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Split-dose preparations

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https://www.readbyqxmd.com/read/29790278/the-split-dose-4-l-polyethylene-glycol-regimen-for-patients-with-previous-colorectal-surgery-in-bowel-preparation-before-colonoscopy-a-randomized-controlled-single-blind-study
#1
Zhu Liu, Yue-Yue Li, Xue-Ting Luo, Chuan-Guo Guo, Ming-Ming Zhang, Zhen Li, Li-Xiang Li, Yan Zhang, Yan-Qing Li
AIM: In some Asian countries, guidelines recommend 2-L polyethylene glycol (PEG) without any additions as the standard bowel preparation (BP) regimen before colonoscopy, which is not sufficient for patients with previous colorectal surgery. The objective of this study was to investigate the efficacy of the split-dose 4-L PEG regimen on the quality of BP in Asian patients with previous colorectal surgery. METHODS: This was a single-center, prospective, randomized-controlled, endoscopist-blinded study...
May 22, 2018: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29743843/prospective-analysis-of-factors-associated-with-inadequate-bowel-preparation-for-colonoscopy-in-actual-clinical-practice
#2
Dae Hyung Woo, Kyeong Ok Kim, Da Eun Jeong, Yoon Jeong Nam, Si Hyung Lee, Byung Ik Jang, Tae Nyeun Kim
Background/Aims: Inadequate bowel preparation can result in prolonged procedure time and increased missed lesion and complication rates. This prospective study aimed to evaluate bowel preparation quality and identify the predictive factors for inadequate bowel preparation in actual clinical practice. Methods: We included 399 patients who underwent colonoscopy between June 2015 and July 2016. Using the Aronchick bowel preparation scale, we defined a score ≤2 as adequate preparation and a score >2 as inadequate preparation...
April 2018: Intestinal Research
https://www.readbyqxmd.com/read/29736830/comparison-of-small-versus-large-volume-split-dose-preparation-for-colonoscopy-a-study-of-colonoscopy-outcomes
#3
Hassan Siddiki, Sreya Ravi, Mohanad T Al-Qaisi, Ayman R Fath, Francisco Ramirez, Michael D Crowell, Rahul Pannala, Douglas O Faigel, Suryakanth R Gurudu
BACKGROUND: Split dose bowel preparations (SDP) have superior outcomes for colonoscopy as compared to evening before regimens. However, the association of the actual volume of the SDP to colonoscopy outcome measures has not been well studied. AIMS: Compare adenoma detection rate (ADR), sessile serrated polyp detection rate (SDR), mean bowel cleanse score, and predictors of inadequate exams between small volume SDP and large volume SDP. METHODS: We have conducted a retrospective study in patients undergoing colonoscopy with small volume SDP versus large volume SDP between July 2014 and December 2014...
May 7, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29720862/split-versus-single-dose-preparation-tolerability-in-a-multiethnic-population-decreased-side-effects-but-greater-social-barriers
#4
Gabriel Perreault, Adam Goodman, Sebastian Larion, Ahana Sen, Kirsten Quiles, Michael Poles, Renee Williams
Background: This study was performed to compare patient-reported tolerability and its barriers in single- vs. split-dose 4-L polyethylene glycol (PEG) bowel preparation for colonoscopy in a large multiethnic, safety-net patient population. Methods: A cross-sectional, dual-center study using a multi-language survey was used to collect patient-reported demographic, medical, socioeconomic, and tolerability data from patients undergoing outpatient colonoscopy. Univariate and multivariate analyses were used to identify demographic and clinical factors significantly associated with patient-reported bowel preparation tolerability...
May 2018: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29720849/split-dose-bowel-preparation-versus-water-exchange-and-adenoma-detection-rate-have-we-arrived-there-yet
#5
EDITORIAL
Felix W Leung
No abstract text is available yet for this article.
