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https://www.readbyqxmd.com/read/29224235/long-term-cardiovascular-re-programming-by-short-term-perinatal-exposure-to-nicotine-s-main-metabolite-cotinine
#1
Stefano Bastianini, Viviana Lo Martire, Alessandro Silvani, Giovanna Zoccoli, Chiara Berteotti, Hugo Lagercrantz, Anders Arner, Gary Cohen
AIM: Gather "proof-of-concept" evidence of the adverse developmental potential of cotinine (a seemingly benign biomarker of recent nicotine / tobacco smoke exposure). METHODS: Pregnant C57 mice drank nicotine or cotinine-laced water for 6wks from conception (NPRE = 2% saccharin+100μg nicotine/ml; CPRE = 2% saccharin + 10μg cotinine/ml) or 3wks after birth (CPOST = 2% saccharin + 30μg cotinine/ml). Controls drank 2% saccharin (CTRL). At 17±1weeks (male pups; CTRL n=6; CPOST n=6; CPRE n=8; NPRE n=9) we assessed (i) cardiovascular control during sleep; (ii) arterial reactivity ex vivo; (iii) expression of genes involved in arterial constriction / dilation...
December 9, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29210627/pharmacokinetic-analysis-of-nevirapine-extended-release-400%C3%A2-mg-once-daily-vs-nevirapine-immediate-release-200%C3%A2-mg-twice-daily-formulation-in-treatment-na%C3%A3-ve-patients-with-hiv-1-infection
#2
Chan-Loi Yong, Joseph C Gathe, Gabriele Knecht, Catherine Orrell, Josep Mallolas, Daniel Podzamczer, Benoit Trottier, Wei Zhang, John P Sabo, Richard Vinisko, Murray Drulak, Anne-Marie Quinson
BACKGROUND: VERxVE data showed non-inferior virologic efficacy with extended release nevirapine (NVP-XR) dosed 400 mg once daily (QD) versus immediate release nevirapine (NVP-IR) 200 mg twice daily in a double-blind, non-inferiority study in treatment-naïve HIV-1-positive patients. OBJECTIVE: To study the pharmacokinetics (PK) of the NVP formulations and identify possible associations with demographic factors. METHODS: Patients with viral load ≥1000 copies/mL and CD4+ count > 50- <400 cells/mm3 (males) and >50- <250 cells/mm3 (females) at screening received NVP-IR 200 mg QD during a 14-day lead-in and were then stratified by baseline viral load and randomized to NVP-XR or -IR...
November 2017: HIV Clinical Trials
https://www.readbyqxmd.com/read/29148130/a-pseudo-one-compartment-model-of-phosphorus-kinetics-during-hemodialysis-further-supporting-evidence
#3
John K Leypoldt, Baris U Agar, Alfred K Cheung, Angelito A Bernardo
A pseudo-one compartment model has been proposed to describe phosphorus kinetics during hemodialysis and the immediate post-dialysis period. This model assumes that phosphorus mobilization from tissues is proportional to the difference between the pre-dialysis serum concentration (a constant) and the instantaneous serum concentration. The current study is exploratory and evaluated the ability of a pseudo-one compartment model to describe the kinetics of phosphorus during two short hemodialysis treatments separated by a 60-min inter-treatment period without dialysis; the latter is the post-dialysis rebound period for the first short hemodialysis treatment...
November 2017: Artificial Organs
https://www.readbyqxmd.com/read/29138385/parameters-for-contrast-enhanced-ultrasound-ceus-of-enlarged-superficial-lymph-nodes-for-the-evaluation-of-therapeutic-response-in-lymphoma-a-preliminary-study
#4
Lei Xin, Zhimei Yan, Xiaojuan Zhang, Yichen Zang, Zhaoyan Ding, Hongwei Xue, Cheng Zhao
BACKGROUND The aims of this preliminary study were to evaluate contrast-enhanced ultrasound (CEUS) imaging and the therapeutic response of enlarged superficial lymph nodes in patients with lymphoma before and after chemotherapy and to determine the most useful CEUS response parameters. MATERIAL AND METHODS Forty-three patients with lymphoma, with 43 enlarged superficial lymph nodes, underwent CEUS and conventional ultrasound (US), before treatment and after the first three cycles of chemotherapy. Clinical responses included overall response (OR) and no response (NR)...
