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https://www.readbyqxmd.com/read/29744043/genome-based-analysis-of-carbapenemase-producing-klebsiella-pneumoniae-isolates-from-german-hospital-patients-2008-2014
#1
Laura Becker, Martin Kaase, Yvonne Pfeifer, Stephan Fuchs, Annicka Reuss, Anja von Laer, Muna Abu Sin, Miriam Korte-Berwanger, Sören Gatermann, Guido Werner
Background: By using whole genome sequence data we aimed at describing a population snapshot of carbapenemase-producing K. pneumoniae isolated from hospitalized patients in Germany between 2008 and 2014. Methods: We selected a representative subset of 107 carbapenemase-producing K. pneumoniae clinical isolates possessing the four most prevalent carbapenemase types in Germany (KPC-2, KPC-3, OXA-48, NDM-1). Isolates were processed via illumina NGS. Data were analysed using different SNP-based mapping and de-novo assembly approaches...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29735827/molecular-characterisation-for-clonality-and-transmission-dynamics-of-an-outbreak-of-klebsiella-pneumoniae-amongst-neonates-in-a-tertiary-care-centre-in-south-india
#2
Chaitra Shankar, Manish Kumar, Ashtawarthani Baskaran, Miracle Magdelene Paul, Nithya Ponmudi, Sridhar Santhanam, Joy Sarojini Michael, Balaji Veeraraghavan
Purpose: Sepsis is a significant cause of morbidity and mortality amongst neonates. Klebsiella pneumoniae is a common cause of nosocomial outbreaks causing bacteraemia and having potential of acquiring plasmids enhancing antimicrobial resistance. In the present study, we investigate K. pneumoniae outbreak causing bacteraemia amongst neonates over a span of 2 months. Isolates were characterised for antimicrobial resistance, virulence, molecular typing for clonality and plasmid typing for transmission dynamics, and patient outcome was investigated...
January 2018: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29712659/carbapenem-resistant-hypervirulent-klebsiella-pneumoniae-of-sequence-type-36
#3
Yu Feng, Yang Lu, Zhihong Yao, Zhiyong Zong
ST36 Klebsiella pneumoniae distributes worldwide. We found that a ST36 K. pneumoniae clinical isolate was carbapenem resistant, carried bla KPC-2 , had mucoid regulator gene rmpA and exhibited high virulence. The findings suggest the emergence of carbapenem-resistant hypervirulent K. pneumoniae of ST36 and surveillance on carbapenem-resistant hypervirulent K. pneumoniae is required.
April 30, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29708041/comparative-analysis-of-klebsiella-pneumoniae-strains-isolated-in-2012-2016-that-differ-by-antibiotic-resistance-genes-and-virulence-genes-profiles
#4
Anastasia I Lev, Eugeny I Astashkin, Angelina A Kislichkina, Ekaterina V Solovieva, Tatiana I Kombarova, Olga V Korobova, Olga N Ershova, Irina A Alexandrova, Vladimir E Malikov, Alexander G Bogun, Alexander I Borzilov, Nikolay V Volozhantsev, Edward A Svetoch, Nadezhda K Fursova
The antibacterial resistance and virulence genotypes and phenotypes of 148 non-duplicate Klebsiella pneumoniae strains collected from 112 patients in Moscow hospitals in 2012-2016 including isolates from the respiratory system (57%), urine (30%), wounds (5%), cerebrospinal fluid (4%), blood (3%), and rectal swab (1%) were determined. The majority (98%) were multidrug resistant (MDR) strains carrying blaSHV (91%), blaCTX-M (74%), blaTEM (51%), blaOXA (38%), and blaNDM (1%) beta-lactamase genes, class 1 integrons (38%), and the porin protein gene ompK36 (96%)...
