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https://www.readbyqxmd.com/read/28221811/deformation-localisation-in-molecular-layers-constrained-between-self-assembled-au-nanoparticles
#1
Guillaume Copie, Moussa Biaye, Heinrich Diesinger, Thierry Mélin, Christophe Krzeminski, Fabrizio Cleri
The localised deformation of molecular monolayers constrained between the spherical surfaces of Au nanoparticles is studied by means of molecular dynamics simulations. Alkyl or polyethylene glycol long-chain molecules were homogeneously distributed over the curved Au surface, pushed against each other by repeated cycles of force relaxation and constant-volume equilibration, at temperatures increasing from 50 to 300K, before being slowly quenched down to near-zero temperature. Plots of minimum configurational energy can be obtained as a function of the nanoparticle distance, according to different directions of approach; therefore, such simulations describe a range of deformations, from perfectly uniaxial compression, to a combination of compression and shear...
February 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28221759/fast-decomposition-procedure-of-solid-samples-by-lithium-borates-fusion-employing-salicylic-acid
#2
Miha Trdin, Marijan Nečemer, Ljudmila Benedik
A new fast decomposition procedure for solid samples was developed. In this study, we investigated decomposition of samples by lithium borates fusion in combination with salicylic acid. The method described shortens the time required for the sample to be digested and loaded to a resin to up to 2 h, and it was especially suitable for alpha spectrometry measurements in emergency situations. Additionally, the method results in high radiochemical recoveries and when compared to other digestion methods (classical digestion utilizing mineral acids, microwave digestion, and lithium borates fusion in combination with polyethylene glycol (PEG)) gives comparable activity concentration values...
February 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28221732/facile-fabrication-of-aie-active-fluorescent-polymeric-nanoparticles-with-ultra-low-critical-micelle-concentration-based-on-ce-iv-redox-polymerization-for-biological-imaging-applications
#3
Qing Wan, Dazhuang Xu, Liucheng Mao, Ziyang He, Guangjian Zeng, Yingge Shi, Fengjie Deng, Meiying Liu, Xiaoyong Zhang, Yen Wei
Fluorescent polymeric nanoparticles (FPNs) with aggregation-induced emission (AIE) property have received increasing attention and possess promising biomedical application potential in the recent years. Many efforts have been devoted to the fabrication methodologies of FPNs and significant advance has been achieved. In this contribution, a novel strategy for the fabrication of AIE-active amphiphilic copolymers is reported for the first time based on the Ce(IV) redox polymerization. As an example, ene group containing AIE-active dye (named as Phe-alc) is directly grafted onto a water soluble polymer polyethylene glycol (PEG) in H2 O/THF system under low temperature...
February 21, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28220760/focused-electron-beam-induced-deposition-of-copper-with-high-resolution-and-purity-from-aqueous-solutions
#4
Samaneh Esfandiarpour, Lindsay Boehme, J Todd Hastings
Electron-beam induced deposition of high-purity copper nanostructures is desirable for nanoscale rapid prototyping, interconnection of chemically synthesized structures, and integrated circuit editing. However, metalorganic, gas-phase precursors for copper introduce high levels of carbon contamination. Here we demonstrate electron beam induced deposition of high-purity copper nanostructures from aqueous solutions of copper sulfate. The addition of sulfuric acid eliminates oxygen contamination from the deposit and produces a deposit with ∼95 at% copper...
February 21, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28219808/photoluminescent-and-biodegradable-polycitrate-polyethylene-glycol-polyethyleneimine-polymers-as-highly-biocompatible-and-efficient-vectors-for-bioimaging-guided-sirna-and-mirna-delivery
#5
Min Wang, Yi Guo, Meng Yu, Peter X Ma, Cong Mao, Bo Lei
: Development of biodegradable and biocompatible non-viral vectors with intrinsical multifunctional properties such as bioimaging ability for highly efficient nucleic acids delivery still remains a challenge. Here, a biodegradable poly (1, 8-octanedio-citric acid)-co-polyethylene glycol grafted with polyethyleneimine (PEI) (POCG-PEI) polymers with the photoluminescent capacity were synthesized for nucleic acids delivery (siRNA and miRNA). POCG-PEI polymers can efficiently bind various nucleic acids, protect them against enzymatic degradation and release the genes in the presence of polyanionic heparin...
