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https://www.readbyqxmd.com/read/27932656/draft-genome-sequences-of-two-historical-listeria-monocytogenes-strains-from-human-listeriosis-cases-in-1933
#1
Vikrant Dutta, Sangmi Lee, Todd J Ward, Nathane Orwig, Eric Altermann, Dereje Jima, Cameron Parsons, Sophia Kathariou
We report here the draft genome sequences of two Listeria monocytogenes strains from some of the earliest reported cases of human listeriosis in North America. The strains were isolated in 1933 from patients in Massachusetts and Connecticut, USA, and belong to the widely disseminated hypervirulent clonal complex 1 (CC1) and CC2.
December 8, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27932638/draft-genome-sequences-of-three-hypervirulent-carbapenem-resistant-klebsiella-pneumoniae-isolates-from-bacteremia
#2
Chaitra Shankar, Laura E B Nabarro, Naveen Kumar Devanga Ragupathi, Dhiviya Prabaa Muthuirulandi Sethuvel, Jones Lionel Kumar Daniel, George Priya Doss C, Balaji Veeraraghavan
Hypervirulent Klebsiella pneumoniae strains have been increasingly reported worldwide, and there is emergence of carbapenem resistance among them. Here, we report the genome sequences of three carbapenem-resistant hypervirulent K. pneumoniae isolates isolated from bacteremic patients at a tertiary-care center in South India.
December 8, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27923372/community-acquired-meningitis-caused-by-a-cg86-hypervirulent-klebsiella-pneumoniae-strain-first-case-report-in-the-caribbean
#3
Bénédicte Melot, Sylvain Brisse, Sébastien Breurec, Virginie Passet, Edith Malpote, Isabelle Lamaury, Guillaume Thiery, Bruno Hoen
BACKGROUND: Community-acquired bacterial meningitis due to Klebsiella pneumoniae has mainly been described in Southeast Asia and has a poor prognosis. Severe invasive infections caused by K. pneumoniae, including meningitis, are often due to hypervirulent strains (hvKP), which are characterized by capsular serotypes K1 and K2, a gene responsible for hypermucoviscosity, and the cluster for synthesis of the siderophore aerobactin. CASE PRESENTATION: A 55 year old man with a history of essential hypertension, benign prostate hyperplasia, hyperlipidemia, obstructive sleep apnea, and chronic alcoholism was admitted for meningitis due to Klebsiella pneumoniae with a wild-type susceptibility profile...
December 7, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27914959/virulence-traits-and-different-nle-profiles-in-cattle-and-human-verotoxin-producing-escherichia-coli-o157-h7-strains-from-argentina
#4
Juliana González, Andrea Mariel Sanso, Jimena Soledad Cadona, Ana Victoria Bustamante
Verotoxin-producing E. coli (VTEC) O157:H7 is the dominant serotype isolated from patients with HUS and, Argentina has the highest rate of HUS in the world. Molecular typing had allowed to identify subpopulations related to the origin and virulence of O157:H7 strains. Our aim was to perform a genetic characterization of 43 O157:H7 strains isolated in Argentine mostly from cattle and humans in order to establish the potential public health risk. For it, we used a combination of molecular subtyping methods in order to identify clade 8_rhsA (C3468G), LSPA-6 and virulence profiles and, a cytotoxicity assay on Vero cell...
November 30, 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27908697/clostridium-difficile-carriage-in-adult-cystic-fibrosis-cf-implications-for-patients-with-cf-and-the-potential-for-transmission-of-nosocomial-infection
#5
D G Burke, M J Harrison, C Fleming, M McCarthy, C Shortt, I Sulaiman, D M Murphy, J A Eustace, F Shanahan, C Hill, C Stanton, M C Rea, R P Ross, B J Plant
Clostridium difficile is an anaerobic Gram-positive, spore-forming, toxin-producing bacillus transmitted among humans through the faecal-oral route. Despite increasing carriage rates and the presence of C. difficile toxin in stool, patients with CF rarely appear to develop typical manifestations of C. difficile infection (CDI). In this study, we examined the carriage, toxin production, ribotype distribution and antibiotic susceptibility of C. difficile in a cohort of 60 adult patients with CF who were pre-lung transplant...
