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https://www.readbyqxmd.com/read/28705676/current-antifungal-treatment-of-fusariosis
#1
Abdullah M S Al-Hatmi, Alexandro Bonifaz, Stephane Ranque, G Sybren de Hoog, Paul E Verweij, Jacques F Meis
Fungi of the genus Fusarium are well known as major plant pathogens and soil inhabitants but also cause a broad spectrum of human infections. Fusariosis is the second most common mould infection after aspergillosis and keratitis is the most encountered implantation infection in immunocompetent individuals. Natamycin is active against Fusarium species both in vitro and in vivo, and it is used along with voriconazole as the mainstay of treatment for Fusarium keratitis. Onychomycosis is treated with terbinafine, voriconazole and sometimes itraconazole...
July 10, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28616680/melanization-of-fusarium-keratoplasticum-f-solani-species-complex-during-disseminated-fusariosis-in-a-patient-with-acute-leukemia
#2
Siri Chiewchanvit, Siriporn Chongkae, Pongsak Mahanupab, Joshua D Nosanchuk, Soraya Pornsuwan, Nongnuch Vanittanakom, Sirida Youngchim
Fusarium spp. are recognized as the second most frequently filamentous fungi causing opportunistic infections and particularly important due to the increasing number of immunocompromised patients. F. keratoplasticum (a member of F. solani species complex) is one of the Fusarium species commonly associated with human infection, and therefore, studies on the virulence of this fungus are needed. This study aimed to confirm the presence of melanin in F. keratoplasticum from a patient with systemic fusariosis. Immunofluorescence labeling with anti-melanin monoclonal antibody (MAb) was used to examine an expression of melanin in F...
June 14, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28528498/lipopeptides-produced-by-bacillus-subtilis-as-new-biocontrol-products-against-fusariosis-in-ornamental-plants
#3
Gabriela Mihalache, Tiberius Balaes, Irina Gostin, Marius Stefan, François Coutte, François Krier
In this study, we have investigated the effects of three lipopeptides (fengycin, surfactin and mycosubtilin) produced by different strains of Bacillus subtilis against the phytopathogenic fungi Fusarium oxysporum f. sp. iridacearum, which affects the ornamental bulb plant populations of Iris sp. The antifungal effects were tested using minimum inhibitory concentration assay, determination of mycelium growth and spore germination inhibition rates. Also, in vivo tests on infected rhizomes and scanning electron microscopy were employed...
May 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28481795/the-use-of-fdg-pet-ct-imaging-for-the-assessment-of-early-antifungal-treatment-response-in-disseminated-fusariosis
#4
Romain-David Seban, Gérald Bonardel, Mohamed Guernou, David Lussato, Mathieu Queneau
Fusariosis is an opportunistic infection, caused by a filamentous fungus, found on plants and in soil. The treatment of disseminated pattern, seen in immunocompromised patients with severe neutropenia, is difficult because of antifungal therapy resistance. A 12-year-old girl, who was diagnosed with B-cell acute lymphoblastic leukemia, developed multiple widespread skin papules and subcutaneous nodules, at day 20 of consolidation therapy. Histological examination with cultures of skin tissue revealed Fusarium species...
