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Fusariosis

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https://www.readbyqxmd.com/read/29652746/fluorine-18-fluorodeoxyglucose-pet-ct-in-hematopoietic-stem-cell-transplant-patients-with-fusariosis-initial-findings-of-a-case-series-review
#1
Marcelo R Schirmer, Michel P Carneiro, Luiz S Machado, Alessandra L da S Chaves, Flávia P P L Lopes
BACKGROUND: Fusariosis is an opportunistic fungal infection that affects mostly leukemic and hematopoietic stem cell transplant patients. Locally invasive and disseminated infection may occur. Treatment is challenging, and besides evaluation of immune status, one also needs to take into account organ involvement to predict the duration and prognosis. OBJECTIVE: The aim of this study was to present the findings and clinical follow-up from a series of cases of Fusarium spp...
April 12, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29622705/native-valve-endocarditis-fusarium-and-end-stage-renal-disease
#2
Supradip Ghosh, Atul Phillips, Sonali Ghosh, Amandeep Singh
We would like to report a case of invasive Fusariosis involving the native mitral valve and complicated by septic thromboembolism. The patient was a known case of end-stage renal disease on maintenance haemodialysis and did not have any of the known risk factors for invasive Fusariosis like neutropaenia, severe T cell immunodeficiency, postsolid organ transplant recipients, posthaematopoietic stem cell transplant recipients and patients who received cytotoxic and/or high-dose corticosteroid therapy.
April 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29569576/urinary-tract-infection-due-to-fusarium-oxysporum-in-an-immunocompetent-patient-with-chronic-kidney-disease
#3
Khetan Seema, Khetan Prakash, Katkar Venkatesh, Kusulkar Minal
Infections due to Fusarium species are collectively referred to as fusariosis. Fusarium oxysporum has been reported to cause keratitis, onychomycosis, skin infections, catheter associated fungemia and has not been described as a cause of urinary tract infection. Here, we present the first case of fusariosis with urinary tract involvement in a 67 year old male, with chronic kidney disease and type 2 diabetes mellitus. This case illustrates the ever increasing spectrum of rare but offending pathogenic fungi. Early diagnosis of infection with a specific pathogen may lead to changes in antifungal therapy and may be critical for an improved outcome...
November 1, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29564632/infections-caused-by-fusarium-species-in-pediatric-cancer-patients-and-review-of-published-literature
#4
Mariana Volpe Arnoni, Claudete Rodrigues Paula, Marcos Ereno Auler, Cirilo Cesar Naozuka Simões, Shirley Nakano, Maria Walderez Szeszs, Márcia de Souza Carvalho Melhem, Virgínia Bodelão Richini Pereira, Hans Garcia Garces, Eduardo Bagagli, Eriques Gonçalves Silva, Melissa Ferreira de Macêdo, Luciana da Silva Ruiz
Fusarium species have emerged as responsible for a broad spectrum of infections, including superficial, locally invasive and disseminated ones, especially in the hospital environment. Since there are few reports of invasive and disseminated fusariosis in children, the aim of this study was to report four cases of nosocomial infection caused by this microorganism in children with cancer hospitalized in a public children's hospital located in Brazil. Two of these patients were female and two were male. All patients presented febrile neutropenia, while three patients had acute lymphocytic leukemia and one patient had Wilms' tumor as underlying disease...
March 21, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29525269/fusarium-riograndense-sp-nov-a-new-species-in-the-fusarium-solani-species-complex-causing-fungal-rhinosinusitis
#5
P Dallé Rosa, M Ramirez-Castrillon, P Valente, A Meneghello Fuentefria, A D Van Diepeningen, L Z Goldani
Invasive fusariosis has a high mortality and is predominantly observed in patients with leukemia. We report the first case of a novel species of Fusarium, Fusarium riograndense sp. nov, isolated from a lesion in the nasal cavity lesion of a patient with acute lymphoblastic leukemia. The etiological agent was identified by Multilocus Sequencing Typing (MLST), including RPB2, TEF-1α, and ITS-LSU sequences, the gold standard technique to identify new species of Fusarium. MLST and phenotypic data strongly supported its inclusion in the F...
