keyword
https://read.qxmd.com/read/38536976/an-insight-into-seed-priming-response-of-crotalaria-ochroleuca-and-crotalaria-spectabilis-during-storage
#1
JOURNAL ARTICLE
B N P Silva, T E Masetto, L G Rocha
The proper establishment of plants is essential for the efficient use of resources such as water and light. Besides, even after seed storage and sowing the uniform establishment of plants is essential for their success. Crotalaria ochroleuca and Crotalaria spectabilis are important medicinal plants with poor seed germination rate, occasionally. The effects of seed priming in both C. ochroleuca and C. spectabilis were evaluated in seed performance even after seeds storage for up 90-days. Experimental assays were performed in a randomized design with gibberellic acid (GA3, 100 ppm), polyethylene glycol (PEG 6000, -0...
2024: Brazilian Journal of Biology
https://read.qxmd.com/read/38535492/iron-oxide-magnetite-based-nanobiomaterial-with-medical-applications-environmental-hazard-assessment-using-terrestrial-model-species
#2
JOURNAL ARTICLE
Susana I L Gomes, Janeck J Scott-Fordsmand, Mónica J B Amorim
Nanobiomaterials (NBMs) have tremendous potential applications including in cancer diagnosis and treatment. However, the health and environmental effects of NBMs must be thoroughly assessed to ensure safety. Fe3 O4 (magnetite) nanoparticles coated with polyethylene glycol (PEG) and poly (lactic-co-glycolic acid) (PLGA) were one of the focus NBMs within the EU project BIORIMA. Fe3 O4 PEG-PLGA has been proposed to be used as a contrast agent in magnetic resonance imaging for the identification of solid tumors and has revealed low cytotoxicity in several cell lines...
February 22, 2024: Journal of Xenobiotics
https://read.qxmd.com/read/38535255/hybrid-coatings-based-on-polyvinylpyrrolidone-polyethylene-glycol-enriched-with-collagen-and-hydroxyapatite-incubation-studies-and-evaluation-of-mechanical-and-physiochemical-properties
#3
JOURNAL ARTICLE
Dagmara Słota, Josef Jampilek, Agnieszka Sobczak-Kupiec
Coating materials offers an intriguing solution for imparting inert implants with additional bioactive characteristics without changing underlying parameters such as mechanical strength. Metallic implants like endoprostheses or polymeric implants can be coated with a thin layer of bioactive film capable of stimulating bone-forming cells to proliferate or release a drug. However, irrespective of the final implantation site of such a coating biomaterial, it is necessary to conduct detailed mechanical and physicochemical in vitro analyses to determine its likely behavior under biological conditions...
March 1, 2024: Journal of Functional Biomaterials
https://read.qxmd.com/read/38534837/electrospun-materials-based-on-cellulose-acetate-loaded-with-rosmarinic-acid-with-antioxidant-and-antifungal-properties
#4
JOURNAL ARTICLE
Mariya Spasova, Nikoleta Stoyanova, Olya Stoilova
Fibrous cellulose acetate (CA) materials loaded with rosmarinic acid (RA) were successfully created by one-pot electrospinning. In order to improve the water solubility of the polyphenolic acid and to facilitate its release from the fibrous materials, the non-ionic water-soluble polyethylene glycol (PEG) was added. Detailed characterization of the fabricated fibrous CA/RA and CA/PEG/RA materials was performed using scanning electron microscopy (SEM), X-ray diffraction analysis (XRD), UV-Vis spectroscopy and water contact angle analysis...
March 1, 2024: Biomimetics
https://read.qxmd.com/read/38534606/hydrogels-in-cutaneous-wound-healing-insights-into-characterization-properties-formulation-and-therapeutic-potential
#5
REVIEW
Mariana Ribeiro, Marco Simões, Carla Vitorino, Filipa Mascarenhas-Melo
Hydrogels are polymeric materials that possess a set of characteristics meeting various requirements of an ideal wound dressing, making them promising for wound care. These features include, among others, the ability to absorb and retain large amounts of water and the capacity to closely mimic native structures, such as the extracellular matrix, facilitating various cellular processes like proliferation and differentiation. The polymers used in hydrogel formulations exhibit a broad spectrum of properties, allowing them to be classified into two main categories: natural polymers like collagen and chitosan, and synthetic polymers such as polyurethane and polyethylene glycol...
