keyword
https://read.qxmd.com/read/38523261/mapk-dependent-control-of-mitotic-progression-in-s-pombe
#1
JOURNAL ARTICLE
Ana Belén Iglesias-Romero, Terersa Soto, Ignacio Flor-Parra, Silvia Salas-Pino, Gabriel Ruiz-Romero, Kathleen L Gould, José Cansado, Rafael R Daga
BACKGROUND: Mitogen-activated protein kinases (MAPKs) preserve cell homeostasis by transducing physicochemical fluctuations of the environment into multiple adaptive responses. These responses involve transcriptional rewiring and the regulation of cell cycle transitions, among others. However, how stress conditions impinge mitotic progression is largely unknown. The mitotic checkpoint is a surveillance mechanism that inhibits mitotic exit in situations of defective chromosome capture, thus preventing the generation of aneuploidies...
March 25, 2024: BMC Biology
https://read.qxmd.com/read/38495453/the-camp-pka-signalling-crosstalks-with-cwi-and-hog-mapk-pathways-in-yeast-cell-response-to-osmotic-and-thermal-stress
#2
REVIEW
Fiorella Galello, Mariana Bermúdez-Moretti, María Clara Ortolá Martínez, Silvia Rossi, Paula Portela
The yeast Saccharomyces cerevisiae is widely used in food and non-food industries. During industrial fermentation yeast strains are exposed to fluctuations in oxygen concentration, osmotic pressure, pH, ethanol concentration, nutrient availability and temperature. Fermentation performance depends on the ability of the yeast strains to adapt to these changes. Suboptimal conditions trigger responses to the external stimuli to allow homeostasis to be maintained. Stress-specific signalling pathways are activated to coordinate changes in transcription, translation, protein function, and metabolic fluxes while a transient arrest of growth and cell cycle progression occur...
2024: Microbial Cell
https://read.qxmd.com/read/38493662/differences-in-mineral-and-osmotic-balances-enhance-zinc-translocation-in-an-aquaporin-overexpressing-poplar
#3
JOURNAL ARTICLE
Andrea Neri, Alessandra Francini, Alessio Giovannelli, Silvia Traversari, Luca Sebastiani
Zinc (Zn) is an essential micronutrient for plants, but it is toxic beyond a certain threshold. Populus alba (L.) 'Villafranca' clone is known for its good tolerance to high Zn concentration compared to other poplar species. A line of this species overexpressing the tonoplast intrinsic aquaporin AQUA1 gene has showed an improved tolerance to Zn excess in comparison to the wild-type (wt) line. The aims of this work were to: 1) verify if AQUA1 plants can uptake Zn more efficiently after a longer period of exposure; 2) evaluate if a higher Zn uptake in transgenic lines can have negative effects; 3) assess Zn competing elements (iron and manganese), soluble sugars, osmolytes, and potassium to investigate differences in water and osmotic homeostasis between lines...
March 11, 2024: Plant Physiology and Biochemistry: PPB
https://read.qxmd.com/read/38492055/differential-drought-tolerance-among-dichondra-dichondra-repens-genotypes-in-relation-to-alterations-in-chlorophyll-metabolism-osmotic-adjustment-and-accumulation-of-organic-metabolites
#4
JOURNAL ARTICLE
Yao Ling, Meng Tan, Yi Xi, Zhou Li
Dichondra (Dichondra repens) is an important ground cover plant for landscaping and establishment of green space, but adaptive mechanism of drought tolerance is not well understood in this species. This study was conducted to compare differential response to drought stress among three genotypes (Dr5, Duliujiang, and Dr29) based on integrated physiological, ultrastructural, and metabolic assays. Results showed that drought significantly inhibited photosynthesis, accelerated lipids peroxidation, and also disrupted water balance and cellular metabolism in dichondra plants...
