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Mucormycoses

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https://www.readbyqxmd.com/read/27768645/non-exenteration-management-of-sino-orbital-fungal-disease
#1
Dnyaneshwar D Athavale, Robin Jones, Brett A O'Donnell, Martin Forer, Nigel Biggs
PURPOSE: To describe the non-exenteration management of sino-orbital fungal infection, a life-threatening condition for which orbital exenteration is generally considered a first-line treatment. METHODS: A retrospective case series is presented of 7 orbits in 6 consecutive patients admitted and treated at 2 major metropolitan tertiary teaching hospitals in Sydney, New South Wales, Australia. RESULTS: Seven orbits in 6 consecutive patients with sino-orbital fungal infection were treated conservatively with surgical debridement and intravenous antifungal agents...
October 20, 2016: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27475007/-sinonasal-fungal-infections-are-not-exclusively-due-to-mucorales-and-aspergillus
#2
Arnault Tauziède-Espariat, Michel Wassef, Homa Adle-Biassette, Alexandre Alanio, Stéphane Bretagne, Fanny Lanternier, Mohammed Boui, Olivier Bouchaud, Pierre Vironneau, Romain Kania, Grégory Jouvion, Fabrice Chrétien, Marion Classe
Rhino-sinusal infections are serious diseases and possibly lethal. When they are invasive, we easily discuss apergilloses and mucormycoses. The confirmation of the diagnosis of mucormycosis need an extensive surgery for precise histopathological and mycological evaluation. The pathologist may be faced to other rare mycoses such as phaeohyphomycoses, which present different morphological features than mucormycoses and Aspergillus. Once the diagnosis is established, an appropriate antifungal treatment is quickly started...
August 2016: Annales de Pathologie
https://www.readbyqxmd.com/read/27399143/cutaneous-mucormycosis-postcosmetic-surgery-a-case-report-and-review-of-the-literature
#3
Khaled Al-Tarrah, Mahmoud Abdelaty, Ahmad Behbahani, Eman Mokaddas, Helmy Soliman, Ahdi Albader
BACKGROUND: Mucormycosis is a rare, aggressive, and life-threatening infection that is caused by organisms belonging to the order Mucorales. It is usually acquired through direct means and virtually always affects immunocompromised patients with the port of entry reflecting the site of infection, in this case, cutaneous. Unlike other mucormycoses, patients affected by Apophysomyces elegans (A elegans) are known to be immunocompetent. This locally aggressive disease penetrates through different tissue plains invading adjacent muscles, fascia, and even bone causing extensive morbidity and may prove fatal if treated inadequately...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27317443/a-cohort-study-on-breakthrough-invasive-fungal-infections-in-high-risk-patients-receiving-antifungal-prophylaxis
#4
Lena M Biehl, J Janne Vehreschild, Blasius Liss, Bernd Franke, Birgid Markiefka, Thorsten Persigehl, Vanessa Bücker, Hilmar Wisplinghoff, Christof Scheid, Oliver A Cornely, Maria J G T Vehreschild
OBJECTIVES: Antifungal prophylaxis is recommended for haematological patients at high risk of invasive fungal infections (IFIs). Incidence, optimal therapeutic management and outcome of breakthrough IFIs (bIFIs) are largely unknown. METHODS: To assess bIFI incidence, treatment and outcomes, data on patients undergoing AML remission-induction and consolidation chemotherapy and from allogeneic HSCT recipients on antifungal prophylaxis with itraconazole, micafungin or posaconazole were extracted from the Cologne Cohort of Neutropenic Patients (CoCoNut)...
September 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/26897065/mucormycoses
#5
REVIEW
Dimitrios Farmakiotis, Dimitrios P Kontoyiannis
Life-threatening infections from virulent, angioinvasive molds of the order Mucorales are being recognized with increasing frequency in immunosuppressed hosts. Advances in the understanding of pathogenesis, early diagnosis, and the recent availability of active, nontoxic drugs have improved the prospects for effective control and even cure of this devastating infection. However, rates of delayed diagnosis and mortality are still high, partially because of the low yield and complexity of culture-based and molecular diagnostic methods...