March 7, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29512240/fatal-fusarium-infection-manifesting-as-osteomyelitis-following-previous-treatment-with-amphotericin-b-in-a-multi-visceral-transplant-case-report-and-review-of-fusarium-infections-in-solid-organ-transplantation
#6
P Nambiar, E Cober, L Johnson, K D Brizendine
Invasive fusariosis in solid organ transplant is uncommon and usually presents as localized infection with favorable outcomes compared to hematologic malignancies or bone marrow transplants. We report the first case of Fusarium osteomyelitis in a patient following multi-visceral transplant and review Fusarium in organ transplant recipients and Fusarium bone and joint infections. Our case underscores the importance of early recognition and multidisciplinary approach to treatment and highlights potential failure to eradicate with amphotericin B monotherapy...
March 7, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29438132/successful-combination-therapy-of-liposomal-amphotericin-b-and-caspofungin-for-disseminated-fusariosis-in-a-pediatric-patient-with-acute-lymphoblastic-leukemia
#7
Suguru Uemura, Akihiro Tamura, Nobuyuki Yamamoto, Atsuro Saito, Sayaka Nakamura, Takahiro Fujiwara, Teppei Tahara, Aiko Kozaki, Kenji Kishimoto, Toshiaki Ishida, Daiichiro Hasegawa, Yasunori Muraosa, Katsuhiko Kamei, Yoshiyuki Kosaka
Disseminated fusariosis is a fatal infection in immunocompromised hosts. However, the optimal antifungal treatment for disseminated fusariosis has not yet been established. We report a case of disseminated fusariosis after chemotherapy for acute lymphoblastic leukemia, presenting with multiple skin, lung, and kidney lesions and cerebrospinal fluid invasion. The combination therapy of liposomal amphotericin B and caspofungin resolved disseminated fusariosis successfully.
February 12, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29373264/disseminated-fusariosis-emerged-from-prolonged-local-genital-infection-after-cord-blood-transplantation
#8
Kohei Okada, Tomoyuki Endo, Daigo Hashimoto, Tomoyuki Saga, Takahide Ara, Reiki Ogasawara, Atsushi Yasumoto, Makoto Ibata, Mutsumi Takahata, Akio Shigematsu, Takeshi Kondo, Yasunori Muraosa, Toshifumi Nomura, Hiromi Kanno-Okada, Satoshi Hashino, Shinya Tanaka, Katsuhiko Kamei, Takanori Teshima
Disseminated fusariosis (DF) is a rare life threatening fungal infection in immunocompromised hosts. We herein report a case of a fatal DF mimicking varicella zoster virus (VZV) infection that was emerged from a localized genital infection during cord blood transplantation (CBT) in a patient with severe aplastic anemia (SAA). The patient developed an ulcer following small painful vesicles mimics herpes simplex virus infection (HSV) on the glans penis before CBT, but a Fusarium species was identified. Despite administration of voriconazole, liposomal amphotericin B and granulocyte transfusion, the lesion was extended to extensive skin looked like VZV infection and the patients died after CBT...
January 16, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29371536/reduced-multidrug-susceptibility-profile-is-a-common-feature-of-opportunistic-fusarium-species-fusarium-multi-drug-resistant-pattern
#9
REVIEW
Saad J Taj-Aldeen
The resistance among various opportunistic Fusarium species to different antifungal agents has emerged as a cause of public health problems worldwide. Considering the significance of multi-drug resistant (MDR), this paper emphasizes the problems associated with MDR and the need to understand its clinical significance to combat microbial infections. The search platform PubMed/MEDLINE and a review of 32 cases revealed a common multidrug-resistant profile exists, and clinically relevant members of Fusarium are intrinsically resistant to most currently used antifungals...
April 10, 2017: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29327700/disseminated-cutaneous-fusariosis-in-human-immunodeficiency-virus-infected-patient-and-dramatic-response-with-oral-itraconazole
#10
Indu Kumari, Satyendra Kumar Singh, Rishabh Kumar Chauhan, Satyendra Kumar Kaushal
Fusarium species are known to cause disseminated cutaneous lesions in immunocompromised patients. Some cases of fusariosis are reported in patients infected with the human immunodeficiency virus. There are two reports in such patients with systemic comorbidities like lymphoma, neutropenia and infective port-a-catheter. Another reported patient had systemic fusariosis, without skin involvement. Diagnosis and treatment of cutaneous fusariosis is difficult and resistance to antifungals is a problem. Our patient was at an advanced human immunodeficiency virus infection stage with disseminated cutaneous fusariosis, without any systemic involvement, who responded completely to oral itraconazole...
