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Acute Posterior Multifocal Placoid Pigment Epitheliopathy

Rosa Dolz-Marco, David Sarraf, Vincent Giovinazzo, K Bailey Freund
PURPOSE: To describe multimodal imaging findings of an evolving case of acute posterior multifocal placoid pigment epitheliopathy occurring in a young healthy male. METHODS: Case report of a patient with acute posterior multifocal placoid pigment epitheliopathy including comprehensive systemic and ocular examinations. Ultra-widefield autofluorescence, fluorescein angiography, indocyanine green angiography, and serial optical coherence tomography angiography were performed...
October 18, 2016: Retinal Cases & Brief Reports
Alain Gaudric, Sarah Mrejen
PURPOSE: To determine what retinal layer is primarily involved in multiple evanescent white dot syndrome compared with acute posterior multifocal placoid pigment epitheliopathy using multimodal imaging including indocyanine green angiography. METHODS: Color fundus photographs and fluorescein angiography, ICGA and spectral domain optical coherence tomography images of two typical acute cases, one of acute posterior multifocal placoid pigment epitheliopathy and one of multiple evanescent white dot syndrome, were assessed and compared...
September 21, 2016: Retinal Cases & Brief Reports
Bo Li, Ricarda J Bentham, John R Gonder
INTRODUCTION: VKH disease is a chronic, bilateral, granulomatous panuveitis with potential involvement of neurological, auditory and integumentary systems. On the other hand, APMPPE is believed to be an immune-driven chorioretinal vascular disease characterized by multifocal, flat, grey-white placoid lesions at the level of the RPE. We describe a case with overlapping figures of both conditions. CASE DESCRIPTION: A 19-year-old female presented with unilateral blurry vision and was found to have clinical and IVFA findings consistent with APMPPE...
2016: SpringerPlus
Fabio Scarinci, Amani A Fawzi, Amr Shaarawy, Joseph M Simonett, Lee M Jampol
PURPOSE: To quantify the external limiting membrane (ELM) disruption and photoreceptor volume changes in eyes with acute posterior multifocal placoid pigment epitheliopathy (APMPPE) using Spectral Domain Optical Coherence Tomography (SD-OCT) at the acute and resolution phases. METHODS: Retrospective study of 10 eyes of 5 patients with APMPPE. Intact ELM and the Bruch's membrane were manually traced using ImageJ software and their lengths from each scan of the Spectral Domain Optical Coherence Tomography macular volume were summed...
August 23, 2016: Retina
Reiko Kinouchi, Noriko Nishikawa, Akihiro Ishibazawa, Akitoshi Yoshida
Few cases have been reported describing choroidal vasculature in acute posterior multifocal placoid pigment epitheliopathy (APMPPE) using optical coherence tomography (OCT) angiography. We report choroidal vasculature changes in an APMPPE patient with the clinical course characterized by OCT angiography. A 39-year-old female was referred to us for bilateral multiple white spots in bilateral fundus. The best-corrected visual acuity was 20/20 in the right eye and 20/50 in the left eye. Multiple yellowish-white placoid lesions were observed in bilateral fundus, and fluorescein angiography showed a "block early, stain late" pattern at the placoid lesions characteristic of APMPPE...
July 28, 2016: International Ophthalmology
Serena Salvatore, Laura R Steeples, Adam H Ross, Clare Bailey, Richard W J Lee, Ester Carreño
Optical coherence tomography angiography (OCTA) provides noninvasive in vivo vascular imaging of the retina and choriocapillaris. To highlight OCTA utility, the authors align structural changes and their resolution with functional outcome. The authors present a case of acute posterior multifocal placoid pigment epitheliopathy (APMPPE) and sequential changes during transition to inactive disease. In the acute phase, altered flow and nonperfusion were seen in defined islands of choriocapillaris. Over time, progressive reperfusion was observed and accompanied clinical resolution and functional visual restoration...