April 30, 2018: Pathogens and Global Health
https://www.readbyqxmd.com/read/29703246/clostridium-difficile-cure-with-fecal-microbiota-transplantation-in-a-child-with-pompe-disease-a-case-report
#5
D E Dow, P C Seed
BACKGROUND: Recurrent Clostridium difficile infection is a growing problem among children due to both the increasing survival of medically fragile children with complicated chronic medical conditions resulting in prolonged antibiotic exposure and hospitalization and the emergence of strains of Clostridium difficile that are hypervirulent and associated with high rates of relapse. CASE PRESENTATION: This case describes a medically complex 21-month-old Hispanic girl with Pompe disease and B cell immunodeficiency with recurrent Clostridium difficile infection refractory to antimicrobial management...
April 28, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29702577/genotypic-features-of-clinical-and-bovine-escherichia-coli-o157-strains-isolated-in-countries-with-different-associated-disease-incidences
#6
REVIEW
Luis Pianciola, Marta Rivas
There is great geographical variation in the frequency of Escherichia coli O157 infections that correlates with important differences in the bovine reservoir of each country. Our group carried out a broad molecular characterization of human and bovine E. coli O157 strains circulating in Argentina using different methodologies. Our data allows us to conclude that in Argentina, a high homogeneity is observed in both cattle and human strains, with almost exclusive circulation of strains belonging to the hypervirulent clade 8 described by Manning...
April 27, 2018: Microorganisms
https://www.readbyqxmd.com/read/29683780/emergence-of-the-third-generation-cephalosporin-resistant-hypervirulent-klebsiella-pneumoniae-due-to-the-acquisition-of-a-self-transferable-bla-dha-1-carrying-plasmid-by-an-st23-strain
#7
Yingzhou Xie, Lijun Tian, Gang Li, Hongping Qu, Jingyong Sun, Wei Liang, Xiaobin Li, Xiaoli Wang, Zixin Deng, Jialin Liu, Hong-Yu Ou
No abstract text is available yet for this article.
December 31, 2018: Virulence
https://www.readbyqxmd.com/read/29678299/molecular-epidemiology-of-klebsiella-pneumoniae-k1-and-k2-isolates-in-japan
#8
Sohei Harada, Yoshikazu Ishii, Tomoo Saga, Kotaro Aoki, Kazuhiro Tateda
Although severe infections caused by hypervirulent Klebsiella pneumoniae isolates, such as K1 isolates belonging to sequence type (ST) 23, have been a significant problem in Asian countries, epidemiology of these isolates in Japan remains unclear. We performed a nationwide molecular epidemiological study of K. pneumoniae K1 and K2 isolates in Japan. Of the 259K. pneumoniae isolates collected, 14 and 16 isolates were identified as capsular genotypes K1 and K2, respectively. All K1 isolates were ST23 or its closely related clones and showed high genetic similarity by pulsed-field gel electrophoresis (PFGE) and the DiversiLab system (DL)...
March 20, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29671715/potential-of-double-crested-cormorants-phalacrocorax-auritus-american-white-pelicans-pelecanus-erythrorhynchos-and-wood-storks-mycteria-americana-to-transmit-a-hypervirulent-strain-of-aeromonas-hydrophila-between-channel-catfish-culture-ponds
#9
Fred L Cunningham, Madison M Jubirt, Katie C Hanson-Dorr, Lorelei Ford, Paul Fioranelli, Larry A Hanson
Aeromonas hydrophila is a Gram-negative bacterium ubiquitous to freshwater and brackish aquatic environments that can cause disease in fish, humans, reptiles, and birds. Recent severe outbreaks of disease in commercial channel catfish ( Ictalurus punctatus) aquaculture ponds have been associated with a hypervirulent Aeromonas hydrophila strain (VAH) that is genetically distinct from less virulent strains. The epidemiology of this disease has not been determined. Given that research has shown that Great Egrets ( Ardea alba) can shed viable hypervirulent A...
April 19, 2018: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/29666282/listeria-monocytogenes-source-distribution-analysis-indicates-regional-heterogeneity-and-ecological-niche-preference-among-serotype-4b-clones
#10
Sangmi Lee, Yi Chen, Lisa Gorski, Todd J Ward, Jason Osborne, Sophia Kathariou
Biodiversity analysis of the foodborne pathogen Listeria monocytogenes recently revealed four serotype 4b major hypervirulent clonal complexes (CCs), i.e., CC1, CC2, CC4, and CC6. Hypervirulence was indicated by overrepresentation of these clones, and serotype 4b as a whole, among human clinical isolates in comparison to food. However, data on potential source-dependent partitioning among serotype 4b clones in diverse regions are sparse. We analyzed a panel of 347 serotype 4b isolates, primarily from North America, to determine the distribution of clones in humans, other animals, food, and water...
