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https://www.readbyqxmd.com/read/27880667/the-current-treatment-landscape-other-fungal-diseases-cryptococcosis-fusariosis-and-mucormycosis
#1
Olivier Lortholary, Mario Fernández-Ruiz, John R Perfect
Compared with major invasive mycoses such as aspergillosis and candidiasis, the antifungal stewardship management strategies of other fungal diseases have different opportunities and considerations. Cryptococcosis, fusariosis and mucormycosis are globally prevalent invasive fungal diseases (IFDs), but are not currently included in antifungal prophylaxis guidelines for immunocompromised hosts. Since the implementation of biomarkers as part of diagnostic screening strategies, the concept of pre-emptive antifungal therapy has emerged for these IFDs...
November 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27846057/disseminated-fusariosis-in-immunocompromised-children-analysis-of-recent-cases-identified-in-the-global-fungiscope-registry
#2
Angela Hassler, Adrian Lieb, Danila Seidel, Simone Cesaro, Johann Greil, Nikolay Klimko, Sofya Khostelidi, Galina Solopova, Dilara Ogunc, Luisa Durán Graeff, Oliver A Cornely, Maria J G T Vehreschild, Thomas Lehrnbecher
Disseminated fusariosis is a rare disease, and data are scant in pediatric patients. In the FungiScope registry we identified 10 children with disseminated fusariosis between 2006 and 2015. Our analysis of the largest pediatric case series reported to date adds pediatric-specific experience to the management of this opportunistic infection in children.
November 11, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27759698/occlusive-nonvasculitic-vasculopathy-a-review
#3
Mar Llamas-Velasco, Victoria Alegría, Ángel Santos-Briz, Lorenzo Cerroni, Heinz Kutzner, Luis Requena
We review the most characteristic clinical and histopathologic findings of the cutaneous manifestations of the occlusive nonvasculitic vasculopathic disorders. Clinically, most of these conditions are characterized by retiform purpura. Histopathologic findings consist of occlusion of the vessel lumina with no vasculitis. Different disorders may produce nonvasculitic occlusive vasculopathy in cutaneous blood and lymphatic vessels, including embolization due to cholesterol and oxalate emboli, cutaneous intravascular metastasis from visceral malignancies, atrial myxomas, intravascular angiosarcoma, intralymphatic histiocytosis, intravascular lymphomas, endocarditis, crystal globulin vasculopathy, hypereosinophilic syndrome, and foreign material...
October 18, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27741094/enucleation-caused-by-fusarium-infection-in-a-child-with-toxic-epidermal-necrolysis
#4
Isabel Barranco-Fernández, Alberto García-Salido, Montserrat Nieto-Moro, Montserrat Sierra-Colomina, Belén Gutierrez-Partida, Inmaculada de Prada-Vicente, Antonio Torrelo-Fernández, Ana Serrano-González
Fusarium species are a known cause of ocular infection. The misuse of contact lenses is the main risk factor in immunocompetent people. In immunocompromised patients, Fusarium infection can produce local and/or systemic invasive fusariosis which is associated with complications, poor prognosis and low response to treatment.Fusarium ocular infection can evolve to keratitis, endophthalmitis and, in extreme cases, ocular perforation. We report, for the first time in children, the case of a 5 year old girl diagnosed with toxic epidermal necrolysis who developed Fusarium ocular infection requiring ocular enucleation...
October 12, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27698695/rare-case-of-disseminated-fusariosis-in-a-young-patient-with-graft-vs-host-disease-following-an-allogeneic-transplant
#5
Alina Tanase, Anca Colita, Gabriel Ianosi, Daniela Neagoe, Daciana Elena Branisteanu, Daniela Calina, Anca Oana Docea, Aristidis Tsatsakis, Simona Laura Ianosi
Fusarium infection is a severe fungal infection caused by fungi of the genus Fusarium. It most commonly occurs in immunocompromised patients with malignant hematological comorbidities or secondary to hematopoietic stem cell transplant. The classical route of contamination is through inhalation but infection may also occur through contiguity with a skin lesion. This report describes the case of a 24-year-old woman who developed graft-vs.-host disease (GVHD) at 220 days after receiving an allogeneic stem cell transplant from a sibling donor for Hodgkin disease...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27682849/banana-fruits-affected-by-fusarium-post-harvest-disease-as-source-of-human-fusariosis
#6
David Triest
No abstract text is available yet for this article.