March 2016: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/26137308/outcome-of-mucormycosis-after-treatment-report-of-five-cases
#6
F Bellazreg, Z Hattab, S Meksi, S Mansouri, W Hachfi, N Kaabia, M Ben Said, A Letaief
Mucormycoses are serious infections caused by filamentous fungi of the order Mucorales. They occur most often in immunocompromised patients. We report five cases of mucormycosis in patients hospitalized in the Infectious Diseases Department in Sousse - Tunisia between 2000 and 2013. They were 4 males and one female, mean age 60 years. Three patients were diabetic and one patient had acute leukemia. The locations of mucormycosis were rhinocerebral, rhino-orbital, auricular, pulmonary and cutaneous. The Mucorales isolated were Rhizopus arrhizus in 3 cases and Lichteimia in 2 cases...
July 2015: New Microbes and New Infections
https://www.readbyqxmd.com/read/26065324/adaptation-to-thermotolerance-in-rhizopus-coincides-with-virulence-as-revealed-by-avian-and-invertebrate-infection-models-phylogeny-physiological-and-metabolic-flexibility
#7
Kerstin Kaerger, Volker U Schwartze, Somayeh Dolatabadi, Ildikó Nyilasi, Stella A Kovács, Ulrike Binder, Tamás Papp, Sybren de Hoog, Ilse D Jacobsen, Kerstin Voigt
Mucormycoses are fungal infections caused by the ancient Mucorales. They are rare, but increasingly reported. Predisposing conditions supporting and favoring mucormycoses in humans and animals include diabetic ketoacidosis, immunosuppression and haematological malignancies. However, comprehensive surveys to elucidate fungal virulence in ancient fungi are limited and so far focused on Lichtheimia and Mucor. The presented study focused on one of the most important causative agent of mucormycoses, the genus Rhizopus (Rhizopodaceae)...
2015: Virulence
https://www.readbyqxmd.com/read/25467816/-post-traumatic-mucormycosis-due-to-lichtheimia-corymbifera-three-case-reports
#8
D Lambert, C Nerot, A Huguenin, S Diallo, A Mzabi, X Ohl, V Noel, C Rouger, C Strady, I Villena, F Bani-Sadr, D Toubas
We report 3 cases of post-traumatic cutaneous mucormycosis caused by Lichtheimia corymbifera, two of them occurring after a farm working accident. Management of post-traumatic mucormycoses consists of a wide excision of the infected tissue, combined with immediate antifungal therapy. Liposomal amphotericin B is the recommended first line treatment. Few studies have evaluated the efficacy of posaconazole. All 3 patients received a surgical debridement and liposomal amphotericin B, which was followed by posaconazole in 2 cases...
December 2014: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/25449676/-state-of-the-art-in-invasive-diseases-by-filamentous-fungi
#9
REVIEW
Javier Pemán, Guillermo Quindós
Invasive fungal infections have become a major cause of morbimortality in intensive care patients, persons suffering from cancer or immune deficiencies, and other diseases with impaired immunity. Candida albicans remains the most frequent fungal pathogen, but advances in the diagnosis, prevention and treatment of invasive candidiasis are leading to important etiological changes. Among the emerging invasive mycoses, are those caused by filamentous fungi, such as Aspergillus, Lomentospora/Scedosporium, Fusarium or the Mucorales...
October 2014: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/25231156/immunotherapeutic-strategies-against-mucormycosis-in-haematopoietic-stem-cell-transplantation
#10
REVIEW
Stanislaw Schmidt, Lars Tramsen, Andreas Schneider, Ada Balan, Thomas Lehrnbecher
Mucormycoses remain a serious complication in patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT). In these patients, mortality rates of mucormycosis reach up to 90%, which is due, at least in part, to the severe and prolonged immunosuppression after transplantation. Although prolonged neutropaenia is one of the most important risk factors for mucormycosis, other cell populations, such as CD4(+) T cells may also provide critical defence mechanisms against this infection. The management of mucormycosis includes antifungal therapy, surgery and, most importantly, the control of the underlying predisposing conditions, such as the correction of an impaired immune system...
