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schizophrenia siblings

Simona Caldani, Maria Pia Bucci, Jean-Charles Lamy, Magali Seassau, Narjes Bendjemaa, Rémi Gadel, Raphael Gaillard, Marie-Odile Krebs, Isabelle Amado
Schizophrenia is a neurodevelopmental disease with cognitive and motor impairments. Motor dysfunctions, such as eye movements or Neurological Soft Signs (NSS), are proposed as endophenotypic markers. Antisaccade (AS) and memory-guided saccades (MGS), two markers of inhibitory control mechanism, are altered in both patients with schizophrenia and their relatives, although these tools may have different sensitivities. Recently, emphasis has been put on identifying markers predictive of psychosis transition in subjects with ultra-high-risk psychosis in order to develop targeted prevention...
September 14, 2016: Schizophrenia Research
R Landin-Romero, P J McKenna, A Romaguera, E Álvarez-Moya, S Sarró, C Aguirre, C Sarri, A Compte, C Bosque, R Salvador, E Pomarol-Clotet
BACKGROUND: A key finding underlying the continuum of psychosis concept is the presence of psychotic-like experiences (PLEs) in healthy subjects. However, it remains uncertain to what extent these experiences are related to the genetic risk for schizophrenia and how far they actually resemble attenuated forms of psychotic symptoms. METHODS: Forty-nine adults with no history of mental illness in first-degree relatives and 59 siblings of patients with schizophrenia were rated on the psychosis section of the Computerized Diagnostic Interview Schedule IV (C DIS-IV) and the Rust Inventory of Schizotypal Cognitions (RISC)...
September 12, 2016: Schizophrenia Research
Jitendra Rohilla
No abstract text is available yet for this article.
July 2016: Indian Journal of Psychological Medicine
Marina Mihaljevic, Katarina Zeljic, Ivan Soldatovic, Sanja Andric, Tijana Mirjanic, Alexander Richards, Kiran Mantripragada, Tatjana Pekmezovic, Ivana Novakovic, Nadja P Maric
Increased reactivity to stress is observed in patients with schizophrenia spectrum disorders and their healthy siblings in comparison with the general population. Additionally, higher levels of neuroticism, as a proposed psychological measure of stress sensitivity, increase the risk of schizophrenia. HPA axis dysregulation is one of the possible mechanisms related to the vulnerability-stress model of schizophrenia, and recent studies revealed a possible role of the functional genetic variants of FK506-binding protein 51 (FKBP5) gene which modulate activity of HPA axis...
August 23, 2016: European Archives of Psychiatry and Clinical Neuroscience
E M Frans, P Lichtenstein, C M Hultman, R Kuja-Halkola
BACKGROUND: Advancing paternal age has been linked to psychiatric disorders. These associations might be caused by the increased number of de novo mutations transmitted to offspring of older men. It has also been suggested that the associations are confounded by a genetic liability for psychiatric disorders in parents. The aim of this study was to indirectly test the confounding hypotheses by examining if there is a genetic component to advancing paternal age and if men with a genetic liability for psychiatric disorders have children at older ages...
October 2016: Psychological Medicine
Carolyn E Cesta, Mattias Månsson, Camilla Palm, Paul Lichtenstein, Anastasia N Iliadou, Mikael Landén
Polycystic ovary syndrome (PCOS) is an endocrine disorder affecting 5-15% of reproductive-aged women and characterized by high levels of circulating androgens. Given that androgens have been implicated in the aetiology of several psychiatric disorders, it was hypothesized that women with PCOS have high risk for psychiatric comorbidity. We aimed to investigate this risk amongst women with PCOS, as well as in their siblings, to elucidate if familial factors underlie any potential associations. Using the Swedish national registers, we identified all women diagnosed with PCOS between 1990 and 2013 (n=24,385), their full-siblings (n=25,921), plus matched individuals (1:10/100) from the general population and their full-siblings...
November 2016: Psychoneuroendocrinology
Giulio Pergola, Silvestro Trizio, Pasquale Di Carlo, Paolo Taurisano, Marina Mancini, Nicola Amoroso, Maria Antonietta Nettis, Ileana Andriola, Grazia Caforio, Teresa Popolizio, Antonio Rampino, Annabella Di Giorgio, Alessandro Bertolino, Giuseppe Blasi
Previous evidence suggests reduced thalamic grey matter volume (GMV) in patients with schizophrenia (SCZ). However, it is not considered an intermediate phenotype for schizophrenia, possibly because previous studies did not assess the contribution of individual thalamic nuclei and employed univariate statistics. Here, we hypothesized that multivariate statistics would reveal an association of GMV in different thalamic nuclei with familial risk for schizophrenia. We also hypothesized that accounting for the heterogeneity of thalamic GMV in healthy controls would improve the detection of subjects at familial risk for the disorder...
