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Jianhua Jia, Kaixiang Zhou, Jiapei Dai, Boli Liu, Mengchao Cui
An array of complexes, (99m)Tc/Re-labeled cyclopentadienyl tricarbonyl and 2-phenyl/pyridylbenzothiazoles, conjugated through an ester linkage were tested as potential β-amyloid (Aβ) probes for SPECT imaging. The [CpRe/(99m)Tc(CO)3] complexes were prepared by double ligand transfer reactions from ferrocene precursors, and the X-ray structure of one rhenium surrogate revealed a classical "piano stool" like geometry. Several of the rhenium complexes displayed high affinity for Aβ1-42 aggregates in in vitro inhibition assays, and they could intensely stain Aβ deposits on brain sections from transgenic mice and Alzheimer's disease (AD) patients...
September 2, 2016: European Journal of Medicinal Chemistry
Ossamah Alsowayan, John Paul Capolicchio, Roman Jednak, Mohamed El-Sherbiny
INTRODUCTION: In this study, we present our experience managing bladder exstrophy (BE) in a low-volume centre over 24 years. METHODS: Charts of patients with BE between 1990 and 2014 were retrospectively reviewed. Patients with BE closure and ≥5 years followup were included. BE closure was carried out in the first two days of life using either complete primary repair (CPRE) or modern-staged repair (MSRE). Daytime urinary continence (UC) was evaluated by the age of five years...
March 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
Shruti Taparia, Aparna Khanna
BACKGROUND: Over the last 400 years, cocoa and chocolate have been described as having potential medicinal value, being consumed as a beverage or eaten as food. Concentration-dependant, antiproliferation, and cytotoxic effects of some of their polyphenolic constituents have been demonstrated against various cancers. Such an effect remains to be demonstrated in ovarian cancer. OBJECTIVE: To investigate the effect of cocoa procyanidins against ovarian cancer in vitro using OAW42 and OVCAR3 cell lines...
May 2016: Pharmacognosy Magazine
J S Ellison, M Shnorhavorian, K Willihnganz-Lawson, R Grady, P A Merguerian
INTRODUCTION: Long-term continence outcomes for patients with bladder exstrophy are lacking in the literature. The complete primary repair of exstrophy (CPRE) is a widely adopted approach that seeks to normalize anatomy at the initial repair, thereby allowing early bladder filling and cycling. Previous reports of continence following CPRE, however, are limited by variable follow-up duration and continence definitions. OBJECTIVE: To assess continence and factors associated with a positive outcome in a cohort of patients following CPRE with long-term follow-up...
August 2016: Journal of Pediatric Urology
Jonathan S Ellison, Margarett Shnorhavorian, Paul A Merguerian, Richard Grady
BACKGROUND: Inguinal hernias are common in the bladder exstrophy population. As these hernias may present with incarceration following bladder closure, several groups recommend inguinal exploration and hernia repair at the time of initial bladder closure. However, the benefits of such an approach are not well defined. In 2006, we modified our approach to this condition by routinely performing concomitant inguinal herniorraphy (CIH) repair at the time of initial exstrophy repair. The aim of this study was to test the hypothesis that simultaneous inguinal hernia repair will be safe and effective in reducing subsequent unplanned inguinal procedures in this high-risk group...
August 2016: Journal of Pediatric Urology
Everson L A Artifon, Mauricio K Minata, Marco Antonio B Cunha, Jose P Otoch, Dayse P Aparicio, Carlos K Furuya, José L B Paione
INTRODUCTION: Duodenal perforations are an uncommon adverse event during ERCP. Patients can develop significant morbidity and mortality. Even though surgery has been used to manage duodenal complications, therapeutic endoscopy has seen significant advances. OBJECTIVE: To compare endoscopic approach with surgical intervention in patients with duodenal perforations post-ERCP. MATERIAL AND METHODS: prospective randomized study in a tertiary center with 23 patients divided in 2 groups...
October 2015: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
Hon Man Yau, Alasdair I McKay, Henrique Hesse, Ran Xu, Mushi He, Camille E Holt, Graham E Ball
In seeking to create more-stable transition metal-alkane complexes, we generated cationic alkane complexes of the type [(HEB)Re(CO)2(alkane)][Al(OR(f))4] (HEB = η(6)-hexaethylbenzene; alkane = cyclopentane (16) or pentane (17-19); OR(f) = perfluoro-tert-butoxy) via photolysis of the precursor complex [(HEB)Re(CO)3][Al(OR(f))4] (15) in the presence of the added alkane. The alkane complexes were generated in a hydrofluorocarbon (HFC) solvent, most often CF3CH2CF3, which is capable of simultaneously dissolving the ionic complex 15 and a small amount of alkane at low temperature (183 K)...
