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https://www.readbyqxmd.com/read/27906041/implementation-of-the-better-2-program-a-qualitative-study-exploring-barriers-and-facilitators-of-a-novel-way-to-improve-chronic-disease-prevention-and-screening-in-primary-care
#1
Nicolette Sopcak, Carolina Aguilar, Mary Ann O'Brien, Candace Nykiforuk, Kris Aubrey-Bassler, Richard Cullen, Eva Grunfeld, Donna Patricia Manca
BACKGROUND: BETTER (Building on Existing Tools to Improve Chronic Disease Prevention and Screening in Primary Care) is a patient-based intervention to improve chronic disease prevention and screening (CDPS) for cardiovascular disease, diabetes, cancer, and associated lifestyle factors in patients aged 40 to 65. The key component of BETTER is a prevention practitioner (PP), a health care professional with specialized skills in CDPS who meets with patients to develop a personalized prevention prescription, using the BETTER toolkit and Brief Action Planning...
December 1, 2016: Implementation Science: IS
https://www.readbyqxmd.com/read/27900439/non-ribosomal-peptide-synthases-from-pseudomonas-aeruginosa-play-a-role-in-cyclodipeptide-biosynthesis-quorum-sensing-regulation-and-root-development-in-a-plant-host
#2
Omar González, Randy Ortíz-Castro, César Díaz-Pérez, Alma L Díaz-Pérez, Viridiana Magaña-Dueñas, José López-Bucio, Jesús Campos-García
Diverse molecules mediate cross-kingdom communication between bacteria and their eukaryotic partners and determine pathogenic or symbiotic relationships. N-acyl-L-homoserine lactone-dependent quorum-sensing signaling represses the biosynthesis of bacterial cyclodipeptides (CDPs) that act as auxin signal mimics in the host plant Arabidopsis thaliana. In this work, we performed bioinformatics, biochemical, and plant growth analyses to identify non-ribosomal peptide synthase (NRPS) proteins of Pseudomonas aeruginosa, which are involved in CDP synthesis...
November 30, 2016: Microbial Ecology
https://www.readbyqxmd.com/read/27895718/consensus-diversity-plots-a-global-diversity-analysis-of-chemical-libraries
#3
Mariana González-Medina, Fernando D Prieto-Martínez, John R Owen, José L Medina-Franco
BACKGROUND: Measuring the structural diversity of compound databases is relevant in drug discovery and many other areas of chemistry. Since molecular diversity depends on molecular representation, comprehensive chemoinformatic analysis of the diversity of libraries uses multiple criteria. For instance, the diversity of the molecular libraries is typically evaluated employing molecular scaffolds, structural fingerprints, and physicochemical properties. However, the assessment with each criterion is analyzed independently and it is not straightforward to provide an evaluation of the "global diversity"...
2016: Journal of Cheminformatics
https://www.readbyqxmd.com/read/27892478/continuous-single-cell-imaging-reveals-sequential-steps-of-plasmacytoid-dendritic-cell-development-from-common-dendritic-cell-progenitors
#4
Ezgi Dursun, Max Endele, Andrea Musumeci, Henrik Failmezger, Shu-Hung Wang, Achim Tresch, Timm Schroeder, Anne B Krug
Functionally distinct plasmacytoid and conventional dendritic cells (pDC and cDC) shape innate and adaptive immunity. They are derived from common dendritic cell progenitors (CDPs) in the murine bone marrow, which give rise to CD11c(+) MHCII(-) precursors with early commitment to DC subpopulations. In this study, we dissect pDC development from CDP into an ordered sequence of differentiation events by monitoring the expression of CD11c, MHC class II, Siglec H and CCR9 in CDP cultures by continuous single cell imaging and tracking...
November 28, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27844416/two-synthetic-methods-for-preparation-of-chiral-stationary-phases-using-crystalline-degradation-products-of-vancomycin-column-performance-for-enantioseparation-of-acidic-and-basic-drugs
#5
Assem Abdollahpour, Rouhollah Heydari, Mojtaba Shamsipur
Two chiral stationary phases (CSPs) based on crystalline degradation products (CDPs) of vancomycin by using different synthetic methods were prepared and compared. Crystalline degradation products of vancomycin were produced by hydrolytic loss of ammonia from vancomycin molecules. Performances of two chiral columns prepared with these degradation products were investigated using several acidic and basic drugs as model analytes. Retention and resolution of these analytes on the prepared columns, as two main parameters, in enantioseparation were studied...
