Uyen Do, Charbel El-Kefraoui, Makena Pook, Saba Balvardi, Natasha Barone, Philip Nguyen-Powanda, Lawrence Lee, Gabriele Baldini, Liane S Feldman, Julio F Fiore, Mohsen Alhashemi, Alen Antoun, Jeffrey S Barkun, Krista M Brecht, Prosanto K Chaudhury, Dan Deckelbaum, Elise Di Lena, Sinziana Dumitra, Hiba Elhaj, Paola Fata, David Fleiszer, Gerald M Fried, Jeremy Grushka, Pepa Kaneva, Kosar Khwaja, Maxime Lapointe-Gagner, Katherine M McKendy, Ari N Meguerditchian, Sarkis H Meterissian, Haley Montgomery, Fateme Rajabiyazdi, Nadia Safa, Nawar Touma, Francine Tremblay
IMPORTANCE: The overprescription of opioids to surgical patients is recognized as an important factor contributing to the opioid crisis. However, the value of prescribing opioid analgesia (OA) vs opioid-free analgesia (OFA) after postoperative discharge remains uncertain. OBJECTIVE: To investigate the feasibility of conducting a full-scale randomized clinical trial (RCT) to assess the comparative effectiveness of OA vs OFA after outpatient general surgery. DESIGN, SETTING, AND PARTICIPANTS: This parallel, 2-group, assessor-blind, pragmatic pilot RCT was conducted from January 29 to September 3, 2020 (last follow-up on October 2, 2020)...
July 1, 2022: JAMA Network Open