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https://www.readbyqxmd.com/read/29776450/the-role-of-surgical-margins-in-atypical-lipomatous-tumours-of-the-extremities
#1
Jessica Rauh, Alexander Klein, Andrea Baur-Melnyk, Thomas Knösel, Lars Lindner, Falk Roeder, Volkmar Jansson, Hans Roland Dürr
BACKGROUND: Atypical lipomatous tumours (ALT) are common adipocytic tumours. Due to their large size and deep-seated location, wide resection might result in severe functional deficits. The question which margins should be aimed is hence discussed controversially. METHODS: Forty consecutive patients underwent limb-sparing resections. Margins were defined as R0 (wide resection), R1 (marginal resection) or R2 if tumour was left. All patients were followed for evidence of local recurrence or remote metastases...
May 17, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29758934/adipose-tissue-derived-stem-cells-from-affected-and-unaffected-areas-in-patients-with-multiple-symmetric-lipomatosis-show-differential-regulation-of-mtor-pathway-genes
#2
Oliver Felthaus, Teresa Schön, Daniel Schiltz, Thiha Aung, Britta Kühlmann, Friedrich Jung, Alexandra Anker, Silvan Klein, Lukas Prantl
BACKGROUND: Multiple symmetric lipomatosis is a rare disease characterized by the excessive growth of uncapsulated masses of adipose tissue. Although the etiology has yet to be elucidated, a connection to brown adipose tissue has been proposed recently. The mTOR pathway which is found to be regulated in lipomatous tissue as well as associated with brown adipose tissue can be inhibited by a compound called rapamycin. METHODS: We isolated adipose tissue derived stem cells from both affected and unaffected tissue and treated these cells with different concentrations of rapamycin...
2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29755284/the-value-of-mri-in-distinguishing-subtypes-of-lipomatous-extremity-tumors-needs-reassessment-in-the-era-of-mdm2-and-cdk4-testing
#3
Sean Ryan, Julia Visgauss, David Kerr, Joshua Helmkamp, Nicholas Said, Emily Vinson, Patrick O'Donnell, Xuechan Li, Sin-Ho Jung, Diana Cardona, William Eward, Brian Brigman
Introduction: Extremity lipomas and well-differentiated liposarcomas (WDLs) are difficult to distinguish on MR imaging. We sought to evaluate the accuracy of MRI interpretation using MDM2 amplification, via fluorescence in-situ hybridization (FISH), as the gold standard for pathologic diagnosis. Furthermore, we aimed to investigate the utility of a diagnostic formula proposed in the literature. Methods: We retrospectively collected 49 patients with lipomas or WDLs utilizing MDM2 for pathologic diagnosis...
2018: Sarcoma
https://www.readbyqxmd.com/read/29748845/lipomas-of-the-oral-cavity-utility-of-mdm2-and-cdk4-in-avoiding-overdiagnosis-as-atypical-lipomatous-tumor
#4
Ivan J Stojanov, Adrian Mariño-Enriquez, Nacef Bahri, Vickie Y Jo, Sook-Bin Woo
Traumatized lipomas with degenerative change may demonstrate histopathologic features that mimic atypical lipomatous tumor (ALT). Previously reported series of ALT involving the oral cavity preceded routine use of MDM2 and CDK4 immunohistochemistry. Our aim is to evaluate MDM2 and CDK4 immunohistochemical expression in adipocytic tumors arising in this site, in conjunction with the histiocytic marker PU.1, to determine whether MDM2 and CDK4 impacts classification. 17 cases originally diagnosed as ALT were retrieved and immunohistochemical studies for MDM2, CDK4 and PU...
May 10, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29743748/lipomatous-hypertrophy-of-the-interatrial-septum
#5
Renato Niemeyer de Freitas Ribeiro, Bruno Niemeyer de Freitas Ribeiro, Wolney de Andrade Martins, Lívia de Oliveira Antunes, Edson Marchiori
No abstract text is available yet for this article.
