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https://www.readbyqxmd.com/read/29145001/in-vitro-and-in-vivo-evaluation-of-10-hydroxycamptothecin-loaded-poly-n-butyl-cyanoacrylate-nanoparticles-prepared-by-miniemulsion-polymerization
#1
Xin Jin, Sajid Asghar, Xieting Zhu, Zhipeng Chen, Cihui Tian, Lining Yin, Qineng Ping, Yanyu Xiao
In this paper, 10-hydroxycamptothecin (HCPT)-loaded poly (n-butyl cyanoacrylate) nanoparticles (HCPT-PBCA-NPs) co-modified with polysorbate 80, soybean phospholipids, and polyethylene glycol (100) monostearate were successfully prepared via miniemulsion polymerization, and were characterized for particle size, morphology, zeta potential, encapsulation efficiency (EE) and drug loading capacity (DL). The chemical structure of HCPT-PBCA-NPs and the state of HCPT in the PBCA-NPs were investigated by DSC, FTIR and (1)H NMR...
November 12, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29144767/evaluation-of-polyvinyl-caprolactam-polyvinyl-acetate-polyethylene-glycol-graft-copolymer-nanomicelle-for-trigeminal-ganglion-neurons-delivering-with-intranasal-administration
#2
Mengshuang Li, Meng Xin, Kaichao Song, Fengyuan Sun, Yuzhen Hou, Jun Li, Xianggen Wu
Purpose How to deliver enough medical agents to the trigeminal ganglion (TG) neurons conveniently still remains a challenge in pharmaceutics and clinics. The purpose of this study was to reveal that intranasal administration of polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (PVCL-PVA-PEG) nanomicelle formulation could efficiently deliver agent to TG neurons in mice. Methods Ocular topical or intranasal administration of nanomicelle coumarin-6 was performed in mice, and tissue distribution after administration (0...
November 16, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29144410/evaluation-of-different-single-walled-carbon-nanotube-surface-coatings-for-single-particle-tracking-applications-in-biological-environments
#3
Zhenghong Gao, Noémie Danné, Antoine Guillaume Godin, Brahim Lounis, Laurent Cognet
Fluorescence imaging of biological systems down to the single-molecule level has generated many advances in cellular biology. For applications within intact tissue, single-walled carbon nanotubes (SWCNTs) are emerging as distinctive single-molecule nanoprobes, due to their near-infrared photoluminescence properties. For this, SWCNT surfaces must be coated using adequate molecular moieties. Yet, the choice of the suspension agent is critical since it influences both the chemical and emission properties of the SWCNTs within their environment...
November 16, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29142877/removal-efficacy-and-cytotoxicity-of-a-calcium-hydroxide-paste-using-n-2-methyl-pyrrolidone-as-a-vehicle
#4
Myung-Jin Lim, Hyun-Jin Jang, Mi-Kyung Yu, Kwang-Won Lee, Kyung-San Min
Objectives: This study investigated the removal efficacy and cytotoxicity of a newly developed calcium hydroxide paste (cleaniCal, Maruchi) using N-2-methyl-pyrrolidone (NMP) as a vehicle in comparison with ApexCal (Ivoclar Vivadent) and Calcipex II (Nishika), which use different vehicles such as polyethylene glycol and propylene glycol, respectively. Materials and Methods: Thirty maxillary premolars with oval-shaped canals were divided into 3 groups and the teeth were filled with one of the pastes...