November 29, 2016: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/27897206/the-incidence-and-drug-resistance-of-clostridium-difficile-infection-in-mainland-china-a-systematic-review-and-meta-analysis
#6
Chenjie Tang, Lunbiao Cui, Yuqiao Xu, Le Xie, Pengfei Sun, Chengcheng Liu, Wenying Xia, Genyan Liu
It has been widely reported that the incidence and severity of Clostridium difficile infection (CDI) have increased dramatically in North America and Europe. However, little is known about CDI in Mainland China. In this study, we aimed to investigate the incidence of CDI and the main epidemic and drug-resistant strains of C. difficile in Mainland China through meta-analysis of related studies published after the year 2010. A total of 51 eligible studies were included. The pooled incidence of toxigenic C. difficile among patients with diarrhoea was 14% (95% CI = 12-16%)...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27895637/high-prevalence-of-esbl-producing-klebsiella-pneumoniae-causing-community-onset-infections-in-china
#7
Jing Zhang, Kai Zhou, Beiwen Zheng, Lina Zhao, Ping Shen, Jinru Ji, Zeqing Wei, Lanjuan Li, Jianying Zhou, Yonghong Xiao
The aim of this work was to investigate the epidemiological and genetic characteristics of ESBL-producing Klebsiella pneumoniae (ESBL-Kp) causing community-onset infections. K. pneumoniae isolates were collected from 31 Chinese secondary hospitals between August 2010 and 2011. Genes encoding ESBL and AmpC beta-lactamases were detected by PCR. The isolates were assigned to sequence types (STs) using multi-locus sequence typing (MLST). Eleven ESBL-Kp strains were selected for whole-genome sequencing (WGS) for investigating the genetic environment and plasmids encoding ESBL genes...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27880834/overexpressed-proteins-in-hypervirulent-clade-8-and-clade-6-strains-of-escherichia-coli-o157-h7-compared-to-e-coli-o157-h7-edl933-clade-3-strain
#8
Natalia Amigo, Qi Zhang, Ariel Amadio, Qunjie Zhang, Wanderson M Silva, Baiyuan Cui, Zhongjian Chen, Mariano Larzabal, Jinlong Bei, Angel Cataldi
Escherichia coli O157:H7 is responsible for severe diarrhea and hemolytic uremic syndrome (HUS), and predominantly affects children under 5 years. The major virulence traits are Shiga toxins, necessary to develop HUS and the Type III Secretion System (T3SS) through which bacteria translocate effector proteins directly into the host cell. By SNPs typing, E. coli O157:H7 was separated into nine different clades. Clade 8 and clade 6 strains were more frequently associated with severe disease and HUS. In this study, we aimed to identify differentially expressed proteins in two strains of E...
2016: PloS One
https://www.readbyqxmd.com/read/27876650/viruses-of-parasites-as-actors-in-the-parasite-host-relationship-a-m%C3%A3-nage-%C3%A3-trois
#9
REVIEW
Amaranta Gómez-Arreaza, Anne-Lise Haenni, Irene Dunia, Luisana Avilán
The complex parasite-host relationship involves multiple mechanisms. Moreover, parasites infected by viruses modify this relationship adding more complexity to the system that now comprises three partners. Viruses infecting parasites were described several decades ago. However, until recently little was known about the viruses involved and their impact on the resulting disease caused to the hosts. To clarify this situation, we have concentrated on parasitic diseases caused to humans and on how virus-infected parasites could alter the symptoms inflicted on the human host...
November 19, 2016: Acta Tropica
https://www.readbyqxmd.com/read/27860495/campylobacter-associated-diseases-in-animals
#10
Orhan Sahin, Michael Yaeger, Zuowei Wu, Qijing Zhang
Campylobacter includes a group of genetically diverse species causing a range of diseases in animals and humans. The bacterium is frequently associated with two economically important and epidemiologically distinct reproductive diseases in ruminants: enzootic infectious infertility in cattle owing to Campylobacter fetus subsp. venerealis and abortions in sheep, goats, and cattle. Septic abortion, usually epizootic in sheep, has been historically associated with C. fetus subsp. fetus and to a lesser extent with Campylobacter jejuni...
November 9, 2016: Annual Review of Animal Biosciences
https://www.readbyqxmd.com/read/27856595/draft-genome-sequence-of-pseudomonas-mosselii-gil3-isolated-from-catfish-and-antagonistic-against-hypervirulent-aeromonas-hydrophila
#11
Dunhua Zhang, De-Hai Xu, Junqiang Qiu, Cody R Rasmussen-Ivey, Mark R Liles, Benjamin H Beck
Pseudomonas mosselii Gil3 was isolated from a catfish that survived from lethal challenge with hypervirulent Aeromonas hydrophila (vAh). When assayed in vitro, the bacterium showed antagonism against vAh. Sequence analysis revealed that the genome of P. mosselii Gil3 encodes numerous aromatic metabolism pathways and proteins for biosynthesis of antimicrobial compounds.