May 2018: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29705101/how-close-is-the-dose-manipulation-of-10mg-hydrocortisone-tablets-to-provide-appropriate-doses-to-children
#6
Cameron Watson, Emma A Webb, Stephanie Kerr, Justin H Davies, Heather Stirling, Hannah Batchelor
This study explores the methodology advised by healthcare professionals and the methods used by parents/carers to identify whether there is a best practice method for manipulation of 10mg hydrocortisone tablets to provide an accurate dose to children. Bespoke surveys were used to identify methods recommended and used in manipulation of tablets. Hydrocortisone tablets were manipulated to provide a specified dose by both naïve participants and parents/carers. The accuracy of manipulation was assessed using HPLC analysis...
April 26, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29560691/patients-with-history-of-colonoscopy-are-less-likely-to-achieve-high-quality-preparation-after-implementing-split-dose-bowel-preparation
#7
M F Madhoun, H Bitar, P Parava, M H Bashir, H Zia
BACKGROUND: Anecdotally, we observed that patients who had previous colonoscopies were less likely to follow newly implemented split-dose bowel preparation (SDBP) instructions. We investigated whether the indication for colonoscopy is an independent factor for achieving high quality bowel preparation among patients asked to follow SDBP. METHODS: We performed a retrospective study of data from 1478 patients who received outpatient colonoscopies in 2014 (the year of SDBP implementation) at our Veterans Affairs Medical Center...
April 2017: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/29533397/same-day-single-dose-of-2-liter-polyethylene-glycol-is-not-inferior-to-the-standard-bowel-preparation-regimen-in-low-risk-patients-a-randomized-controlled-trial
#8
Xiaoyu Kang, Lina Zhao, Zhiyong Zhu, Felix Leung, Limei Wang, Xiangping Wang, Hui Luo, Linhui Zhang, Tao Dong, Pingying Li, Zhangqin Chen, Gui Ren, Hui Jia, Xiaoyang Guo, Yanglin Pan, Xuegang Guo, Daiming Fan
OBJECTIVES: Split dose of 4 l polyethylene glycol (PEG) is currently the standard regimen for bowel preparation (BP). However, it may be unnecessary for patients without high risks (e.g., old age, constipation, and diabetes, and so on) for inadequate BP. The study aimed to compare the efficacy of bowel cleansing between low-risk patients receiving same-day, single dose of low-volume (SSL) PEG vs. standard regimen. METHODS: This prospective, randomized, observer-blinded, non-inferiority study enrolled low-risk patients in three centers...
April 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29511558/educational-strategies-for-colonoscopy-bowel-prep-overcome-barriers-against-split-dosing-a-randomized-controlled-trial
#9
Alida Andrealli, Silvia Paggi, Arnaldo Amato, Emanuele Rondonotti, Gianni Imperiali, Nicoletta Lenoci, Giovanna Mandelli, Natalia Terreni, Giancarlo Spinzi, Franco Radaelli
Background: A split-dose (SD) regimen is crucial for colonoscopy quality. Compliance with SD for early morning colonoscopy is generally poor. The present study evaluated whether pre-colonoscopy counselling, in addition to a dedicated leaflet, might increase SD uptake. Methods: Consecutive 50-69-year-old patients undergoing screening colonoscopy before 10 a.m. were randomized to either receive written information only on bowel preparation (Written Group, WG) or written and oral instructions (Written and Oral Group, WaOG)...
March 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29507459/in-split-dose-prepared-patients-water-exchange-could-significantly-improve-overall-and-segmental-bowel-preparation-scores-and-increase-adenoma-detection-rate
#10
EDITORIAL
Felix W Leung
No abstract text is available yet for this article.
March 2018: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29456410/split-dose-bowel-preparation-improves-adequacy-of-bowel-preparation-and-gastroenterologists-adherence-to-national-colorectal-cancer-screening-and-surveillance-guidelines
#11
Stacy Bartnik Menees, H Myra Kim, Philip Schoenfeld
AIM: To quantify the impact of split-dose regimen on endoscopists' compliance with guideline recommendations for timing of repeat colonoscopy in patients with normal colonoscopy or 1-2 small polyps (< 10 mm). METHODS: A retrospective chart review of all endoscopy reports was undertaken in average-risk individuals > 50 years old with a normal screening colonoscopy and 1-2 small polyps. Data were abstracted from two time periods, pre and post-split-dose bowel preparation institution...
