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https://www.readbyqxmd.com/read/29346701/identifying-prevalence-and-characteristics-of-behavioral-health-education-in-family-medicine-clerkships-a-cera-study
#1
Mario P DeMarco, Renée M Betancourt, Kelly M Everard, Kent D W Bream
BACKGROUND AND OBJECTIVES: Many patients with behavioral health disorders do not seek or receive adequate care for their conditions. Among those that do, most will receive care in a primary care setting. To best meet this need, clinicians will need to demonstrate proficiency of behavioral health skills and evidence-based practices. We sought to explore the degree to which these skills are being taught in family medicine clerkships. METHODS: The Council of Academic Family Medicine's (CAFM) Educational Research Alliance (CERA) 2016 survey of clerkship directors (CDs) was sent to 141 CDs at US and Canadian medical schools with a required family medicine run course...
January 2018: Family Medicine
https://www.readbyqxmd.com/read/29346631/anticardiolipin-antibodies-and-12-month-graft-function-in-kidney-transplant-recipients-a-prognosis-cohort-survey
#2
Marion Gauthier, Florence Canoui-Poitrine, Esther Guéry, Dominique Desvaux, Sophie Hue, Guillaume Canaud, Thomas Stehle, Philippe Lang, Tomek Kofman, Philippe Grimbert, Marie Matignon
Background: In kidney transplant recipients, anticardiolipin (ACL) antibodies without antiphospholipid syndrome (APS) are found in up to 38% of patients and could be associated with thrombotic events (TEs). However, the prognostic role of ACL regarding kidney transplant and patients outcomes have still not been well defined. Methods: We conducted an observational, monocentric, retrospective cohort study including 446 kidney transplant recipients and standardized follow-up: 36-month allograft and patient survival, 12-month estimated glomerular filtration rate (eGFR) and 3- and 12-month screening biopsies...
January 16, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29346475/current-status-of-radiology-training-in-otolaryngology-residency-programs
#3
Kirkland N Lozada, Joseph M Bernstein
Importance: Otolaryngologists use head and neck imaging on a daily basis. However, little is known about the training residents receive on the subject. Understanding the current training environment is important to identify areas of improvement for resident education. Objective: To assess the current state of radiology training in otolaryngology residency programs. Design, Setting, and Participants: This was a cross-sectional survey of 106 otolaryngology residency program directors involving multiple academic institutions...
January 18, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29346286/a-more-efficient-transportable-and-scalable-system-for-real-time-activities-and-exercises-recognition
#4
Kévin Chapron, Valère Plantevin, Florentin Thullier, Kévin Bouchard, Elise Duchesne, Sébastien Gaboury
Many people in the world are affected by muscle wasting, especially the population hits by myotonic dystrophy type 1 (DM1). Those people are usually given a program of multiple physical exercises to do. While DM1 and many other people have difficulties attending commercial centers to realize their program, a solution is to develop such a program completable at home. To this end, we developed a portable system that patients could bring home. This prototype is an improved version of the previous one using Wi-Fi, as this new prototype runs on BLE technology...
January 18, 2018: Sensors
https://www.readbyqxmd.com/read/29346090/fast-2d-complex-gabor-filter-with-kernel-decomposition
#5
Jaeyoon Kim, Suhyuk Um, Dongbo Min
2D complex Gabor filtering has found numerous applications in the fields of computer vision and image processing. Especially, in some applications, it is often needed to compute 2D complex Gabor filter bank consisting of filtering outputs at multiple orientations and frequencies. Although several approaches for fast Gabor filtering have been proposed, they focus primarily on reducing the runtime for performing filtering once at specific orientation and frequency. To obtain the Gabor filter bank, the existing methods are repeatedly applied with respect to multiple orientations and frequencies...