April 17, 2018: MBio
https://www.readbyqxmd.com/read/29618511/structural-and-functional-delineation-of-aerobactin-biosynthesis-in-hypervirulent-klebsiella-pneumoniae
#11
Daniel C Bailey, Evan Alexander, Matthew R Rice, Eric J Drake, Lisa S Mydy, Courtney C Aldrich, Andrew M Gulick
Aerobactin, a citryl-hydroxamate siderophore, is produced by a number of pathogenic Gram-negative bacteria to aid in iron assimilation. Interest in this well-known siderophore was reignited by recent investigations suggesting that it plays a key role in mediating the enhanced virulence of a hypervirulent pathotype of Klebsiella pneumoniae (hvKP). In contrast to classical opportunistic strains of Klebsiella pneumoniae, hvKP causes serious life-threatening infections in previously healthy individuals in the community...
April 4, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29610254/hypervirulent-group-a-streptococcus-of-genotype-emm-3-invades-the-vascular-system-in-pulmonary-infection-of-mice
#12
Benfang Lei, Dylan Minor, Wenchao Feng, Mengyao Liu
Natural mutations of the two-component regulatory system CovRS are frequently associated with invasive Group A Streptococcus (GAS) isolates and lead to the enhancement in virulence gene expression, innate immune evasion, systemic dissemination, and virulence. How CovRS mutations enhance systemic dissemination is not well understood. A hypervirulent GAS isolate of the emm3 genotype, MGAS315, was characterized using a mouse model of pulmonary infection to understand systemic dissemination. This strain has a G1370T mutation in the sensor kinase covS gene of CovRS...
April 2, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29599157/draft-genome-sequence-of-an-ndm-1-and-kpc-2-coproducing-hypervirulent-carbapenem-resistant-klebsiella-pneumoniae-strain-isolated-from-burn-wound-infections
#13
Dan-Dan Wei, La-Gen Wan, Yang Liu
We report here the draft genome sequence of an NDM-1- and KPC-2-coproducing hypervirulent carbapenem-resistant Klebsiella pneumoniae strain, isolated from a 58-year-old male in the People's Republic of China with a burn injury.
March 29, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29593684/group-b-streptococcal-colonization-molecular-characteristics-and-epidemiology
#14
REVIEW
Sarah Shabayek, Barbara Spellerberg
Streptococcus agalactiae or group B streptococcus (GBS) is a leading cause of serious neonatal infections. GBS is an opportunistic commensal constituting a part of the intestinal and vaginal physiologic flora and maternal colonization is the principal route of GBS transmission. GBS is a pathobiont that converts from the asymptomatic mucosal carriage state to a major bacterial pathogen causing severe invasive infections. At present, as many as 10 serotypes (Ia, Ib, and II-IX) are recognized. The aim of the current review is to shed new light on the latest epidemiological data and clonal distribution of GBS in addition to discussing the most important colonization determinants at a molecular level...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29571838/multidrug-resistant-infections-in-long-term-care-facilities-extended-spectrum-%C3%AE-lactamase-producing-enterobacteriaceae-and-hypervirulent-antibiotic-resistant-clostridium-difficile
#15
Maria Giufrè, Marisa Accogli, Enrico Ricchizzi, Fabrizio Barbanti, Claudio Farina, Paolo Fazii, Romano Mattei, Mario Sarti, Agostino Barozzi, Rossella Buttazzi, Marina Cosentino, Maria Nardone, Vincenzo Savini, Patrizia Spigaglia, Maria Luisa Moro, Marina Cerquetti
Infections due to multidrug-resistant (MDR) organisms in long-term care facilities (LTCFs) residents constitute a public health concern. This multicenter study investigated the frequency of ESBL-producing pathogens and MDR Clostridium difficile in clinical specimens from LTCF residents in Italy. During October 2014-March 2015, all urine and diarrheic fecal samples from LTCF residents (≥65 years) with suspected urinary tract infection or C. difficile infection, respectively, received for diagnosis by 4 hospital laboratories located in different cities were analyzed...