July 20, 2016: Schizophrenia Research
Mette C Tollånes, Allen J Wilcox, Camilla Stoltenberg, Rolv T Lie, Dag Moster
OBJECTIVES: To explore the presence of shared underlying causes of cerebral palsy (CP) and other neurodevelopmental disorders, by examining risks of other disorders in siblings of children with CP. METHODS: We used Norwegian national registries to identify 1.4 million pairs of full siblings (singletons) and 28 000 sets of twins born from 1967 to 2006, identify stillbirths and neonatal deaths, and find individuals with CP, epilepsy, intellectual disability, autism spectrum disorders, attention-deficit/hyperactivity disorder, blindness, deafness, schizophrenia, and bipolar disorder...
August 2016: Pediatrics
Max de Leeuw, Marc M Bohlken, René Cw Mandl, Manon Hj Hillegers, René S Kahn, Matthijs Vink
Schizophrenia is associated with fronto-striatal network impairments underlying clinical and cognitive symptoms. We previously found disruptions in anatomical pathways, including the tract connecting the left nucleus accumbens and left dorsolateral prefrontal cortex (DLPFC). Similar deficits are observed in unaffected siblings of schizophrenia patients indicating that these deficits are linked to a genetic vulnerability for the disorder. Fronto-striatal tract disruptions may arise during adolescence, preceding the clinical manifestation of the disorder...
July 21, 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
Stephen Pow, Frank W Stahnisch
Biological psychiatry in the early twentieth century was based on interrelated disciplines, such as neurology and experimental biology. Neuropsychiatrist Franz Josef Kallmann (1897-1965) was a product of this interdisciplinary background who showed an ability to adapt to different scientific contexts, first in the field of neuromorphology in Berlin, and later in New York. Nonetheless, having innovative ideas, as Kallmann did, could be an ambiguous advantage, since they could lead to incommensurable scientific views and marginalization in existing research programs...
July 2016: Journal of the History of the Neurosciences
Paweł Krukow, Hanna Karakuła-Juchnowicz, Dariusz Juchnowicz, Justyna Morylowska-Topolska, Marta Flis, Kamil Jonak
BACKGROUND: Processing speed turns out to be the central area of research on cognition in schizophrenia. So far the relationship between this dimension and the IQ level of patients and their healthy siblings has not been investigated. AIM: To investigate the differences in cognitive speed in patients with schizophrenia and their healthy siblings, and to determine whether cognitive speed as a covariate affects differences in IQ and cognitive profiles between groups...
July 8, 2016: Nordic Journal of Psychiatry
Martin Cederlöf, Henrik Larsson, Paul Lichtenstein, Catarina Almqvist, Eva Serlachius, Jonas F Ludvigsson
BACKGROUND: To assess the risk of psychiatric disorders in Ehlers-Danlos syndrome (EDS) and hypermobility syndrome. METHODS: Nationwide population-based matched cohort study. EDS, hypermobility syndrome and psychiatric disorders were identified through Swedish national registries. Individuals with EDS (n = 1,771) were matched with comparison individuals (n = 17,710). Further, siblings to individuals with EDS who did not have an EDS diagnosis themselves were compared with matched comparison siblings...
2016: BMC Psychiatry
Katharine N Thakkar, Lara Rösler, Jannie P Wijnen, Vincent O Boer, Dennis W J Klomp, Wiepke Cahn, René S Kahn, Sebastiaan F W Neggers
BACKGROUND: The N-methyl-D-aspartate receptor hypofunction model of schizophrenia predicts dysfunction in both glutamatergic and gamma-aminobutyric acidergic (GABAergic) transmission. We addressed this hypothesis by measuring GABA, glutamate, glutamine, and the sum of glutamine plus glutamate concentrations in vivo in patients with schizophrenia using proton magnetic resonance spectroscopy at 7T, which allows separation of metabolites that would otherwise overlap at lower field strengths...