July 1, 2016: Ophthalmic Surgery, Lasers & Imaging Retina
Susanna S Park, Sumeer Thinda, Dae Yu Kim, Robert J Zawadzki, John S Werner
No abstract text is available yet for this article.
August 1, 2016: JAMA Ophthalmology
Constantine D Georgakopoulos, Ioannis Antonopoulos, Olga E Makri, Panagiotis Vasilakis, Stamatis-Nick C Liossis, Andrew P Andonopoulos
No abstract text is available yet for this article.
July 2016: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
M Maier, K Wehrmann, C P Lohmann, N Feucht
This article reports the case of a 32-year-old female patient who presented with severe spasmodically occurring retrobulbar pain, headaches and light sensitivity. The neurological examination confirmed cephalalgia but no evidence of other neurological symptoms was found. Ophthalmoscopy revealed yellowish patchy lightened spots in the middle periphery. Fluorescein angiography (FLA) and indocyanine green angiography (ICGA) revealed findings typical for acute posterior multifocal placoid pigment epitheliopathy (APMPPE)...
May 9, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
Alessandro Invernizzi, Aniruddha Agarwal, Mariano Cozzi, Francesco Viola, Quan Dong Nguyen, Giovanni Staurenghi
PURPOSE: To detect choriocapillaris changes by enhanced depth imaging optical coherence tomography (EDI-OCT) in areas of choriocapillaris hypoperfusion visualized on indocyanine green angiography. METHODS: Combined indocyanine green angiography and EDI-OCT from patients diagnosed with inflammatory choriocapillaris hypoperfusion were retrospectively analyzed. The EDI-OCTs were compared with indocyanine green angiography to detect choriocapillaris changes suggestive of choriocapillaris hypoperfusion in both active stage (AS) and inactive stage of the disease...
October 2016: Retina
Kiriko Hirooka, Wataru Saito, Michiyuki Saito, Yuki Hashimoto, Shohei Mori, Kousuke Noda, Susumu Ishida
PURPOSE: To quantitatively examine changes in choroidal circulation hemodynamics in patients with acute posterior multifocal placoid pigment epitheliopathy (APMPPE). METHODS: Retrospective observational case series. Five eyes of 3 APMPPE patients were included. In all APMPPE eyes, laser speckle flowgraphy was conducted to evaluate the mean blur rate (MBR), a quantitative index of relative blood flow velocity. The changes in MBR at the initial visit and after 3 and 6 months were statistically analyzed...
May 2016: Japanese Journal of Ophthalmology
Andrew R Lee, Sumit Sharma, Tamer H Mahmoud
PURPOSE: To report a case of tubulointerstitial nephritis and uveitis syndrome with a primary presentation of acute posterior multifocal placoid pigment epitheliopathy after use of lamotrigine. METHODS: Retrospective case report with ultra-widefield fundus imaging, optical coherence tomography, and fluorescein angiography. RESULTS: A 19-year-old woman presented with decreased visual acuity and acute renal failure after starting lamotrigine...
March 10, 2016: Retinal Cases & Brief Reports
Pieter Lambrecht, Marnix Claeys, Ilse De Schryver
PURPOSE: Presentation of a case report of a unilateral ampiginous choroiditis. METHODS: This is an observational case report. RESULTS: A 70-year-old woman was referred to us with unilateral scattered chorioretinal lesions. The multifocal pattern of the lesions and the angiographic features led to the diagnosis of ampiginous choroiditis. CONCLUSION: Ampiginous choroiditis is a primary inflammatory choriocapillaropathy with characteristics of both acute posterior multifocal placoid pigment epitheliopathy and serpiginous choroiditis...
September 2015: Case Reports in Ophthalmology
Raquel Goldhardt, Heena Patel, Janet L Davis
PURPOSE: An association between antecedent viral illness and acute posterior multifocal placoid pigment epitheliopathy (APMPPE) has long been suspected. The authors propose dengue fever as a possible cause of APMPPE, based on three patients who travelled to or lived in endemic areas and had serologic evidence of prior exposure. METHODS: Review of case records of two patients. RESULTS: The index patient presented with APMPPE after her second confirmed dengue infection...