January 13, 2016: Journal of the American Chemical Society
Malgorzata Debowska, Jan Poleszczuk, Alicja Wojcik-Zaluska, Andrzej Ksiazek, Wojciech Zaluska
Both hyperphosphatemia and hypophosphatemia are associated with increased morbidity and mortality among patients on dialysis. The control of serum phosphate concentration is a considerable clinical problem. Our study aimed to improve understanding of phosphate kinetics in patients on dialysis using mathematical modeling. Three consecutive hemodialysis sessions with breaks of 2-2-3 days were monitored in 25 patients. Phosphate concentration was measured every hour and 45 min after the end of dialysis in blood serum and every 30 min in dialysate during each session...
December 2015: Artificial Organs
Bryan S Sack, John V Kryger, Michael E Mitchell, Charles T Durkee, Roger Lyon, Travis W Groth
INTRODUCTION/OBJECTIVE: Secure closure of the pubic diastasis during bladder exstrophy and epispadias repair decreases the abdominal wall tension at the time of reconstruction. Pelvic osteotomies are routinely performed at the time of abdominal wall and bladder reconstruction in order to more easily facilitate pubic symphyseal diastasis approximation. Postoperative pelvic immobilization is performed by methods that include modified Buck's traction, modified Bryant's traction, and spica casting...
August 2015: Journal of Pediatric Urology
Bassem S Wadie, Tamer E Helmy, Mohamed E Dawaba, Mohamed A Ghoneim
AIMS: Post-exstrophy incontinence is a challenge because continence is difficult to achieve and more difficult to maintain. Feasibility and outcomes of a bulbourethral sling to treat post-exstrophy incontinence is shown in this report. METHODS: A retropubic bulbourethral sling was applied to male patients with incontinence post-exstrophy-epispadius repair. The study included children with total (continuous) incontinence who underwent multiple previous anti-incontinence procedures, ranging from bladder neck injection to bladder neck reconstruction...
April 2016: Neurourology and Urodynamics
Chris Medcraft, Robert Wolf, Melanie Schnell
Heavy-metal containing chiral compounds have been suggested as promising candidates for studying parity-violation effects. We report herein the broadband rotational spectroscopy study of the chiral complex [CpRe(CH3)(CO)(NO)] in the gas phase. The spectra obtained are very rich due to the two rhenium isotopologues ((185)Re and (187)Re), hyperfine structure arising from the rhenium and nitrogen nuclei, and the asymmetry of the chiral complex. Since rhenium is located very close to the molecular center of mass, the rotational constants for the two rhenium isotopologues are very similar...
October 20, 2014: Angewandte Chemie
Eric S Wiedner, Aaron M Appel
To gain insight into thermodynamic barriers for reduction of CO into CH3OH, free energies for reduction of [CpRe(PPh3)(NO)(CO)](+) into CpRe(PPh3)(NO)(CH2OH) have been determined from experimental measurements. Using model complexes, the free energies for the transfer of H(+), H(-), and e(-) have been determined. A pKa of 10.6 was estimated for [CpRe(PPh3)(NO)(CHOH)](+) by measuring the pKa for the analogous [CpRe(PPh3)(NO)(CMeOH)](+). The hydride donor ability (ΔG°H(-)) of CpRe(PPh3)(NO)(CH2OH) was estimated to be 58...
June 18, 2014: Journal of the American Chemical Society
Sohail Muhammad, Salvador Moncho, Edward N Brothers, Ashfaq A Bengali
Photolysis of CpRe(CO)3 in the presence of H3BNEt3 yields the trans-CpRe(CO)2(H)2 complex. This preliminary finding presents a rare example of transition metal mediated dehydrogenation of a tertiary amine-borane and suggests that the abstracted hydrogens may be stored in the form of metal hydride complexes.
June 4, 2014: Chemical Communications: Chem Comm
Gustavo Ieno Judas, Sueli Gomes Ferreira, Rafael Simas, Paulina Sannomiya, Anderson Benício, Luiz Fernando Ferraz da Silva, Luiz Felipe Pinho Moreira
OBECTIVES: Spinal cord ischaemia with resulting paraplegia remains a devastating and unpredictable complication after thoraco-abdominal aortic surgery. With the advent of stem cell therapy and its potential to induce nervous tissue regeneration processes, the interest in the use of these cells as a treatment for neurological disorders has increased. Human stem cells, derived from the umbilical cord, are one of the strong candidates used in cell therapy for spinal cord injury because of weak immunogenicity and ready availability...