March 16, 2024: Protoplasma
https://read.qxmd.com/read/38458350/the-bbotf1-zn-%C3%A2-2-cys-6-transcription-factor-contributes-to-antioxidant-response-fatty-acid-assimilation-peroxisome-proliferation-and-infection-cycles-in-insect-pathogenic-fungus-beauveria-bassiana
#5
JOURNAL ARTICLE
Chenhua Zhu, Jingxin Sun, Fangfang Tian, Xinting Tian, Qi Liu, Yunxia Pan, Yongjun Zhang, Zhibing Luo
The abilities to withstand oxidation and assimilate fatty acids are critical for successful infection by many pathogenic fungi. Here, we characterized a Zn(II)2 Cys6 transcription factor Bbotf1 in the insect pathogenic fungus Beauveria bassiana, which links oxidative response and fatty acid assimilation via regulating peroxisome proliferation. The null mutant ΔBbotf1 showed impaired resistance to oxidants, accompanied by decreased activities of antioxidant enzymes including CATs, PODs and SODs, and down-regulated expression of many antioxidation-associated genes under oxidative stress condition...
March 6, 2024: Journal of Invertebrate Pathology
https://read.qxmd.com/read/38456298/cnp-ameliorates-macrophage-inflammatory-response-and-atherosclerosis
#6
JOURNAL ARTICLE
Qiankun Bao, Bangying Zhang, Lu Zhou, Qian Yang, Xiaofeng Mu, Xing Liu, Shiying Zhang, Meng Yuan, Yue Zhang, Jingjin Che, Wen Wei, Tong Liu, Guangping Li, Jinlong He
BACKGROUND: CNP (C-type natriuretic peptide), an endogenous short peptide in the natriuretic peptide family, has emerged as an important regulator to govern vascular homeostasis. However, its role in the development of atherosclerosis remains unclear. This study aimed to investigate the impact of CNP on the progression of atherosclerotic plaques and elucidate its underlying mechanisms. METHODS: Plasma CNP levels were measured in patients with acute coronary syndrome...
March 8, 2024: Circulation Research
https://read.qxmd.com/read/38432092/zinc-oxide-nanoparticles-alleviate-cadmium-toxicity-and-promote-tolerance-by-modulating-programmed-cell-death-in-alfalfa-medicago-sativa-l
#7
JOURNAL ARTICLE
Zhao Chen, Yuxi Feng, Zhipeng Guo, Mengli Han, Xuebing Yan
Cadmium (Cd) can induce programmed cell death (PCD) and zinc oxide nanoparticles (ZnO NPs) effectively alleviate Cd stress. However, the mechanisms of ZnO NPs-mediated Cd detoxification in alfalfa (Medicago sativa L.) are limited. The pot experiment was conducted with Cd soil (19.2 mg kg-1 ) and foliar ZnO NPs (100 mg L-1 ) on alfalfa. The results showed that Cd reduced shoot height and biomass, and accumulated reactive oxygen species (ROS), resulting in oxidative stress and further PCD (plasmolysis, cytosolic and nuclear condensation, subcellular organelle swelling, and cell death)...
February 29, 2024: Journal of Hazardous Materials
https://read.qxmd.com/read/38428158/mitochondrial-complex-i-subunit-ndufs8-2-modulates-responses-to-stresses-associated-with-reduced-water-availability
#8
JOURNAL ARTICLE
Laura Zsigmond, Annabella Juhász-Erdélyi, Ildikó Valkai, Dávid Aleksza, Gábor Rigó, Kamal Kant, Ágnes Szepesi, Fabio Fiorani, Niklas Körber, László Kovács, László Szabados
Mitochondria are important sources of energy in plants and are implicated in coordination of a number of metabolic and physiological processes including stabilization of redox balance, synthesis and turnover of a number of metabolites, and control of programmed cell death. Mitochondrial electron transport chain (mETC) is the backbone of the energy producing process which can influence other processes as well. Accumulating evidence suggests that mETC can affect responses to environmental stimuli and modulate tolerance to extreme conditions such as drought or salinity...
