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https://www.readbyqxmd.com/read/29128968/involvement-of-cyclodipeptides-in-the-competition-of-bacterial-communities-in-the-oligotrophic-churince-aquatic-system-of-cuatro-ci%C3%A3-negas-basin-dominated-by-gammaproteobacteria
#1
Enrique Martínez-Carranza, Gabriel Y Ponce-Soto, Alma L Díaz-Pérez, Erasmo Cadenas, Valeria Souza, Jesús Campos-García
The Cuatro Ciénegas Basin (CCB) within the Chihuahuan Desert in México is an extremely oligotrophic oasis with negligible phosphorous levels, described as a hot spot of biodiversity, not only in stromatolites and microbial mats, but also in living forms in general. The microorganisms possess the capability to produce a wide variety of virulence factors, antibiotics, and quorum-sensing (QS) crosstalk signals such as non-ribosomal cyclodipeptides (CDPs) which enables them to colonize diverse ecological niches...
November 11, 2017: Extremophiles: Life Under Extreme Conditions
https://www.readbyqxmd.com/read/29106601/flexible-fate-commitment-of-e2-2high-common-dc-progenitors-implies-tuning-in-tissue-microenvironments
#2
Nobuyuki Onai, Jumpei Asano, Rumiko Kurosaki-Nakamura, Shoko Kuroda, Toshiaki Ohteki
The basic helix-loop-helix transcription factor E2-2 is essential for the development of plasmacytoid dendritic cells (pDCs) but not conventional DCs (cDCs). Here, we generated E2-2 reporter mice and demonstrated that an E2-2high fraction among common DC progenitors (CDPs), which are a major source of pDCs and cDCs in the steady state, strictly gave rise to pDCs in the presence of Flt3 ligand ex vivo or in the secondary lymphoid organs when transferred in vivo. However, in the small intestine, some of these E2-2high progenitors differentiated into cDCs that produced retinoic acid...
November 2, 2017: International Immunology
https://www.readbyqxmd.com/read/29065531/cyclodipeptides-an-overview-of-their-biosynthesis-and-biological-activity
#3
REVIEW
Awdhesh Kumar Mishra, Jaehyuk Choi, Seong-Jin Choi, Kwang-Hyun Baek
Cyclodipeptides (CDP) represent a diverse family of small, highly stable, cyclic peptides that are produced as secondary functional metabolites or side products of protein metabolism by bacteria, fungi, and animals. They are widespread in nature, and exhibit a broad variety of biological and pharmacological activities. CDP synthases (CDPSs) and non-ribosomal peptide synthetases (NRPSs) catalyze the biosynthesis of the CDP core structure, which is further modified by tailoring enzymes often associated with CDP biosynthetic gene clusters...
October 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29064250/mutations-of-residues-in-pocket-p1-of-a-cyclodipeptide-synthase-strongly-increase-product-formation
#4
Kirsten Brockmeyer, Shu-Ming Li
Expression of a cyclodipeptide synthase gene from Nocardiopsis prasina (CDPS-Np) in Escherichia coli resulted in the formation of cyclo-(l-Tyr-l-Tyr) (1) as the minor and cyclo-(l-Tyr-l-Phe) (2) as the major products. Site-directed mutagenesis revealed a strong influence on product accumulation of the amino acid residues in pocket P1. An 8-fold increase in product formation for 1 and 10-fold for 2 were detected in the double mutant T82V_Y196F compared with the wild type.
October 24, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/29032486/population-pharmacokinetics-of-subcutaneous-pasireotide-in-healthy-volunteers-and-cushing-s-disease-patients
#5
Jerry Nedelman, Roland Fisch, Ke Hu, Ines Paule, Jocelyn Zhou
BACKGROUND AND OBJECTIVE: Pasireotide (SOM230, Signifor(®)) is a somatostatin analog approved in a subcutaneous formulation for the treatment of Cushing's disease. This analysis characterizes the population pharmacokinetics (PopPK) of subcutaneous pasireotide jointly in healthy volunteers (HVs) and Cushing's disease patients (CDPs), evaluating the effects of age, body size, and population on pasireotide pharmacokinetics. METHODS: The analysis dataset included five phase I studies and one each from phase II and phase III...
