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inflammatory bowel disease and diet

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https://www.readbyqxmd.com/read/29909020/diet-modifies-colonic-microbiota-and-cd4-t-cell-repertoire-to-induce-flares-of-colitis-in-mice-with-myeloid-cell-expression-of-interleukin-23
#1
Lili Chen, Zhengxiang He, Alina Cornelia Iuga, Sebastião N Martins Filho, Jeremiah J Faith, Jose C Clemente, Madhura Deshpande, Anitha Jayaprakash, Jean-Frederic Colombel, Juan J Lafaille, Ravi Sachidanandam, Glaucia C Furtado, Sergio A Lira
BACKGROUND & AIMS: Several studies have shown that signaling via the interleukin 23 (IL23) receptor is required for development of colitis. We studied the roles of IL23, dietary factors, alterations to the microbiota, and T cells in development and progression of colitis in mice. METHODS: All mice were maintained on lab diet 5053, unless otherwise noted. We generated mice that express IL23 in CX3CR1-positive myeloid cells (R23FR mice) upon cyclic administration of tamoxifen dissolved in diet 2019...
June 14, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29892152/neonatal-presentation-of-unremitting-inflammatory-bowel-disease
#2
Sara Ebrahimi, Gholamreza Khademi, Seyed Ali Jafari, Nona Zaboli Nejad, Abdolreza Norouzy, Bahareh Imani
Very-early-onset inflammatory bowel disease (VEO-IBD) has a distinct phenotype and should be considered a specific entity. VEO-IBD presents with very severe clinical pictures and is frequently known by an indeterminate colitis whose clinical remission is unmanageable. This study examines the case of a neonate with VEO-IBD, not responding to medical and surgical treatment. A 7-day-old Iranian female neonate presented with severe bloody diarrhea, poor feeding, abdominal distention, and dehydration suggesting severe proctocolitis due to an allergy to the protein in cow's milk...
May 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29866614/inflammation-modulating-effect-of-butyrate-in-the-prevention-of-colon-cancer-by-dietary-fiber
#3
Jiezhong Chen, Luis Vitetta
The intestinal microbiota plays key roles in human health, and adverse dysbiosis shifts of the microbiota have been associated with chronic diseases, including large bowel cancer. High-fiber diets may reduce the risk for large bowel cancer in association with gut microbiota modulation and butyrate production. Butyrate can inhibit histone deacetylases and associated signaling pathways in cultured cancer cells, promoting cancer cell apoptosis. However, butyrate has prevented colon cancer through the regulation of immune homeostasis rather than histone deacetylases inhibition...
May 17, 2018: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29804077/seronegative-enteropathy-and-malnutrition-a-diagnostic-challenge
#4
James McCulloch, Miriam Barclay, Adam Levene, Robert Fearn
A 21-year-old woman presented with a 2-week history of vomiting, diarrhoea and epigastric pain, with 9 kg weight loss over the last two months. Laboratory tests were normal with negative coeliac serology. Duodenal biopsies revealed total villous atrophy, crypt hypertrophy and intraepithelial lymphocytosis. A diagnosis of seronegative coeliac disease was made, and she started a gluten-free diet. However, she did not respond and her weight fell to 30.6 kg (body mass index 11), becoming dependent on parenteral nutrition...
May 26, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29789682/the-role-of-diet-in-the-aetiopathogenesis-of-inflammatory-bowel-disease
#5
REVIEW
Hamed Khalili, Simon S M Chan, Paul Lochhead, Ashwin N Ananthakrishnan, Andrew R Hart, Andrew T Chan
Crohn's disease and ulcerative colitis, collectively known as IBD, are chronic inflammatory disorders of the gastrointestinal tract. Although the aetiopathogenesis of IBD is largely unknown, it is widely thought that diet has a crucial role in the development and progression of IBD. Indeed, epidemiological and genetic association studies have identified a number of promising dietary and genetic risk factors for IBD. These preliminary studies have led to major interest in investigating the complex interaction between diet, host genetics, the gut microbiota and immune function in the pathogenesis of IBD...