March 8, 2024: Gels
https://read.qxmd.com/read/38534014/macroprolactin-over-time-is-there-any-point-in-rechecking-it-in-people-with-a-persistently-elevated-serum-prolactin
#6
JOURNAL ARTICLE
Mark Livingston, Syeda F Hashmi, Sudarshan Ramachandran, Ian Laing, Adrian Heald
OBJECTIVE AND DESIGN: Macroprolactinemia may influence the interpretation of serum prolactin levels-a recognised phenomenon since 1981. The degree of macroprolactinaemia over time is less well described. We determined how macroprolactin status (based on polyethylene glycol (PEG) precipitation) varied by analysing serial measurements in hyperprolactinaemic individuals over a period of 9 years. PATIENTS AND MEASUREMENTS: Results from 1810 individuals were included...
March 27, 2024: Clinical Endocrinology
https://read.qxmd.com/read/38533277/heterophilic-interference-of-rheumatoid-factor-in-tsh-immunometric-assay-a-cross-sectional-observational-study
#7
JOURNAL ARTICLE
Shaikh N Nayeemuddin, Akash Panigrahi, Rana Bhattacharjee, Subhankar Chowdhury
INTRODUCTION: Considering the inherent vulnerability of immunoassays for heterophilic interference and the potential of Rheumatoid Factor (RF) to act as a heterophile-like antibody, we conducted this study to investigate if RF leads to any such heterophilic interference in seropositive rheumatoid arthritis (RA) patients. The study was done on the TSH assay as it is a noncompetitive, double antibody sandwich assay, which is known to be vulnerable to heterophilic interference. METHODS: In this cross-sectional observational study, eighty-four consecutive newly diagnosed RF-positive RA patients underwent TSH, Free T4, and anti-TPO estimation using the chemiluminescence technique (CLIA) on Siemens Immulite 1000 platform...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38533241/capping-agents-enable-well-dispersed-and-colloidally-stable-metallic-magnesium-nanoparticles
#8
JOURNAL ARTICLE
Thomas M R Wayman, Vladimir Lomonosov, Emilie Ringe
Mg nanoparticles are an emerging plasmonic material due to Mg's abundance and ability to sustain size- and shape-dependent localized surface plasmon resonances across a broad range of wavelengths from the ultraviolet to the near infrared. However, Mg nanoparticles are colloidally unstable due to their tendency to aggregate and sediment. Nanoparticle aggregation can be inhibited by the addition of capping agents that impart surface charges or steric repulsion. Here, we report that the common capping agents poly(vinyl) pyrrolidone (PVP), polyethylene glycol (PEG), cetyltrimethylammonium bromide (CTAB), and sodium dodecyl sulfate (SDS) interact differently and have varied effects on the aggregation and colloidal stability of Mg nanoparticles...
March 21, 2024: Journal of Physical Chemistry. C, Nanomaterials and Interfaces
https://read.qxmd.com/read/38532602/enhancing-the-antiproliferative-activity-of-perillyl-alcohol-against-glioblastoma-cell-lines-through-synergistic-formulation-with-natural-oils
#9
JOURNAL ARTICLE
Waleed S Alharbi, Abdullah A Alshehri, Tarek A Ahmed, Shadab Md, Alshaimaa M Almehmady, Manal A Alshabibi, Reem M Altamimi, Khalid M El-Say
BACKGROUND: Due to its volatility, photostability, and gastrointestinal toxicity, Perillyl Alcohol (POH), a monoterpenoid component of various plant species, is a chemotherapeutic drug with insufficient efficacy. Many naturally occurring bioactive compounds have well-known antiproliferative properties, including sefsol, jojoba, tea tree, and moringa oils. OBJECTIVE: This study sought to develop an oil-based Self Nanoemulsifying Drug Delivery System (SNEDDS) using tween 80 as the surfactant and Dimethyl Sulfoxide (DMSO) or Polyethylene Glycol (PEG) 400 as the cosurfactant; the oils were used in a range of 10-20% to boost POH's anticancer efficacy...
March 26, 2024: Current Pharmaceutical Design
https://read.qxmd.com/read/38531946/synthesis-of-castor-oil-peg-as-textile-softener
#10
JOURNAL ARTICLE
H M Fahmy, A Amr
New castor oil/polyethylene glycol (CAO/PEG) hybrids were synthesized by reacting of CAO with PEG 300, 600, 1000, 2000 or 4000, in presence of ammonium per sulfate (APS) as an initiator. The optimum conditions to synthesis such hybrids are: PEG/CAO weight ratio, 35%; APS/PEG weight ratio, 15%; reaction temperature, 80 °C; and reaction time, 60 min. Only the hybrids based on PEG 1000 and 2000 formed oil in water stable emulsions. Treating cotton fabric samples with easy care finishing formulation containing 40 g/L of the synthesized hybrids emulsions results in an enhancement in softness, tensile strength, whiteness index, and stiffness along with a reduction in nitrogen content, wrinkle recovery angle, and wettability properties of treated fabric, compared to that sample finished in absence of that emulsions...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38530013/the-influence-of-frequency-volume-and-viscosity-on-the-ultrasonic-atomization-threshold-of-sessile-droplets
#11
JOURNAL ARTICLE
Josué Meneses-Díaz, Yolanda Vargas-Hernández, Eduardo Cancino-Jaque, Luis Gaete-Garretón
In this research, we present a study on the atomization threshold (ATh) of sessile droplets, analyzing its relationship with the excitation frequency fexc (55-48 kHz), droplet volume Vdrop (1-100 μl), and droplet viscosity μ (1-6 mPa⋅s). The investigation focused on the atomization thresholds using ultrasonic excitation of distilled water droplets and water- polyethylene glycol (PEG)-8000 mixtures deposited on vibrating surfaces. The obtained results are compared with previously reported theoretical models...
