Haoyuan Song, Liuyang Wang, Jiaxu Wu, Jie Liu, Chao Liu, Jianpeng Guo, Liang Fang
In transdermal drug delivery system (TDDS) patches, achieving prolonged adhesion, high drug loading, and rapid drug release simultaneously presented a significant challenge. In this study, a PHT-SP-Cu2+ adhesive was synthesized using polyethylene glycol (PEG), hexamethylene diisocyanate (HDI), trimethylolpropane (TMP), and silk protein (SP) as functional monomers which were combined with Cu2+ to improve the adhesion, drug loading, and drug release of the patch. The structure of the adhesion chains and the formation of Cu2+ -p-π conjugated network in PHT-SP-Cu2+ were characterized and elucidated using different characterization methods including FT-IR, 13 C NMR, XPS, SEM imaging and thermodynamic evaluation...
April 17, 2024: Acta Biomaterialia