June 2014: Interactive Cardiovascular and Thoracic Surgery
Alan P Dickson
AIM: Bladder exstrophy (BE) is a severe congenital malformation with life-long implications. This article discusses the current surgical management and describes the development of the nationally commissioned bladder exstrophy service in Manchester, UK. METHODS: Outcome of BE surgery in Manchester was retrospectively reviewed. A Medline search was also undertaken and the published outcomes reviewed for the Modern Staged Repair of Bladder Exstrophy (MSRE), the Complete Primary Repair of Exstrophy (CPRE), and Radical Soft-Tissue Mobilisation (RSTM)...
February 2014: Journal of Pediatric Surgery
Hrair-George O Mesrobian
OBJECTIVE: To test the hypothesis that complete primary repair of bladder exstrophy (CPRE) is associated with detrussor underactivity. For this purpose, we review (1) our experience, (2) the results of the published literature as it pertains to bladder function, and (3) the known anatomic basis on which the mechanism of the observed outcome can be understood. METHODS: The medical records of all patients who underwent CPRE by the author between 2004 and 2010 were reviewed...
May 2014: Urology
Santosh B Kurbet, Gowda P Prashanth, Mahantesh V Patil, Shivaji Mane
OBJECTIVE: To study the problems faced during the surgery and follow-up of modified complete primary repair of exstrophy (CPRE) technique. Initial experience with CPRE and its short- and long-term outcomes with respect to continence status and psychosocial impact are reported. MATERIALS AND METHODS: A retrospective review of the hospital case records from March 2008 to September 2012 was performed. Data of patients with bladder exstrophy managed by a single paediatric surgeon using modified CPRE technique were analysed...
September 2013: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
Carlo Giaquinto, Gabriel Anabwani, Cornelia Feiterna-Sperling, James Nuttall, Kgosidialwa Mompati, Christoph Königs, Federico J Mensa, John P Sabo, Chan-Loi Yong, Thomas R MacGregor, Thuy Nguyen, Anne-Marie Quinson
BACKGROUND: To compare steady-state (ss) pharmacokinetic targets of nevirapine extended-release (NVP-XR) tablets once-daily (QD) with immediate-release (NVP-IR) tablet or oral suspension twice-daily in HIV-1-infected children and adolescents. METHODS: Phase I, open-label, multidose, cross-over study with optional extension phase, in 85 patients 3 to <18 years of age, previously on an NVP-IR-based regimen for ≥18 weeks with baseline viral load <50 copies/mL...
July 2014: Pediatric Infectious Disease Journal
Edmundo Mori, Katherine Yuen, Héctor Medrano, José Torres, Cesar García, Jaime Montes
INTRODUCTION: Cystic tumors of the pancreas comprise 1% of all neoplasms of the pancreas and 10 to 15% of pancreatic cysts. There are a variety of cystic lesions, of which 90% is made up of serous cystadenomas, mucinous cystic neoplasms, intraductal mucinous neoplasms and solid pseudopapillary neoplasms. MATERIALS AND METHODS: This study describes and analyzes retrospectively the clinical, radiological, surgical, pathological and follow up of 12 patients operated on for cystic tumors of the pancreas in the hospital IV Alberto Sabogal Sologuren, in the period 2005 to 2010...
April 2012: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
Lotta Glans, Wanning Hu, Christian Jöst, Carmen de Kock, Peter J Smith, Matti Haukka, Heike Bruhn, Ulrich Schatzschneider, Ebbe Nordlander
Organometallic analogues of chloroquine show promise as new antimalarial agents capable of overcoming resistance to the parent drug chloroquine. Here, the synthesis and characterization of three new cymantrene (CpMn(CO)(3)) and cyrhetrene (CpRe(CO)(3)) 4-aminoquinoline conjugates with either an amine or amide linker are reported. The antimalarial activity of the new organometallic conjugates N-(2-(7-chloroquinolin-4-ylamino)ethyl)-4-cymantrenylbutanamide (3), N-(2-(7-chloroquinolin-4-ylamino)ethyl)-4-cyrhetrenylbutanamide (4) and N-(7-chloroquinolin-4-yl)-N'-(cymantrenylmethyl)ethane-1,2-diamine (6) was evaluated against a chloroquine-sensitive (CQS) and a chloroquine-resistant strain (CQR) of the malaria parasite Plasmodium falciparum...
June 7, 2012: Dalton Transactions: An International Journal of Inorganic Chemistry
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