July 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28384871/a-fortuitous-turn-of-evidence-in-an-elderly-female-a-case-of-pulmonary-fusariosis
#5
Saraswathy Sreeram, Flora Dorothy Lobo, Vishak Acharya, Vishwas Saralaya
Pulmonary mycosis is seen infrequently in our country. It is more common in the immunocompromised. The infections caused by less known species like Fusarium have been found to be increasing in incidence in other parts of the world. We hereby report its occurrence in a 79-year-old, non-immunocompromised female who presented with pyrexia of unknown origin. Her Alanine Phosphatase (ALP) and Lactate Dehydrogenase (LHD) levels were raised. CT scan showed interstitial thickening in subpleural aspect of lungs and multiple enlarged lymph nodes in mediastinum...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28250364/epidemiological-study-of-fusarium-species-causing-invasive-and-superficial-fusariosis-in-japan
#6
Yasunori Muraosa, Misato Oguchi, Maki Yahiro, Akira Watanabe, Takashi Yaguchi, Katsuhiko Kamei
In Japan, Fusarium species are known etiological agents of human fungal infection; however, there has been no report of a large-scale epidemiological study on the etiological agents of fusariosis. A total of 73 Fusarium isolates from patients with invasive fusariosis (IF, n= 36) or superficial fusariosis (SF, n= 37), which were obtained at hospitals located in 28 prefectures in Japan between 1998 and 2015, were used for this study. Fusarium isolates were identified using Fusarium- and Fusarium solani species complex (FSSC) -specific real-time PCR and partial DNA sequences of the elongation factor-1 alpha (EF-1α) gene and the nuclear ribosomal internal transcribed spacer (ITS) region...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/28166614/a-rare-case-of-subcutaneous-fusariosis-in-an-immunocompetent-patient
#7
Elisabetta T Mapelli, Amilcare Cerri, Elisa Borghi, Marina Palvarini, Paola Abramo, Giulia Morace, Silvano Menni
Fusarium species can cause diseases in immunocompromised patients, whereas have rarely been reported as pathogens in immunocompetent individuals. Fusarium oxysporum and F. solani species complex are the most frequent pathogenic species. Primary subcutaneous hyalohyphomycosis due to these filamentous fungi is an extremely rare pathology, especially in immunocompetent patients. Only 37 cases of deep Fusarium infection in healthy patient have been reported in international literature. We report a case of subcutaneous infection due to F...
April 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/27924809/global-molecular-epidemiology-and-genetic-diversity-of-fusarium-a-significant-emerging-group-of-human-opportunists-from-1958-to-2015
#8
Abdullah Ms Al-Hatmi, Ferry Hagen, Steph Bj Menken, Jacques F Meis, G Sybren de Hoog
Fusarium is a rapidly emerging, multidrug-resistant genus of fungal opportunists that was first identified in 1958 and is presently recognized in numerous cases of fusariosis each year. The authors examined trends in global Fusarium distribution, clinical presentation and prevalence since 1958 with the assumption that their distributions in each region had remained unaltered. The phylogeny and epidemiology of 127 geographically diverse isolates, representing 26 Fusarium species, were evaluated using partial sequences of the RPB2 and TEF1 genes, and compared with AFLP fingerprinting data...
December 7, 2016: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/27880667/the-current-treatment-landscape-other-fungal-diseases-cryptococcosis-fusariosis-and-mucormycosis
#9
Olivier Lortholary, Mario Fernández-Ruiz, John R Perfect
Compared with major invasive mycoses such as aspergillosis and candidiasis, the antifungal stewardship management strategies of other fungal diseases have different opportunities and considerations. Cryptococcosis, fusariosis and mucormycosis are globally prevalent invasive fungal diseases (IFDs), but are not currently included in antifungal prophylaxis guidelines for immunocompromised hosts. Since the implementation of biomarkers as part of diagnostic screening strategies, the concept of pre-emptive antifungal therapy has emerged for these IFDs...
November 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27846057/disseminated-fusariosis-in-immunocompromised-children-analysis-of-recent-cases-identified-in-the-global-fungiscope-registry
#10
Angela Hassler, Adrian Lieb, Danila Seidel, Simone Cesaro, Johann Greil, Nikolay Klimko, Sofya Khostelidi, Galina Solopova, Dilara Ogunc, Luisa Durán Graeff, Oliver A Cornely, Maria J G T Vehreschild, Thomas Lehrnbecher
Disseminated fusariosis is a rare disease, and data are scant in pediatric patients. In the FungiScope registry, we identified 10 children with disseminated fusariosis between 2006 and 2015. Our analysis of the largest pediatric case series reported to date adds pediatric-specific experience to the management of this opportunistic infection in children.