September 2016: Acta Microbiologica et Immunologica Hungarica
https://www.readbyqxmd.com/read/27671065/anti-mold-prophylaxis-may-reduce-the-risk-of-invasive-fusariosis-in-hematologic-patients-with-superficial-skin-lesions-with-positive-culture-for-fusarium
#7
Andrea G Varon, Simone A Nouér, Gloria Barreiros, Beatriz Moritz Trope, Tiyomi Akiti, Marcio Nucci
Hematologic patients with superficial skin lesions on admission growing Fusarium spp. are at high risk to develop invasive fusariosis during neutropenia. We evaluated the impact of primary prophylaxis with a mold-active azole in preventing the occurrence of invasive fusariosis in these patients. From August 2008 to December 2014, patients with acute leukemia, aplastic anemia, or recipients of hematopoietic cell transplantation were screened on admission with dermatologic examination and direct exam and fungal culture of superficial skin lesions...
September 26, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27605714/discrimination-of-aspergillosis-mucormycosis-fusariosis-and-scedosporiosis-in-formalin-fixed-paraffin-embedded-tissue-specimens-using-multiple-real-time-quantitative-pcr-assays
#8
Elham Salehi, Mohammad T Hedayati, Jan Zoll, Haleh Rafati, Maryam Ghasemi, Atosa Doroudinia, Mahdi Abastabar, Ali Tolooe, Eveline Snelders, Henrich A van der Lee, Antonius J M M Rijs, Paul E Verweij, Seyedmojtaba Seyedmousavi, Willem J G Melchers
In a retrospective multicenter study, 102 formalin-fixed paraffin-embedded (FFPE) tissue specimens with histopathology results were tested. Two 4-5 μm FFPE tissue sections from each specimen was digested with proteinase K followed by automated nucleic acid extraction.A specific quantitative real-time quantitative PCR (qPCR) assay targeting the internal transcribed spacer (ITS2) region of ribosomal DNA, using fluorescently labeled primers, was performed to identify clinically important genus and species of Aspergillus, Fusarium, Scedosporium and the Mucormycetes...
September 7, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27503915/molecular-and-pathological-characterization-of-fusarium-solani-species-complex-infection-in-the-head-and-lateral-line-system-of-sphyrna-lewini
#9
Nopadon Pirarat, Komsil Sahatrakul, Sitthichok Lacharoje, Eric Lombardini, Nantarika Chansue, Somporn Techangamsuwan
A severe fungal infection affecting the head and lateral line system was diagnosed in 7 captive scalloped hammerhead sharks Sphyrna lewini in an aquarium in Thailand. Extensive and severe necrotizing cellulitis was consistently observed microscopically along the cephalic and lateral line canals in conjunction with positive fungal cultures for Fusarium sp. Molecular phylogenetic analysis was performed from 3 isolates based on the nucleotide sequences containing internally transcribed spacer (ITS) and a portion of 5...
August 9, 2016: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/27470138/radiologic-findings-of-fusarium-pneumonia-in-neutropenic-patients
#10
Claudia Sassi, Marta Stanzani, Russell E Lewis, Nicola Vianelli, Andrea Tarsi, Antonio Poerio, Michele Cavo, Giuseppe Battista
In neutropenic patients, lungs are involved in 50%-80% of cases of fusariosis, but imaging of pulmonary fusariosis has been previously described as indistinguishable from other invasive mould diseases. Our attempt was to identify a radiological pattern that may distinguish pulmonary fusariosis from other mould diseases. We examined the CT findings of nine neutropenic haematology patients with invasive fusariosis. As control group for comparison, we examined 14 invasive mould diseases (11 aspergillosis, 3 mucormycosis) in haematology patients with similar underlying disease and timing of CT imaging...