November 14, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27711768/three-and-four-coordinate-fe-carbodiphosphorane-complexes
#6
Conor Pranckevicius, Diana A Iovan, Douglas W Stephan
Carbodiphosphoranes (CDPs) are a family of divalent carbon ligands that are known for their exceptional electron donor properties. Herein, the preparation and reactivity of a family of three and four co-ordinate Fe carbodiphosphorane complexes is described. Hexaphenylcarbodiphosphorane (HCDP) [1] is shown to react with FeCl2(PPh3)2 to form the three coordinate adduct Fe(HCDP)Cl2 [2], which is equilibrium with its four coordinate dimer. Reaction of [2] with two equivalents of benzyl Grignard yields the corresponding dialkyl complex (HCDP)FeBn2 [3]...
September 28, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27637449/preliminary-characterizations-antioxidant-and-hepatoprotective-activity-of-polysaccharide-from-cistanche-deserticola
#7
Yuanheng Guo, Lili Cao, Qingsheng Zhao, Lijun Zhang, Jinjin Chen, Boyan Liu, Bing Zhao
To research the preliminary characterizations, antioxidant and hepatoprotective activity of polysaccharides from Cistanche deserticola (CDPs), three polysaccharide fractions, CDP-A, CDP-B and CDP-C, were obtained by successively membrane filtration (microfiltration, ultrafiltration and nanofiltration). Molecular weights, monosaccharide compositions, purities and IR spectra of the three fractions were analyzed. Results showed that CDP-C contained higher proportion of galacturonic acid (GalUA) than CDP-B and CDP-A...
September 13, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27306540/laboratory-evaluation-of-a-new-coagulant-disinfectant-point-of-use-water-treatment-product-for-emergencies
#8
J-T Marois-Fiset, A Shaheed, J Brown, C C Dorea
AIMS: There is emerging evidence that point-of-use (POU) water treatment can be effective in the improvement of microbial water quality and the decrease in diarrhoeal disease incidence in humanitarian emergencies. Coagulant/disinfection products (CDPs) have the distinct advantage of providing microbial quality improvement, turbidity reductions and a free chlorine residual (FCR). The laboratory treatment performance of a novel CDP, the 'Pureit(®) ' sachet, has been evaluated under different water quality conditions...
September 2016: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/27142008/isolation-of-dendritic-cell-progenitor-and-bone-marrow-progenitor-cells-from-mouse
#9
Nobuyuki Onai, Toshiaki Ohteki
Dendritic cells (DCs) comprise two major subsets, conventional DC (cDC) and plasmacytoid DC (pDC) in the steady-state lymphoid organ. These cells have a short half-life and therefore, require continuous generation from hematopoietic stem cells and progenitor cells. Recently, we identified DC-restricted progenitors called common DC progenitors (CDPs) in the bone marrow of mouse. The CDPs can be isolated from mouse bone marrow based on the hematopoietic cytokine receptors, such as Flt3 (Fms-related tyrosine kinase 3) (CD135), c-kit (CD117), M-CSF (macrophage colony-stimulating factor) receptor (CD115), and IL-7 (interleukin-7) receptor-α (CD127)...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27058451/retaining-faculty-in-academic-medicine-the-impact-of-career-development-programs-for-women
#10
Shine Chang, Page S Morahan, Diane Magrane, Deborah Helitzer, Hwa Young Lee, Sharon Newbill, Ho-Lan Peng, Michele Guindani, Gina Cardinali
BACKGROUND: For more than two decades, national career development programs (CDPs) have addressed underrepresentation of women faculty in academic medicine through career and leadership curricula. We evaluated CDP participation impact on retention. METHODS: We used Association of American Medical Colleges data to compare 3268 women attending CDPs from 1988 to 2008 with 17,834 women and 40,319 men nonparticipant faculty similar to CDP participants in degree, academic rank, first year of appointment in rank, and home institution...
July 2016: Journal of Women's Health
https://www.readbyqxmd.com/read/26848548/crosslinked-dendronized-polyols-as-a-general-approach-to-brighter-and-more-stable-fluorophores
#11
Ying Li, Yugang Bai, Nan Zheng, Yang Liu, Gretchen A Vincil, Benjamin J Pedretti, Jianjun Cheng, Steven C Zimmerman
Fluorescent, aqueous-soluble, crosslinked dendronized polyols (CDPs) are obtained through a sequential process involving ring-opening metathesis polymerization (ROMP), intra-chain ring-closing metathesis (RCM), and hydrolysis. This general strategy improves the quantum yields (QYs), brightness, and photostability of five common fluorophores whose emission wavelengths cover 150 nm. Additionally, the availability of the polymeric fluorophore to the cytosomes opens the door to applications in bioimaging and intracellular delivery...
