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https://www.readbyqxmd.com/read/28320139/10-year-outcomes-after-rituximab-for-myasthenia-gravis-efficacy-safety-costs-of-inhospital-care-and-impact-on-childbearing-potential
#1
Karl Stieglbauer, Robert Pichler, Raffi Topakian
Rituximab (RTX) has emerged as an attractive off-label treatment option for patients with myasthenia gravis (MG) refractory to other immune therapies. However, data on long-term outcome after RTX for MG are still scarce. Here we present the 10-year outcomes [median (range) 10.1 (6.7-11.2) years] with respect to efficacy, safety, costs of inhospital care, and impact on childbearing potential in all four MG patients treated by one of the authors with RTX. In all patients, RTX led to sustained clinical improvement and eventual tapering of other immune therapies...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28319087/erratum-model-based-projections-of-zika-virus-infections-in-childbearing-women-in-the-americas
#2
T Alex Perkins, Amir S Siraj, Corrine W Ruktanonchai, Moritz U G Kraemer, Andrew J Tatem
No abstract text is available yet for this article.
March 20, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28318463/decreasing-the-overall-environmental-impact-of-the-dutch-diet-how-to-find-healthy-and-sustainable-diets-with-limited-changes
#3
Gerard Fh Kramer, Marcelo Tyszler, Pieter Van't Veer, Hans Blonk
OBJECTIVE: To find diets optimised on nutrition and environmental impact close to the current Dutch diet and to identify the most effective and acceptable options for mitigating environmental impact. DESIGN: Linear programming was used to optimise diets of Dutch men and women aged 9-69 years, divided into ten age-gender groups. The analysis included nutrient composition, a metric for popularity and life cycle assessments of 207 food products. Greenhouse gas emissions, fossil energy use and land occupation were used to calculate a weighted score for the overall environmental impact...
March 20, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28318393/pathways-to-adolescent-childbearing-among-kaqchikel-women-in-guatemala
#4
Emily Lemon, Monique Hennink, Nely Amparo Can Saquic
One-in-five children in Guatemala is born to a mother aged 15-19 years, which poses social, economic and health risks to both mother and child. In Guatemala, adolescent childbearing is directly associated with education, ethnicity and poverty, which increases vulnerability among Indigenous young women living in poverty. This study examines the context and experiences of adolescent childbearing from the perspectives of young mothers in the Kaqchikel Indigenous ethnic group of Sololá, Guatemala. Data were collected in 19 qualitative in-depth interviews with women who had given birth to one or more children when aged 15 to 19 years...
March 20, 2017: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/28318365/effects-of-tgf-%C3%AE-on-uterine-fibroids-of-women-of-childbearing-age-and-uterine-artery-embolization
#5
Tao Shen, Hongjian Shi, Qiang Xu, Qian Song, Yuanfen Xu, Youhua Huang
PURPOSE: To evaluate the effects of transforming growth factor-β (TGF-β) on uterine fibroids of women of childbearing age and uterine artery embolization (UAE) using Embosphere microspheres. MATERIAL AND METHODS: A total of 128 eligible women were randomly divided into an experimental group and a control group (n = 64) who received UAE using Embosphere microspheres and panhysterectomy, respectively. Another 128 healthy women receiving physical examination in the same period were also enrolled...
March 20, 2017: Minimally Invasive Therapy & Allied Technologies: MITAT
https://www.readbyqxmd.com/read/28316343/own-choice-marriage-and-fertility-in-turkey
#6
Nicolette D Manglos-Weber, Alexander A Weinreb
Goode's foundational work on the fertility transition identified own-choice marriage as a factor driving fertility decline, part of a widening repertoire of choice pertaining to marriage and childbearing. Yet research supporting this connection in today's transitional societies is scarce and somewhat contradictory, and it is unclear how other marital traditions, such as consanguineous marriage, shape this relationship. This study evaluates Goode's theorized connection using pooled Demographic and Health Survey data from Turkey, comparing children ever born, use of contraception, and parity progression across four types of marriage: own-choice and arranged marriage; and marriage to a cousin versus an unrelated spouse...
April 2017: Journal of Marriage and the Family
https://www.readbyqxmd.com/read/28316342/anticipated-emotions-about-unintended-pregnancy-in-relationship-context-are-latinas-really-happier
#7
Abigail R A Aiken, James Trussell
This study examined differences in women's anticipated emotional orientations towards unintended pregnancy by relationship status and race/ethnicity. Data from a prospective survey of 437 women aged 18-44 who intended no more children for at least two years were analyzed along with 27 in-depth interviews among a diverse sub-sample. Cohabiting women and women in a romantic relationship not living together were less likely to profess happiness (OR=0.42, p<.05, OR=0.25, p<.01, respectively), even when partners' intentions/feelings were controlled...
