Jae Hyun Kim, Heewon Jeong, Yoon-Hee Choo, Moinay Kim, Eun Jin Ha, Jiwoong Oh, Youngbo Shim, Seung Bin Kim, Han-Gil Jung, So Hee Park, Jung Ook Kim, Junhyung Kim, Hye Seon Kim, Seungjoo Lee
Mannitol, derived from mannose sugar, is crucial in treating patients with elevated intracranial pressure (ICP). Its dehydrating properties at the cellular and tissue levels increase plasma osmotic pressure, which is studied for its potential to reduce ICP through osmotic diuresis. While clinical guidelines support mannitol use in these cases, the best approach for its application continues to be debated. Important aspects needing further investigation include: 1) bolus administration versus continuous infusion, 2) ICP-based dosing versus scheduled bolus, 3) identifying the optimal infusion rate, 4) determining the appropriate dosage, 5) establishing fluid replacement plans for urinary loss, and 6) selecting monitoring techniques and thresholds to assess effectiveness and ensure safety...
June 2023: Korean Journal of Neurotrauma