February 17, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28219034/preparation-of-core-shell-nanostructure-fe3o4-peg400-so3h-as-heterogeneous-and-magnetically-recyclable-nanocatalyst-for-one-pot-synthesis-of-substituted-pyrroles-by-paal-knorr-reaction-at-room-temperature
#6
Fahimeh Bonyasi, Malak Hekmati, Hojat Veisi
An efficient procedure has been proposed for the loading of sulfonic acid groups on the surface of polyethylene glycol 400 (PEG400)-encapsulated Fe3O4 nanoparticles to synthesize a core-shell Fe3O4@PEG400-SO3H nano catalyst. Surface functionalization of magnetic particles in such a way is a refined method of bridging the gap amongst heterogeneous and homogeneous catalysis. The procured nano catalyst was classified through Fourier transformed infrared spectroscopy (FT-IR), X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), energy dispersive X-ray spectroscopy (EDS), wavelength-dispersive X-ray spectroscopy (WDX), thermogravimetric analysis (TGA), vibrating sample magnetometer (VSM), X-ray photoelectron spectroscopy (XPS), BET, and back titration...
February 13, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28218512/the-performance-of-doxorubicin-conjugated-gold-nanoparticles-regulation-of-drug-location
#7
Teng Cui, Juan-Juan Liang, Huan Chen, Dong-Dong Geng, Lei Jiao, Jian-Yong Yang, Hai Qian, Can Zhang, Ya Ding
Drug-conjugated gold nanoparticles (GNPs), which are generally constructed with many molecules of thiol-terminated polyethylene glycol (PEG)-drug decorated on their surfaces via a thiol-Au covalent bond, are promising and efficient nanoprodrugs. However, due to the exposure of the hydrophobic drug molecules on the surface of the conjugate, in vivo stability, opsonization, and subsequent inefficient therapy become the main issues of this system. To solve these problems without complicating the structures of gold conjugates, herein we propose a method to change the relative position of PEG and the drug...
February 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28217547/a-study-of-the-formation-of-magnetically-active-solid-dispersions-of-phenacetin-using-atomic-and-magnetic-force-microscopy
#8
Liana Stanislavovna Usmanova, Marat Akhmedovich Ziganshin, Valery Vilenovich Gorbatchuk, Sufia Askhatovna Ziganshina, Dmitry Anatolevich Bizyaev, Anastas Akhmetovich Bukharaev, Timur Anvarovich Mukhametzyanov, Alexander Vladimirovich Gerasimov
A lot of pharmaceutical substances have a poor solubility that limits their absorption and distribution to the targeted sites to elicit the desired action without causing untoward effects on healthy cells or tissues. For such drugs, new modes of delivery have to be developed for efficient and effective delivery of the drug to the target site. Formation of magnetically active solid dispersion of such drugs could be a useful approach to addressing this problem because they combine targeted delivery and good solubility...
January 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/28216468/enhanced-ocular-efficacy-of-topically-delivered-dorzolamide-with-nanostructured-mucoadhesive-microparticles
#9
Chun Gwon Park, Young Kook Kim, Se-Na Kim, Seung Ho Lee, Beom Kang Huh, Min-A Park, Hyein Won, Ki Ho Park, Young Bin Choy
Dorzolamide eye drops are widely prescribed to reduce intraocular pressure (IOP) in the treatment of ocular hypertension and glaucoma. However, in an eye drop formulation, dorzolamide is rapidly cleared from the preocular space, hence requiring multiple daily administrations. Here, we sought to increase the preocular retention of dorzolamide using nanostructured, mucoadhesive microparticles (MUCO_NM) as carriers for topical delivery to the eye. MUCO_NM were prepared by freeze-milling dorzolamide-loaded, electrospun nanofibers composed of poly(lactic-co-glycolic acid) and polyethylene glycol...
February 16, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28216297/high-water-content-and-resilient-peg-containing-hydrogels-with-low-fibrotic-response
#10
Yu Zhang, Duo An, Yehudah Pardo, Alan Chiu, Wei Song, Qingsheng Liu, Fang Zhou, Sean P McDonough, Minglin Ma
: Hydrogels such as those based on polyethylene glycol (PEG) are broadly used in biomedicine where high water contents, robust mechanical properties such as resilience and favorable interactions with the body are often simultaneously desirable. However, the mechanical properties of conventional hydrogels often degrade rapidly after swelling or with increasing water content, limiting their potential in many applications. Here we describe a new class of PEG-containing hydrogels that remain highly resilient after maximum swelling...