March 2018: Radiologia Brasileira
https://www.readbyqxmd.com/read/29738363/pancreatic-lipomatous-hamartoma-a-hitherto-unrecognized-variant
#6
Mariko Tanaka, Tetsuo Ushiku, Masako Ikemura, Yutaka Takazawa, Toru Igari, Michio Shimizu, Hiroshi Yamaguchi, Noriyoshi Fukushima, Kei Sakuma, Junichi Arita, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Takeyuki Watadani, Yousuke Nakai, Kazuhiko Koike, Masashi Fukayama
Pancreatic masses consisting of lipomatous components clinically include lipoma, liposarcoma, lipomatous pseudohypertrophy of the pancreas, fat-containing neoplasms such as perivascular epithelioid cell tumor, and malignant neoplasm with lipoid degeneration. We present pancreatic lipomatous hamartoma, which has not been reported hitherto. A solid pancreatic mass was detected from a computed tomographic scan check-up in each of 3 cases of Japanese men. Macroscopically, well-demarcated solid lipomatous masses were detected at the uncus, body, and tail of the pancreas, respectively...
May 4, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29709714/molecular-analyses-in-the-diagnosis-and-prediction-of-prognosis-in-non-gist-soft-tissue-sarcomas-a-systematic-review-and-meta-analysis
#7
REVIEW
Rita A Kandel, Xiaomei Yao, Brendan C Dickson, Michelle Ghert, Snezana Popovic, Bibianna M Purgina, Shailendra Verma, Joel Werier
BACKGROUND: The molecular pathogenesis of many forms of soft tissue sarcomas (STS) have been rigorously characterized in the medical literature, which may be particularly important for the diagnosis and prediction of prognosis in STS. METHODS: Electronic databases (2005 to October 2016) were searched. Gastrointestinal stromal tumor and pediatric sarcomas were excluded. The eligible individual study's risk of bias and the quality of aggregate evidence were assessed...
April 22, 2018: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29701405/deep-vein-thrombosis-as-first-manifestation-of-hibernoma-a-case-report
#8
Ana Mesquita, José Vidoedo, Miguel Maia, João Vasconcelos, João Almeida Pinto, Abreu De Sousa
INTRODUCTION: Hibernoma is a very rare benign tumor that arises from vestigial remnants of fetal brown adipose cells and usually manifests as a slowly growing, painless soft-tissue mass. It mainly occurs in adults, in the third and fourth decade of life, slightly more in women and is commonly seen in the subcutaneous regions of the back, neck, thighs and retroperitoneum. It was originally described in 1906 by Merkel, who named it "pseudolipoma". In 1914, Gery derived the name hibernoma from the tumor's histological similarity to brown fat in hibernating animals...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29689704/whole-blood-mirna-expression-analysis-reveals-mir-3613-3p-as-a-potential-biomarker-for-dedifferentiated-liposarcoma
#9
A Fricke, A F V Cimniak, P V Ullrich, C Becherer, C Bickert, D Pfeifer, J Heinz, G B Stark, H Bannasch, D Braig, S U Eisenhardt
BACKGROUND: Liposarcoma constitute about 13% of all soft tissue sarcoma and are associated with a high risk of metastases. As the preoperative differentiation between benign and malign lipomatous tumors is restricted to magnetic resonance imaging, computed tomography and biopsy, we performed a miRNA array to distinguish dedifferentiated liposarcoma patients from healthy controls and lipoma patients. METHODS: Blood samples of patients with dedifferentiated liposarcoma, healthy controls and lipoma patients were collected...
April 9, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29682479/submandibular-lipoblastoma-case-report-of-a-rare-tumor-in-childhood
#10
Olfa El Amine, Meyssa Belghith, Hasna Salhi, Aida Goucha, Amor Gamoudi
Lipoblastoma is a rare, benign tumor usually occurring in childhood. It is essentially localized in the extremities and trunk, with few cases reported in the neck. We report the case of a 2-year-old girl with a rapidly enlarging, painless neck mass. Magnetic resonance imaging (MRI) revealed a 3-cm mass in the right submandibular region. Review of literature, diagnostic methods, and genetics of lipomatous tumors are discussed. Complete surgical excision via a lateral cervical approach demonstrated a white soft tissue with an adherent ganglion...