December 2014: Mycoses
https://www.readbyqxmd.com/read/25186921/mucormycoses-caused-by-lichtheimia-species
#11
REVIEW
Volker U Schwartze, Ilse D Jacobsen
Mucormycoses are life-threatening infections with fungi from the order Mucorales (Mucoromycotina). Although mucormycoses are uncommon compared to other fungal infections, e.g. aspergillosis and candidiasis, the number of cases is increasing especially in immunocompromised patients. Lichtheimia (formerly Absidia) species represent the second to third most common cause of mucormycoses in Europe. This mini review presents current knowledge about taxonomy and clinical relevance of Lichtheimia species. In addition, clinical presentation and risk factors will be discussed...
December 2014: Mycoses
https://www.readbyqxmd.com/read/24451567/-parotid-mucormycosis-a-new-case-and-review-of-the-literature
#12
B Ben Dhaou, F Boussema, Z Aydi, L Baili, E Ben Brahim, O Khayat, M Ben Amor, A Khedim, A Debbiche, L Rokbani
INTRODUCTION: Mucormycosis is a rare, devastating, fungal infection, which disproportionately affects non-controlled diabetic patients, notably during ketoacidosis. The authors report the case of cervical mucormycoses with a particularly favorable evolution in diabetic woman. REPORT: A 54-year-old woman, type 2 diabetic, had presented a left lateral cervical mass. The diagnosis was confirmed by histological examination. She was treated with Amphotericin B with favorable evolution...
September 2011: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/24139734/three-cases-of-cutaneous-mucormycosis-with-lichtheimia-spp-ex-absidia-mycocladus-in-icu-possible-cross-transmission-in-an-intensive-care-unit-between-2-cases
#13
P Poirier, C Nourrisson, L Gibold, E Chalus, D Guelon, S Descamp, O Traore, M Cambon, C Aumeran
Mucormycoses are rare but emerging diseases with poor prognosis caused by ubiquitous fungi from the environment. In November 2008, our teaching hospital experienced three cutaneous mucormycosis due to Lichtheimia spp. (ex Absidia/Mycocladus) in the intensive care and orthopaedic units. Environmental and epidemiological investigations suggested a possible cross-transmission of L. ramosa between two patients in intensive care. This is the first report of possible person-to-person transmission of mucormycosis species...
December 2013: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/23519243/antifungal-activity-of-thymus-vulgaris-l-essential-oil-and-its-constituent-phytochemicals-against-rhizopus-oryzae-interaction-with-ergosterol
#14
Kelly Samara de Lira Mota, Fillipe de Oliveira Pereira, Wylly Araújo de Oliveira, Igara Oliveira Lima, Edeltrudes de Oliveira Lima
Mucormycoses are emerging infections that have high rates of morbidity and mortality. They show high resistance to antifungal agents, and there is a limited therapeutic arsenal currently available, therefore, there is a great need to give priority to testing therapeutic agents for the treatment of mucormycosis. Along this line, the use of essential oils and phytoconstituents has been emphasized as a new therapeutic approach. The objective of this work was to investigate the antifungal activity of the essential oil (EO) of Thymus vulgaris, and its constituents thymol and p-cymene against Rhizopus oryzae, through microbiological screening, determination of minimal inhibitory concentration (MICs) and minimal fungicidal concentration (MFCs), effects on mycelial growth and germination of sporangiospores and interaction with ergosterol...
2012: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/23510523/-rhino-orbito-cerebral-mucormycosis-surgical-treatment-state-of-the-art
#15
REVIEW
Pierre Vironneau, Benjamin Verillaud, Hugo Tran, Khaled Altabaa, Jean-Philippe Blancal, Elisabeth Sauvaget, Philippe Herman, Romain Kania
Rhino-orbito-cerebral mucormycoses constitute a severe fungal infection. These infections mostly arise in immunosuppressed patients. The surgery aiming at resecting necrosed hurts showed its interest in term of survival for lung and cutaneous mucormycosis. However, treatment of rhino-orbito-cerebral location of mucormycosis is not well defined. Transnasal endoscopic surgery allows local control of the disease, better post-operative outcomes than transfacial approaches and less sequelae. However, transfacial approaches are sometimes necessary to allow cutaneous resection or exenteration, the indications of which still remain controversial...