November 2017: Restorative Dentistry & Endodontics
https://www.readbyqxmd.com/read/29142408/correlation-between-polyphenol-oxidase-ppo-activity-and-total-phenolic-contents-in-crocus-sativus-l-corms-during-dormancy-and-sprouting-stages
#5
Nardana Esmaeili, Hassan Ebrahimzadeh, Khosrou Abdi
Purification and characterization of polyphenol oxidase (PPO) enzyme and determination of total phenolic contents during dormancy and sprouting stages in Crocus sativus corms were performed. PPO enzyme was purified by ammonium sulfate precipitation and ion-exchange chromatography using DEAE-Sephadex A25 and two isoenzymes were obtained on the SDS-PAGE, which corresponded to molecular weights of 70 and 54 kDa. The Km values of the enzyme were 4.87 and 2.12 mM for l-DOPA in dormancy and waking stages, respectively...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29141885/a-role-for-bacterial-urease-in-gut-dysbiosis-and-crohn-s-disease
#6
Josephine Ni, Ting-Chin David Shen, Eric Z Chen, Kyle Bittinger, Aubrey Bailey, Manuela Roggiani, Alexandra Sirota-Madi, Elliot S Friedman, Lillian Chau, Andrew Lin, Ilana Nissim, Justin Scott, Abigail Lauder, Christopher Hoffmann, Gloriany Rivas, Lindsey Albenberg, Robert N Baldassano, Jonathan Braun, Ramnik J Xavier, Clary B Clish, Marc Yudkoff, Hongzhe Li, Mark Goulian, Frederic D Bushman, James D Lewis, Gary D Wu
Gut dysbiosis during inflammatory bowel disease involves alterations in the gut microbiota associated with inflammation of the host gut. We used a combination of shotgun metagenomic sequencing and metabolomics to analyze fecal samples from pediatric patients with Crohn's disease and found an association between disease severity, gut dysbiosis, and bacterial production of free amino acids. Nitrogen flux studies using (15)N in mice showed that activity of bacterial urease, an enzyme that releases ammonia by hydrolysis of host urea, led to the transfer of murine host-derived nitrogen to the gut microbiota where it was used for amino acid synthesis...
November 15, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/29141149/surface-modification-of-cisplatin-complexed-gold-nanoparticles-and-its-influence-on-colloidal-stability-drug-loading-and-release
#7
Jiaojie Tan, Tae Joon Cho, De-Hao Tsai, Jingyu Liu, John M Pettibone, Rian You, Vincent A Hackley, Michael R Zachariah
Cisplatin-complexed gold nanoparticles (PtII-AuNP) provide a promising strategy for chemo-radiation based anticancer drugs. Effective design of such platforms necessitates reliable assessment of surface engineering on a quantitative basis, and its influence on drug payload, stability and release. In this paper, polyethylene glycol (PEG) stabilized PtII-AuNP was synthesized as a model anti-tumor drug platform, where PtII is attached via a carboxyl terminated dendron ligand. Surface modification by PEG and its influence on drug loading, colloidal stability and drug release were assessed...
November 15, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29141139/the-effect-of-synthetic-high-density-lipoproteins-modification-with-polyethylene-glycol-on-pharmacokinetics-and-pharmacodynamics
#8
Dan Li, Maria V Fawaz, Emily E Morin, Ran Ming, Denis Sviridov, Jie Tang, Rose Ackerman, Karl Olsen, Alan T Remaley, Anna Schwendeman
Synthetic high density lipoprotein nanoparticles (sHDL) capable of mobilizing excess cholesterol from atherosclerotic arteries and delivering it to the liver for elimination have been shown to reduce plaque burden in patients. Unfortunately, sHDLs have a narrow therapeutic index and relative to the endogenous HDL shorter circulation half-life. Surface modification with polyethylene glycol (PEG) was investigated for its potential to extend sHDL circulation in vivo. Various amounts (2.5, 5 and 10%) and different chain lengths (2 and 5 kDa) of PEG-modified lipids were incorporated in sHDL's lipid membrane...
November 15, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29138557/improving-intestinal-absorption-and-oral-bioavailability-of-curcumin-via-taurocholic-acid-modified-nanostructured-lipid-carriers
#9
Cihui Tian, Sajid Asghar, Yifan Wu, Zhipeng Chen, Xin Jin, Lining Yin, Lin Huang, Qineng Ping, Yanyu Xiao
The expression of multiple receptors on intestinal epithelial cells enables an actively targeted carrier to significantly enhance the oral delivery of payloads. Conjugating the receptors' ligands on the surfaces of a particulate-delivery system allows site-specific targeting. Here, we used taurocholic acid (TCA) as a ligand for uptake of nanostructured lipid carriers (NLCs) mediated by a bile-acid transporter to improve oral bioavailability of curcumin (Cur). First, synthesis of TCA-polyethylene glycol 100-monostearate (S100-TCA) was carried out...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29137771/solvent-effect-in-sonochemical-synthesis-of-metal-alloy-nanoparticles-for-use-as-electrocatalysts
#10
Celest U Okoli, Kurian A Kuttiyiel, Jesse Cole, J McCutchen, Hazem Tawfik, Radoslav R Adzic, Devinder Mahajan
