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Near Death Experiences

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https://www.readbyqxmd.com/read/29242248/causes-of-death-after-a-hospitalization-with-aki
#1
Samuel A Silver, Ziv Harel, Eric McArthur, Danielle M Nash, Rey Acedillo, Abhijat Kitchlu, Amit X Garg, Glenn M Chertow, Chaim M Bell, Ron Wald
Mortality after AKI is high, but the causes of death are not well described. To better understand causes of death in patients after a hospitalization with AKI and to determine patient and hospital factors associated with mortality, we conducted a population-based study of residents in Ontario, Canada, who survived a hospitalization with AKI from 2003 to 2013. Using linked administrative databases, we categorized cause of death in the year after hospital discharge as cardiovascular, cancer, infection-related, or other...
December 14, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29235388/early-outcomes-of-the-t-branch-off-the-shelf-multibranched-stent-graft-in-urgent-thoracoabdominal-aortic-aneurysm-repair
#2
Konstantinos Spanos, Tilo Kölbel, Myrto Theodorakopoulou, Franziska Heidemann, Fiona Rohlffs, Eike Sebastian Debus, Nikolaos Tsilimparis
PURPOSE: To assess the short-term outcomes of the multibranched off-the-shelf t-Branch stent-graft for urgent thoracoabdominal aortic aneurysm (TAAA) repair and to evaluate the impact on outcomes of the learning curve and adherence to the instruction for use (IFU). METHODS: Between 2014 and 2017, 42 patients (mean age 73.3±7 years; 26 men) underwent urgent TAAA treatment using the t-Branch stent-graft [18 in the early (2014-2015) period and 24 in the late (2016-2017) period]...
December 1, 2017: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/29201415/contraceptive-utilization-and-associated-factors-among-women-of-reproductive-age-group-in-southern-nations-nationalities-and-peoples-region-ethiopia-cross-sectional-survey-mixed-methods
#3
Misganu Endriyas, Akine Eshete, Emebet Mekonnen, Tebeje Misganaw, Mekonnen Shiferaw, Sinafikish Ayele
Background: Though contraceptive utilization has comprehensive benefit for women, it was one of underutilized public intervention in Ethiopia and in the study area. Thus, assessing status and factors affecting contraceptive utilization among women of reproductive age group was found key step for program improvement. Methods: Community based cross-sectional study was conducted from March to April, 2015 in Southern Nations and Nationalities Peoples' Region, Ethiopia...
2017: Contraception and Reproductive Medicine
https://www.readbyqxmd.com/read/29188026/is-temperature-an-important-variable-in-recovery-after-mild-traumatic-brain-injury
#4
REVIEW
Coleen M Atkins, Helen M Bramlett, W Dalton Dietrich
With nearly 42 million mild traumatic brain injuries (mTBIs) occurring worldwide every year, understanding the factors that may adversely influence recovery after mTBI is important for developing guidelines in mTBI management. Extensive clinical evidence exists documenting the detrimental effects of elevated temperature levels on recovery after moderate to severe TBI. However, whether elevated temperature alters recovery after mTBI or concussion is an active area of investigation. Individuals engaged in exercise and competitive sports regularly experience body and brain temperature increases to hyperthermic levels and these temperature increases are prolonged in hot and humid ambient environments...
2017: F1000Research
https://www.readbyqxmd.com/read/29178334/suppression-of-oxidative-phosphorylation-confers-resistance-against-bevacizumab-in-experimental-glioma
#5
Jule A Eriksson, Christina Wanka, Michael C Burger, Hans Urban, Ines Hartel, Janusz von Renesse, Patrick N Harter, Michel Mittelbronn, Joachim P Steinbach, Johannes Rieger
Although bevacizumab initially shows high response rates in gliomas and other tumors, therapy resistance usually develops later. Because antiangiogenic agents are supposed to induce hypoxia, we asked whether rendering glioma cells independent of oxidative phosphorylation modulates their sensitivity against hypoxia and bevacizumab. LNT-229 glioma cells without functional mitochondria (rho0 ) and control (rho+ ) cells were generated. LNT-229 rho0 -cells displayed reduced expression of oxidative phosphorylation-related genes and diminished oxygen consumption...