April 2018: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/29346009/automation-on-an-open-access-platform-of-alzheimer-s-disease-biomarker-immunoassays
#6
Benjamin Gille, Lieselot Dedeene, Erik Stoops, Leentje Demeyer, Cindy Francois, Stefanie Lefever, Maxim De Schaepdryver, Britta Brix, Rik Vandenberghe, Jos Tournoy, Hugo Vanderstichele, Koen Poesen
The lack of (inter-)laboratory standardization has hampered the application of universal cutoff values for Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers and their transfer to general clinical practice. The automation of the AD biomarker immunoassays is suggested to generate more robust results than using manual testing. Open-access platforms will facilitate the integration of automation for novel biomarkers, allowing the introduction of the protein profiling concept. A feasibility study was performed on an automated open-access platform of the commercial immunoassays for the 42-amino-acid isoform of amyloid-β (Aβ1-42), Aβ1-40, and total tau in CSF...
January 1, 2018: SLAS Technology
https://www.readbyqxmd.com/read/29345601/vaccine-effectiveness-and-use-of-collar-impregnated-with-insecticide-for-reducing-incidence-of-leishmania-infection-in-dogs-in-an-endemic-region-for-visceral-leishmaniasis-in-brazil
#7
E G Lopes, A P Sevá, F Ferreira, C M Nunes, L B Keid, R M Hiramoto, H L Ferreira, T M F S Oliveira, F G Ovallos, E A B Galati, T J Villegas, D V Bortoletto, S Y O B Valadas, R M Soares
Although a national programme for control of visceral leishmaniosis (VL) is being run in Brazil, the disease continues to spread. This programme is essentially based on culling infected dogs from endemic regions. Thus, there is an urgent need to develop other control measures against VL to deter its advance. Here, a subunit vaccine, a recombinant vaccine, an insecticide-impregnated collar and the associations between these measures were evaluated for reducing the incidence of Leishmania infection in dogs. This was through a cohort study conducted in an endemic region of Brazil, considering the incidence and time of total exposure over a period of 1 year...
January 18, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29345547/are-current-physical-match-performance-metrics-in-elite-soccer-fit-for-purpose-or-is-the-adoption-of-an-integrated-approach-needed
#8
Paul S Bradley, Jack D Ade
Time-motion analysis is a valuable data-collection technique used to quantify the physical match performance of elite soccer players. For over 40 years researchers have adopted a 'traditional' approach when evaluating match demands by simply reporting the distance covered or time spent along a motion continuum of walking through to sprinting. This methodology quantifies physical metrics in isolation without integrating other factors and this ultimately leads to a one-dimensional insight into match performance...
January 18, 2018: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29345541/running-mechanics-and-metabolic-responses-with-water-bottles-and-bottle-belt-holders
#9
Heather K Vincent, Laura A Zdziarski, Kyle Fallgatter, Giorgio Negron, Cong Chen, Trevor Leavitt, MaryBeth Horodyski, Joseph G Wasser, Kevin R Vincent
PURPOSE: This study determined whether differential kinematics, kinetics, rates of energy use and cardiopulmonary responses occurred during running with water bottles and bottle belt holders compared to running only. METHODS: Trained runners (N=42; 27.2±6.4 yr) ran on an instrumented treadmill for four conditions in a randomized order: 1) control run (CON); 2) hand-held full water bottle (FULL, 16.9 fluid oz; 454 g); 3) hand-held half-full water bottle (HALF, 8...
January 18, 2018: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29345514/design-and-validation-of-an-instrumented-uneven-terrain-treadmill
#10
Alexandra S Voloshina, Daniel P Ferris
Studying human and animal locomotion on uneven terrain can be beneficial to basic science and applied studies for clinical and robotic applications. Traditional biomechanical analysis of human locomotion has often been limited to laboratory environments with flat, smooth runways and treadmills. We modified a regular exercise treadmill by attaching wooden blocks to the treadmill belt to yield an uneven locomotion surface. To ensure that these treadmill modifications facilitated biomechanical measurements, we compared ground reaction force data collected during running on the modified instrumented treadmill with a smooth surface to data collected using a conventional instrumented treadmill...
January 18, 2018: Journal of Applied Biomechanics
https://www.readbyqxmd.com/read/29345252/optimization-of-lentiviral-vector-production-for-scale-up-in-fixed-bed-bioreactor
#11
A J Valkama, H M Leinonen, E M Lipponen, V Turkki, J Malinen, T Heikura, S Ylä-Herttuala, H P Lesch
Lentiviral vectors (LVs) are promising tools for gene therapy. However, scaling up the production methods of LVs in order to produce high-quality vectors for clinical purposes has proven to be difficult. In this article, we present a scalable and efficient method to produce LVs with transient transfection of adherent 293T cells in a fixed-bed bioreactor. The disposable iCELLis bioreactors are scalable with a large three-dimensional (3D) growth area range between 0.53 and 500 m2, an integrated perfusion system, and a controllable environment for production...