January 9, 2018: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29249044/endogenous-fusarium-endophthalmitis-during-treatment-for-acute-myeloid-leukemia-successfully-treated-with-25-gauge-vitrectomy-and-antifungal-medications
#11
Masaaki Yoshida, Naoki Kiyota, Kazuichi Maruyama, Hiroshi Kunikata, Masahiro Toyokawa, Shigehiro Hagiwara, Koichi Makimura, Naomi Sato, Shinji Taniuchi, Toru Nakazawa
Endogenous fungal endophthalmitis (EFE) caused by disseminated fusariosis is a rare condition that generally has a poor outcome, even with intensive therapy. Here, we describe a case in which this type of EFE was diagnosed with vitreous sampling and was successfully treated with 25-gauge vitrectomy and antifungals, including liposomal amphotericin B and voriconazole. A 16-year-old male patient undergoing treatment for acute myeloid leukemia complained of eye pain and blurred vision in his right eye. Treatment was initiated for a vitreous opacity, possibly associated with herpetic retinitis, but the patient worsened and he was referred to us...
April 2018: Mycopathologia
https://www.readbyqxmd.com/read/28948024/first-description-of-spontaneous-fungal-peritonitis-caused-by-fusarium-solani-in-a-critically-ill-patient-with-liver-cirrhosis
#12
U Mayr, S Rasch, R M Schmid, W Huber, T Lahmer
Fusarium spp., common soil moulds, are emerging fungal pathogens in immunocompromised subjects. We report the first case of Fusarium solani peritonitis in a patient with liver cirrhosis. Because of the high morbidity and mortality associated with fusariosis, an aggressive approach to treatment as well as identification of the species and drug susceptibilities is warranted.
November 2017: New Microbes and New Infections
https://www.readbyqxmd.com/read/28845953/vasculopathies-cutaneous-necrosis-and-emergency-in-dermatology
#13
Constanza Martinez-Mera, Javier Fraga, Tania M Capusan, Maria Herrero-Moyano, Almudena Godoy-Trapero, Yosmar Gonzales Perez, Mar Llamas-Velasco
Most emergencies in dermatology comprise a variety of entities with a usually benign course. However, vasculopathies and vasculitis are not common, but they could represent respectively 1.9% and 4.4% of these entities according to some studies of Emergency Dermatology Department. They become an important disease which has to be identified early to establish appropriate management and treatment. Some of them are well known, such as the leukocitoclastic vasculitis, Schölein-Henoch, panarteritis nodosa, antineutrophil cytoplasmic antibody associated vasculitis, giant cell arteritis, cryoglobulinemic vasculitis and antiphospholipid syndrome...
December 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28705676/current-antifungal-treatment-of-fusariosis
#14
Abdullah M S Al-Hatmi, Alexandro Bonifaz, Stephane Ranque, G Sybren de Hoog, Paul E Verweij, Jacques F Meis
Fungi of the genus Fusarium are well known as major plant pathogens and soil inhabitants but also cause a broad spectrum of human infections. Fusariosis is the second most common mould infection after aspergillosis and keratitis is the most encountered implantation infection in immunocompetent individuals. Natamycin is active against Fusarium species both in vitro and in vivo, and it is used along with voriconazole as the mainstay of treatment for Fusarium keratitis. Onychomycosis is treated with terbinafine, voriconazole and sometimes itraconazole...
July 10, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28616680/melanization-of-fusarium-keratoplasticum-f-solani-species-complex-during-disseminated-fusariosis-in-a-patient-with-acute-leukemia
#15
Siri Chiewchanvit, Siriporn Chongkae, Pongsak Mahanupab, Joshua D Nosanchuk, Soraya Pornsuwan, Nongnuch Vanittanakom, Sirida Youngchim
Fusarium spp. are recognized as the second most frequently filamentous fungi causing opportunistic infections and particularly important due to the increasing number of immunocompromised patients. F. keratoplasticum (a member of F. solani species complex) is one of the Fusarium species commonly associated with human infection, and therefore, studies on the virulence of this fungus are needed. This study aimed to confirm the presence of melanin in F. keratoplasticum from a patient with systemic fusariosis. Immunofluorescence labeling with anti-melanin monoclonal antibody (MAb) was used to examine an expression of melanin in F...