February 26, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29563724/hypervirulent-regulator-of-mucoid-phenotype-a-positive-klebsiella-pneumoniae-liver-abscess
#16
Manesh Abi, Shankar Chaitra, Leb Nabarro, M Varghese George, Veeraraghavan Balaji
No abstract text is available yet for this article.
January 2018: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/29555697/the-influence-of-chemotaxis-and-swimming-patterns-on-the-virulence-of-the-coral-pathogen-vibrio-coralliilyticus
#17
Blake Ushijima, Claudia C Häse
Chemotaxis, the directed movement towards or away from a chemical signal, can be essential to bacterial pathogens for locating hosts or avoiding hostile environments. The coral pathogen Vibrio coralliilyticus chemotaxes towards coral mucus; however, chemotaxis has not been experimentally demonstrated to be important for virulence. To further examine this, in-frame mutations were constructed in genes predicted to be important for V. coralliilyticus chemotaxis. Most Vibrio genomes encode multiple homologs of various chemotaxis-related genes and two paralogs of each for cheB , cheR , and cheA were identified...
March 19, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29553310/evolution-of-sequence-type-4821-clonal-complex-meningococcal-strains-in-china-from-prequinolone-to-quinolone-era-1972-2013
#18
Qinglan Guo, Mustapha M Mustapha, Mingliang Chen, Di Qu, Xi Zhang, Min Chen, Yohei Doi, Minggui Wang, Lee H Harrison
The expansion of hypervirulent sequence type 4821 clonal complex (CC4821) lineage Neisseria meningitidis bacteria has led to a shift in meningococcal disease epidemiology in China, from serogroup A (MenA) to MenC. Knowledge of the evolution and genetic origin of the emergent MenC strains is limited. In this study, we subjected 76 CC4821 isolates collected across China during 1972-1977 and 2005-2013 to phylogenetic analysis, traditional genotyping, or both. We show that successive recombination events within genes encoding surface antigens and acquisition of quinolone resistance mutations possibly played a role in the emergence of CC4821 as an epidemic clone in China...
April 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29537694/presence-and-characterization-of-klebsiella-pneumoniae-from-the-intestinal-tract-of-diarrhea-patients
#19
Xinfeng Zhang, Lei Wang, Renpeng Li, Peiqiang Hou, Yuanqing Zhang, Ming Fang, Bin Hu
The objective of this study was to investigate the presence and characterization of Klebsiella pneumoniae (KP) from the intestinal tract. 43 KP strains were isolated from 551 stool specimens from diarrhea patients from 2013 to 2016,with a carriage rate of 7.80%. All isolates were hypervirulent KP (hvKp) strains with hypermucoviscosity (HM) phenotype. The virulence factors and antibiotic resistance exhibited diverse distribution. 2.33% (1/43), 2.33% (1/43), 6.98% (3/43), 6.98% (3/43), 4.65% (2/43), 11.63% (5/43) and 18...
March 14, 2018: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29524654/binary-clostridium-difficile-toxin-cdt-a-virulence-factor-disturbing-the-cytoskeleton
#20
Klaus Aktories, Panagiotis Papatheodorou, Carsten Schwan
Clostridium difficile infection causes antibiotics-associated diarrhea and pseudomembranous colitis. Major virulence factors of C. difficile are the Rho-glucosylating toxins TcdA and TcdB. In addition, many, so-called hypervirulent C. difficile strains produce the binary actin-ADP-ribosylating toxin CDT. CDT causes depolymerization of F-actin and rearrangement of the actin cytoskeleton. Thereby, many cellular functions, which depend on actin, are altered. CDT disturbs the dynamic balance between actin and microtubules in target cells...
March 7, 2018: Anaerobe
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