April 19, 2016: Biological Psychiatry
Jianpo Su, Hui Shen, Ling-Li Zeng, Jian Qin, Zhening Liu, Dewen Hu
Previous static resting-state functional connectivity (FC) MRI (rs-fcMRI) studies have suggested certain heredity characteristics of schizophrenia. Recently, dynamic rs-fcMRI analysis, which can better characterize the time-varying nature of intrinsic activity and connectivity and may therefore unveil the special connectivity patterns that are always lost in static FC analysis, has shown a potential neuroendophenotype of schizophrenia. In this study, we have extended previous static rs-fcMRI studies to a dynamic study by exploring whether healthy siblings share aberrant dynamic FC patterns with schizophrenic patients, which may imply a potential risk for siblings to develop schizophrenia...
August 3, 2016: Neuroreport
Angela M Reiersen
BACKGROUND: Schizophrenia is a heterogeneous disorder that is characterized by varying levels of hallucinations, delusions, negative symptoms, and disorganized features. The presence and severity of neurodevelopmental precursors and premorbid psychopathology also vary among individuals. To fully understand individual patients and to sort out phenotypic heterogeneity for genetic research studies, instruments designed to collect developmental history relevant to schizophrenia may be helpful...
2016: Scandinavian Journal of Child and Adolescent Psychiatry and Psychology
Kerime Bademli, Zekiye Çetinkaya Duman
"Family to Family Support Program" is a significant intervention program to assist families by informing them about treatment procedures and coping strategies, increasing their functionality, helping them to overcome the challenges of the disease. This study was particularly designed to investigate the emotions, thoughts, and experiences of caregivers of schizophrenia patients who participated in "Family to Family Support Program." The study was conducted with one of the qualitative research methods, phenomenological method...
June 2016: Archives of Psychiatric Nursing
Sarah A Eisenstein, Ryan Bogdan, Latisha Love-Gregory, Nadia S Corral-Frías, Jonathan M Koller, Kevin J Black, Stephen M Moerlein, Joel S Perlmutter, Deanna M Barch, Tamara Hershey
In humans, the A1 (T) allele of the dopamine (DA) D2 receptor/ankyrin repeat and kinase domain containing 1 (DRD2/ANKK1) TaqIA (rs1800497) single nucleotide polymorphism has been associated with reduced striatal DA D2/D3 receptor (D2/D3R) availability. However, radioligands used to estimate D2/D3R are displaceable by endogenous DA and are nonselective for D2R, leaving the relationship between TaqIA genotype and D2R specific binding uncertain. Using the positron emission tomography (PET) radioligand, (N-[(11) C]methyl)benperidol ([(11) C]NMB), which is highly selective for D2R over D3R and is not displaceable by endogenous DA, the current study examined whether DRD2/ANKK1 TaqIA genotype predicts D2R specific binding in two independent samples...
October 2016: Synapse
Claire M Kaplan, Debjani Saha, Juan L Molina, William D Hockeimer, Elizabeth M Postell, Jose A Apud, Daniel R Weinberger, Hao Yang Tan
SEE STEPHAN ET AL DOI101093/AWW120 FOR A SCIENTIFIC COMMENTARY ON THIS WORK: Real world information is often abstract, dynamic and imprecise. Deciding if changes represent random fluctuations, or alterations in underlying contexts involve challenging probability estimations. Dysfunction may contribute to erroneous beliefs, such as delusions. Here we examined brain function during inferences about context change from noisy information. We examined cortical-subcortical circuitry engaging anterior and dorsolateral prefrontal cortex, and midbrain...
July 2016: Brain: a Journal of Neurology
Patrick Domen, Sanne Peeters, Stijn Michielse, Ed Gronenschild, Wolfgang Viechtbauer, Alard Roebroeck, Jim van Os, Machteld Marcelis
BACKGROUND: Although widespread reduced white matter (WM) integrity is a consistent finding in cross-sectional diffusion tensor imaging (DTI) studies of schizophrenia, little is known about the course of these alterations. This study examined to what degree microstructural WM alterations display differential trajectories over time as a function of level of psychosis liability. METHODS: Two DTI scans with a 3-year time interval were acquired from 159 participants (55 patients with a psychotic disorder, 55 nonpsychotic siblings and 49 healthy controls) and processed with tract-based spatial statistics...
May 17, 2016: Schizophrenia Bulletin
Matthew J Smith, Jan S Greenberg, Sarah A Sciortino, Gisela M Sandoval, Ellen P Lukens
BACKGROUND: Research suggests siblings of individuals with schizophrenia are at a heightened risk for depressive symptomatology. Research has not yet examined whether the strains of growing up with a brother or sister with schizophrenia contribute to this risk. This study examined whether early life course burdens associated with an emerging mental illness, and current objective and subjective caregiver burden predicted depressive symptoms in siblings of individuals with schizophrenia...
2016: Mental Health in Family Medicine
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