March 7, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/26712018/protein-carbamylation-is-a-hallmark-of-aging
#12
Laëtitia Gorisse, Christine Pietrement, Vincent Vuiblet, Christian E H Schmelzer, Martin Köhler, Laurent Duca, Laurent Debelle, Paul Fornès, Stéphane Jaisson, Philippe Gillery
Aging is a progressive process determined by genetic and acquired factors. Among the latter are the chemical reactions referred to as nonenzymatic posttranslational modifications (NEPTMs), such as glycoxidation, which are responsible for protein molecular aging. Carbamylation is a more recently described NEPTM that is caused by the nonenzymatic binding of isocyanate derived from urea dissociation or myeloperoxidase-mediated catabolism of thiocyanate to free amino groups of proteins. This modification is considered an adverse reaction, because it induces alterations of protein and cell properties...
February 2, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/26641496/two-distinct-cyclodipeptide-synthases-from-a-marine-actinomycete-catalyze-biosynthesis-of-the-same-diketopiperazine-natural-product
#13
Elle D James, Bryan Knuckley, Norah Alqahtani, Suheel Porwal, Jisun Ban, Jonathan A Karty, Rajesh Viswanathan, Amy L Lane
Diketopiperazine natural products are structurally diverse and offer many biological activities. Cyclodipeptide synthases (CDPSs) were recently unveiled as a novel enzyme family that employs aminoacyl-tRNAs as substrates for 2,5-diketopiperazine assembly. Here, the Nocardiopsis sp. CMB-M0232 genome is predicted to encode two CDPSs, NozA and NcdA. Metabolite profiles from E. coli expressing these genes and assays with purified recombinant enzymes revealed that NozA and NcdA catalyze cyclo(l-Trp-l-Trp) (1) biosynthesis from tryptophanyl-tRNA and do not accept other aromatic aminoacyl-tRNA substrates...
July 15, 2016: ACS Synthetic Biology
https://www.readbyqxmd.com/read/26525957/bioinspired-reductionistic-peptide-engineering-for-exceptional-mechanical-properties
#14
M B Avinash, Devaraj Raut, Manish Kumar Mishra, Upadrasta Ramamurty, T Govindaraju
A simple solution-processing and self-assembly approach that exploits the synergistic interactions between multiple hydrogen bonded networks and aromatic interactions was utilized to synthesize molecular crystals of cyclic dipeptides (CDPs), whose molecular weights (~0.2 kDa) are nearly three orders of magnitude smaller than that of natural structural proteins (50-300 kDa). Mechanical properties of these materials, measured using the nanoindentation technique, indicate that the stiffness and strength are comparable and sometimes better than those of natural fibres...
2015: Scientific Reports
https://www.readbyqxmd.com/read/26524144/activation-of-ahr-mediated-toxicity-pathway-by-emerging-pollutants-polychlorinated-diphenyl-sulfides
#15
Junjiang Zhang, Xiaowei Zhang, Pu Xia, Rui Zhang, Yang Wu, Jie Xia, Guanyong Su, Jiamin Zhang, John P Giesy, Zunyao Wang, Daniel L Villeneuve, Hongxia Yu
Polychlorinated diphenyl sulfides (PCDPSs) are a group of environmental pollutants for which limited toxicological information is available. This study tested the hypothesis that PCDPSs could activate the mammalian aryl hydrocarbon receptor (AhR) mediated toxicity pathways. Eighteen PCDPSs were tested in the H4IIE-luc transactivation assay, with 13/18 causing concentration-dependent AhR activation. Potencies of several congeners were similar to those of mono-ortho substituted polychlorinated biphenyls. A RNA sequencing (RNA-seq)-based transcriptomic analysis was performed on H4IIE cells treated with two PCDPS congeners, 2,2',3,3',4,5,6-hepta-CDPS, and 2,4,4',5-tetra-CDPS...