July 29, 2016: Mycoses
https://www.readbyqxmd.com/read/27447804/favorable-outcomes-of-filamentous-fungal-endophthalmitis-following-aggressive-management
#11
Diem K Bui, Petros E Carvounis
PURPOSE: To evaluate the visual outcomes following aggressive management of filamentous fungal endophthalmitis with prompt surgical intervention and oral and intravitreal voriconazole. METHODS: Retrospective chart review study of consecutive patients with culture- or biopsy-proven filamentous fungal endophthalmitis treated at an academic referral center. Clinical characteristics, treatment regimens, and visual outcomes were analyzed. RESULTS: Included were 5 patients, 1 with endogenous endophthalmitis due to systemic fusariosis and 4 due to exogenous endophthalmitis (1 with Fusarium, 2 with Scedosporium apiospermum, and 1 with Glomerella spp...
July 22, 2016: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27357655/in-vitro-synergistic-combinations-of-pentamidine-polymyxin-b-tigecycline-and-tobramycin-with-antifungal-agents-against-fusarium-spp
#12
Tarcieli Pozzebon Venturini, Luana Rossato, Francieli Chassot, Jéssica Tairine Keller, Fernanda Baldissera Piasentin, Janio Morais Santurio, Sydney Hartz Alves
The genus Fusarium is characterized by hyaline filamentous fungi that cause infections predominantly in immunocompromised patients. The remarkable primary resistance to antifungal agents of this genus requires a search for new therapeutic possibilities. This study assessed the in vitro susceptibility of 25 clinical isolates of Fusarium against antifungal agents (amphotericin B, caspofungin, itraconazole and voriconazole) and antimicrobials (pentamidine, polymyxin B, tigecycline and tobramycin) according to the broth microdilution method (M38-A2)...
August 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27317443/a-cohort-study-on-breakthrough-invasive-fungal-infections-in-high-risk-patients-receiving-antifungal-prophylaxis
#13
Lena M Biehl, J Janne Vehreschild, Blasius Liss, Bernd Franke, Birgid Markiefka, Thorsten Persigehl, Vanessa Bücker, Hilmar Wisplinghoff, Christof Scheid, Oliver A Cornely, Maria J G T Vehreschild
OBJECTIVES: Antifungal prophylaxis is recommended for haematological patients at high risk of invasive fungal infections (IFIs). Incidence, optimal therapeutic management and outcome of breakthrough IFIs (bIFIs) are largely unknown. METHODS: To assess bIFI incidence, treatment and outcomes, data on patients undergoing AML remission-induction and consolidation chemotherapy and from allogeneic HSCT recipients on antifungal prophylaxis with itraconazole, micafungin or posaconazole were extracted from the Cologne Cohort of Neutropenic Patients (CoCoNut)...
September 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27311328/successful-treatment-of-disseminated-fusariosis-with-the-combination-of-voriconazole-and-liposomal-amphotericin-b
#14
Nur Efe İris, Serkan Güvenç, Tülay Özçelik, Aslıhan Demirel, Safiye Koculu, Esin Çevik, Mutlu Arat
No abstract text is available yet for this article.
June 17, 2016: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/27251318/a-case-of-cutaneous-fusariosis-of-the-scrotum-as-a-complication-of-acute-myeloid-leukemia
#15
Motoi Takenaka
Fusarium, a hyphomyocetous fungus, is often isolated from the environment as a laboratory contaminant, but is also known as a pathogen causing keratomycosis, onychomycosis, and opportunistic infection of the skin and viscera. We report a 67-year-old man with localized cutaneous fusariosis of the scrotum, as a complication of acute myeloid leukemia (AML) under chemotherapy. An induration of 25 mm in diameter, which was covered by necrosis and black crust and with pain upon pressure, was found on the scrotum...
2016: Medical Mycology Journal
https://www.readbyqxmd.com/read/27195070/fusarium-musae-infected-banana-fruits-as-potential-source-of-human-fusariosis-may-occur-more-frequently-than-we-might-think-and-hypotheses-about-infection
#16
David Triest, Denis Piérard, Koen De Cremer, Marijke Hendrickx
The banana fruit infecting fungus Fusarium musae was originally known as a distinct population within Fusarium verticillioides. However, recently, Fusarium musae was installed as a separate species and the first cases of human infection associated with Fusarium musae were found. In this article, we report an additional survey indicating that human pathogenic Fusarium musae infections may occur more frequently than we might think. Moreover, we evaluate the hypotheses on how infection can be acquired. A first hypothesis is that banana fruits act as carriers of Fusarium musae spores and thereby be the source of human infection with Fusarium musae...