November 27, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29175140/comparison-of-in-vivo-targeting-ability-between-crgd-and-collagen-targeting-peptide-conjugated-nano-carriers-for-atherosclerosis
#6
Manse Kim, Abhishek Sahu, Gi Beom Kim, Gi Hoon Nam, Wooram Um, So Jin Shin, Yong Yeon Jeong, In-San Kim, Kwangmeyung Kim, Ick Chan Kwon, Giyoong Tae
Atherosclerosis plaque is a major cause of cardiovascular diseases across the globe and a silent killer. There are no physical symptoms of the disease in its early stage and current diagnostic techniques cannot detect the small plaques effectively or safely. Plaques formed in blood vessels can cause serious clinical problems such as impaired blood flow or sudden death, regardless of their size. Thus, detecting early stage of plaques is especially more important to effectively reduce the risk of atherosclerosis...
November 21, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29174783/improving-results-of-surgery-for-ebstein-anomaly-where-are-we-after-235-cone-repairs
#7
Kimberly A Holst, Joseph A Dearani, Sameh Said, Roxann B Pike, Heidi M Connolly, Bryan C Cannon, Kristen L Sessions, Megan M O'Byrne, Patrick W O'Leary
BACKGROUND: Ebstein anomaly has heterogeneous anatomy and numerous operative techniques are described. Cone repair provides a near anatomic tricuspid valve repair. The purpose of this study was to examine our experience with cone repair. METHODS: Cone repair was performed in 235 consecutive patients with Ebstein anomaly, 134 children (57%) and 101 adults (43%), from June 2007 to October 2015. Median age was 15.6 years (range, 6 months to 73 years). Cone repair was the first operation in 192 patients (82%), the second in 41 (17%), and the third in 2 (1%)...
November 23, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29173831/an-exploration-of-medical-emergency-team-intervention-at-the-end-of-life-for-people-with-advanced-cancer
#8
Christine Brown, Allison Drosdowsky, Meinir Krishnasamy
PURPOSE: Recent advances in cancer therapies offer survival benefit when cure is no longer possible. The contribution of the Medical Emergency Teams (METs) in the context of advancing disease has received little empirical consideration. This study set out to explore MET intervention at the end of life for people with advanced cancer in an Australian comprehensive cancer centre, and its impact on quality of death. METHOD: A retrospective medical chart review was undertaken to explore MET response for people with advanced (incurable) cancer nearing end of life...
December 2017: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/29166390/criticism-by-community-people-and-poor-workplace-communication-as-risk-factors-for-the-mental-health-of-local-welfare-workers-after-the-great-east-japan-earthquake-a-cross-sectional-study
#9
Ikki Ueda, Atsushi Sakuma, Yoko Takahashi, Wataru Shoji, Ayami Nagao, Mikika Abe, Yuriko Suzuki, Hiroo Matsuoka, Kazunori Matsumoto
After a large-scale natural disaster, demand for social welfare services increases, and the mental health of local social welfare workers becomes a matter of great concern because of their dual role as support providers and disaster survivors. We examined whether work-related social stressors, including criticism by community people and poor workplace communication, were associated with increased risk of post-traumatic stress disorder (PTSD), depression, or psychological distress 20-22 months after the Great East Japan Earthquake (GEJE; March 11, 2011) in local social welfare workers...
2017: PloS One
https://www.readbyqxmd.com/read/29095071/n-n-dimethyltryptamine-and-the-pineal-gland-separating-fact-from-myth
#10
David E Nichols
The pineal gland has a romantic history, from pharaonic Egypt, where it was equated with the eye of Horus, through various religious traditions, where it was considered the seat of the soul, the third eye, etc. Recent incarnations of these notions have suggested that N,N-dimethyltryptamine is secreted by the pineal gland at birth, during dreaming, and at near death to produce out of body experiences. Scientific evidence, however, is not consistent with these ideas. The adult pineal gland weighs less than 0...