February 2016: Chemosphere
https://www.readbyqxmd.com/read/26379651/purification-and-synergistic-antibacterial-activity-of-arginine-derived-cyclic-dipeptides-from-achromobacter-sp-associated-with-a-rhabditid-entomopathogenic-nematode-against-major-clinically-relevant-biofilm-forming-wound-bacteria
#16
Indira Deepa, Sasidharan N Kumar, Ravikumar S Sreerag, Vishnu S Nath, Chellapan Mohandas
Skin and chronic wound infections caused by various pathogenic bacteria are an increasing and urgent health problem worldwide. In the present investigation ethyl acetate extract of an Achromobacter sp. associated with a Rhabditis entomopathogenic nematode (EPN), displayed promising antibacterial property and was further purified by silica gel column chromatography to get three different cyclic dipeptides (CDPs). Based on the spectral data and Marfey's analyses, the CDPs were identified as cyclo(D-Leu-D-Arg) (1), cyclo(L-Trp-L-Arg) (2), and cyclo(D-Trp-D-Arg) (3), respectively...
2015: Frontiers in Microbiology
https://www.readbyqxmd.com/read/26379540/a-machine-learning-methodology-for-the-selection-and-classification-of-spontaneous-spinal-cord-dorsum-potentials-allows-disclosure-of-structured-non-random-changes-in-neuronal-connectivity-induced-by-nociceptive-stimulation
#17
Mario Martin, Enrique Contreras-Hernández, Javier Béjar, Gennaro Esposito, Diógenes Chávez, Silvio Glusman, Ulises Cortés, Pablo Rudomin
Previous studies aimed to disclose the functional organization of the neuronal networks involved in the generation of the spontaneous cord dorsum potentials (CDPs) generated in the lumbosacral spinal segments used predetermined templates to select specific classes of spontaneous CDPs. Since this procedure was time consuming and required continuous supervision, it was limited to the analysis of two specific types of CDPs (negative CDPs and negative positive CDPs), thus excluding potentials that may reflect activation of other neuronal networks of presumed functional relevance...
2015: Frontiers in Neuroinformatics
https://www.readbyqxmd.com/read/26263178/efficient-generation-of-plasmacytoid-dendritic-cell-from-common-lymphoid-progenitors-by-flt3-ligand
#18
Yi-Ling Chen, Shiun Chang, Ting-Ting Chen, Chien-Kuo Lee
Dendritic cells (DCs), including conventional DCs (cDCs) and plasmacytoid DCs (pDCs) are critical for initiating and controlling the immune response. However, study of DC, particularly pDC, function is hampered by their low frequency in lymphoid organs, and existing methods for in vitro DC generation preferentially favor the production of cDCs over pDCs. Here, we demonstrated that pDCs could be efficiently generated in vitro from common lymphoid progenitors (CLPs) using Flt3 ligand (FL) in three different culture systems, namely feeder-free, BM-feeder and AC-6-feeder...
2015: PloS One
https://www.readbyqxmd.com/read/26262600/tissue-distribution-excretion-and-the-metabolic-pathway-of-2-2-4-4-5-penta-chlorinated-diphenylsulfide-cdps-99-in-icr-mice
#19
Xiaolan Zeng, Xuesheng Zhang, Li Qin, Zunyao Wang
The tissue distribution, excretion, and metabolic pathway of 2,2',4,4',5-penta-chlorinated diphenylsulfide (CDPS-99) in ICR mice were investigated after oral perfusion at 10mg/kg body weight (b.w.). Biological samples were extracted and separated and, for the first time, were determined by a novel, sensitive, and specific GC-MS method under the full scan and selected ion monitoring (SIM) modes. The results showed that the concentrations of CDPS-99 in the liver, kidneys, and serum reached a maximum after a one-day exposure and that the CDPS-99 concentration in the liver was the highest (3...
September 15, 2015: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/26238338/developing-clinical-decision-tools-to-implement-chronic-disease-prevention-and-screening-in-primary-care-the-better-2-program-building-on-existing-tools-to-improve-chronic-disease-prevention-and-screening-in-primary-care
#20
Donna Patricia Manca, Denise Campbell-Scherer, Kris Aubrey-Bassler, Kami Kandola, Carolina Aguilar, Julia Baxter, Christopher Meaney, Ginetta Salvalaggio, June C Carroll, Vee Faria, Candace Nykiforuk, Eva Grunfeld
BACKGROUND: The Building on Existing Tools to Improve Chronic Disease Prevention and Screening in Family Practice (BETTER) trial demonstrated the effectiveness of an approach to chronic disease prevention and screening (CDPS) through a new skilled role of a 'prevention practitioner'(PP). The PP has appointments with patients 40-65 years of age that focus on primary prevention activities and screening of cancer (breast, colorectal, cervical), diabetes and cardiovascular disease and associated lifestyle factors...
2015: Implementation Science: IS
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