Chunxiao Li, Ting Li, Xinya Tian, Wei An, Zhenlong Wang, Bing Han, Hui Tao, Jinquan Wang, Xiumin Wang
With the rapid advancement of genetic and protein engineering, proteins and peptides have emerged as promising drug molecules for therapeutic applications. Consequently, there has been a growing interest in the field of chemical modification technology to address challenges associated with their clinical use, including rapid clearance from circulation, immunogenicity, physical and chemical instabilities (such as aggregation, adsorption, deamination, clipping, oxidation, etc.), and enzymatic degradation. Polyethylene glycol (PEG) modification offers an effective solution to these issues due to its favorable properties...
2024: Frontiers in Pharmacology