May 22, 2018: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29788266/dietary-magnesium-alleviates-experimental-murine-colitis-through-upregulation-of-the-transient-receptor-potential-melastatin-6-channel
#6
Valentina Trapani, Valentina Petito, Angelica Di Agostini, Daniela Arduini, Willem Hamersma, Giuseppe Pietropaolo, Francesca Luongo, Vincenzo Arena, Egidio Stigliano, Loris R Lopetuso, Antonio Gasbarrini, Federica I Wolf, Franco Scaldaferri
Background: Magnesium (Mg) is essential for human health and is absorbed mainly in the intestine. In view of the likely occurrence of an Mg deficit in inflammatory bowel disease (IBD) and the documented role of Mg in modulating inflammation, the present study addresses whether Mg availability can affect the onset and progression of intestinal inflammation. Methods: To study the correlation between Mg status and disease activity, we measured magnesemia by atomic absorption spectroscopy in a cohort of IBD patients...
May 18, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29785173/phytochemicals-that-influence-gut-microbiota-as-prophylactics-and-for-the-treatment-of-obesity-and-inflammatory-diseases
#7
REVIEW
Lucrecia Carrera-Quintanar, Rocío I López Roa, Saray Quintero-Fabián, Marina A Sánchez-Sánchez, Barbara Vizmanos, Daniel Ortuño-Sahagún
Gut microbiota (GM) plays several crucial roles in host physiology and influences several relevant functions. In more than one respect, it can be said that you "feed your microbiota and are fed by it." GM diversity is affected by diet and influences metabolic and immune functions of the host's physiology. Consequently, an imbalance of GM, or dysbiosis, may be the cause or at least may lead to the progression of various pathologies such as infectious diseases, gastrointestinal cancers, inflammatory bowel disease, and even obesity and diabetes...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29777041/evolving-role-of-diet-in-the-pathogenesis-and-treatment-of-inflammatory-bowel-diseases
#8
REVIEW
Arie Levine, Rotem Sigall Boneh, Eytan Wine
Recent advances in basic and clinical science over the last 3 years have dramatically altered our appreciation of the role of diet in inflammatory bowel diseases (IBD). The marked increase in incidence of these diseases along with the important role of non-genetic susceptibility among patients with IBD has highlighted that these diseases have a strong environmental component. Progress in the field of microbiome and IBD has demonstrated that microbiome appears to play an important role in pathogenesis, and that diet may in turn impact the composition and functionality of the microbiome...
May 18, 2018: Gut
https://www.readbyqxmd.com/read/29763907/beyond-irritable-bowel-syndrome-the-efficacy-of-the-low-fodmap-diet-for-improving-symptoms-in-inflammatory-bowel-diseases-and-celiac-disease
#9
Anna Testa, Nicola Imperatore, Antonio Rispo, Matilde Rea, Raffaella Tortora, Olga Maria Nardone, Lucia Lucci, Grazia Accarino, Nicola Caporaso, Fabiana Castiglione
BACKGROUND AND AIM: To evaluate the usefulness of a low FODMAP (Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols) diet on patients with irritable bowel syndrome (IBS), non-active inflammatory bowel diseases (IBD), and celiac disease (CD) on a gluten-free diet (GFD). METHODS: Dietetic interventional prospective study. IBS, IBD, and CD subjects were evaluated to check if they fulfilled the Rome III criteria. Each subject was educated to follow a low FODMAP diet after being evaluated by filling out questionnaires that assessed the quality of life (QoL) and symptoms experienced (IBS-SSS and SF-36), and was reevaluated after 1 and 3 months...
May 15, 2018: Digestive Diseases
https://www.readbyqxmd.com/read/29709462/faecal-high-mobility-group-box-1-in-children-with-celiac-disease-a-pilot-study
#10
Francesca Palone, Roberta Vitali, Chiara Maria Trovato, Monica Montuori, Anna Negroni, Saverio Mallardo, Laura Stronati
BACKGROUND: Celiac disease (CD) is a gluten-related immunological disorder resulting in inflammatory enteropathy. AIMS: We assessed a stool marker of intestinal inflammation, the HMGB1 protein, in children with CD on a gluten free diet (GFD) at baseline and at follow up (FU). METHODS: Thirty-nine children were investigated at diagnosis and at FU. Traditional serum markers of CD (anti-transglutaminase and anti-endomysial antibodies) and faecal HMGB1 (by enzyme-linked immunosorbent assay and immunoblotting) were tested...
