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https://read.qxmd.com/read/36278136/-monascus-fermented-grain-vinegar-enhances-glucose-homeostasis-through-the-irs-1-pi3k-akt-and-ampk-signaling-pathways-in-hepg2-cell-and-db-db-mice
#1
JOURNAL ARTICLE
Ye-Won Lee, Young-Hee Pyo
MV was reported to have beneficial effects in ameliorating insulin resistance in db/db mice, but the intrinsic mechanisms for glucose homeostasis are unclear. This study examined the anti-diabetic mechanism of MV using HepG2 cells and C57BL/KsJ- db/db mice. MV increased insulin sensitivity by promoting insulin-dependent glucose uptake and activating glycogen accumulation in HepG2 cells. Furthermore, the glucose homeostasis was enhanced in db/db mice administered 1 mg/kg/day of MV for eight weeks by activating the IRS-1/PI3K/Akt and AMPK pathways in the skeletal muscle and liver tissue...
November 2022: Food Science and Biotechnology
https://read.qxmd.com/read/35333623/hypoglycemic-and-hypolipogenic-action-of-acetic-acid-and-monascus-fermented-grain-vinegar-a-comparative-study
#2
JOURNAL ARTICLE
Young-Hee Pyo, Da-Bin Lee, Ye-Won Lee, Su-Min Yoon, A-Rang Lee
Acetic acid has been proposed to improve lifestyle-related diseases, including hyperlipidemia and hyperglycemia. This study compared the hypoglycemic and hypolipogenic effects of acetic acid vinegar (AV, contains only 4% acetic acid) and Monascus -fermented grain vinegar (MV) containing various bioactive compounds in 3T3L1 cells and C57BL/KsJ- db/db mice (DB). The DB were divided randomly into three treatment groups containing nine mice each; DB-, AV-, and MV-groups were orally administered 1 mL/kg/day of distilled water, acetic acid vinegar, and Monascus vinegar, respectively, for 8 weeks...
March 23, 2022: Journal of Medicinal Food
https://read.qxmd.com/read/34631878/exercise-or-dietotherapy-is-not-better-than-returning-to-a-regular-diet-to-rebuild-lipid-homeostasis-of-rats
#3
JOURNAL ARTICLE
Yuan Yang, Nan-Jun Xu, Jia-Hui Li, Ling-Feng Zeng, Gui-Hong Liang, Feng Zhang, Ming-Hui Luo, Jian-Ke Pan, He-Tao Huang, Yan-Hong Han, Jin-Long Zhao, Xiao Xiao, Chunlian Ma, Hua Liu, Yi Yang, Wei-Yi Yang, Jun Liu
Our aim was to explore the effects of dietary and behavior interventions on lipometabolism caused by an unhealthy high-fat diet and the best method to rebuild lipid homeostasis of this lifestyle. Apart from normal diet rats, 34 rats were fed with high-fat emulsion for 4 weeks and then intervened for another 4 weeks. Eight of them were classified into high-fat control group, and 9 were sorted into high-fat diet with rice vinegar group. Meanwhile, 10 were put into high-fat diet in swimming group, and 7 were just for refeeding normal diet group...
2021: BioMed Research International
https://read.qxmd.com/read/31901136/modulation-effects-of-black-vinegar-based-supplement-against-a-high-fat-dietary-habit-antiobesity-hypolipidemic-antioxidative-and-energy-metabolism-effects
#4
JOURNAL ARTICLE
Ming-En Liu, Chung-Hsi Chou, Lu Li, Yi-Hsieng Samuel Wu, Yi-Ling Lin, Dom-Gene Tu, Yi-Chen Chen
BACKGROUND: An imbalanced fat or excess energy intake always results in obesity and increased serum/liver lipids, thus leading to metabolic syndromes. Given the bioactive components in the black vinegar (BV), such as branched amino acids, phenolic profile, and mineral contents. Here, we investigated the antiobesity effects of BV-based supplements in rats fed a high-fat diet. RESULTS: A high-fat diet (HFD, 30% fat, w/w) feeding increased (p<0.05) body weight gains, weights of livers, as well as mesenteric, epididymal, and perirenal adipose tissues, and serum/liver triglyceride levels relative to those of normal-diet (4% fat, w/w) fed (CON) rats...
January 4, 2020: Journal of the Science of Food and Agriculture
https://read.qxmd.com/read/26476634/vinegar-decreases-blood-pressure-by-down-regulating-at1r-expression-via-the-ampk-pgc-1%C3%AE-ppar%C3%AE-pathway-in-spontaneously-hypertensive-rats
#5
JOURNAL ARTICLE
Lixin Na, Xia Chu, Shuo Jiang, Chunjuan Li, Gang Li, Ying He, Yuanxiu Liu, Ying Li, Changhao Sun
PURPOSE: Vinegar has been reported to lower blood pressure, but its mechanism is unclear. This study explored whether vinegar plays antihypertensive effect by activating AMP-activated protein kinase (AMPK) pathway. METHODS: Male spontaneously hypertensive rats (SHRs) were assigned to vinegar, acetic acid, nifedipine, nifedipine + vinegar, or distilled water by oral gavage for 8 weeks. Blood and aortas were analyzed for biochemical indices and protein expression levels...