November 15, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28731998/laparoendoscopic-rendez-vous-a-safe-alternative-to-the-treatment-of-choledocholithiasis
#5
Fernanda Kreve, Jonas Takada, Janaina Gatto, Francisco S Loss, Everson L A Artifon
The choice treatment for choledocholithiasis when associated with lithiasic cholecystitis is endoscopic retrograde cholangiopancreatography (ERCP). However, in some cases this therapeutic fails, which requires an alternative method to extract the stones. The surgical approach tends to be the next step, but it is related to greater complexity of achievement and higher complications rates. In 1993, Deslandres et al. developed the combined treatment called laparoendoscopic rendez-vous, that unites in a single stage the endoscopic treatment of choledocholithiasis and laparoscopic removal of the gallbladder...
April 2017: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/28592391/long-term-fate-of-the-upper-tracts-following-complete-primary-repair-of-bladder-exstrophy
#6
Jonathan S Ellison, Jennifer Ahn, Margarett Shnorhavorian, Richard Grady, Paul A Merguerian
INTRODUCTION: Complete primary repair of bladder exstrophy (CPRE) is widely used for classic bladder exstrophy (CBE) closure. Long-term renal function with or without dilation in these patients is poorly characterized and may be impacted by bladder storage parameters or recurrent urinary tract infections (UTIs). OBJECTIVE: We sought to assess our long-term experience with CPRE and investigate factors that may influence upper-tract deterioration. STUDY DESIGN: A retrospective review of patients at our institution with CBE undergoing CPRE from 1990 to 2015 was performed...
August 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28314702/short-term-outcomes-of-the-multi-institutional-bladder-exstrophy-consortium-successes-and-complications-in-the-first-two-years-of-collaboration
#7
J G Borer, E Vasquez, D A Canning, J V Kryger, A Bellows, D Weiss, T Groth, A Shukla, M P Kurtz, M E Mitchell
INTRODUCTION/BACKGROUND: Bladder exstrophy is a rare diagnosis that presents major reconstructive challenges. To increase experience and proficiency in the care of bladder exstrophy (BE), the Multi-Institutional BE Consortium (MIBEC) was formed, with a focus on refining technical aspects of complete primary repair of bladder exstrophy (CPRE) and subsequent care. OBJECTIVE: Outcome measures included successful CPRE (absence of dehiscence), complications, and integrated points of technique and care over the short-term...
June 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28079704/modeling-perceived-exertion-during-graded-arm-cycling-exercise-in-spinal-cord-injury
#8
Jason S Au, Julia O Totosy de Zepetnek, Maureen J MacDonald
PURPOSE: Ratings of perceived exertion (RPE) may be useful for exercise testing and prescription in individuals with spinal cord injury (SCI), though the roles of differentiated central and peripheral fatigue during exercise are not clear. We aimed to model differentiated RPE responses during graded arm cycling in individuals with SCI and describe their relationship to cardiorespiratory outcomes. METHODS: Thirty-six individuals with SCI (13 paraplegia; 23 tetraplegia) completed a maximal graded-arm cycling exercise test to volitional exhaustion (5W/min paraplegia; 10W/min tetraplegia)...
January 10, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27828758/gentamicin-and-ciprofloxacin-resistant-enterobacteriaceae-in-cattle-farms-in-israel-risk-factors-for-carriage-and-the-effect-of-microbiological-methodology-on-the-measured-prevalence
#9
Amos Adler, Na'ama Sturlesi, Noga Fallach, Deniz Zilberman-Barzilai, Omar Hussein, Shlomo E Blum, Eyal Klement, Mitchell J Schwaber, Yehuda Carmeli
Our objectives were to establish a methodology for surveillance of ciprofloxacin-resistant Enterobacteriaceae and gentamicin-resistant Enterobacteriaceae (CPRE and GNRE, respectively) in cattle and to study the prevalence and risk factors for carriage of these bacteria in a national survey. This was a point prevalence study conducted from July to October 2013 in Israel. Stool samples were collected from 1,226 cows in 123 sections of 40 farms of all production types. The number of CPRE- and GNRE-positive cows was highest in quarantine stations and fattening farms and was lowest in pasture farms (p < 0...