April 11, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29697827/diet-and-anthropometrics-of-children-with-inflammatory-bowel-disease-a-comparison-with-the-general-population
#11
Kay Diederen, Hilde Krom, Jeffrey C D Koole, Marc A Benninga, Angelika Kindermann
Background: There is a lack of knowledge regarding the diet of children with inflammatory bowel disease (IBD). Therefore, we investigated dietary intake in pediatric IBD compared to the general population and assessed anthropometrics and food avoidance. Methods: In this cross-sectional cohort study, patients younger than 18 years with IBD were included (2014-2017). Dietary intake (total energy, macro nutrients, food types) was assessed using a Food Frequency Questionnaire (FFQ) and compared with a matched reference population (n = 306)...
April 25, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29693729/inflammatory-bowel-disease-and-immunonutrition-novel-therapeutic-approaches-through-modulation-of-diet-and-the-gut-microbiome
#12
REVIEW
Larissa S Celiberto, Franziska A Graef, Genelle R Healey, Else S Bosman, Kevan Jacobson, Laura M Sly, Bruce A Vallance
Inflammatory Bowel Disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract, thought to at least in part reflect an aberrant immune response to gut bacteria. IBD is increasing in incidence, particularly in populations that have recently immigrated to Western countries. This suggests that environmental factors are involved in its pathogenesis. We hypothesize that the increase in IBD rates might reflect the consumption of an unhealthy Western diet, containing excess calories and lacking in key nutritional factors, such as fiber and vitamin D...
April 25, 2018: Immunology
https://www.readbyqxmd.com/read/29680064/fermented-non-digestible-fraction-from-combined-nixtamalized-corn-zea-mays-l-cooked-common-bean-phaseolus-vulgaris-l-chips-modulate-anti-inflammatory-markers-on-raw-264-7-macrophages
#13
I Luzardo-Ocampo, R Campos-Vega, M L Cuellar-Nuñez, P A Vázquez-Landaverde, L Mojica, J A Acosta-Gallegos, G Loarca-Piña
Chronic non-communicable diseases (NCDs) are low-level inflammation processes affected by several factors including diet. It has been reported that mixed whole grain and legume consumption, e.g. corn and common bean, might be a beneficial combination due to its content of bioactive compounds. A considerable amount would be retained in the non-digestible fraction (NDF), reaching the colon, where microbiota produce short-chain fatty acids (SCFAs) and phenolic compounds (PC) with known anti-inflammatory effect...
September 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29670469/dietary-n-3-pufa-may-attenuate-experimental-colitis
#14
Cloé Charpentier, Ronald Chan, Emmeline Salameh, Khaly Mbodji, Aito Ueno, Moïse Coëffier, Charlène Guérin, Subrata Ghosh, Guillaume Savoye, Rachel Marion-Letellier
Background: Inflammatory bowel diseases (IBD) occurred in genetically predisposed people exposed to environmental triggers. Diet has long been suspected to contribute to the development of IBD. Supplementation with n-3 polyunsaturated fatty acids (PUFA) protects against intestinal inflammation in rodent models while clinical trials showed no benefits. We hypothesized that intervention timing is crucial and dietary fatty acid pattern may influence intestinal environment to modify inflammation genesis...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29670252/urbanization-and-the-gut-microbiota-in-health-and-inflammatory-bowel-disease
#15
REVIEW
Tao Zuo, Michael A Kamm, Jean-Frédéric Colombel, Siew C Ng
In the 21st century, urbanization represents a major demographic shift in developed and developing countries. Rapid urbanization in the developing world has been associated with an increasing incidence of several autoimmune diseases, including IBD. Patients with IBD exhibit a decrease in the diversity and richness of the gut microbiota, while urbanization attenuates the gut microbial diversity and might have a role in the pathogenesis of IBD. Environmental exposures during urbanization, including Westernization of diet, increased antibiotic use, pollution, improved hygiene status and early-life microbial exposure, have been shown to affect the gut microbiota...
April 18, 2018: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29669023/the-relevance-of-vitamin-and-iron-deficiency-in-patients-with-inflammatory-bowel-diseases-in-patients-of-the-swiss-ibd-cohort
#16
Matiar Madanchi, Stefania Fagagnini, Nicolas Fournier, Luc Biedermann, Jonas Zeitz, Edouard Battegay, Lukas Zimmerli, Stephan R Vavricka, Gerhard Rogler, Michael Scharl
Background andAims: Vitamin and iron deficiencies are common in patients with inflammatory bowel disease (IBD) as a result of chronic intestinal inflammation, increase in demand, or dietary restrictions. Here, we assessed the frequency of complications in relation to deficiency of iron, folate acid, and vitamin B12 in patients enrolled in the nationwide Swiss Inflammatory Bowel Disease Cohort Study (SIBDCS). Methods: A total of 2666 patients were included in the study, 1558 with Crohn's disease (CD) and 1108 with ulcerative colitis (UC)...