November 17, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27848981/listeria-monocytogenes-sequence-type-1-is-predominant-in-ruminant-rhombencephalitis
#12
Margaux Dreyer, Lisandra Aguilar-Bultet, Sebastian Rupp, Claudia Guldimann, Roger Stephan, Alexandra Schock, Arthur Otter, Gertraud Schüpbach, Sylvain Brisse, Marc Lecuit, Joachim Frey, Anna Oevermann
Listeria (L.) monocytogenes is an opportunistic pathogen causing life-threatening infections in diverse mammalian species including humans and ruminants. As little is known on the link between strains and clinicopathological phenotypes, we studied potential strain-associated virulence and organ tropism in L. monocytogenes isolates from well-defined ruminant cases of clinical infections and the farm environment. The phylogeny of isolates and their virulence-associated genes were analyzed by multilocus sequence typing (MLST) and sequence analysis of virulence-associated genes...
November 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27834717/draft-genome-sequence-of-an-extended-spectrum-%C3%AE-lactamase-positive-hypervirulent-klebsiella%C3%A2-pneumoniae-strain-with-novel-sequence-type-2318-isolated-from-a-neonate
#13
Chaitra Shankar, Sridhar Santhanam, Manish Kumar, Vijay Gupta, Naveen Kumar Devanga Ragupathi, Balaji Veeraraghavan
Antimicrobial resistance among hypervirulent Klebsiella pneumoniae is increasingly reported. Here, we report the draft genome sequence of a hypervirulent K. pneumoniae strain isolated from a neonate with sepsis belonging to novel sequence type 2318 (ST2318).
November 10, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27807434/perplexing-metabolomes-in-fungal-insect-trophic-interactions-a-terra-incognita-of-mycobiocontrol-mechanisms
#14
REVIEW
Digar Singh, Su Y Son, Choong H Lee
The trophic interactions of entomopathogenic fungi in different ecological niches viz., soil, plants, or insect themselves are effectively regulated by their maneuvered metabolomes and the plethora of metabotypes. In this article, we discuss a holistic framework of co-evolutionary metabolomes and metabotypes to model the interactions of biocontrol fungi especially with mycosed insects. Conventionally, the studies involving fungal biocontrol mechanisms are reported in the context of much aggrandized fungal entomotoxins while the adaptive response mechanisms of host insects are relatively overlooked...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27803692/classification-of-a-hypervirulent-aeromonas-hydrophila-pathotype-responsible-for-epidemic-outbreaks-in-warm-water-fishes
#15
Cody R Rasmussen-Ivey, Mohammad J Hossain, Sara E Odom, Jeffery S Terhune, William G Hemstreet, Craig A Shoemaker, Dunhua Zhang, De-Hai Xu, Matt J Griffin, Yong-Jie Liu, Maria J Figueras, Scott R Santos, Joseph C Newton, Mark R Liles
Lineages of hypervirulent Aeromonas hydrophila (vAh) are the cause of persistent outbreaks of motile Aeromonas septicemia in warm-water fishes worldwide. Over the last decade, this virulent lineage of A. hydrophila has resulted in annual losses of millions of tons of farmed carp and catfish in the People's Republic of China and the United States (US). Multiple lines of evidence indicate US catfish and Asian carp isolates of A. hydrophila affiliated with sequence type 251 (ST251) share a recent common ancestor...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27795303/antibody-based-immunotherapy-to-treat-and-prevent-infection-with-hypervirulent-klebsiella-pneumoniae
#16
Elizabeth Diago-Navarro, Isabel Calatayud-Baselga, Donglei Sun, Camille Khairallah, Inderjit Mann, Amaia Ulacia-Hernando, Brian Sheridan, Meiqing Shi, Bettina C Fries
Hypervirulent Klebsiella pneumoniae (hvKp) strains are predicted to become a major threat in Asia if antibiotic resistance continues to spread. Anticapsular antibodies (Abs) were developed because disseminated infections caused by hvKp are associated with significant morbidity and mortality even with antibiotic sensitive strains. K1-serotype polysaccharide capsules (K1-CPS) are expressed by the majority of hvKp strains. In this study K1-CPS specific IgG Abs were generated by conjugation of K1-CPS to immunogenic Anthrax Protective Antigen (PA) protein...