February 23, 2024: Plant Physiology and Biochemistry: PPB
https://read.qxmd.com/read/38422850/biochar-and-nano-biochar-enhancing-salt-resilience-in-plants-and-soil-while-mitigating-greenhouse-gas-emissions-a-comprehensive-review
#9
JOURNAL ARTICLE
Haider Sultan, Yusheng Li, Waqas Ahmed, Mu Yixue, Asad Shah, Mohammad Faizan, Aqeel Ahmad, Mazhar Abbas, Lixiao Nie, Mohammad Nauman Khan
Salinity stress poses a significant challenge to agriculture, impacting soil health, plant growth and contributing to greenhouse gas (GHG) emissions. In response to these intertwined challenges, the use of biochar and its nanoscale counterpart, nano-biochar, has gained increasing attention. This comprehensive review explores the heterogeneous role of biochar and nano-biochar in enhancing salt resilience in plants and soil while concurrently mitigating GHG emissions. The review discusses the effects of these amendments on soil physicochemical properties, improved water and nutrient uptake, reduced oxidative damage, enhanced growth and the alternation of soil microbial communities, enhance soil fertility and resilience...
February 28, 2024: Journal of Environmental Management
https://read.qxmd.com/read/38421476/-consensus-recommendations-on-the-diagnosis-and-treatment-of-hyponatremia-from-the-austrian-society-for-nephrology-2024
#10
JOURNAL ARTICLE
Christoph Schwarz, Gregor Lindner, Martin Windpessl, Maarten Knechtelsdorfer, Marcus D Saemann
Hyponatremia is a disorder of water homeostasis. Water balance is maintained by the collaboration of renal function and cerebral structures, which regulate thirst mechanisms and secretion of the antidiuretic hormone. Measurement of serum-osmolality, urine osmolality and urine-sodium concentration help to diagnose the different reasons for hyponatremia. Hyponatremia induces cerebral edema and might lead to severe neurological symptoms, which need acute therapy. Also, mild forms of hyponatremia should be treated causally, or at least symptomatically...
February 2024: Wiener Klinische Wochenschrift
https://read.qxmd.com/read/38409238/integrated-transcriptomics-and-proteomics-analysis-reveals-muscle-metabolism-effects-of-dietary-ulva-lactuca-and-ulvan-lyase-supplementation-in-weaned-piglets
#11
JOURNAL ARTICLE
David Miguel Ribeiro, Diogo Coelho, Mónica Costa, Daniela Filipa Pires Carvalho, Céline C Leclercq, Jenny Renaut, João Pedro Bengala Freire, André Martinho Almeida, José António Mestre Prates
Seaweeds, including the green Ulva lactuca, can potentially reduce competition between feed, food, and fuel. They can also contribute to the improved development of weaned piglets. However, their indigestible polysaccharides of the cell wall pose a challenge. This can be addressed through carbohydrase supplementation, such as the recombinant ulvan lyase. The objective of our study was to assess the muscle metabolism of weaned piglets fed with 7% U. lactuca and 0.01% ulvan lyase supplementation, using an integrated transcriptomics (RNA-seq) and proteomics (LC-MS) approach...
February 26, 2024: Scientific Reports
https://read.qxmd.com/read/38397419/characterization-of-nac-gene-family-in-ammopiptanthus-mongolicus-and-functional-analysis-of-amnac24-an-osmotic-and-cold-stress-induced-nac-gene
#12
JOURNAL ARTICLE
Tashi Dorjee, Yican Cui, Yuxin Zhang, Qi Liu, Xuting Li, Batu Sumbur, Hongxi Yan, Jie Bing, Yuke Geng, Yijun Zhou, Fei Gao
The NAC family of transcription factors (TFs) is recognized as a significant group within the plant kingdom, contributing crucially to managing growth and development processes in plants, as well as to their response and adaptation to various environmental stressors. Ammopiptanthus mongolicus , a temperate evergreen shrub renowned for its remarkable resilience to low temperatures and drought stress, presents an ideal subject for investigating the potential involvement of NAC TFs in stress response mechanisms...