October 5, 2017: Gene Therapy
https://www.readbyqxmd.com/read/29344540/standing-height-as-a-prevention-measure-for-overuse-injuries-of-the-back-in-alpine-ski-racing-a-kinematic-and-kinetic-study-of-giant-slalom
#12
Jörg Spörri, Josef Kröll, Benedikt Fasel, Kamiar Aminian, Erich Müller
Background: In alpine ski racing, typical loading patterns of the back include a combined occurrence of spinal bending, torsion, and high peak loads. These factors are known to be associated with high spinal disc loading and have been suggested to be attributable to different types of spine deterioration. However, little is known about the effect of standing height (ie, the distance between the bottom of the running surface of the ski and the ski boot sole) on the aforementioned back loading patterns...
January 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29344459/module-for-interns-in-medical-ethics-a-developmental-diegesis
#13
Rajiv Mahajan, Parmod Kumar Goyal, Tanvir Kaur Sidhu, Upinder Kaur, Sandeep Kaur, Vitull Gupta
Background: Media report is rife with incidences of doctor-patients' conflict, and this partly is due to communication gap and unethical practices being adopted by the doctors. Our regular curriculum fails to impart any training in ethical issues in patient care. Imparting training to students in these soft-skills is the need of the hour. Aim and Objectives: To develop a module for interns in medical ethics (MIME) in patient care, validate it and pilot run the module for standardization...
December 2017: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/29344184/therapeutic-effects-of-adenovirus-mediated-cd-and-nis-expression-combined-with-na131i-5-fc-on-human-thyroid-cancer
#14
Meng-Hui Yuan, Long-Xiao Wei, Run-Suo Zhou, Hai-Feng Xu, Jun-Yan Wang, Qian-Rong Bai
Thyroid cancer is the most common type of malignant endocrine tumor diagnosed. Previous studies have indicated that gene therapy is the most promising and effective therapeutic method for thyroid cancer. Therefore, in the present study, Na131I/5-fluorocytosine (5-FC) treatment was combined with cytosine deaminase (CD, encoded by the CDA gene) and sodium iodide symporter (NIS, encoded by the SLC5A5 gene) to act together as a therapeutic tool for thyroid cancer. The present study explored the combined cytotoxic effects of adenovirus-mediated CD and NIS under the control of the progression elevated gene-3 (PEG-3) promoter (Ad-PEG-3-CD-NIS) with Na131I/5-FC against the human thyroid cancer TT cell line in vitro...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29343890/first-two-bilateral-hand-transplantations-in-india-part-2-technical-details
#15
Mohit Sharma, Subramania Iyer, P Kishore, Jimmy Mathew, Raghuveer Reddy, Janarthanan Ramu, Sundeep Vijayaraghavan, Abhijeet Wakure, S M Mali Chetan, Visakh Varma, Ashish Chaudhari, Swapnil Dhake, Akshay Omkumar, Jerry Paul, Sunil Rajan, Ayyappan Nair, Druvan Shaji
Introduction: This article deals with two patients who underwent bilateral hand transplantation following amputation of both upper limbs at the distal third of the foream. Materials and Methods: The first patient had a history of loss of hands in a train accident , with possiblity of a run over element during the injury. The second patient lost his both hands in a mine blast. The preoperative work up included detailed clinical and psychological evaluation. The donor retrieval was similar in both the cases and the donors were housed in our own instittution...