Nanomaterials are now widely used in the fabrication of electrodes and electrocatalysts. Herein, we report a sonochemical study of the synthesis of molybdenum and palladium alloy nanomaterials supported on functionalized carbon material in various solvents: hexadecane, ethanol, ethylene glycol, polyethylene glycol (PEG 400) and Ionic liquids (ILs). The objective was to identify simple and more environmentally friendly design and fabrication methods for nanomaterial synthesis that are suitable as electrocatalysts in electrochemical applications...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29136916/magnetophoretic-separation-icp-ms-immunoassay-using-cs-doped-multicore-magnetic-nanoparticles-for-the-determination-of-salmonella-typhimurium
#11
Arong Jeong, H B Lim
In this work, a magnetophoretic separation ICP-MS immunoassay using newly synthesized multicore magnetic nanoparticles (MMNPs) was developed for the determination of salmonella typhimurium (typhi). The uniqueness of this method was the use of MMNPs doped with Cs for both separation and detection, which enable us to achieve fast analysis, high sensitivity, and good reliability. For demonstration, heat-killed typhi in a phosphate buffer solution was determined by ICP-MS after the MMNP-typhi reaction product was separated from unreacted MMNPs in a micropipette tip filled with 25% polyethylene glycol through magnetophoretic separation...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29134552/intranasal-delivery-of-%C3%AE-asarone-to-the-brain-with-lactoferrin-modified-mpeg-pla-nanoparticles-prepared-by-premix-membrane-emulsification
#12
Linmei Pan, Jing Zhou, Feng Ju, Huaxu Zhu
Alpha-asarone is a bioactive component of Acorus tatarincuii Schott with low bioavailability, which is often used for treatments of various brain diseases in clinical setting. This study was to formulate biodegradable methoxy polyethylene glycol-polylactic acid (mPEG-PLA) nanoparticles (NPs) surface-modified by lactoferrin (Lf), for delivering α-asarone into the brain following intranasal administration. Alpha-asarone NPs were prepared by premix membrane emulsification. The relative parameters were optimized by a Box-Behnken experimental design...
November 13, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29134085/gene-delivery-ability-of-polyethylenimine-and-polyethylene-glycol-dual-functionalized-nanographene-oxide-in-11-different-cell-lines
#13
Liping Wu, Jinshan Xie, Tan Li, Zihao Mai, Lu Wang, Xiaoping Wang, Tongsheng Chen
We recently developed a polyethylenimine (PEI) and polyethylene glycol (PEG) dual-functionalized reduced graphene oxide (GO) (PEG-nrGO-PEI, RGPP) for high-efficient gene delivery in HepG2 and Hela cell lines. To evaluate the feasibility and applicability of RGPP as a gene delivery carrier, we here assessed the transfection efficiency of RGPP on gene plasmids and siRNA in 11 different cell lines. Commercial polyalkyleneimine cation transfection reagent (TR) was used as comparison. In HepG2 cells, RGPP exhibited much stronger delivery ability for siRNA and large size plasmids than TR...
October 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/29132435/vasculotide-reduces-pulmonary-hyperpermeability-in-experimental-pneumococcal-pneumonia
#14
Birgitt Gutbier, Xiaohui Jiang, Kristina Dietert, Carolin Ehrler, Jasmin Lienau, Paul Van Slyke, Harold Kim, Van C Hoang, Jason T Maynes, Daniel J Dumont, Achim D Gruber, Norbert Weissmann, Timothy J Mitchell, Norbert Suttorp, Martin Witzenrath
BACKGROUND: Community-acquired pneumonia (CAP) is a significant cause of morbidity and mortality worldwide. Despite effective antimicrobial therapy, CAP can induce pulmonary endothelial hyperpermeability resulting in life-threatening lung failure due to an exaggerated host-pathogen interaction. Treatment of acute lung injury is mainly supportive because key elements of inflammation-induced barrier disruption remain undetermined. Angiopoietin-1 (Ang-1)-mediated Tie2 activation reduces, and the Ang-1 antagonist Ang-2 increases, inflammation and endothelial permeability in sepsis...
November 13, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29132208/organic-chemical-characterization-and-mass-balance-of-a-hydraulically-fractured-well-from-fracturing-fluid-to-produced-water-over-405-days
#15
James S Rosenblum, E Michael Thurman, Imma Ferrer, George R Aiken, Karl G Linden
A long-term field study (405 days) of a hydraulically fractured well from the Niobrara Formation in the Denver-Julesburg Basin was completed. Characterization of organic chemicals used in hydraulic fracturing and their changes through time, from the pre-injected fracturing fluid to the produced water, was conducted. The characterization consisted of a mass balance by dissolved organic carbon (DOC), volatile organic analysis by gas chromatography/mass spectrometry, and nonvolatile organic analysis by liquid chromatography/mass spectrometry...