February 2, 2024: Biomolecules
https://read.qxmd.com/read/38390363/the-role-of-mechanically-sensitive-ion-channel-piezo1-in-bone-remodeling
#13
REVIEW
Yugui Du, Bowen Xu, Quiying Li, Chuhan Peng, Kai Yang
Piezo1 (2010) was identified as a mechanically activated cation channel capable of sensing various physical forces, such as tension, osmotic pressure, and shear force. Piezo1 mediates mechanosensory transduction in different organs and tissues, including its role in maintaining bone homeostasis. This review aimed to summarize the function and possible mechanism of Piezo1 in the mechanical receptor cells in bone tissue. We found that it is a potential therapeutic target for the treatment of bone diseases.
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38384762/no-enhances-the-adaptability-to-high-salt-environments-by-regulating-osmotic-balance-antioxidant-defense-and-ion-homeostasis-in-eelgrass-based-on-transcriptome-and-metabolome-analysis
#14
JOURNAL ARTICLE
Xianyan Wang, Tongtong Wang, Pei Yu, Yuchun Li, Xinfang Lv
INTRODUCTION: Eelgrass is a typical marine angiosperm that exhibits strong adaptability to high-salt environments. Previous studies have shown that various growth and physiological indicators were significantly affected after the nitrate reductase (NR) pathway for nitric oxide (NO) synthesis in eelgrass was blocked. METHODS: To analyze the molecular mechanism of NO on the adaptability to high-salt environment in eelgrass, we treated eelgrass with artificial seawater (control group) and artificial seawater with 1 mM/L Na2 WO4 (experimental group)...
2024: Frontiers in Plant Science
https://read.qxmd.com/read/38363605/impact-of-different-severity-hyperglycemia-on-erythrocyte-rheological-properties1
#15
JOURNAL ARTICLE
M Mantskava, L Chkhitauri, E Shekiladze, N Tskhvediani, S Kalmakhelidze, N Momtselidze, L Prantl, F Jung, B Machalinski, P Wojciech, T Sanikidze
BACKGROUND: The triad "insulin resistance, prediabetes, diabetes" is three independent neologies with characteristic features and development. In addition, each are characterized by progression and the possibility of transition from one form to other. Due to the fact that diabetes is one of the common diseases associated with high rates of disability, it is necessary to improve diagnostic methods and educational regimens for successful prevention and treatment of the disease. OBJECTIVE: We investigated Band 3 protein (B3p) level, osmotic resistance of erythrocytes, the total antioxidant activity (TAA) of blood serum, level of HbA1 in group patients with insulin resistance (IR), prediabetes, and Type 2 Diabetes Mellitus (T2DM) and comparative with health control group...
February 15, 2024: Clinical Hemorheology and Microcirculation
https://read.qxmd.com/read/38354692/melatonin-modulates-the-tolerance-of-plants-to-water-stress-morphological-response-of-the-molecular-mechanism
#16
JOURNAL ARTICLE
Minmin He, Gui Geng, Shuyang Mei, Gang Wang, Lihua Yu, Yao Xu, Yuguang Wang
Water stress (drought and waterlogging) leads to an imbalance in plant water distribution, disrupts cell homeostasis, and severely inhibits plant growth. Melatonin is a growth hormone that plants synthesise and has been shown to resist adversity in many plants. This review discusses the biosynthesis and metabolism of melatonin, as well as the changes in plant morphology and physiological mechanisms caused by the molecular defence process. Melatonin induces the expression of related genes in the process of plant photosynthesis under stress and protects the structural integrity of chloroplasts...