May 2017: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/29343749/testosterone-boosts-physical-activity-in-male-mice-via-dopaminergic-pathways
#16
Ferran Jardí, Michaël R Laurent, Nari Kim, Rougin Khalil, Dimitri De Bundel, Ann Van Eeckhaut, Lawrence Van Helleputte, Ludo Deboel, Vanessa Dubois, Dieter Schollaert, Brigitte Decallonne, Geert Carmeliet, Ludo Van den Bosch, Rudi D'Hooge, Frank Claessens, Dirk Vanderschueren
Low testosterone (T) in men, especially its free fraction, has been associated with loss of energy. In accordance, orchidectomy (ORX) in rodents results in decreased physical activity. Still, the mechanisms through which T stimulates activity remain mostly obscure. Here, we studied voluntary wheel running behavior in three different mouse models of androgen deficiency: ORX, androgen receptor (AR) knock-out (ARKO) and sex hormone binding globulin (SHBG)-transgenic mice, a novel mouse model of "low free T". Our results clearly show a fast and dramatic action of T stimulating wheel running, which is not explained by its action on muscle, as evidenced by neuromuscular studies and in a muscle-specific conditional ARKO mouse model...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343184/foot-strike-pattern-in-preschool-children-during-running-sex-and-shod-unshod-differences
#17
Pedro Á Latorre-Román, Juan A Párraga-Montilla, Ignacio Guardia-Monteagudo, Felipe García-Pinillos
PURPOSE: This study aims to determine the foot strike patterns (FSPs) and neutral support (no inversion [INV]/eversion [EVE] and no foot rotation) in preschool children, as well as to determine the influence of shod/unshod conditions and sex. METHODS: A total of 1356 children aged 3-6 years (673 boys and 683 girls) participated in this study. A sagittal and frontal-plane video (240 Hz) was recorded using a high-speed camcorder to record the following variables: rearfoot strike (RFS), midfoot strike (MFS), forefoot strike (FFS), inversion/ eversion (INV/EVE) and foot rotation on initial contact...
January 17, 2018: European Journal of Sport Science
https://www.readbyqxmd.com/read/29342443/test-retest-reliability-of-transcranial-magnetic-stimulation-eeg-evoked-potentials
#18
Lewis J Kerwin, Corey J Keller, Wei Wu, Manjari Narayan, Amit Etkin
BACKGROUND: Transcranial magnetic stimulation (TMS)-evoked potentials (TEPs), recorded using electroencephalography (TMS-EEG), offer a powerful tool for measuring causal interactions in the human brain. However, the test-retest reliability of TEPs, critical to their use in clinical biomarker and interventional studies, remains poorly understood. OBJECTIVE/HYPOTHESIS: We quantified TEP reliability to: (i) determine the minimal TEP amplitude change which significantly exceeds that associated with simply re-testing, (ii) locate the most reliable scalp regions of interest (ROIs) and TEP peaks, and (iii) determine the minimal number of TEP pulses for achieving reliability...
December 29, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29342355/convergence-of-kirkwood-buff-integrals-of-ideal-and-non-ideal-aqueous-solutions-using-molecular-dynamics-simulations
#19
Jasmin Milzetti, Divya Nayar, Nico F A van der Vegt
The computation of Kirkwood-Buff integrals (KBIs) using molecular simulations of closed systems is challenging due to finite system-size effects. One of the problems involves the incorrect asymptotic behavior of the radial distribution function. Corrections to rectify such effects have been proposed in the literature. This study reports a systematic comparison of the proposed corrections (as given by Ganguly et al. J. Chem. Theory Comput. 2013, 9, 1347-1355 and Krueger et al. J. Phys. Chem. Lett. 2013, 4, 4-7) to assess the asymptotic behavior of the RDFs, the KBIs as well as the estimation of thermodynamic quantities for ideal urea--water and non-ideal modified-urea--water mixtures using molecular dynamics simulations...
January 17, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29342232/informational-and-linguistic-analysis-of-large-genomic-sequence-collections-via-efficient-hadoop-cluster-algorithms
#20
Umberto Ferraro Petrillo, Gianluca Roscigno, Giuseppe Cattaneo, Raffaele Giancarlo
Motivation: Information theoretic and compositional/linguistic analysis of genomes have a central role in bioinformatics, even more so since the associated methodologies are becoming very valuable also for epigenomic and meta-genomic studies. The kernel of those methods is based on the collection of k-mer statistics, i.e., how many times each k-mer in {A;C; G; T}k occurs in a DNA sequence. Although this problem is computationally very simple and efficiently solvable on a conventional computer, the sheer amount of data available now in applications demands to resort to parallel and distributed computing...
January 12, 2018: Bioinformatics
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