October 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29078888/long-term-survival-after-resection-of-sarcomatoid-carcinoma-of-the-pancreas-an-updated-experience
#11
Alex B Blair, Richard A Burkhart, James F Griffin, James A Miller, Matthew J Weiss, John L Cameron, Christopher L Wolfgang, Jin He
BACKGROUND: Sarcomatoid carcinoma of the pancreas (SCP) is a rare histologic subtype of undifferentiated pancreatic carcinoma. Historically, this has been associated with a worse overall prognosis than adenocarcinoma. However, the clinical course and surgical outcomes of SCP remain poorly characterized owing to its rarity. METHODS: A single-institution, prospectively maintained database was queried for patients who underwent pancreatic resection with a final diagnosis of SCP...
November 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29065871/q-a-cellular-near-death-experiences-what-is-anastasis
#12
Gongping Sun, Denise J Montell
Apoptosis is a form of programmed cell death that is carried out by proteolytic enzymes called caspases. Executioner caspase activity causes cells to shrink, bleb, and disintegrate into apoptotic bodies and has been considered a point of no return for apoptotic cells. However, relatively recent work has shown that cells can survive transient apoptotic stimuli, even after executioner caspase activation. This process is called anastasis. In this Q&A, we answer common questions that arise regarding anastasis, including how it is defined, the origin of the name, the potential physiological consequences, molecular mechanisms, and open questions for this new field of study...
October 24, 2017: BMC Biology
https://www.readbyqxmd.com/read/29045916/suicide-deaths-among-patients-with-end-stage-renal-disease-receiving-dialysis-a-population-based-retrospective-cohort-study-of-64-000-patients-in-taiwan
#13
I-Ming Chen, Po-Hsien Lin, Vin-Cent Wu, Chi-Shin Wu, Jia-Chi Shan, Shu-Sen Chang, Shih-Cheng Liao
BACKGROUND: Patients with end-stage renal disease (ESRD) who receive dialysis may experience increased distress and risk of suicide. METHODS: This population-based retrospective cohort study linked Taiwan's national register of ESRD patients on dialysis and the cause-of-death mortality data file. A separate multiple-cause-of-death data file was used to investigate the detailed suicide methods used. Standardized mortality ratios (SMRs) were calculated for the overall patient group and by sex, age, year of initiating dialysis, method of suicide, and time since initiation of dialysis...
October 9, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29044801/differential-physiological-responses-to-central-leptin-overexpression-in-male-and-female-rats
#14
Isabelle Côté, Sara M Green, Hale Z Toklu, Drake Morgan, Christy S Carter, Nihal Tümer, Philip J Scarpace
Brains of females are more sensitive to the acute catabolic actions of leptin. However, sex differences in the long-term physiological responses to central leptin receptor modulation are unknown. To this end, we centrally delivered a viral vector to overexpress leptin (Leptin), a neutral leptin receptor antagonist (Leptin-Antagonist), or a green fluorescence protein (Control). We examined chronic changes in body weight and composition in male and female rats. Females displayed greater and sustained responses to Leptin whereas males rapidly lost physiological effects and developed leptin resistance confirmed by lower acute leptin-mediated phosphorylation of STAT3 (P-STAT3)...
October 17, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29040114/association-of-adverse-childhood-experiences-with-co-occurring-health-conditions-in-early-childhood
#15
Melissa A Bright, Lindsay A Thompson
OBJECTIVE: To understand how adverse childhood experiences (ACEs) are associated with co-occurring physical, mental and developmental problems during early childhood. METHOD: A subsample of 19,957 children aged 2-5 years were selected from the 2011-2012 National Survey for Child Health. Outcomes included 18 health conditions organized in singular condition domains (physical, mental, and developmental), and combinations of condition domains (e.g., physical plus mental, mental plus developmental, etc...
