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Telaprevir in childrens

M El-Shabrawi, F Hassanin
Chronic viral hepatitis B and C infections are highly prevalent and create a substantial burden to healthcare systems globally. These two chronic infections are the cause of significant global morbidity and mortality with approximately 1 million annual deaths attributable to them and their sequelae. Children are vulnerable to both infections. The availability of new drugs and new therapeutic strategies are increasing the complexity and individualizing the management of children with viral hepatitis. Therefore, it is extremely important to educate and advise pediatricians concerning the new lines of treatment...
October 2014: Minerva Pediatrica
Clara T M M de Kanter, Joost P H Drenth, Joop E Arends, Henk W Reesink, Marc van der Valk, Robert J de Knegt, David M Burger
Chronic hepatitis C is a global health problem. To prevent or reduce complications, the hepatitis C virus (HCV) infection needs to be eradicated. There have been several developments in treating these patients since the discovery of the virus. As of 1 January 2014, the drugs that are approved for treatment of chronic HCV infection are peginterferon-α, ribavirin, boceprevir, telaprevir, simeprevir and sofosbuvir. In this review we provide an overview of the clinical pharmacokinetic characteristics of these agents by describing their absorption, distribution, metabolism and excretion...
May 2014: Clinical Pharmacokinetics
Tatsuo Kanda, Osamu Yokosuka, Masao Omata
OBJECTIVE: To review the updated research on direct antiviral agents (DAAs)-including regimens for hepatitis C virus (HCV), and focus on "difficult-to-treat" HCV-infected patients. DATA SOURCES: The literature concerning DAAs and hepatitis C cited in this review was collected from PubMed and Google Scholar databases published in English up to July 2013. STUDY SELECTION: Data from published articles regarding HCV and DAAs in clinical trials and in clinical use were identified and reviewed...
December 2013: Chinese Medical Journal
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