April 2018: Avicenna Journal of Medicine
https://www.readbyqxmd.com/read/29663025/imaging-appearance-of-well-differentiated-liposarcomas-with-myxoid-stroma
#11
Yoav Morag, Corrie Yablon, Monica Kalume Brigido, Jon Jacobson, David Lucas
OBJECTIVE: Describe the imaging appearance of well-differentiated liposarcoma with myxoid stroma (WDLMS) and correlate with histopathology. MATERIALS AND METHODS: A keyword search of the institution medical records was performed from 1 January 2000 to 30 June 2017. The histopathology slides of cases identified in this fashion were then reviewed by a pathologist. Additional cases were prospectively collected from extramural referrals and tumor boards. Diagnostic imaging studies of pathologically proven cases of WDLMS were then reviewed in consensus and correlated with pathology...
April 16, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29659409/liposarcoma-preoperatively-diagnosed-as-lipoma-10-year-experience-at-a-single-institution
#12
Daisuke Sato, Hirotaka Suga, Akihiko Takushima
BACKGROUND: On rare occasions, a lesion preoperatively diagnosed as a lipoma is ultimately diagnosed as a liposarcoma. It is important to differentiate liposarcomas from lipomas preoperatively. OBJECTIVE: To examine characteristic features of liposarcomas preoperatively diagnosed as lipomas. METHODS: Patients (n = 637) who underwent resection of tumors preoperatively diagnosed as lipomas from January 2006 to October 2016 were retrospectively reviewed...
April 13, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29629919/hibernoma-mimicking-atypical-lipomatous-tumor-64-cases-of-a-morphologically-distinct-subset
#13
Youssef Al Hmada, Inga-Marie Schaefer, Christopher D M Fletcher
Hibernoma is a benign adipocytic tumor with predilection for subcutaneous tissue of the thigh, upper trunk, and neck of middle-aged adults. 11q13 rearrangement resulting in MEN1/AIP codeletion is characteristic. Hibernomas are composed, in varying proportions, of brown fat cells, mature adipocytes, and microvacuolated lipoblast-like cells. Examples containing predominantly multivacuolated lipoblast-like cells are uncommon and distinction from atypical lipomatous tumor (ALT) is important for clinical management...
April 6, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29624714/two-cases-of-discrete-adenoid-pseudogland-formation-within-benign-intradermal-melanocytic-nevi
#14
Jonathan C Banta, Justin P Bandino
We report two cases of benign intradermal melanocytic nevi with discrete glandular elements and mucin deposition engendering a diagnostic dilemma. The preliminary differential included entrapment of adnexal structures, collision with an adnexal neoplasm such as adenoid cystic carcinoma, or metastatic adenocarcinoma. A colloidal iron special stain confirmed the deposition of mucin, however a pankeratin AE1/AE3 immunohistochemical cocktail was surprisingly negative. Closer cytological examination of the discrete "glands" combined with nearby pseudoangiomatous (almost Kaposiform) change hinted at melanocytic origin, and was confirmed with a positive MART-1 immunohistochemical stain...
April 6, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29607758/nonepithelial-tumors-and-tumor-like-lesions-of-the-skin-and-subcutis-in-children
#15
Louis P Dehner, Alejandro A Gru
This overview of mesenchymal tumors presenting in the skin and/or subcutis in children brings together the range of neoplasms and hamartomas which are seen in this age-group. It is not surprising from the perspective of the pediatric or general surgical pathologist that vascular anomalies, including true neoplasms and vascular malformations, are the common phenotypic category. Since there is considerable morphologic overlap among these lesions, clinicopathologic correlation may be more important than for many of the other mesenchymal tumors...