July 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/27639367/2-arylbenzothiazoles-labeled-with-cpre-99m-tc-co-3-and-evaluated-as-%C3%AE-amyloid-imaging-probes
#10
Jianhua Jia, Kaixiang Zhou, Jiapei Dai, Boli Liu, Mengchao Cui
An array of complexes, (99m)Tc/Re-labeled cyclopentadienyl tricarbonyl and 2-phenyl/pyridylbenzothiazoles, conjugated through an ester linkage were tested as potential β-amyloid (Aβ) probes for SPECT imaging. The [CpRe/(99m)Tc(CO)3] complexes were prepared by double ligand transfer reactions from ferrocene precursors, and the X-ray structure of one rhenium surrogate revealed a classical "piano stool" like geometry. Several of the rhenium complexes displayed high affinity for Aβ1-42 aggregates in in vitro inhibition assays, and they could intensely stain Aβ deposits on brain sections from transgenic mice and Alzheimer's disease (AD) patients...
November 29, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27330586/long-term-functional-outcomes-after-bladder-exstrophy-repair-a-single-low-volume-centre-experience
#11
Ossamah Alsowayan, John Paul Capolicchio, Roman Jednak, Mohamed El-Sherbiny
INTRODUCTION: In this study, we present our experience managing bladder exstrophy (BE) in a low-volume centre over 24 years. METHODS: Charts of patients with BE between 1990 and 2014 were retrospectively reviewed. Patients with BE closure and ≥5 years followup were included. BE closure was carried out in the first two days of life using either complete primary repair (CPRE) or modern-staged repair (MSRE). Daytime urinary continence (UC) was evaluated by the age of five years...
March 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/27279694/effect-of-procyanidin-rich-extract-from-natural-cocoa-powder-on-cellular-viability-cell-cycle-progression-and-chemoresistance-in-human-epithelial-ovarian-carcinoma-cell-lines
#12
Shruti Taparia, Aparna Khanna
BACKGROUND: Over the last 400 years, cocoa and chocolate have been described as having potential medicinal value, being consumed as a beverage or eaten as food. Concentration-dependant, antiproliferation, and cytotoxic effects of some of their polyphenolic constituents have been demonstrated against various cancers. Such an effect remains to be demonstrated in ovarian cancer. OBJECTIVE: To investigate the effect of cocoa procyanidins against ovarian cancer in vitro using OAW42 and OVCAR3 cell lines...
May 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27267990/a-critical-appraisal-of-continence-in-bladder-exstrophy-long-term-outcomes-of-the-complete-primary-repair
#13
J S Ellison, M Shnorhavorian, K Willihnganz-Lawson, R Grady, P A Merguerian
INTRODUCTION: Long-term continence outcomes for patients with bladder exstrophy are lacking in the literature. The complete primary repair of exstrophy (CPRE) is a widely adopted approach that seeks to normalize anatomy at the initial repair, thereby allowing early bladder filling and cycling. Previous reports of continence following CPRE, however, are limited by variable follow-up duration and continence definitions. OBJECTIVE: To assess continence and factors associated with a positive outcome in a cohort of patients following CPRE with long-term follow-up...
August 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27264049/impact-of-concomitant-hernia-repair-at-the-time-of-complete-primary-repair-of-bladder-exstrophy
#14
Jonathan S Ellison, Margarett Shnorhavorian, Paul A Merguerian, Richard Grady
BACKGROUND: Inguinal hernias are common in the bladder exstrophy population. As these hernias may present with incarceration following bladder closure, several groups recommend inguinal exploration and hernia repair at the time of initial bladder closure. However, the benefits of such an approach are not well defined. In 2006, we modified our approach to this condition by routinely performing concomitant inguinal herniorraphy (CIH) repair at the time of initial exstrophy repair. The aim of this study was to test the hypothesis that simultaneous inguinal hernia repair will be safe and effective in reducing subsequent unplanned inguinal procedures in this high-risk group...
August 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/26802884/surgical-or-endoscopic-management-for-post-ercp-large-transmural-duodenal-perforations-a-randomized-prospective-trial
#15
RANDOMIZED CONTROLLED TRIAL
Everson L A Artifon, Mauricio K Minata, Marco Antonio B Cunha, Jose P Otoch, Dayse P Aparicio, Carlos K Furuya, José L B Paione
INTRODUCTION: Duodenal perforations are an uncommon adverse event during ERCP. Patients can develop significant morbidity and mortality. Even though surgery has been used to manage duodenal complications, therapeutic endoscopy has seen significant advances. OBJECTIVE: To compare endoscopic approach with surgical intervention in patients with duodenal perforations post-ERCP. MATERIAL AND METHODS: prospective randomized study in a tertiary center with 23 patients divided in 2 groups...