April 13, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29644870/a-novel-polyphenolic-prebiotic-and-probiotic-formulation-have-synergistic-effects-on-the-gut-microbiota-influencing-drosophila-melanogaster-physiology
#17
Susan Westfall, Nikita Lomis, Satya Prakash
The gut microbiota is a vast community of synergistic bacterial species providing health benefits to the host. Imbalances in the gut microbiota (dysbiosis) due to diet, antibiotic use, age and stress contribute to disease development including diabetes, obesity, colon cancer, inflammatory bowel disease, inflammaging and neurodegeneration. Fortunately, a probiotic regime with a diet rich in prebiotics may reverse dysbiosis promoting health and wellness in age. The current study designs, optimizes and tests a novel probiotic and synbiotic formulation consisting of three metabolically active probiotics Lactobacillus plantarum, Lactobacillus fermentum and Bifidobacteria infantis together with a novel polyphenol-rich prebiotic, Triphala...
April 12, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29607792/nutritional-strategies-to-prevent-gastrointestinal-toxicity-during-pelvic-radiotherapy
#18
Linda J Wedlake
Radiotherapy-induced damage to non-cancerous gastrointestinal mucosa has effects on secretory and absorptive functions and can interfere with normal gastrointestinal physiology. Nutrient absorption and digestion may be compromised. Dietary manipulation is an attractive option with sound rationale for intervention. The aim of this review was to synthesise published evidence for the use of elemental formulae, low or modified fat diets, fibre, lactose restriction and probiotics, prebiotics and synbiotics to protect the bowel from gastrointestinal side effects during long-course, radical pelvic radiotherapy...
April 2, 2018: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/29570147/nutrition-in-pediatric-inflammatory-bowel-disease-a-position-paper-on-behalf-of-the-porto-inflammatory-bowel-disease-group-of-the-european-society-of-pediatric-gastroenterology-hepatology-and-nutrition
#19
Erasmo Miele, Raanan Shamir, Marina Aloi, Amit Assa, Christian Braegger, Jiri Bronsky, Lissy de Ridder, Johanna C Escher, Iva Hojsak, Sanja Kolaček, Sibylle Koletzko, Arie Levine, Paolo Lionetti, Massimo Martinelli, Frank Ruemmele, Richard K Russell, Rotem Sigall Boneh, Johan van Limbergen, Gigi Veereman, Annamaria Staiano
BACKGROUND AND AIMS: A growing body of evidence supports the need for detailed attention to nutrition and diet in children with inflammatory bowel disease (IBD). We aimed to define the steps in instituting dietary or nutritional management in light of the current evidence and to offer a useful and practical guide to physicians and dieticians involved in the care of pediatric IBD patients. METHODS: A group of 20 experts in pediatric IBD participated in an iterative consensus process including 2 face-to-face meetings, following an open call to Nutrition Committee of the European Society of Pediatric Gastroenterology, Hepatology and Nutrition Porto, IBD Interest, and Nutrition Committee...
April 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29549916/comprehensive-genetic-study-of-fatty-acids-helps-explain-the-role-of-noncoding-inflammatory-bowel-disease-associated-snps-and-fatty-acid-metabolism-in-disease-pathogenesis
#20
Gregor Jezernik, Uroš Potočnik
Fatty acids and their derivatives play an important role in inflammation. Diet and genetics influence fatty acid profiles. Abnormalities of fatty acid profiles have been observed in inflammatory bowel diseases (IBD), a group of complex diseases defined by chronic gastrointestinal inflammation. IBD associated fatty acid profile abnormalities were observed independently of nutritional status or disease activity, suggesting a common genetic background. However, no study so far has attempted to look for overlap between IBD loci and fatty acid associated loci or investigate the genetics of fatty acid profiles in IBD...
March 2018: Prostaglandins, Leukotrienes, and Essential Fatty Acids
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