March 2018: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/29600904/a-case-of-junctional-neural-tube-defect-associated-with-a-lipoma-of-the-filum-terminale-a-new-subtype-of-junctional-neural-tube-defect
#16
Simona Mihaela Florea, Alice Faure, Hervé Brunel, Nadine Girard, Didier Scavarda
The embryological development of the central nervous system takes place during the neurulation process, which includes primary and secondary neurulation. A new form of dysraphism, named junctional neural tube defect (JNTD), was recently reported, with only 4 cases described in the literature. The authors report a fifth case of JNTD. This 5-year-old boy, who had been operated on during his 1st month of life for a uretero-rectal fistula, was referred for evaluation of possible spinal dysraphism. He had urinary incontinence, clubfeet, and a history of delayed walking ability...
March 30, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29600214/an-intramuscular-chondrolipoma-of-the-scapula-a-case-report-of-a-rare-tumor-in-an-unusual-location
#17
Ying-Cheng Huang, Shan-Wei Yang, Chun-Yu Chen, Jenn-Huei Renn
Introduction: Chondrolipomas are rare benign mesenchymal tumors primarily occurring in the shoulder region. To the best of our knowledge, only one case of chondrolipoma arising from the shoulder has been reported. We herein report an intramuscular chondrolipoma located in an unusual area of the scapula. Our case is interesting because magnetic resonance imaging (MRI) that shows lipomatous tumor masses with cartilaginous nodules may mislead surgeons into not considering the possibility of chondrolipomas...
November 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29595117/non-alcoholic-fatty-pancreas-disease-nafpd-a-silent-spectator-or-the-fifth-component-of-metabolic-syndrome-a-literature-review
#18
Bhupinder Romana, Harleen Chela, Francis Dailey, Fatiha Nassir, Veysel Tahan
Fat accumulation in the pancreas has remained a relatively unknown disease since it was initially described in 1933. However, it has gained increasing attention in the past two decades with the emergence of the obesity epidemic. Pancreatic steatosis is a general term used for fat accumulation in the pancreas. It is further classified into fatty replacement, fatty infiltration, lipomatous pseudo-hypertrophy, non-alcoholic fatty pancreas disease (NAFPD) and non-alcoholic fatty steatopancreatitis (NASP). NAFPD is defined as obesity-associated accumulation of fat in the pancreas without significant alcohol consumption...
March 27, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29594062/liposarcoma-of-the-thyroid-a-case-report-with-a-review-of-the-literature
#19
Vittoria Guarda, Anja Pickhard, Melanie Boxberg, Katja Specht, Anna Maria Stefanie Buchberger
Background: Liposarcomas of the thyroid gland are extremely rare tumors, and, to our knowledge, only 12 cases have been reported in the English literature. An accurate diagnosis is challenging due to the nonspecific clinical presentation of this cancer, frequently defined just by a swelling of the neck. Patient Findings: We present an 82-year-old woman with liposarcoma of the thyroid, complaining of a fast-growing neck mass. MRI and neck ultrasound showed a large lipomatous mass, which corresponded to a cold nodule in the thyroid scan...
March 2018: European Thyroid Journal
https://www.readbyqxmd.com/read/29580047/the-feasibility-of-shear-wave-elastography-for-diagnosing-superficial-benign-soft-tissue-masses
#20
Hyun Jung Yeoh, Tae-Yoon Kim, Jeong Ah Ryu
Purpose: The purpose of this study was to investigate the feasibility of shear wave ultrasound elastography for differentiating superficial benign soft tissue masses through a comparison of their shear moduli. Methods: We retrospectively analyzed 48 masses from 46 patients from February 2014 to May 2016. Surgical excision, fine-needle aspiration, and clinical findings were used for the differential diagnosis. The ultrasonographic examinations were conducted by a single musculoskeletal radiologist, and the ultrasonographic findings were reviewed by two other radiologists who were blinded to the final diagnosis...
January 19, 2018: Ultrasonography
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