November 14, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29132175/simethicone-improves-bowel-cleansing-with-low-volume-polyethylene-glycol-a-multicenter-randomized-trial
#16
Shenghong Zhang, Danping Zheng, Jinping Wang, Jianwei Wu, Pingguang Lei, Qi Luo, Liping Wang, Beiping Zhang, Hong Wang, Yi Cui, Minhu Chen
Background and study aims For bowel preparation, using a reduced volume of polyethylene glycol (PEG) solution without influencing its effectiveness would be preferable. While simethicone shows great potential as an adjunctive agent, data on its use are limited. We aimed to clarify whether simethicone added to low-volume PEG solution improved bowel cleansing. Patients and methods Consecutive adult patients registered for colonoscopy were recruited from seven medical centers in South China between 15 April and 15 July 2015 and prospectively randomized into two groups: 2 L PEG (conventional group) and 2 L PEG plus simethicone (simethicone group)...
November 13, 2017: Endoscopy
https://www.readbyqxmd.com/read/29131929/insights-on-the-structure-molecular-weight-and-activity-of-an-antibacterial-protein-polymer-hybrid
#17
Yanxiong Pan, Sunanda Neupane, Jasmin Farmakes, Myungkeun Oh, Kylie Bentz, Yongki Choi, Zhongyu Yang
Protein-polymer conjugates are attractive biomaterials which combine the functions of both proteins and polymers. The bioactivity of these hybrid materials, however, is often reduced upon the conjugation. It is important to determine and monitor the protein structure and active site availability, in order to optimize the polymer composition, attachment point, and abundance. The challenges in probing these insights are the large size and high complexity in the conjugates. Here, we overcome the challenges by combining Electron Paramagnetic Resonance (EPR) spectroscopy and Atomic Force Microscopy (AFM) and characterize the structural insights of antibacterial hybrids formed by polyethylene glycol (PEG) and an antibacterial protein...
November 13, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29130090/arrested-and-temporarily-arrested-states-in-a-protein-polymer-mixture-studied-by-usaxs-and-vsans
#18
Stefano Da Vela, Christian Exner, Richard Santiago Schäufele, Johannes Möller, Zhendong Fu, Fajun Zhang, Frank Schreiber
We investigate the transition of the phase separation kinetics from a complete to an arrested liquid-liquid phase separation (LLPS) in mixtures of bovine γ-globulin with polyethylene glycol (PEG). The solutions feature LLPS with upper critical solution temperature phase behavior. At higher PEG concentrations or low temperatures, non-equilibrium, gel-like states are found. The kinetics is followed during off-critical quenches by ultra-small angle X-ray scattering (USAXS) and very-small angle neutron scattering (VSANS)...
November 13, 2017: Soft Matter
https://www.readbyqxmd.com/read/29129967/single-particle-analyzer-of-mass-a-charge-detection-mass-spectrometer-with-a-multi-detector-electrostatic-ion-trap
#19
Andrew G Elliott, Samuel I Merenbloom, Satrajit Chakrabarty, Evan R Williams
A new charge detection mass spectrometer that combines array detection and electrostatic ion trapping to repeatedly measure the masses of single ions is described. This instrument has four detector tubes inside an electrostatic ion trap with conical electrodes (cone trap) to provide multiple measurements of an ion on each pass through the trap resulting in a signal gain over a conventional trap with a single detection tube. Simulations of a cone trap and a dual ion mirror trap design indicate that more passes through the trap per unit time are possible with the latter...
March 2017: International Journal of Mass Spectrometry
https://www.readbyqxmd.com/read/29129570/poly-vinyl-pyrrolidone-lipid-based-hybrid-nanoparticles-for-anti-viral-drug-delivery
#20
K S Joshy, S Snigdha, George Anne, Kalarikkal Nandakumar, Pothen Laly A, Thomas Sabu
Zidovudine (AZT) is an antiviral drug with moderate solubility in water. It has limited application due to its short half life in vivo and consequent requirement for frequent administrations. To solve this problem, zidovudine loaded polyvinylpyrrolidone (PVP)/stearic acid (SA)-polyethylene glycol (PEG) nanoparticles (PSNPs) were developed.The hybrid nanoparticles were prepared by emulsification-solvent evaporation method. The physico chemical characterizations of the PSNPs was done by dynamic light scattering (DLS), transmission electron microscopy (TEM), and fourier transform infra-red spectroscopy (FT-IR)...
November 9, 2017: Chemistry and Physics of Lipids
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