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Mohammad R Boroumand, M Yashar S Kalani, Robert F Spetzler
CLOVES (congenital lipomatous overgrowth, vascular malformations, epidermal nevi, and scoliosis/skeletal/spinal anomalies) syndrome is a congenital and almost exclusively pediatric syndrome associated with vascular malformations of the neuroaxis. We report the case of a complex spinal arteriovenous fistula in an adult woman with CLOVES syndrome treated using a multidisciplinary approach with endovascular embolization and microsurgical technique, and review the medical literature on this disease.
October 8, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Justin E Bird, Lee Jae Morse, Lei Feng, Wei-Lien Wang, Patrick P Lin, Bryan S Moon, Alexander J Lazar, Robert L Satcher, John E Madewell, Valerae O Lewis
PURPOSE: To determine non-radiographic risk factors differentiating atypical lipomatous tumors (ALTs) from lipomas. METHODS: All patients with deep-seated lipomatous tumors of the extremities treated from January 2000 to October 2010 were retrospectively reviewed. Factors reviewed included age, gender, tumor location, size, histology, local recurrence, dedifferentiation, and metastasis. Multivariate logistic regression models were used to evaluate the effects of patient characteristics on ALT status...
2016: Frontiers in Oncology
Alisson Roberto Teles, Guilherme Finger, Marcelo N Schuster, Pedro Luis Gobbato
Adipose lesions rarely affect the peripheral nerves. This can occur in two different ways: Direct compression by an extraneural lipoma, or by a lipoma originated from the adipose cells located inside the nerve. Since its first description, many terms have been used in the literature to mention intraneural lipomatous lesions. In this article, the authors report a case of a 62-year-old female who presented with an intraneural median nerve lipoma and review the literature concerning the classification of adipose lesions of the nerve, radiological diagnosis and treatment...
October 2016: Asian Journal of Neurosurgery
Sofiene Bouali, Nidhal Maatar, Asma Bouhoula, Khansa Abderrahmen, Imed Ben Said, Adnen Boubaker, Jalel Kallel, Hafedh Jemel
PURPOSE: The spinal epidural angiolipomas are rare expansive processes made of mature lipomatous and angiomatous elements. They often have a benign character. Their etiology, pathogenesis remains uncertain, and it is a cause of spinal cord compression. The magnetic resonance imaging is the most important neuroradiological examination. Histological examination is the only examination to confirm the diagnosis. Surgery is the treatment of choice. METHODS: A retrospective study of all patients operated on for a spinal epidural angiolipoma at the Department of Neurosurgery at the National Institute of Neurology of Tunis between January 2000 and December 2014 (15 years) was performed...
October 2016: Asian Journal of Neurosurgery
Luiza Ohasi de Figueiredo, D P C Garcia, Luiz Ronaldo Alberti, R A Paiva, Andy Petroianu, Luiza Barbosa Paolucci, M R L G Costa
INTRODUCTION: Intussusception in adult is rarely caused by idiopathic conditions. Main causes are inflammatory diseases, benign or malignant tumors and motility disorders. As a benign cause, lipomas appear as a particularly rare gastrointestinal intraluminal tumor occurring with highest incidence in the colon, mostly in the caecum and ascending colon. PRESENTATION OF CASE: A 57-year-old male patient was admitted at the surgical emergency in Belo Horizonte, with history of chronic and intermittent diffuse abdominal pain, associated with variations of his bowel habits and rare episodes of vomiting starting around 3days prior to admission...
September 21, 2016: International Journal of Surgery Case Reports
Nasir Ud Din, Pingchuan Zhang, William R Sukov, Christopher A Sattler, Sarah M Jenkins, Leona A Doyle, Andrew L Folpe, Karen J Fritchie
OBJECTIVES: Spindle cell lipomas (SCLs) are benign lipomatous neoplasms that classically arise in the posterior neck, upper back, and shoulders of older male patients. We sought to characterize the occurrence of this entity at nonclassic sites. METHODS: All cases of SCL arising at atypical sites were retrieved from our archives. RESULTS: Of 439 total cases of SCL, 57 arose at atypical locations in 32 men and 25 women (age range, 27-79 years)...