October 14, 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/28962763/a-crosslinked-%C3%AE-cyclodextrin-polymer-used-for-rapid-removal-of-a-broad-spectrum-of-organic-micropollutants-from-water
#6
Zhanghui Wang, Peibin Zhang, Fan Hu, Yifan Zhao, Liping Zhu
Organic micropollutants in aquatic environment such as plasticizer, pesticide and pharmaceuticals, have posed a serious threat to human health and are emerging as a great challenge to humanity. Traditional water treatment techniques fail to achieve high removal efficiency for low concentration of organic micropollutants. Here we demonstrate a water-insoluble crosslinked β-cyclodextrin (β-CD) polymer able to remove a broad-spectrum of organic micropollutants from water by rapid adsorption. A family of β-CD polymers (β-CDPs) were synthesized by nucleophilic aromatic substitution of β-CD hydroxyl groups and 4,4'-difluorodiphenylsulfone...
December 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28962558/better-health-durham-protocol-for-a-cluster-randomized-trial-of-better-in-community-and-public-health-settings
#7
Lawrence Paszat, Rinku Sutradhar, Mary Ann O'Brien, Aisha Lofters, Andrew Pinto, Peter Selby, Nancy Baxter, Peter D Donnelly, Regina Elliott, Richard H Glazier, Robert Kyle, Donna Manca, Mary-Anne Pietrusiak, Linda Rabeneck, Nicolette Sopcak, Jill Tinmouth, Becky Wall, Eva Grunfeld
BACKGROUND: The Building on Existing Tools to Improve Chronic Disease Prevention and Screening (BETTER) cluster randomized trial in primary care settings demonstrated a 30% improvement in adherence to evidence-based Chronic Disease Prevention and Screening (CDPS) activities. CDPS activities included healthy activities, lifestyle modifications, and screening tests. We present a protocol for the adaptation of BETTER to a public health setting, and testing the adaptation in a cluster randomized trial (BETTER HEALTH: Durham) among low income neighbourhoods in Durham Region, Ontario (Canada)...
September 29, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28856890/cyclic-dipeptide-based-ambidextrous-supergelators-minimalistic-rational-design-structure-gelation-studies-and-in-situ-hydrogelation
#8
Shivaprasad Manchineella, N Arul Murugan, Thimmaiah Govindaraju
Ambidextrous supergelators are developed through structure-gelation screening of rationally designed cyclic dipeptides (CDPs). The organo- and hydrogels of CDPs were thoroughly characterized by their minimal gelation concentration (MGC) for organic and aqueous solvents, thermal stability (Tg), and viscoelastic properties. Intermolecular hydrogen bonding, the major driving force for gelation was evaluated using temperature-dependent nuclear magnetic resonance (NMR) spectroscopy. The contribution of attractive van der Waals interaction of tBoc group in driving CDP gelation was ascertained using β-cyclodextrin (β-CD)-adamantane carboxylic acid (AC)-based host-guest gelation and (1)H NMR studies...
September 14, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28819625/antagonistic-properties-of-some-halophilic-thermoactinomycetes-isolated-from-superficial-sediment-of-a-solar-saltern-and-production-of-cyclic-antimicrobial-peptides-by-the-novel-isolate-paludifilum-halophilum
#9
Donyez Frikha Dammak, Ziad Zarai, Soumaya Najah, Rayed Abdennabi, Lassaad Belbahri, Mostafa E Rateb, Hafedh Mejdoub, Sami Maalej
This study has focused on the isolation of twenty-three halophilic actinomycetes from two ponds of different salinity and the evaluation of their ability to exert an antimicrobial activity against both their competitors and several other pathogens. From the 23 isolates, 18 strains showed antagonistic activity, while 19 showed activities against one or more of the seven pathogen strains tested. Six strains exhibited consistent antibacterial activity against Gram-negative and Gram-positive pathogens characterized at the physiological and molecular levels...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28811757/cyclic-dipeptides-from-bacillus-vallismortis-bs07-require-key-components-of-plant-immunity-to-induce-disease-resistance-in-arabidopsis-against-pseudomonas-infection
#10
Seong Woo Noh, Rira Seo, Jung-Kwon Park, Md Maniruzzaman Manir, Kyungseok Park, Mee Kyung Sang, Surk-Sik Moon, Ho Won Jung
Cyclic dipeptides (CDPs) are one of the simplest compounds produced by living organisms. Plant-growth promoting rhizobacteria (PGPRs) also produce CDPs that can induce disease resistance. Bacillus vallismortis strain BS07 producing various CDPs has been evaluated as a potential biocontrol agent against multiple plant pathogens in chili pepper. However, plant signal pathway triggered by CDPs has not been fully elucidated yet. Here we introduce four CDPs, cyclo(Gly-L-Pro) previously identified from Aspergillus sp...