February 16, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28216002/stealth-nanocarriers-based-sterosomes-using-peg-post-insertion-process
#11
Anna Cieślak, Nathalie Wauthoz, Alejandro Nieto Orellana, Nolwenn Lautram, Jérôme Béjaud, José Hureaux, Michel Lafleur, Jean-Pierre Benoit, Claudio J Salomon, Guillaume Bastiat
Sterosomes (STEs), a new and promising non-phospholipidic liposome platform based on palmitic acid (PA) and cholesterol (Chol) mixtures, need to have polyethylene glycol (PEG) chains grafted to their surface in order to obtain long-circulating nanocarriers in the blood stream. A post-insertion method was chosen to achieve this modification. The post-insertion process of PEG-modified distearoylphosphoethanolamine (DSPE-PEG) was monitored using the zeta potential value of STEs. Various conditions including PEG chain length and the DSPE-PEG/PA-Chol ratio, were explored...
February 16, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28215671/dual-ligand-%C3%AE-5%C3%AE-1-and-%C3%AE-6%C3%AE-4-integrin-targeting-enhances-gene-delivery-and-selectivity-to-cancer-cells
#12
Rachel M Levine, Efrosini Kokkoli
Nanoparticles functionalized with cancer-targeting ligands have shown promise but are still limited by off-tumor binding to healthy tissues that express low levels of the molecular target. Targeting two cancer biomarkers using dual-targeted heteromultivalent nanoparticles presents a possible solution to this challenge by requiring overexpression of two separate ligands for localization. In order to guide experimental design, a kinetic model was built to explore how the affinity and valency of dual-ligand liposomes affect the binding and selectivity of delivery to cells with various receptor expression...
February 16, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28214995/development-and-characterization-of-monoclonal-antibody-against-human-il-37b
#13
Yu-Chi Gao, Yan Jia, De-Qian Xiao, Xin Wang, You-Chao Dai, Shi-Yan Yu, Chen Chen, Ze-Gang Zhuang, Xiao-Xia Fu, Jun-Ai Zhang, Bi-Ying Zheng, Zhi-Hong Chen, Ji-Xin Zhong, Zhang-Quan Chen, Jun-Fa Xu
IL-37 has been described as a natural inhibitor of immune responses. Monoclonal antibody (mAb) against human IL-37b with high affinity and specificity can serve as a molecular probe to detect IL-37 and study IL-37 functions, mechanisms and related signal pathways in inflammatory diseases. However, there are very few such mAbs against human IL-37 commercially available so far. In the current study, monoclonal antibodies against human IL-37b were developed by fusing splenocytes from immunized mouse with SP2/0 myeloma cells and polyethylene glycol...
February 18, 2017: Cytotechnology
https://www.readbyqxmd.com/read/28214970/optimal-bowel-cleansing-for-colonoscopy-in-the-elderly-patient
#14
Samuel B Ho, Rita Hovsepians, Samir Gupta
Colonoscopy is an important diagnostic and screening tool for colorectal cancer detection and prevention, and adequate bowel preparation is critical for successful colonoscopy. Complications related to colonoscopy, either directly or indirectly related to the procedure, are increased in elderly patients, and the risks and benefits of colonoscopy procedures need to be carefully considered in these patients. Recent studies have shown that 4 L polyethylene glycol with a split preparation is safe and effective for elderly patients, and is the preferred preparation for patients with medical comorbidities...
February 18, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/28213650/alleviation-of-water-and-osmotic-stress-induced-changes-in-nitrogen-metabolizing-enzymes-in-triticum-aestivum-l-cultivars-by-potassium
#15
Mohammad Abass Ahanger, Megha Tittal, Rayees Ahmad Mir, R M Agarwal
Present communication reports laboratory and pot experiments conducted to study the influence of water and osmotic stress on nitrogen uptake and metabolism in two wheat (Triticum aestivum L) cultivars with and without potassium supplementation. Polyethylene glycol 6000-induced osmotic stress/restricted irrigation caused a considerable decline in the activity of nitrate reductase, glutamate synthase, alanine and aspartate aminotransferases, and glutamate dehydrogenase. Potassium considerably improved nitrogen metabolism under normal water supply conditions and also resulted in amelioration of the negative impact of water and osmotic stresses indicating that potassium supplementation can be used as a potential tool for enhancing the nitrogen use efficiency in wheat for exploiting its genetic potential...