October 11, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/29026675/advantages-of-using-a-detachable-tip-microcatheter-and-liquid-embolic-agents-in-the-preoperative-embolization-of-a-recurrent-cerebellar-hemangioblastoma-a-case-report
#16
Nicolas Yanez, Luisa K Cifuentes, Marcela Mejia, Juan N Useche
BACKGROUND: The preferred treatment for intracranial hemangioblastomas is surgical resection with or without preoperative embolization, however, embolization remains controversial due to risks such as distal tip entrapment, vascular injury during navigation, and embolic agent migration. CASE DESCRIPTION: A 54-year-old woman was admitted for surgical resection and preoperative embolization of a cerebellar hemangioblastoma. Although experience using Onyx with detachable and nondetachable tip microcatheters has been well reported in a variety of clinical circumstances, we describe the first case of a presurgical embolization of an intra-axial tumor using a second-generation detachable-tip microcatheter and a nonadhesive liquid embolic agent...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28988657/experiences-of-surviving-a-cardiac-arrest-after-therapeutic-hypothermia-treatment-an-interview-study
#17
Margareta Brännström, Camilla Niederbach, Ann-Charlotte Rödin
BACKGROUND: Cardiac arrest (CA) is often associated with high mortality. In Sweden, it is reported that 13-52 per 100,000 people suffer out-of-hospital CA, and survival to one month is 2-14%. OBJECTIVE: This study aimed to describe people's experiences of surviving a CA after therapeutic hypothermia treatment. METHOD: A descriptive qualitative design was used. Data were collected through individual interviews with seven CA survivors. The collected data were analyzed using qualitative content analysis...
October 4, 2017: International Emergency Nursing
https://www.readbyqxmd.com/read/28976794/multicenter-validation-of-enhancer-of-zeste-homolog-2-expression-as-an-independent-prognostic-marker-in-localized-clear-cell-renal-cell-carcinoma
#18
MULTICENTER STUDY
Thai Huu Ho, Payal Kapur, Jeanette E Eckel-Passow, Alana Christie, Richard W Joseph, Daniel J Serie, John C Cheville, R Houston Thompson, Farrah Homayoun, Vandana Panwar, James Brugarolas, Alexander S Parker
Purpose Enhancer of zeste homolog 2 (EZH2), a chromatin remodeler, is implicated in the pathogenesis of clear cell renal cell carcinoma (ccRCC). However, the effect of EZH2 on outcomes in localized ccRCC is unclear, and molecular biomarkers are not currently integrated into prognostic models or adjuvant therapy trials. Methods We performed Cox regression to evaluate the association of tumor-based EZH2 gene and protein expression with survival in three independent cohorts: a cohort from The Cancer Genome Atlas (n = 532), a cohort from University of Texas Southwestern Medical Center (n = 122), and a cohort from Mayo Clinic (n = 1,338)...
November 10, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28952874/is-the-level-of-education-associated-with-transitions-between-care-settings-in-older-adults-near-the-end-of-life-a-nationwide-retrospective-cohort-study
#19
Susanne Kelfve, Jonas Wastesson, Stefan Fors, Kristina Johnell, Lucas Morin
BACKGROUND: End-of-life transitions between care settings can be burdensome for older adults and their relatives. AIM: To analyze the association between the level of education of older adults and their likelihood to experience care transitions during the final months before death. DESIGN: Nationwide, retrospective cohort study using register data. SETTING/PARTICIPANTS: Older adults (⩾65 years) who died in Sweden in 2013 ( n = 75,722)...
September 1, 2017: Palliative Medicine
https://www.readbyqxmd.com/read/28948044/the-117-call-alert-system-in-sierra-leone-from-rapid-ebola-notification-to-routine-death-reporting
#20
REVIEW
Charles Alpren, Mohamed F Jalloh, Reinhard Kaiser, Mariam Diop, Sas Kargbo, Evelyn Castle, Foday Dafae, Sara Hersey, John T Redd, Amara Jambai
A toll-free, nationwide phone alert system was established for rapid notification and response during the 2014-2015 Ebola epidemic in Sierra Leone. The system remained in place after the end of the epidemic under a policy of mandatory reporting and Ebola testing for all deaths, and, from June 2016, testing only in case of suspected Ebola. We describe the design, implementation and changes in the system; analyse calling trends during and after the Ebola epidemic; and discuss strengths and limitations of the system and its potential role in efforts to improve death reporting in Sierra Leone...
2017: BMJ Global Health
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