April 2016: European Journal of Nutrition
https://read.qxmd.com/read/24867606/anti-obesity-and-anti-insulin-resistance-effects-of-tomato-vinegar-beverage-in-diet-induced-obese-mice
#6
JOURNAL ARTICLE
Kwon-Il Seo, Jin Lee, Ra-Yeong Choi, Hae-In Lee, Ju-Hye Lee, Yong-Ki Jeong, Myung-Joo Kim, Mi-Kyung Lee
This study investigated the mechanism of processed tomato vinegar beverage (TVB)-mediated anti-obesity and anti-insulin resistance effects in high-fat diet (HF)-induced obese mice. Oral administration of TVB (14 mL kg(-1) body weight) to HF-fed mice for 6 weeks effectively reduced the body and visceral fat weight and significantly lowered plasma free fatty acid, triglyceride and hepatic triglyceride levels. TVB significantly increased fecal triglyceride excretion, both phosphorylated AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) and peroxisome proliferator-activated receptor (PPAR)α protein levels in the liver, which were associated with increased fatty acid β-oxidation and carnitine palmitoyltransferase activities in HF-fed mice...
July 25, 2014: Food & Function
https://read.qxmd.com/read/24248330/ampk-activation-protean-potential-for-boosting-healthspan
#7
REVIEW
Mark F McCarty
AMP-activated kinase (AMPK) is activated when the cellular (AMP+ADP)/ATP ratio rises; it therefore serves as a detector of cellular "fuel deficiency." AMPK activation is suspected to mediate some of the health-protective effects of long-term calorie restriction. Several drugs and nutraceuticals which slightly and safely impede the efficiency of mitochondrial ATP generation-most notably metformin and berberine-can be employed as clinical AMPK activators and, hence, may have potential as calorie restriction mimetics for extending healthspan...
April 2014: Age (2005-)
https://read.qxmd.com/read/24180378/pomegranate-vinegar-attenuates-adiposity-in-obese-rats-through-coordinated-control-of-ampk-signaling-in-the-liver-and-adipose-tissue
#8
JOURNAL ARTICLE
Elly Ok, Gyeong-Min Do, Yeni Lim, Ji-Eun Park, Yeo-Jin Park, Oran Kwon
BACKGROUND: The effect of pomegranate vinegar (PV) on adiposity was investigated in high-fat diet (HF)-induced obese rats. METHODS: The rats were divided into 5 groups and treated with HF with PV or acetic acid (0, 6.5 or 13% w/w) for 16 weeks. Statistical analyses were performed by the Statistical Analysis Systems package, version 9.2. RESULTS: Compared to control, PV supplementation increased phosphorylation of AMP-activated protein kinase (AMPK), leading to changes in mRNA expressions: increases for hormone sensitive lipase and mitochondrial uncoupling protein 2 and decreases for sterol regulatory element binding protein-1c (SREBP-1c) and peroxisome proliferator-activated receptorγ (PPARγ) in adipose tissue; increases for PPARα and carnitinepalmitoyltransferase-1a (CPT-1a) and decrease for SREBP-1c in the liver...
November 2, 2013: Lipids in Health and Disease
https://read.qxmd.com/read/20460711/vinegar-intake-enhances-flow-mediated-vasodilatation-via-upregulation-of-endothelial-nitric-oxide-synthase-activity
#9
RANDOMIZED CONTROLLED TRIAL
Syoji Sakakibara, Ryuichiro Murakami, Mikio Takahashi, Takashi Fushimi, Toyoaki Murohara, Mikiya Kishi, Yoshitaka Kajimoto, Masafumi Kitakaze, Takayuki Kaga
This study examined the effect of acetate on endothelial nitric oxide synthase (eNOS) in human umbilical vein endothelial cells (HUVECs) by immunoblotting assay and the ability of acetic acid to upregulate flow-mediated vasodilatation in humans. In HUVECs, acetate induced a biphasic increase in the phosphorylated form of eNOS. The amount of phosphorylated eNOS was significantly increased by exposure to 200 mumol/l acetate for 20 min (early phase) and for 4 h (late phase). The inhibitors of cAMP-dependent protein kinase (PKA) and AMP-activated protein kinase (AMPK) blocked acetate-induced eNOS phosphorylation in the early and the late phase respectively...
2010: Bioscience, Biotechnology, and Biochemistry
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