October 2016: American Journal of Clinical Pathology
Gloria Zhang, Christopher P Lanigan, John R Goldblum, Raymond R Tubbs, Erinn Downs-Kelly
CONTEXT: -Atypical lipomatous tumors/well-differentiated liposarcomas contain alterations in the 12q13-15 region resulting in amplification of MDM2 and nearby genes. Identifying MDM2 amplification is a useful ancillary test, as the histologic mimics of atypical lipomatous tumors/well-differentiated liposarcomas have consistently shown a lack of MDM2 amplification. OBJECTIVE: -To assess the interobserver reproducibility of a bright-field assay for MDM2 amplification (dual-color, dual-hapten in situ hybridization [DDISH]) among reviewers with varying degrees of experience with the assay and to assess the concordance of MDM2 DDISH with MDM2 fluorescence in situ hybridization (FISH)...
October 2016: Archives of Pathology & Laboratory Medicine
Davorin Sef, Marko Ivan Turina
We describe the resection for lipomatous hypertrophy of the interatrial septum which necessitated complete reconstruction of the right atrium with Dacron grafts connecting the superior and inferior vena cava with the tricuspid orifice, and connection of the pulmonary veins to the mitral orifice with xenopericardium.
September 28, 2016: Journal of Cardiac Surgery
Christina C Westhoff, Janice Mrozinski, Ina Riedel, Hans W Heid, Roland Moll
PURPOSE: Liposarcomas are the most common soft tissue sarcomas of adults. The identification of lipoblastic cells in soft tissue sarcomas is mandatory for the diagnosis of most subtypes of liposarcomas but may be difficult in conventional histology. The present study focuses on the expression and possible diagnostic impact of two PAT family proteins, perilipin 1/perilipin and perilipin 2/adipophilin in human liposarcomas. METHODS: Eighty-seven cases of liposarcomas and 30 cases of non-lipomatous sarcomas were investigated immunohistochemically for perilipin 1 and 2 using entire tissue sections...
September 19, 2016: Journal of Cancer Research and Clinical Oncology
Jason Y Park, Cynthia Cohen, Dania Lopez, Erica Ramos, Jennifer Wagenfuehr, Dinesh Rakheja
Fibrous hamartoma of infancy (FHI) is a benign mesenchymal tumor histologically characterized by a mixture of intersecting fascicles of fibroblasts/myofibroblasts in collagenous stroma, nests of primitive oval or stellate cells in basophilic mucoid stroma, and mature adipose tissue. We hypothesized that FHI, because of histologic overlap with mesenchymal overgrowth tumors seen in CLOVES (Congenital Lipomatous Overgrowth with Vascular, Epidermal, Skeletal anomalies) and Proteus syndromes, may harbor mutations in signaling pathways associated with cellular proliferation...
September 14, 2016: American Journal of Surgical Pathology
Andrea De Martino, Stefania Blasi, Daniele Lorenzini, Mariagrazia Fornaro, Fulvio Basolo, Uberto Bortolotti, Angela Pucci
Cardiac valve lipomatous hamartomas are very rare lesions with preferential localization on the pericardium, followed by the endocardial surfaces. We report a quite unique case of a lipomatous hamartoma-like lesion involving a bicuspid aortic valve. The lesion was incidentally found in a young patient undergoing cardiac surgery for aortic regurgitation, and the diagnosis was done by histology. It cannot be excluded that the lipomatous hamartoma-like lesion might have contributed to aortic valve regurgitation...
August 28, 2016: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
Sharon Anderson, Susan Sklower Brooks
BACKGROUND: CLOVES (Congenital Lipomatous Overgrowth, Vascular malformations, Epidermal nevi Scoliosis, Skeletal, Spinal) syndrome is an extremely rare, complex, non-Mendelian genetic condition with clinical overlap to several other overgrowth syndromes. PURPOSE: This article shares an interesting case report of the prenatal to postnatal diagnostic course for an infant with this condition. CASE FINDINGS/RESULTS: It shares prenatal and postnatal images and imaging studies which helped confirm the diagnosis...
September 8, 2016: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
Solène-Florence Kammerer-Jacquet, Sixte Thierry, Florian Cabillic, Morgane Lannes, Florence Burtin, Sébastien Henno, Frédéric Dugay, Guillaume Bouzillé, Nathalie Rioux-Leclercq, Marc-Antoine Belaud-Rotureau, Nathalie Stock
The differential diagnosis between atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDLPS) and dedifferentiated liposarcoma (DDLPS) from their morphologic counterparts is challenging. Currently, the diagnosis is guided by MDM2 and CDK4 immunohistochemistry (IHC) and is confirmed by the amplification of the corresponding genes. Recently, p16 IHC has been proposed as a useful diagnostic biomarker. To assess the utility of p16 IHC in the differential diagnosis of ALT/WDLPS and DDLPS. Our series included 101 tumors that were previously analyzed using fluorescence in situ hybridization (FISH) for MDM2 and CDK4 amplification...