March 2016: Communicative & Integrative Biology
https://www.readbyqxmd.com/read/27138574/genotyping-and-in-vitro-antifungal-susceptibility-testing-of-fusarium-isolates-from-onychomycosis-in-india
#17
Chhavi Gupta, Marit Jongman, Shukla Das, K Snehaa, S N Bhattacharya, S Seyedmousavi, Anne D van Diepeningen
Onychomycosis refers to fungal infection of the nail and is commonly caused by dermatophytes, while yeasts and non-dermatophytic molds (NDM) are increasingly recognized as pathogens in nail infections. The present study was done to delineate molecular epidemiology of Fusarium onychomycosis in India. Five hundred nail samples of Indian patients clinically suspected of onychomycosis were subjected to direct microscopy and fungal culture. Representative Fusarium isolates were further identified to species level by multi-locus sequencing for internal transcribed spacer, translation elongation factor 1 alpha (tef1-α) and RNA polymerase II subunit (rpb2) regions (primer pairs: ITS1/ITS4, EF1/EF2, 5f2/7cr, respectively)...
August 2016: Mycopathologia
https://www.readbyqxmd.com/read/27117163/new-insights-for-diagnosis-of-pineapple-fusariosis-by-maldi-tof-ms-technique
#18
Cledir Santos, José Aires Ventura, Nelson Lima
Fusarium is one of the most economically important fungal genus, since it includes many pathogenic species which cause a wide range of plant diseases. Morphological or molecular biology identification of Fusarium species is a limiting step in the fast diagnosis and treatment of plant disease caused by these fungi. Mass spectrometry by matrix-assisted laser/desorption ionisation-time-of-flight (MALDI-TOF)-based fingerprinting approach was applied to the fungal growth monitoring and direct detection of strain Fusarium guttiforme E-480 inoculated in both pineapple cultivars Pérola and Imperial side shoots, that are susceptible and resistant, respectively, to this fungal strain...
August 2016: Current Microbiology
https://www.readbyqxmd.com/read/27008433/fusariosis-in-a-patient-with-acute-myeloid-leukemia-a-case-report-and-review-of-the-literature
#19
REVIEW
Mario Delia, Rosa Monno, Giorgia Giannelli, Amato Antonio Stabile Ianora, Lidia Dalfino, Domenico Pastore, Carmen Capolongo, Carla Calia, Annamaria Tortorano, Giorgina Specchia
Fusarium spp. causes infections mostly in patients with prolonged neutropenia. We describe the case of a disseminated Fusarium solani infection in a patient with acute myeloid leukemia which never reached complete remission during its clinical course. The patient had profound neutropenia and developed skin nodules and pneumonia in spite of posaconazole prophylaxis. F. solani was isolated from blood and skin biopsy, being identified from its morphology and by molecular methods. By broth dilution method, the strain was resistant to azoles, including voriconazole and posaconazole, and to echinocandins...
June 2016: Mycopathologia
https://www.readbyqxmd.com/read/26943726/genotyping-of-fusarium-isolates-from-onychomycoses-in-colombia-detection-of-two-new-species-within-the-fusarium-solani-species-complex-and-in-vitro-antifungal-susceptibility-testing
#20
Marcela Guevara-Suarez, José Francisco Cano-Lira, María Caridad Cepero de García, Leticia Sopo, Catalina De Bedout, Luz Elena Cano, Ana María García, Adriana Motta, Adolfo Amézquita, Martha Cárdenas, Ana Espinel-Ingroff, Josep Guarro, Silvia Restrepo, Adriana Celis
Fusariosis have been increasing in Colombia in recent years, but its epidemiology is poorly known. We have morphologically and molecularly characterized 89 isolates of Fusarium obtained between 2010 and 2012 in the cities of Bogotá and Medellín. Using a multi-locus sequence analysis of rDNA internal transcribed spacer, a fragment of the translation elongation factor 1-alpha (Tef-1α) and of the RNA-dependent polymerase subunit II (Rpb2) genes, we identified the phylogenetic species and circulating haplotypes...
April 2016: Mycopathologia
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