August 2017: Plant Pathology Journal
https://www.readbyqxmd.com/read/28695898/cdps-caspase-dependent-non-lethal-cellular-processes
#11
EDITORIAL
Lior Aram, Keren Yacobi-Sharon, Eli Arama
No abstract text is available yet for this article.
August 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28679537/a-cost-effectiveness-analysis-of-condom-distribution-programmes-for-the-prevention-of-sexually-transmitted-infections-in-england
#12
Susannah Sadler, Jon Tosh, Rebekah Pennington, Andrew Rawdin, Hazel Squires, Carmen Romero, Alastair Fischer, James Chilcott
BACKGROUND: Prevention of sexually transmitted infection (STI) incidence in England is a high priority, particularly among young people, men who have sex with men (MSM) and black ethnic minorities. An economic evaluation of condom distribution programmes (CDPs) to reduce STI transmission is presented. METHODS: An economic model using a Bernoulli process estimated the number of people acquiring an STI as a function of its prevalence, transmission rate, condom use, condom failure rate and number of sexual contacts...
July 5, 2017: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/28650175/bioactive-peptide-natural-products-as-lead-structures-for-medicinal-use
#13
Tam Dang, Roderich D Süssmuth
The need for new drugs for the treatment of various diseases is enormous. From the previous century until the present, numerous peptide and peptide-derived natural products have been isolated from bacteria and fungi. Hence, microorganisms play a pivotal role as sources for novel drugs with an emphasis on anti-infective agents. Various disciplines from biology, chemistry, and medicine are involved in early stages of the search for peptide natural products including taxonomy, microbiology, bioanalytics, bioinformatics, and medicinal chemistry...
June 26, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28632179/the-antiproliferative-effect-of-cyclodipeptides-from-pseudomonas-aeruginosa-pao1-on-hela-cells-involves-inhibition-of-phosphorylation-of-akt-and-s6k-kinases
#14
Laura Hernández-Padilla, Dolores Vázquez-Rivera, Luis A Sánchez-Briones, Alma L Díaz-Pérez, José Moreno-Rodríguez, Mario A Moreno-Eutimio, Victor Meza-Carmen, Homero Reyes-De la Cruz, Jesús Campos-García
Pseudomonas aeruginosa PAO1, a potential pathogen of plants and animals, produces the cyclodipeptides cyclo(l-Pro-l-Tyr), cyclo(l-Pro-l-Phe), and cyclo(l-Pro-l-Val) (PAO1-CDPs), whose effects have been implicated in inhibition of human tumor cell line proliferation. Our purpose was to investigate in depth in the mechanisms of HeLa cell proliferation inhibition by the PAO1-CDPs. The results indicate that PAO1-CDPs, both purified individually and in mixtures, inhibited HeLa cell proliferation by arresting the cell cycle at the G0-G1 transition...
June 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28623911/moderate-mental-illness-as-a-predictor-of-chronic-disease-prevention-and-screening
#15
Ginetta Salvalaggio, Christopher Meaney, Rahim Moineddin, Eva Grunfeld, Donna Manca
BACKGROUND: Primary care plays a pivotal role in the provision of both mental health care and chronic disease prevention and screening (CDPS). Unfortunately, moderate mental illness (MMI) is associated with poorer general health outcomes. Part of this burden of illness may be due to reduced CDPS uptake. The Building on the Existing Tools to Improve Chronic Disease Prevention in Primary Care (BETTER) trial recruited 777 participants ages 40-65 from 32 family practice panels, of whom 135 (18...