February 22, 2016: Ocular Immunology and Inflammation
Hashim Ali Khan, Muhammad Aamir Shahzad
PURPOSE: To report a case of acute posterior multifocal placoid pigment epitheliopathy (APMPPE) with atypical features. CASE REPORT: A 30-year-old otherwise healthy woman presented with a 7-day history of visual disturbance in her left eye. The best corrected visual acuity in her left eye was 6/36. Funduscopy revealed multiple cream-colored placoid lesions, serous macular elevation, and papillitis. Fundus fluorescein angiography revealed early hypofluorescence and late hyperfluorescence...
January 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
David Case, Joshua Seinfeld, David Kumpe, Zach Folzenlogen, William Jones, Jennifer Simpson, Richard Hughes
BACKGROUND: Present a case report of acute posterior multifocal placoid pigment epitheliopathy (APMPPE) associated with stroke along with the serologic findings, diagnostic findings, and treatment in addition to presenting a review of other case reports to date in literature. With this information, we are attempting to identify key diagnostic features and appropriate treatment options for patients with this disease. METHODS: Presentation of case report, background on APMPPE, review of the literature and previous case reports, and discussion of diagnostic workup and treatment options for these patients...
October 2015: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Sergio Eustolio Hernández-Da Mota
BACKGROUND: Acute posterior multifocal placoid pigment epitheliopathy is an unusual, self-limited, inflammatory disease that affects the choriocapillaris, and external retinal layers. CLINICAL CASE: A 26 year-old male patient complained of decreased visual acuity, as well as photopsia in both eyes for the past three days. Best corrected visual acuity was 20/200 in the right eye and 20/80 in the left eye. There was no anterior chamber inflammation or vitritis in either eye...
March 2016: Cirugia y Cirujanos
Liza M Cohen, Marion R Munk, Debra A Goldstein, Lee M Jampol
PURPOSE: To report the case of a patient with recurrent, acute posterior multifocal placoid pigment epitheliopathy. To the best of our knowledge, this is the longest documented course with the greatest number of recurrences reported. METHODS: Observational case report of one patient. A 27-year-old otherwise healthy male patient presented with recurrence of new scotomata over 15 years. Fundus photography, fluorescein angiography, indocyanine green angiography, fundus autofluorescence, and optical coherence tomography documented his clinical course...
2015: Retinal Cases & Brief Reports
Panagiotis Malamos, Panos Masaoutis, Ilias Georgalas, Stelios Maselos, Konstantinos Andrianopoulos, Chryssanthi Koutsandrea, Nikos N Markomichelakis
BACKGROUND: To evaluate the correlation of fundus autofluorescence (FAF) with indocyanine green angiography (ICGA) in patients with various posterior uveitis disorders. METHODS: Interventional case series including 23 eyes of 15 patients with diagnosis of a specific type of retinochoroiditis, such as acute posterior multifocal placoid pigment epitheliopathy (APMPPE), serpiginous-like choroiditis, multifocal choroiditis (MFC), Harada disease, and syphilitic retinochoroiditis...
2015: BioMed Research International
Jordan E Hollsten, Michael McClintock, Hazem Samy, Marc Peden, Christine N Kay
PURPOSE: To describe a case of fulminant bilateral papillitis and chorioretinitis in the setting of positive coxsackievirus B titers, which convalesced months after the patient's presentation. The patient presented with an acute posterior multifocal placoid pigment epitheliopathy-like clinical picture and her visual acuity and visual field improved moderately after initiation of treatment with intravenous immunoglobulin. METHODS: Case report of a white female with bilateral blurred vision is presented in this study...
2013: Retinal Cases & Brief Reports
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