September 2, 2016: Human Pathology
Pantelis Kraniotis, Georgios Pastromas, Irene Tsota, Maria Patsoura, Theodore Petsas
Intussusception in adults is rare, accounting for less than 5% of all cases. Unlike the childhood variant, adult intussusception is often associated with a small bowel lesion acting as the "lead point." We herein report an uncommon case of giant intussusception secondary to 2 separate lipomatous lesions located in the ileum, in an adult admitted to our hospital for acute severe abdominal pain.
September 2016: Radiology case reports
S Wang, L Wm Chan, X Tang, C Su, C Zhang, K Sun, D Shen, H Chen, W Guo
PURPOSE: To construct a scoring system to differentiate malignant liposarcomas from benign lipomas by comparing their clinical and magnetic resonance imaging (MRI) features. METHODS: Clinical and MRI features of 33 women and 33 men aged 17 to 83 (mean, 53) years who underwent resection of malignant liposarcomas (n=32) or benign lipomas (n=34) were reviewed. RESULTS: The 5 strongest predictors of liposarcoma were male gender, larger tumour maximum dimension, deep to fascia, thick non-fatty septum or nodule, and internal cystic change...
August 2016: Journal of Orthopaedic Surgery
Sandeep Halagatti Venkatesh, Bak Siew Steven Wong
A 54-year-old woman presented with a large mass on her right hand that was progressively enlarging over a period of a few years. She had cosmetic concerns about the enlarging mass and experienced interference with routine activity. Physical examination revealed a soft, mobile, non-tender, lobulated mass with well-defined margins. Magnetic resonance imaging showed the soft lump to be a lipomatous mass in the deep palmar space of the hand, which was subsequently surgically resected. The imaging features of deep palmar lipomas of the hand and other common benign lesions at this location are discussed...
August 2016: Singapore Medical Journal
Fatemeh Nili, Nakisa Nicknejad, Samaneh Salarvand, Setareh Akhavan
Angiomyofibroblastoma is a rare and benign tumor that usually involves vulvovaginal area in women of reproductive age and early menopause. We report a lipomatous angiomyofibroblastoma in a 55-year-old multigravid woman. This tumor measured 9 cm in size and contained prominent mature adipose that comprises about 50% of the tumor.
August 10, 2016: International Journal of Gynecological Pathology
Anjali D Amarapurkar, Prachi Nichat, Nitin Narawane, Deepak Amarapurkar
INTRODUCTION: Incidence of colorectal carcinoma is increasing all over world. There is limited data on colorectal polyps from India. We evaluated the histomorphological features of colorectal polyps and determined risk stratification in adenomatous polyps. METHODS: In 4970 consecutive colonoscopies, colorectal polyps were detected in 515 cases (10.3 %). Polyps were classified using standard histological criteria. Each polyp was evaluated for presence of dysplasia...
July 2016: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
Michael R Clay, Anthony P Martinez, Sharon W Weiss, Mark A Edgar
Although most cases of atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL) can be diagnosed solely on the basis of histologic features, those lacking diagnostic histologic features require ancillary studies for accurate classification. Fluorescent in situ hybridization (FISH) for amplification of MDM2 has been considered the gold standard for diagnosis in these situations. Immunostaining for MDM2 and/or CDK4 has been adopted as a surrogate method because of its high concordance rate with FISH and lower cost...
August 9, 2016: American Journal of Surgical Pathology
Osamu Katsuta, Toru Shibata, Yumi Kuriki-Yamamoto, Takaharu Mochizuki, Miwa Yoshimi, Takahisa Noto, Hidetoshi Mano
A 15-year-old male cynomolgus monkey (Macaca fascicularis) showed large bilateral masses in the maxillary sinus. In histopathological examination, both masses revealed benign medullary lipomas within the turbinate bones. The tumors were composed of well-developed lipocytes, trabecular bones and a few blood vessels. Although we initially diagnosed the tumor as bilateral lipomas in the nasal turbinates, it was not differentiated from lipomatous hamartoma. Findings, such as unique symmetrical proliferation, lack of border from the normal marrow and the intact surrounding tissue, indicated a lipomatous hamartoma/hamartomatous lipoma, thought to be a suitable diagnosis of the lesion...
August 6, 2016: Journal of Veterinary Medical Science
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