February 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29450748/water-exchange-versus-split-dose-bowel-preparation-and-the-adr-is-we-there-yet
#12
EDITORIAL
Felix W Leung, Hui Jia
No abstract text is available yet for this article.
May 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29404921/update-on-bowel-preparation-for-colonoscopy
#13
REVIEW
Cristina C Rutherford, Audrey H Calderwood
PURPOSE OF REVIEW: Colonoscopy is the gold standard for visualization and diagnosis of conditions involving the colon and terminal ileum. It also facilitates screening and prevention of colorectal cancer, which is the second leading cause of cancer death in the USA. Adequate cleansing is essential for thorough visualization of the colon with successful detection of colon polyps. RECENT FINDINGS: While the original large-volume polyethylene glycol preparations are still commonly used, several lower volume regimens are widely available and selected based on provider and patient preferences...
March 2018: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/29391310/polyethylene-glycol-3350-miralax%C3%A2-1-9-l-sports-drink-gatorade%C3%A2-2-tablets-of-bisacodyl-results-in-inferior-bowel-preparation-for-colonoscopy-compared-with-polyethylene-glycol-ascorbic-acid-moviprep%C3%A2
#14
Maqsood Ahmed Khan, Kevin B Patel, Mohammed Nooruddin, Garth Swanson, Louis Fogg, Ali Keshavarzian, Michael Brown
BACKGROUND/AIMS: Polyethylene glycol (PEG)-3350, approved by Food and Drug Administration (FDA) only for constipation, combined with 1.9 L of sports drink (SD) (GatoradeR) and bisacodyl (B) is commonly used in outpatient practice for bowel preparation due to cited patient satisfaction and tolerability of this specific regimen. We aim to compare PEG-3350 (MiralaxR) with PEG-AA-based (MoviPrepR) in terms of efficacy, patient satisfaction, and the effects of these two regimen on serum electrolytes...
January 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29337780/efficacy-and-safety-of-sodium-picosulfate-magnesium-citrate-for-bowel-preparation-in-a-physically-disabled-outpatient-population-a-randomized-endoscopist-blinded-comparison-with-ascorbic-acid-enriched-polyethylene-glycol-solution-plus-bisacodyl-the-pico-movi
#15
Elisabeth M H Mathus-Vliegen, Karin van der Vliet, Inge J Wignand-van der Storm, John S Stadwijk
BACKGROUND: Because of its volume, adequate bowel preparation remains problematic in physically unfit patients. OBJECTIVE: This study aimed to compare a small-volume sodium picosulfate/magnesium citrate preparation with a 2-L ascorbic acid-enriched polyethylene glycol solution plus bisacodyl. DESIGN: This study has a noninferiority design, assuming that ascorbic acid-enriched polyethylene glycol solution plus bisacodyl is 70% efficacious in achieving an Ottawa score ≤7 and accepting a difference in success rate of <15% with a target enrollment of 146 patients per group...
February 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29243102/split-dose-bowel-preparation-reduces-the-need-for-early-repeat-colonoscopy-without-improving-adenoma-detection-rate
#16
Li Wang, Brandon S Sprung, Arthur J DeCross, Danielle Marino
BACKGROUND AND AIMS: Split-dose bowel preparation is associated with improved mucosal visualization and patient tolerance, becoming a standard of care. However, quality measures data associated with this preparation are limited. At our academic tertiary-care facility, we aim to study the effect of changing from single- to split-dose preparation on colonoscopy quality measures. METHODS: A retrospective cohort study with quality indicators was conducted using electronic medical record data...