March 2013: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/23233590/delayed-opportunistic-infections-in-hematopoietic-stem-cell-transplantation-patients-a-surmountable-challenge
#16
REVIEW
Kieren A Marr
Changes in the transplantation procedure and the implementation of effective supportive care strategies have decreased the incidence of infectious complications early after conditioning therapy for allogeneic hematopoietic stem cell transplantation (HCT) and have extended the duration of risks later. Therefore, the types of infections that cause significant morbidity and the timing of risks have changed. These late infections are caused by all types of organisms, bacterial, viral, and fungal, but risks are predictable and surmountable with the use of tailored prevention strategies...
2012: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/23020929/estimating-the-burden-of-mucormycosis-infections-in-france-2005-2007-through-a-capture-recapture-method-on-laboratory-and-administrative-data
#17
D Bitar, G Morizot, D Van Cauteren, E Dannaoui, F Lanternier, O Lortholary, F Dromer
BACKGROUND: Mucormycoses are rare but severe fungal infections whose incidence is increasing, particularly in immunosuppressed and diabetic patients. Following a retrospective study on the characteristics and outcomes of cases who were identified through two sources of information, we carried out a capture-recapture method to estimate the actual burden of the disease in France, 2005-2007. METHODS: An administrative dataset from the national hospital discharge system and a laboratory dataset from the National Reference Centre for Mycoses and Antifungals were combined to identify patients from 2005 to 2007...
October 2012: Revue D'épidémiologie et de Santé Publique
https://www.readbyqxmd.com/read/22925358/opportunistic-filamentous-mycoses-aspergillosis-mucormycosis-phaeohyphomycosis-and-hyalohyphomycosis
#18
EDITORIAL
Ana María Perusquía-Ortiz, Denisse Vázquez-González, Alexandro Bonifaz
Opportunistic filamentous mycoses are widely distributed all over the world. They are rarely observed in Europe but are common in developing countries. The most common are the aspergilloses (due to Aspergillus spp.) mostly in neutropenia and immunosuppression; the mucormycoses characterized by rapid progression in patients with diabetic ketoacidosis; the phaeohyphomycoses due to pigmented fungi causing either a mild superficial or a very serious deep disease and the hyalohyphomycoses due to hyaline filamentous fungi (Fusarium spp...
September 2012: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/22135259/direct-analysis-and-identification-of-pathogenic-lichtheimia-species-by-matrix-assisted-laser-desorption-ionization-time-of-flight-analyzer-mediated-mass-spectrometry
#19
Wieland Schrödl, Tilo Heydel, Volker U Schwartze, Kerstin Hoffmann, Anke Grosse-Herrenthey, Grit Walther, Ana Alastruey-Izquierdo, Juan Luis Rodriguez-Tudela, Philipp Olias, Ilse D Jacobsen, G Sybren de Hoog, Kerstin Voigt
Zygomycetes of the order Mucorales can cause life-threatening infections in humans. These mucormycoses are emerging and associated with a rapid tissue destruction and high mortality. The resistance of Mucorales to antimycotic substances varies between and within clinically important genera such as Mucor, Rhizopus, and Lichtheimia. Thus, an accurate diagnosis before onset of antimycotic therapy is recommended. Matrix-assisted laser desorption ionization (MALDI)-time of flight (TOF) mass spectrometry (MS) is a potentially powerful tool to rapidly identify infectious agents on the species level...
February 2012: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/22121366/invasive-mold-infections-virulence-and-pathogenesis-of-mucorales
#20
Giulia Morace, Elisa Borghi
Mucorales have been increasingly reported as cause of invasive fungal infections in immunocompromised subjects, particularly in patients with haematological malignancies or uncontrolled diabetes mellitus and in those under deferoxamine treatment or undergoing dialysis. The disease often leads to a fatal outcome, but the pathogenesis of the infection is still poorly understood as well as the role of specific virulence determinants and the interaction with the host immune system. Members of the order Mucorales are responsible of almost all cases of invasive mucormycoses, the majority of the etiological agents belonging to the Mucoraceae family...
2012: International Journal of Microbiology
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