October 2015: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/26645558/observation-of-cationic-transition-metal-alkane-complexes-with-moderate-stability-in-hydrofluorocarbon-solution
#16
Hon Man Yau, Alasdair I McKay, Henrique Hesse, Ran Xu, Mushi He, Camille E Holt, Graham E Ball
In seeking to create more-stable transition metal-alkane complexes, we generated cationic alkane complexes of the type [(HEB)Re(CO)2(alkane)][Al(OR(f))4] (HEB = η(6)-hexaethylbenzene; alkane = cyclopentane (16) or pentane (17-19); OR(f) = perfluoro-tert-butoxy) via photolysis of the precursor complex [(HEB)Re(CO)3][Al(OR(f))4] (15) in the presence of the added alkane. The alkane complexes were generated in a hydrofluorocarbon (HFC) solvent, most often CF3CH2CF3, which is capable of simultaneously dissolving the ionic complex 15 and a small amount of alkane at low temperature (183 K)...
January 13, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/25994493/phosphate-kinetics-during-weekly-cycle-of-hemodialysis-sessions-application-of-mathematical-modeling
#17
Malgorzata Debowska, Jan Poleszczuk, Alicja Wojcik-Zaluska, Andrzej Ksiazek, Wojciech Zaluska
Both hyperphosphatemia and hypophosphatemia are associated with increased morbidity and mortality among patients on dialysis. The control of serum phosphate concentration is a considerable clinical problem. Our study aimed to improve understanding of phosphate kinetics in patients on dialysis using mathematical modeling. Three consecutive hemodialysis sessions with breaks of 2-2-3 days were monitored in 25 patients. Phosphate concentration was measured every hour and 45 min after the end of dialysis in blood serum and every 30 min in dialysate during each session...
December 2015: Artificial Organs
https://www.readbyqxmd.com/read/25982019/clinical-pathway-for-early-discharge-after-complete-primary-repair-of-exstrophy-and-epispadias-by-using-a-spica-cast
#18
Bryan S Sack, John V Kryger, Michael E Mitchell, Charles T Durkee, Roger Lyon, Travis W Groth
INTRODUCTION/OBJECTIVE: Secure closure of the pubic diastasis during bladder exstrophy and epispadias repair decreases the abdominal wall tension at the time of reconstruction. Pelvic osteotomies are routinely performed at the time of abdominal wall and bladder reconstruction in order to more easily facilitate pubic symphyseal diastasis approximation. Postoperative pelvic immobilization is performed by methods that include modified Buck's traction, modified Bryant's traction, and spica casting...
August 2015: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/25663249/retropubic-bulbourethral-sling-in-incontinence-post-exstrophy-repair-2-year-minimal-follow-up-of-a-salvage-procedure
#19
Bassem S Wadie, Tamer E Helmy, Mohamed E Dawaba, Mohamed A Ghoneim
AIMS: Post-exstrophy incontinence is a challenge because continence is difficult to achieve and more difficult to maintain. Feasibility and outcomes of a bulbourethral sling to treat post-exstrophy incontinence is shown in this report. METHODS: A retropubic bulbourethral sling was applied to male patients with incontinence post-exstrophy-epispadius repair. The study included children with total (continuous) incontinence who underwent multiple previous anti-incontinence procedures, ranging from bladder neck injection to bladder neck reconstruction...
April 2016: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/25195666/high-resolution-spectroscopy-of-the-chiral-metal-complex-cpre-ch%C3%A2-co-no-a-potential-candidate-for-probing-parity-violation
#20
Chris Medcraft, Robert Wolf, Melanie Schnell
Heavy-metal containing chiral compounds have been suggested as promising candidates for studying parity-violation effects. We report herein the broadband rotational spectroscopy study of the chiral complex [CpRe(CH3)(CO)(NO)] in the gas phase. The spectra obtained are very rich due to the two rhenium isotopologues ((185)Re and (187)Re), hyperfine structure arising from the rhenium and nitrogen nuclei, and the asymmetry of the chiral complex. Since rhenium is located very close to the molecular center of mass, the rotational constants for the two rhenium isotopologues are very similar...
October 20, 2014: Angewandte Chemie
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