May 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29217376/safety-tolerability-and-immunogenicity-of-two-zika-virus-dna-vaccine-candidates-in-healthy-adults-randomised-open-label-phase-1-clinical-trials
#17
Martin R Gaudinski, Katherine V Houser, Kaitlyn M Morabito, Zonghui Hu, Galina Yamshchikov, Ro Shauna Rothwell, Nina Berkowitz, Floreliz Mendoza, Jamie G Saunders, Laura Novik, Cynthia S Hendel, LaSonji A Holman, Ingelise J Gordon, Josephine H Cox, Srilatha Edupuganti, Monica A McArthur, Nadine G Rouphael, Kirsten E Lyke, Ginny E Cummings, Sandra Sitar, Robert T Bailer, Bryant M Foreman, Katherine Burgomaster, Rebecca S Pelc, David N Gordon, Christina R DeMaso, Kimberly A Dowd, Carolyn Laurencot, Richard M Schwartz, John R Mascola, Barney S Graham, Theodore C Pierson, Julie E Ledgerwood, Grace L Chen
BACKGROUND: The Zika virus epidemic and associated congenital infections have prompted rapid vaccine development. We assessed two new DNA vaccines expressing premembrane and envelope Zika virus structural proteins. METHODS: We did two phase 1, randomised, open-label trials involving healthy adult volunteers. The VRC 319 trial, done in three centres, assessed plasmid VRC5288 (Zika virus and Japanese encephalitis virus chimera), and the VRC 320, done in one centre, assessed plasmid VRC5283 (wild-type Zika virus)...
December 4, 2017: Lancet
https://www.readbyqxmd.com/read/29163958/systematic-review-and-meta-analysis-sodium-picosulphate-with-magnesium-citrate-as-bowel-preparation-for-colonoscopy
#18
REVIEW
Ilvy van Lieshout, Isabelle D Munsterman, Anne M Eskes, Jolanda M Maaskant, René van der Hulst
Background: An effective and tolerable bowel preparation is important to secure quality of colonoscopies. It remains unclear if sodium picosulphate with magnesium citrate (SPMC), which is considered a tolerable bowel preparation agent, is also an effective alternative for polyethylene glycol (PEG) and sodium phosphate (NaP). Aim: The aim of this article is to compare effectiveness of SPMC to PEG and NaP through assessment of quality of bowel cleansing measured by validated tools...
November 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29112048/results-of-a-community-based-randomized-study-comparing-a-clear-liquid-diet-with-a-low-residue-diet-using-a-magnesium-citrate-preparation-for-screening-and-surveillance-colonoscopies
#19
Chandrashekhar Thukral, Sumeet K Tewani, Adam J Lake, Aaron J Shiels, Kathy Geissler, Sara Popejoy, Megan Stafford, Joseph J Vicari
BACKGROUND: Current bowel preparations for colonoscopy include a clear liquid diet (CLD) along with consumption of a laxative. This dietary restriction along with large volume bowel preparations are barriers to compliance and willingness among patients in scheduling screening examinations. The aim of our study was to compare the efficacy and tolerability of a low-volume split dose magnesium citrate bowel preparation in patients on a low-residue diet (LRD) with those on a CLD. METHODS: In this single center, single blinded, randomized controlled trial, patients scheduled for outpatient colonoscopies were assigned to either a CLD or a LRD 1 day before the examination...
November 3, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29065439/do-adjuvants-add-to-the-efficacy-and-tolerance-of-bowel-preparations-a-meta-analysis-of-randomized-trials
#20
Sophie Restellini, Omar Kherad, Charles Menard, Myriam Martel, Alan N Barkun
BACKGROUND AND STUDY AIMS : Recommendations on adjuvant use with bowel preparations remain disparate. We performed a meta-analysis determining the clinical impact of adding an adjuvant to polyethylene glycol (PEG), sodium phosphate, picosulfate (PICO), or oral sulfate solutions (OSS)-based regimens. METHODS:  Systematic searches were made of MEDLINE, EMBASE, Scopus, CENTRAL and ISI Web of knowledge for randomized trials from January 1980 to April 2016 that assessed preparations with or without adjuvants, given in split and non-split dosing, and PEG high- (> 3 L) or low-dose (≤ 2 L) regimens...
February 2018: Endoscopy
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