February 17, 2017: Protoplasma
https://www.readbyqxmd.com/read/28212490/vitamin-e-succinate-grafted-chitosan-oligosaccharide-rgd-conjugated-tpgs-mixed-micelles-loaded-with-paclitaxel-for-u87mg-tumor-therapy
#16
Yanzuo Chen, Shu Feng, Wenchao Liu, Zeting Yuan, Peihao Yin, Feng Gao
The poor therapeutic efficacy of hydrophobic chemotherapeutic drugs is an intrinsic limitation to successful chemotherapy. In the present study, a multi-task delivery system based on arginine-glycine-aspartic acid peptide (RGD) decorated vitamin E succinate (VES)-grafted-chitosan oligosaccharide (CSO)/RGD-conjugated D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS-RGD) mixed micelles (VeC/T-RGD MM) was first prepared for targeted delivery of paclitaxel (PTX), a hydrophobic anticancer drug, to improve the efficacy of U87MG tumor therapy...
February 17, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28211893/superior-adsorption-and-photoinduced-carries-transfer-behaviors-of-dandelion-shaped-bi2s3-mos2-experiments-and-theory
#17
Mengjiao Li, Junyong Wang, Peng Zhang, Qinglin Deng, Jinzhong Zhang, Kai Jiang, Zhigao Hu, Junhao Chu
The enhanced light-harvesting capacity and effective separation of photogenerated carriers in fantastic hierarchical heterostructures enjoy striking attention for potential applications in the field of solar cells and photocatalysis. A three-dimensional (3D) dandelion-shaped hierarchical Bi2S3 microsphere compactly decorated with wing-shaped few layered MoS2 lamella (D-BM) was fabricated via a facile hydrothermal self-assembly process. Especially, polyethylene glycol (PEG) has been proven as the vital template to form D-BM microsphere...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28209447/topical-aqueous-extract-of-ephedra-alata-can-improve-wound-healing-in-an-animal-model
#18
Naim Kittana, Hanood Abu-Rass, Ruba Sabra, Lama Manasra, Hadeel Hanany, Nidal Jaradat, Fatima Hussein, Abdel Naser Zaid
PURPOSE: Ephedra alata (E. alata) is perennial tough shrub plant that grows in Palestine and other regions. It is used often in folk's medicine for the treatment of various diseases. In this project, E. alata extract was tested for its ability to improve wound and burn healing. METHODS: An aqueous extract of E. alata was prepared and underwent several phytochemical analyses for the presence of the major classes of phytochemical compounds. After that, a polyethylene glycol-based ointment containing the extract of E...
January 20, 2017: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/28207824/evaluation-of-surgical-anti-adhesion-products-to-reduce-postsurgical-intra-abdominal-adhesion-formation-in-a-rat-model
#19
Long-Xiang Lin, Fang Yuan, Hui-Hui Zhang, Ni-Na Liao, Jing-Wan Luo, Yu-Long Sun
BACKGROUND: Adhesions frequently occur after abdominal surgery. Many anti-adhesion products have been used in clinic. However, the evidences are short for surgeons to reasonably choose the suitable anti-adhesion produces in clinical practice. This study provided such evidence by comparing the efficiency of five products to prevent abdominal adhesion formation in a rat model. METHODS: Fifty-six Sprague-Dawley rats were randomly divided into seven groups: sham-operation group, adhesion group, and five product groups (n = 8)...
2017: PloS One
https://www.readbyqxmd.com/read/28205176/determining-the-topology-of-membrane-bound-proteins-using-pegylation
#20
Vicky Howe, Andrew J Brown
Biochemical methods can help elucidate the membrane topology of hydrophobic membrane proteins where X-ray crystallography is difficult or impractical, providing important structural data. Here, we describe the method of PEGylation, which uses a cysteine-reactive molecule, maleimide polyethylene glycol (mPEG), to determine the cytosolic accessibility of introduced cysteine residues. This accessibility is visualized using Western blotting to detect a band shift that indicates cysteine labeling by mPEG. Using scanning cysteine mutagenesis, followed by PEGylation, one can map the accessibility of the introduced cysteines, hence inferring the membrane topology of the protein...
2017: Methods in Molecular Biology
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