March 1, 2024: Journal of the Acoustical Society of America
https://read.qxmd.com/read/38528095/effects-of-prenatal-thc-vapor-exposure-on-body-weight-glucose-metabolism-and-feeding-behaviors-in-chow-and-high-fat-diet-fed-rats
#12
JOURNAL ARTICLE
Catherine Hume, Samantha L Baglot, Lucia Javorcikova, Savannah H M Lightfoot, Jessica Scheufen, Matthew N Hill
BACKGROUND: 4-20% of people report using cannabis during pregnancy, thereby it is essential to assess the associated risks. There is some evidence that prenatal cannabis exposure (PCE) may be associated with increased risk for developing of obesity and diabetes later in life, however this has not been well explored under controlled conditions. The aim of this study was to use a translational THC vapor model in rodents to characterize the effects of PCE on adiposity, glucose metabolism, and feeding patterns in adulthood, with focus on potential sex differences...
March 25, 2024: International Journal of Obesity
https://read.qxmd.com/read/38527681/polyethylene-glycol-crosslinked-modified-chitosan-halloysite-nanotube-composite-aerogel-microspheres-for-efficient-adsorption-of-melanoidin
#13
JOURNAL ARTICLE
Zhaoyang Wang, Zhikun Lv, Qianyu Su, Xinyu Lai, Zhi Huang, Kai Li, Ligao Deng, Jianbin Li
Melanoidins are widely present in molasses wastewater and are dark-colored macromolecules that are hazardous to the environment. Currently, adsorption methods can effectively remove melanoidins from wastewater. However, existing adsorbents have shown unsatisfactory removal efficiency for melanoidins, making practical application challenging. Polyethylene glycol crosslinked modified chitosan/halloysite nanotube composite aerogel microspheres (PCAM@HNTs) were developed as a highly efficient adsorbent for melanoidins...
March 23, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38524880/a-novel-dna-aptamer-probe-recognizing-castration-resistant-prostate-cancer-in-vitro-and-in-vivo-based-on-cell-selex
#14
JOURNAL ARTICLE
Jinman Zhong, Duoduo Liu, Quanxin Yang, Jianke Ding, Xin Chen
BACKGROUND: Early recognition of castration-resistant state is of significance for timely adjustment of treatment regimens and improvement of prognosis. PURPOSE: This study aims to screen new aptamers CRda8 and CRda21 which recognize castration resistant prostate cancer (CRPC) cells with high affinity and specificity by SELEX technology. METHODS: The enrichment of specific aptamer candidates was monitored by flow cytometric analysis. The affinity and specificity of aptamer candidates were evaluated by flow cytometry and immunofluorescence assay...
2024: Drug Design, Development and Therapy
https://read.qxmd.com/read/38523704/engineering-lnps-with-polysarcosine-lipids-for-mrna-delivery
#15
JOURNAL ARTICLE
Diana D Kang, Xucheng Hou, Leiming Wang, Yonger Xue, Haoyuan Li, Yichen Zhong, Siyu Wang, Binbin Deng, David W McComb, Yizhou Dong
Since the approval of the lipid nanoparticles (LNP)-mRNA vaccines against the SARS-CoV-2 virus, there has been an increased interest in the delivery of mRNA through LNPs. However, current LNP formulations contain PEG lipids, which can stimulate the generation of anti-PEG antibodies. The presence of these antibodies can potentially cause adverse reactions and reduce therapeutic efficacy after administration. Given the widespread deployment of the COVID-19 vaccines, the increased exposure to PEG may necessitate the evaluation of alternative LNP formulations without PEG components...