April 2017: Journal of Marriage and the Family
https://www.readbyqxmd.com/read/28303702/studies-on-the-quality-nutrition-in-women-with-polycystic-ovary-syndrome-pcos
#8
Małgorzata Szczuko, Patrycja Sankowska, Marta Zapałowska-Chwyć, Paweł Wysokiński
Background: Polycystic ovary syndrome (PCOS) manifests itself with various symptoms, therefore it interests representatives of many medical specializations: general practitioners, gynecologists, endocrinologists, dermatologists, cardiologists and those who deal with metabolic disorders, such as dieticians. Objective: The aim of this study was perform the qualitative assessment of components of diets of women with PCOS as one of the major factor contributing to the disease...
2017: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/28301792/systemic-lupus-erythematosus-an-update
#9
Vera Golder, Alberta Hoi
Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease predominantly affecting women of childbearing age. New classification criteria for SLE have greater sensitivity and therefore improve the diagnostic certainty for some patients, especially those who may previously have been labelled as having undifferentiated symptoms. Uncontrolled disease activity leads to irreversible end-organ damage, which in turn increases the risk of premature death; early and sustained control of disease activity can usually be achieved by conventional immunosuppressant therapy...
March 20, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28296626/multiple-levels-of-social-influence-on-adolescent-sexual-and-reproductive-health-decision-making-and-behaviors-in-ghana
#10
Sneha Challa, Abubakar Manu, Emmanuel Morhe, Vanessa K Dalton, Dana Loll, Jessica Dozier, Melissa K Zochowski, Andrew Boakye, Richard Adanu, Kelli Stidham Hall
Little is known about the multi-level social determinants of adolescent sexual and reproductive health (SRH) that shape the use of family planning (FP) among young women in Africa. We conducted in-depth, semi-structured, qualitative interviews with 63 women aged 15-24 years in Accra and Kumasi, Ghana. We used purposive, stratified sampling to recruit women from community-based sites. Interviews were conducted in English or local languages, recorded, and transcribed verbatim. Grounded theory-guided thematic analysis identified salient themes...
March 15, 2017: Women & Health
https://www.readbyqxmd.com/read/28295509/measuring-tsh-receptor-antibody-trab-to-influence-treatment-choices-in-graves-disease
#11
Asha Hesarghatta Shyamasunder, Prakash Abraham
TSH receptor antibody (TRAb) plays a key role in the pathogenesis of Graves' disease (GD) and its levels correlate with the clinical course. The 2(nd) and 3(rd) generation TRAb assays have >95% sensitivity and specificity for the diagnosis of GD, and have improved the utility of TRAb to predict relapse. TRAb levels decline with antithyroid drug (ATD) therapy and after thyroidectomy. Its level increases for a year following radioactive iodine (RAI) therapy, with a gradual fall thereafter. TRAb level >12 IU/L at diagnosis of GD is associated with 60% risk of relapse at 2 years and 84% at 4 years...
March 13, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28292306/fertility-and-hiv-following-universal-access-to-art-in-rwanda-a-cross-sectional-analysis-of-demographic-and-health-survey-data
#12
Eric Remera, Kimberly Boer, Stella M Umuhoza, Bethany L Hedt-Gauthier, Dana R Thomson, Patrick Ndimubanzi, Eugenie Kayirangwa, Salomon Mutsinzi, Alice Bayingana, Placidie Mugwaneza, Jean Baptiste T Koama
BACKGROUND: HIV infection is linked to decreased fertility and fertility desires in sub-Saharan Africa due to biological and social factors. We investigate the relationship between HIV infection and fertility or fertility desires in the context of universal access to antiretroviral therapy introduced in 2004 in Rwanda. METHODS: We used data from 3532 and 4527 women aged 20-49 from the 2005 and 2010 Rwandan Demographic and Health Surveys (RDHS), respectively. The RDHSs included blood-tests for HIV, as well as detailed interviews about fertility, demographic and behavioral outcomes...
March 14, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28289215/selective-dietary-supplementation-in-early-postpartum-is-associated-with-high-resilience-against-depressed-mood
#13
Yekta Dowlati, Arun V Ravindran, Zindel V Segal, Donna E Stewart, Meir Steiner, Jeffrey H Meyer
Medical research is moving toward prevention strategies during prodromal states. Postpartum blues (PPB) is often a prodromal state for postpartum depression (PPD), with severe PPB strongly associated with an elevated risk for PPD. The most common complication of childbearing, PPD has a prevalence of 13%, but there are no widespread prevention strategies, and no nutraceutical interventions have been developed. To counter the effects of the 40% increase in monoamine oxidase A (MAO-A) levels that occurs during PPB, a dietary supplement kit consisting of monoamine precursor amino acids and dietary antioxidants was created...