June 17, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28507514/markovian-analysis-of-the-sequential-behavior-of-the-spontaneous-spinal-cord-dorsum-potentials-induced-by-acute-nociceptive-stimulation-in-the-anesthetized-cat
#16
Mario Martin, Javier Béjar, Gennaro Esposito, Diógenes Chávez, Enrique Contreras-Hernández, Silvio Glusman, Ulises Cortés, Pablo Rudomín
In a previous study we developed a Machine Learning procedure for the automatic identification and classification of spontaneous cord dorsum potentials (CDPs). This study further supported the proposal that in the anesthetized cat, the spontaneous CDPs recorded from different lumbar spinal segments are generated by a distributed network of dorsal horn neurons with structured (non-random) patterns of functional connectivity and that these configurations can be changed to other non-random and stable configurations after the noceptive stimulation produced by the intradermic injection of capsaicin in the anesthetized cat...
2017: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/28034297/chemical-classification-of-cyclic-depsipeptides
#17
REVIEW
Lien Taevernier, Evelien Wynendaele, Bert Gevaert, Bart De Spiegeleer
Cyclic depsipeptides (CDPs) are a family of cyclic peptide-related compounds, of which the ring is mainly composed of amino- and hydroxy acid residues joined by amide and ester bonds (at least one), leading to a wide diversity of fascinating chemical structures. They differ in both their ring structure and their side chains, especially by the nature of the unusual and non-amino acid building blocks. To date, however, there is no overall uniform chemical classification system available for CDPs and naming of the diverse family members is done rather arbitrarily...
2017: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/27906041/implementation-of-the-better-2-program-a-qualitative-study-exploring-barriers-and-facilitators-of-a-novel-way-to-improve-chronic-disease-prevention-and-screening-in-primary-care
#18
Nicolette Sopcak, Carolina Aguilar, Mary Ann O'Brien, Candace Nykiforuk, Kris Aubrey-Bassler, Richard Cullen, Eva Grunfeld, Donna Patricia Manca
BACKGROUND: BETTER (Building on Existing Tools to Improve Chronic Disease Prevention and Screening in Primary Care) is a patient-based intervention to improve chronic disease prevention and screening (CDPS) for cardiovascular disease, diabetes, cancer, and associated lifestyle factors in patients aged 40 to 65. The key component of BETTER is a prevention practitioner (PP), a health care professional with specialized skills in CDPS who meets with patients to develop a personalized prevention prescription, using the BETTER toolkit and Brief Action Planning...
December 1, 2016: Implementation Science: IS
https://www.readbyqxmd.com/read/27900439/non-ribosomal-peptide-synthases-from-pseudomonas-aeruginosa-play-a-role-in-cyclodipeptide-biosynthesis-quorum-sensing-regulation-and-root-development-in-a-plant-host
#19
Omar González, Randy Ortíz-Castro, César Díaz-Pérez, Alma L Díaz-Pérez, Viridiana Magaña-Dueñas, José López-Bucio, Jesús Campos-García
Diverse molecules mediate cross-kingdom communication between bacteria and their eukaryotic partners and determine pathogenic or symbiotic relationships. N-acyl-L-homoserine lactone-dependent quorum-sensing signaling represses the biosynthesis of bacterial cyclodipeptides (CDPs) that act as auxin signal mimics in the host plant Arabidopsis thaliana. In this work, we performed bioinformatics, biochemical, and plant growth analyses to identify non-ribosomal peptide synthase (NRPS) proteins of Pseudomonas aeruginosa, which are involved in CDP synthesis...
April 2017: Microbial Ecology
https://www.readbyqxmd.com/read/27895718/consensus-diversity-plots-a-global-diversity-analysis-of-chemical-libraries
#20
Mariana González-Medina, Fernando D Prieto-Martínez, John R Owen, José L Medina-Franco
BACKGROUND: Measuring the structural diversity of compound databases is relevant in drug discovery and many other areas of chemistry. Since molecular diversity depends on molecular representation, comprehensive chemoinformatic analysis of the diversity of libraries uses multiple criteria. For instance, the diversity of the molecular libraries is typically evaluated employing molecular scaffolds, structural fingerprints, and physicochemical properties. However, the assessment with each criterion is analyzed independently and it is not straightforward to provide an evaluation of the "global diversity"...
2016: Journal of Cheminformatics
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