July 2024: Bioactive Materials
https://read.qxmd.com/read/38523641/research-progress-on-the-pegylation-of-therapeutic-proteins-and-peptides-tpps
#16
REVIEW
Chunxiao Li, Ting Li, Xinya Tian, Wei An, Zhenlong Wang, Bing Han, Hui Tao, Jinquan Wang, Xiumin Wang
With the rapid advancement of genetic and protein engineering, proteins and peptides have emerged as promising drug molecules for therapeutic applications. Consequently, there has been a growing interest in the field of chemical modification technology to address challenges associated with their clinical use, including rapid clearance from circulation, immunogenicity, physical and chemical instabilities (such as aggregation, adsorption, deamination, clipping, oxidation, etc.), and enzymatic degradation. Polyethylene glycol (PEG) modification offers an effective solution to these issues due to its favorable properties...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38522178/controlling-spatial-distribution-of-functional-lipids-in-a-supported-lipid-bilayer-prepared-from-vesicles
#17
JOURNAL ARTICLE
Hyun-Su Lee, Ye Chan Kim, Zhicheng Wang, Jacob S Brenner, Vladimir R Muzykantov, Jacob W Myerson, Russell J Composto
Conjugating biomolecules, such as antibodies, to bioconjugate moieties on lipid surfaces is a powerful tool for engineering the surface of diverse biomaterials, including cells and nanoparticles. We developed supported lipid bilayers (SLBs) presenting well-defined spatial distributions of functional moieties as models for precisely engineered functional biomolecular-lipid surfaces. We used quartz crystal microbalance with dissipation (QCM-D) and atomic force microscopy (AFM) to determine how vesicles containing a mixture of 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC) and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[azido(polyethylene glycol)-2000] (DSPE-PEG-N3 ) form SLBs as a function of the lipid phase transition temperature (Tm )...
March 11, 2024: Journal of Colloid and Interface Science
https://read.qxmd.com/read/38522160/upcycle-polyethylene-terephthalate-waste-by-photoreforming-bifunction-of-pt-cocatalyst
#18
JOURNAL ARTICLE
Xiaochi Han, Ming Jiang, Huaxing Li, Rongjie Li, Nashwan H M Sulaiman, Tao Zhang, Hongjiao Li, Lirong Zheng, Jiake Wei, Lirong He, Xuemei Zhou
Upcycle polyethylene terephthalate (PET) waste by photoreforming (PR) is a sustainable and green approach to tackle environmental problems but with challenges to obtain valuable oxidation products and high purity hydrogen simultaneously. Noble metal cocatalysts are essential to enhance the overall PR reaction efficacy. In this work, TiO2 nanotubes (TiO2 NTs) decorated with single Pt atoms (Pt1 /TiO2 ) or Pt nanoparticles (PtNPs /TiO2 ) are used in the photoreforming reaction (in one batch), and the oxidation products from ethylene glycol (EG, hydrolysed product of PET) in liquid phase and hydrogen are detected...
March 13, 2024: Journal of Colloid and Interface Science
https://read.qxmd.com/read/38521114/purification-crystallization-and-preliminary-crystallographic-analysis-of-chlamydophila-pneumoniae-ap-endonuclease-iv
#19
JOURNAL ARTICLE
Yitong Zhang, Yangjie Ren, Ben Wang, Shiyang Guo, Siqi Wang, Jinglin Jin, Lihong Yang, Wei Gao
Base excision is a crucial DNA repair process mediated by endonuclease IV in nucleotide excision. In Chlamydia pneumoniae, CpendoIV is the exclusive AP endonuclease IV, exhibiting DNA replication error-proofreading capabilities, making it a promising target for anti-chlamydial drug development. Predicting the structure of CpendoIV, molecular docking with DNA was performed, analyzing complex binding sites and protein surface electrostatic potential. Comparative structural studies were conducted with E. coli EndoIV and DNA complex containing AP sites...
March 21, 2024: Protein Expression and Purification
https://read.qxmd.com/read/38519751/polyethylene-glycol-based-polymer-drug-conjugates-novel-design-and-synthesis-strategies-for-enhanced-therapeutic-efficacy-and-targeted-drug-delivery
#20
JOURNAL ARTICLE
Vinay Sagar Verma, Aakansha Pandey, Arvind Kumar Jha, Hemant Kumar Ramchandra Badwaik, Amit Alexander, Ajazuddin
Due to their potential to enhance therapeutic results and enable targeted drug administration, polymer-drug conjugates that use polyethylene glycol (PEG) as both the polymer and the linker for drug conjugation have attracted much research. This study seeks to investigate recent developments in the design and synthesis of PEG-based polymer-drug conjugates, emphasizing fresh ideas that fill in existing knowledge gaps and satisfy the increasing need for more potent drug delivery methods. Through an extensive review of the existing literature, this study identifies key challenges and proposes innovative strategies for future investigations...
March 23, 2024: Applied Biochemistry and Biotechnology
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