October 26, 2016: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/27763806/rnaseq-reveals-hypervirulence-specific-host-responses-to-m-tuberculosis-infection
#17
Gina Leisching, Ray-Dean Pietersen, Carel van Heerden, Paul van Helden, Ian Wiid, Bienyameen Baker
The distinguishing factors that characterize the host response to infection with virulent Mycobacterium tuberculosis (M.tb) are largely confounding. We present an infection study with two genetically closely related M.tb strains that have vastly different pathogenic characteristics. The early host response to infection with these detergent-free cultured strains was analysed through RNAseq in an attempt to provide information on the subtleties which may ultimately contribute to the virulent phenotype. Murine bone marrow derived macrophages (BMDMs) were infected with either a hyper- (R5527) or hypovirulent (R1507) Beijing M...
October 20, 2016: Virulence
https://www.readbyqxmd.com/read/27758867/the-type-b-flagellin-of-hypervirulent-clostridium-difficile-is-modified-with-novel-sulfonated-peptidylamido-glycans
#18
Laura Bouché, Maria Panico, Paul Hitchen, Daniel Binet, Federico Sastre, Alexandra Faulds-Pain, Esmeralda Valiente, Evgeny Vinogradov, Annie Aubry, Kelly Fulton, Susan Twine, Susan M Logan, Brendan W Wren, Anne Dell, Howard R Morris
Glycosylation of flagellins is a well recognized property of many bacterial species. In this study, we describe the structural characterization of novel flagellar glycans from a number of hypervirulent strains of C. difficile We used mass spectrometry (nano-LC-MS and MS/MS analysis) to identify a number of putative glycopeptides that carried a variety of glycoform substitutions, each of which was linked through an initial N-acetylhexosamine residue to Ser or Thr. Detailed analysis of a LLDGSSTEIR glycopeptide released by tryptic digestion, which carried two variant structures, revealed that the glycopeptide contained, in addition to carbohydrate moieties, a novel structural entity...
December 2, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27756235/an-outbreak-of-pneumococcal-meningitis-among-older-children-%C3%A2-5%C3%A2-years-and-adults-after-the-implementation-of-an-infant-vaccination-programme-with-the-13-valent-pneumococcal-conjugate-vaccine-in-ghana
#19
Brenda Anna Kwambana-Adams, Franklin Asiedu-Bekoe, Badu Sarkodie, Osei Kuffour Afreh, George Khumalo Kuma, Godfred Owusu-Okyere, Ebenezer Foster-Nyarko, Sally-Ann Ohene, Charles Okot, Archibald Kwame Worwui, Catherine Okoi, Madikay Senghore, Jacob Kweku Otu, Chinelo Ebruke, Richard Bannerman, Kwame Amponsa-Achiano, David Opare, Gemma Kay, Timothy Letsa, Owen Kaluwa, Ebenezer Appiah-Denkyira, Victor Bampoe, Syed M A Zaman, Mark J Pallen, Umberto D'Alessandro, Jason M Mwenda, Martin Antonio
BACKGROUND: An outbreak of pneumococcal meningitis among non-infant children and adults occurred in the Brong-Ahafo region of Ghana between December 2015 and April 2016 despite the recent nationwide implementation of a vaccination programme for infants with the 13-valent pneumococcal conjugate vaccine (PCV13). METHODS: Cerebrospinal fluid (CSF) specimens were collected from patients with suspected meningitis in the Brong-Ahafo region. CSF specimens were subjected to Gram staining, culture and rapid antigen testing...
October 18, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27716140/longitudinal-survey-of-clostridium-difficile-presence-and-gut-microbiota-composition-in-a-belgian-nursing-home
#20
Cristina Rodriguez, Bernard Taminiau, Nicolas Korsak, Véronique Avesani, Johan Van Broeck, Philippe Brach, Michel Delmée, Georges Daube
BACKGROUND: Increasing age, several co-morbidities, environmental contamination, antibiotic exposure and other intestinal perturbations appear to be the greatest risk factors for C. difficile infection (CDI). Therefore, elderly care home residents are considered particularly vulnerable to the infection. The main objective of this study was to evaluate and follow the prevalence of C. difficile in 23 elderly care home residents weekly during a 4-month period. A C. difficile microbiological detection scheme was performed along with an overall microbial biodiversity study of the faeces content by 16S rRNA gene analysis...
October 1, 2016: BMC Microbiology
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