February 15, 2024: Functional Plant Biology: FPB
https://read.qxmd.com/read/38351620/antioxidant-dipeptides-enhance-osmotic-stress-tolerance-by-regulating-the-yeast-cell-wall-and-membrane
#17
JOURNAL ARTICLE
Caiyun Wu, Hexin Zhang, Nana Yang, Na Liu, Huirong Yang, Huaide Xu, Hongjie Lei
This study aimed to investigate the role of the yeast cell wall and membrane in enhancing osmotic tolerance by antioxidant dipeptides (ADs) including Ala-His (AH), Thr-Tyr (TY), and Phe-Cys (FC). Results revealed that ADs could improve the integrity of the cell wall by restructuring polysaccharide structures. Specifically, FC significantly ( p < 0.05) reduced the leakage of nucleic acid and protein by 2.86% and 5.36%, respectively, compared to the control. In addition, membrane lipid composition played a crucial role in enhancing yeast tolerance by ADs, including the increase of cell membrane integrity and the decrease of permeability by regulating the ratio of unsaturated fatty acids...
February 13, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38336645/the-role-of-aquaporins-in-tumorigenesis-implications-for-therapeutic-development
#18
REVIEW
Arkadyuti Bhattacharjee, Ankit Jana, Swagato Bhattacharjee, Sankalan Mitra, Swagata De, Badrah S Alghamdi, Mohammad Zubair Alam, Ahmad Bakur Mahmoud, Zainab Al Shareef, Wael M Abdel-Rahman, Chan Woon-Khiong, Athanasios Alexiou, Marios Papadakis, Ghulam Md Ashraf
Aquaporins (AQPs) are ubiquitous channel proteins that play a critical role in the homeostasis of the cellular environment by allowing the transit of water, chemicals, and ions. They can be found in many different types of cells and organs, including the lungs, eyes, brain, glands, and blood vessels. By controlling the osmotic water flux in processes like cell growth, energy metabolism, migration, adhesion, and proliferation, AQPs are capable of exerting their regulatory influence over a wide range of cellular processes...
February 9, 2024: Cell Communication and Signaling: CCS
https://read.qxmd.com/read/38328180/transcriptomic-interplay-between-acinetobacter-baumannii-human-macrophage-and-polymyxin
#19
Zhi Ying Kho, Mohammad Abul Kalam Azad, Yan Zhu, Mei-Ling Han, Qi Tony Zhou, Tony Velkov, Thomas Naderer, Jian Li
UNLABELLED: Optimization of antibiotic therapy has been hindered by our dearth of understanding on the mechanism of the host-pathogen-drug interactions. Here, we employed dual RNA-sequencing to examine transcriptomic perturbations in response to polymyxin B in a co-culture infection model of Acinetobacter baumannii and human macrophages. Our findings revealed that polymyxin B treatment induced significant transcriptomic response in macrophage-interacting A. baumannii , exacerbating bacterial oxidative stress, disrupting metal homeostasis, affecting osmoadaptation, triggering stringent stress response, and influencing pathogenic factors...
January 23, 2024: bioRxiv
https://read.qxmd.com/read/38326317/n2fxm-a-method-for-joint-nuclear-and-cytoplasmic-volume-measurements-unravels-the-osmo-mechanical-regulation-of-nuclear-volume-in-mammalian-cells
#20
JOURNAL ARTICLE
Fabrizio A Pennacchio, Alessandro Poli, Francesca Michela Pramotton, Stefania Lavore, Ilaria Rancati, Mario Cinquanta, Daan Vorselen, Elisabetta Prina, Orso Maria Romano, Aldo Ferrari, Matthieu Piel, Marco Cosentino Lagomarsino, Paolo Maiuri
In eukaryotes, cytoplasmic and nuclear volumes are tightly regulated to ensure proper cell homeostasis. However, current methods to measure cytoplasmic and nuclear volumes, including confocal 3D reconstruction, have limitations, such as relying on two-dimensional projections or poor vertical resolution. Here, to overcome these limitations, we describe a method, N2FXm, to jointly measure cytoplasmic and nuclear volumes in single cultured adhering human cells, in real time, and across cell cycles. We find that this method accurately provides joint size over dynamic measurements and at different time resolutions...
February 7, 2024: Nature Communications
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