March 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28280497/activation-of-blood-cd3-cd56-cd8-t-cells-during-pregnancy-and-multiple-sclerosis
#14
Clara de Andrés, Lidia Fernández-Paredes, Marta Tejera-Alhambra, Bárbara Alonso, Rocío Ramos-Medina, Silvia Sánchez-Ramón
A striking common feature of most autoimmune diseases is their female predominance, with at least twice as common among women than men in relapsing-remitting multiple sclerosis (MS), the prevailing MS clinical form with onset at childbearing age. This fact, together with the protective effect on disease activity during pregnancy, when there are many biological changes including high levels of estrogens and progesterone, puts sex hormones under the spotlight. The role of natural killer (NK) and NKT cells in MS disease beginning and course is still to be elucidated...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28278227/do-children-born-to-teenage-parents-have-lower-adult-intelligence-a-prospective-birth-cohort-study
#15
Mohsina Khatun, Abdullah Al Mamun, James Scott, Gail M William, Alexandra Clavarino, Jake M Najman
Teenage motherhood has been associated with a wide variety of negative offspring outcomes including poorer cognitive development. In the context of limitations of previous research, this paper assesses the contemporary relevance of this finding. In this study we investigate the long-term cognitive status (IQ) among 21 year adult offspring born to teenage parents using the Mater University Study of Pregnancy- a prospective birth cohort study, which recruited all pregnant mothers attending a large obstetrical hospital in Brisbane, Australia, from 1981 to 1983...
2017: PloS One
https://www.readbyqxmd.com/read/28278019/advanced-reproductive-age-and-childbearing-choices-in-nigeria
#16
Bola Lukman Solanke
This study examined the relationship between advanced reproductive age and childbearing choices measured by ideal family size, contraceptive use, and unmet need for contraception. Data were extracted from the 2013 Nigeria Demographic and Health Survey. The multinomial logistic regression was applied. Results showed that a majority of the women had large ideal family sizes; were not using any method of contraception; and nearly one-fifth of the women had unmet needs for contraception. Results further showed significant associations between advanced reproductive age and childbearing choices...
February 21, 2017: Health Care for Women International
https://www.readbyqxmd.com/read/28275540/a-rare-breed-wild-type-braf-and-ighv-expression-in-a-29-year-old-lady-with-classical-hairy-cell-leukemia
#17
Aneesha Hossain, Hind Rafei, Amar Jariwala, Khaled El-Shami
The V600 BRAF mutation has been described as a key mutation in the pathogenesis of classical hairy cell leukemia (c-HCL) cases without expression of a mutant immunoglobulin heavy chain (IgHV). Here we present a rare case of c-HCL with neither V600 BRAF mutation nor the aforementioned IgHV variant successfully treated with cladribine and review the current literature on its use in women of childbearing age/pregnancy.
2017: Leukemia Research Reports
https://www.readbyqxmd.com/read/28273802/the%C3%A2-prevalence%C3%A2-of%C3%A2-micronutrient%C3%A2-deficiencies%C3%A2-and%C3%A2-inadequacies%C3%A2-in%C3%A2-the%C3%A2-middle%C3%A2-east%C3%A2-and%C3%A2-approaches%C3%A2-to%C3%A2-interventions
#18
REVIEW
Nahla Hwalla, Ayesha Salem Al Dhaheri, Hadia Radwan, Hanan Abdullah Alfawaz, Mona A Fouda, Nasser Mohammed Al-Daghri, Sahar Zaghloul, Jeffrey B Blumberg
Micronutrient deficiencies and inadequacies constitute a global health issue, particularly among countries in the Middle East. The objective of this review is to identify micronutrient deficits in the Middle East and to consider current and new approaches to address this problem. Based on the availability of more recent data, this review is primarily focused on countries that are in advanced nutrition transition. Prominent deficits in folate, iron, and vitamin D are noted among children/adolescents, women of childbearing age, pregnant women, and the elderly...
March 3, 2017: Nutrients
https://www.readbyqxmd.com/read/28272103/impact-of-procedural-specialty-on-maternity-leave-and-career-satisfaction-among-female-physicians
#19
Rebecca E Scully, Jennifer S Davids, Nelya Melnitchouk
OBJECTIVE: The aim of this study was to perform a large-scale, national survey of physician mothers to define the personal, professional, and financial impact of maternity leave and its relationship to career satisfaction for female physicians in procedural and nonprocedural fields. SUMMARY OF BACKGROUND DATA: Little is known about the impact of maternity leave on early career female physicians or how childbearing affects career satisfaction. METHODS: A nationwide sample of physician mothers completed a 45-question anonymous, secure, online questionnaire regarding the impact of pregnancy and childbearing...
March 7, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28271578/fathers-make-a-difference-positive-relationships-with-mother-and-baby-in-relation-to-infant-colic
#20
C P Alexander, J Zhu, I M Paul, K H Kjerulff
BACKGROUND: Maternal psychological factors like depression, anxiety and stress have been associated with infant fussiness or colic. However, little research exists on whether positive factors such as social support and the happiness of the mother-partner relationship are associated with lower rates of infant fussiness or colic. OBJECTIVES: We investigated the association between infant colic and three types of maternal support: general maternal social support (during pregnancy and post partum), the happiness of the mother-partner relationship (during pregnancy and post partum) and partner involvement in caring for the newborn...
March 7, 2017: Child: Care, Health and Development
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