October 2017: Mycopathologia
https://www.readbyqxmd.com/read/28528498/lipopeptides-produced-by-bacillus-subtilis-as-new-biocontrol-products-against-fusariosis-in-ornamental-plants
#16
Gabriela Mihalache, Tiberius Balaes, Irina Gostin, Marius Stefan, François Coutte, François Krier
In this study, we have investigated the effects of three lipopeptides (fengycin, surfactin and mycosubtilin) produced by different strains of Bacillus subtilis against the phytopathogenic fungi Fusarium oxysporum f. sp. iridacearum, which affects the ornamental bulb plant populations of Iris sp. The antifungal effects were tested using minimum inhibitory concentration assay, determination of mycelium growth and spore germination inhibition rates. Also, in vivo tests on infected rhizomes and scanning electron microscopy were employed...
May 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28481795/the-use-of-fdg-pet-ct-imaging-for-the-assessment-of-early-antifungal-treatment-response-in-disseminated-fusariosis
#17
Romain-David Seban, Gérald Bonardel, Mohamed Guernou, David Lussato, Mathieu Queneau
Fusariosis is an opportunistic infection, caused by a filamentous fungus, found on plants and in soil. The treatment of disseminated pattern, seen in immunocompromised patients with severe neutropenia, is difficult because of antifungal therapy resistance. A 12-year-old girl, who was diagnosed with B-cell acute lymphoblastic leukemia, developed multiple widespread skin papules and subcutaneous nodules, at day 20 of consolidation therapy. Histological examination with cultures of skin tissue revealed Fusarium species...
July 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28384871/a-fortuitous-turn-of-evidence-in-an-elderly-female-a-case-of-pulmonary-fusariosis
#18
Saraswathy Sreeram, Flora Dorothy Lobo, Vishak Acharya, Vishwas Saralaya
Pulmonary mycosis is seen infrequently in our country. It is more common in the immunocompromised. The infections caused by less known species like Fusarium have been found to be increasing in incidence in other parts of the world. We hereby report its occurrence in a 79-year-old, non-immunocompromised female who presented with pyrexia of unknown origin. Her Alanine Phosphatase (ALP) and Lactate Dehydrogenase (LHD) levels were raised. CT scan showed interstitial thickening in subpleural aspect of lungs and multiple enlarged lymph nodes in mediastinum...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28250364/epidemiological-study-of-fusarium-species-causing-invasive-and-superficial-fusariosis-in-japan
#19
Yasunori Muraosa, Misato Oguchi, Maki Yahiro, Akira Watanabe, Takashi Yaguchi, Katsuhiko Kamei
In Japan, Fusarium species are known etiological agents of human fungal infection; however, there has been no report of a large-scale epidemiological study on the etiological agents of fusariosis. A total of 73 Fusarium isolates from patients with invasive fusariosis (IF, n= 36) or superficial fusariosis (SF, n= 37), which were obtained at hospitals located in 28 prefectures in Japan between 1998 and 2015, were used for this study. Fusarium isolates were identified using Fusarium- and Fusarium solani species complex (FSSC) -specific real-time PCR and partial DNA sequences of the elongation factor-1 alpha (EF-1α) gene and the nuclear ribosomal internal transcribed spacer (ITS) region...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/28166614/a-rare-case-of-subcutaneous-fusariosis-in-an-immunocompetent-patient
#20
Elisabetta T Mapelli, Amilcare Cerri, Elisa Borghi, Marina Palvarini, Paola Abramo, Giulia Morace, Silvano Menni
Fusarium species can cause diseases in immunocompromised patients, whereas have rarely been reported as pathogens in immunocompetent individuals. Fusarium oxysporum and F. solani species complex are the most frequent pathogenic species. Primary subcutaneous hyalohyphomycosis due to these filamentous fungi is an extremely rare pathology, especially in immunocompetent patients. Only 37 cases of deep Fusarium infection in healthy patient have been reported in international literature. We report a case of subcutaneous infection due to F...
April 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
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