurological complications are rarely reported in the literature. Here we report two new cases of APMPPE that presented with neurological manifestations, one of which was associated with peripheral neuropathy, which has not been described before. METHODS: A retrospective database review of all patients with a diagnosis of APMPPE was performed...
October 2016: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/27759710/optical-coherence-tomography-angiography-shows-inner-choroidal-ischemia-in-acute-posterior-multifocal-placoid-pigment-epitheliopathy
#17
Rosa Dolz-Marco, David Sarraf, Vincent Giovinazzo, K Bailey Freund
PURPOSE: To describe multimodal imaging findings of an evolving case of acute posterior multifocal placoid pigment epitheliopathy occurring in a young healthy male. METHODS: Case report of a patient with acute posterior multifocal placoid pigment epitheliopathy including comprehensive systemic and ocular examinations. Ultra-widefield autofluorescence, fluorescein angiography, indocyanine green angiography, and serial optical coherence tomography angiography were performed...
January 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27662233/why-the-dots-are-black-only-in-the-late-phase-of-the-indocyanine-green-angiography-in-multiple-evanescent-white-dot-syndrome
#18
Alain Gaudric, Sarah Mrejen
PURPOSE: To determine what retinal layer is primarily involved in multiple evanescent white dot syndrome compared with acute posterior multifocal placoid pigment epitheliopathy using multimodal imaging including indocyanine green angiography. METHODS: Color fundus photographs and fluorescein angiography, ICGA and spectral domain optical coherence tomography images of two typical acute cases, one of acute posterior multifocal placoid pigment epitheliopathy and one of multiple evanescent white dot syndrome, were assessed and compared...
January 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27652046/a-case-of-unilateral-and-spontaneously-resolving-posterior-uveitis-with-overlapping-features-of-vogt-koyanagi-harada-disease-and-acute-posterior-multifocal-placoid-pigment-epitheliopathy
#19
Bo Li, Ricarda J Bentham, John R Gonder
INTRODUCTION: VKH disease is a chronic, bilateral, granulomatous panuveitis with potential involvement of neurological, auditory and integumentary systems. On the other hand, APMPPE is believed to be an immune-driven chorioretinal vascular disease characterized by multifocal, flat, grey-white placoid lesions at the level of the RPE. We describe a case with overlapping figures of both conditions. CASE DESCRIPTION: A 19-year-old female presented with unilateral blurry vision and was found to have clinical and IVFA findings consistent with APMPPE...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27557085/longitudinal-quantitative-evaluation-of-outer-retinal-lesions-in-acute-posterior-multifocal-placoid-pigment-epitheliopathy-using-optical-coherence-tomography
#20
Fabio Scarinci, Amani A Fawzi, Amr Shaarawy, Joseph M Simonett, Lee M Jampol
PURPOSE: To quantify the external limiting membrane (ELM) disruption and photoreceptor volume changes in eyes with acute posterior multifocal placoid pigment epitheliopathy (APMPPE) using Spectral Domain Optical Coherence Tomography (SD-OCT) at the acute and resolution phases. METHODS: Retrospective study of 10 eyes of 5 patients with APMPPE. Intact ELM and the Bruch's membrane were manually traced using ImageJ software and their lengths from each scan of the Spectral Domain Optical Coherence Tomography macular volume were summed...
May 2017: Retina
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