February 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27759698/occlusive-nonvasculitic-vasculopathy
#11
Mar Llamas-Velasco, Victoria Alegría, Ángel Santos-Briz, Lorenzo Cerroni, Heinz Kutzner, Luis Requena
We review the most characteristic clinical and histopathologic findings of the cutaneous manifestations of the occlusive nonvasculitic vasculopathic disorders. Clinically, most of these conditions are characterized by retiform purpura. Histopathologic findings consist of occlusion of the vessel lumina with no vasculitis. Different disorders may produce nonvasculitic occlusive vasculopathy in cutaneous blood and lymphatic vessels, including embolization due to cholesterol and oxalate emboli, cutaneous intravascular metastasis from visceral malignancies, atrial myxomas, intravascular angiosarcoma, intralymphatic histiocytosis, intravascular lymphomas, endocarditis, crystal globulin vasculopathy, hypereosinophilic syndrome, and foreign material...
September 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27741094/enucleation-caused-by-fusarium-infection-in-a-child-with-toxic-epidermal-necrolysis
#12
Isabel Barranco-Fernández, Alberto García-Salido, Montserrat Nieto-Moro, Montserrat Sierra-Colomina, Belén Gutierrez-Partida, Inmaculada de Prada-Vicente, Antonio Torrelo-Fernández, Ana Serrano-González
Fusarium species are a known cause of ocular infection that can produce local and/or systemic invasive fusariosis. Fusarium ocular infection can evolve to keratitis, endophthalmitis and, in extreme cases, ocular perforation. We report, for the first time in children, the case of a 5 year old girl diagnosed with toxic epidermal necrolysis who developed Fusarium ocular infection requiring ocular enucleation.
January 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27698695/rare-case-of-disseminated-fusariosis-in-a-young-patient-with-graft-vs-host-disease-following-an-allogeneic-transplant
#13
Alina Tanase, Anca Colita, Gabriel Ianosi, Daniela Neagoe, Daciana Elena Branisteanu, Daniela Calina, Anca Oana Docea, Aristidis Tsatsakis, Simona Laura Ianosi
Fusarium infection is a severe fungal infection caused by fungi of the genus Fusarium. It most commonly occurs in immunocompromised patients with malignant hematological comorbidities or secondary to hematopoietic stem cell transplant. The classical route of contamination is through inhalation but infection may also occur through contiguity with a skin lesion. This report describes the case of a 24-year-old woman who developed graft-vs.-host disease (GVHD) at 220 days after receiving an allogeneic stem cell transplant from a sibling donor for Hodgkin disease...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27682849/banana-fruits-affected-by-fusarium-post-harvest-disease-as-source-of-human-fusariosis
#14
David Triest
No abstract text is available yet for this article.
September 2016: Acta Microbiologica et Immunologica Hungarica
https://www.readbyqxmd.com/read/27671065/antimold-prophylaxis-may-reduce-the-risk-of-invasive-fusariosis-in-hematologic-patients-with-superficial-skin-lesions-with-positive-culture-for-fusarium
#15
Andrea G Varon, Simone A Nouér, Gloria Barreiros, Beatriz Moritz Trope, Tiyomi Akiti, Marcio Nucci
Hematologic patients with superficial skin lesions on admission growing Fusarium spp. are at a high risk for developing invasive fusariosis during neutropenia. We evaluated the impact of primary prophylaxis with a mold-active azole in preventing invasive fusariosis in these patients. Between August 2008 and December 2014, patients with acute leukemia or aplastic anemia and recipients of hematopoietic cell transplants were screened on admission with dermatologic and direct exams and fungal cultures of superficial skin lesions...
December 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27605714/discrimination-of-aspergillosis-mucormycosis-fusariosis-and-scedosporiosis-in-formalin-fixed-paraffin-embedded-tissue-specimens-by-use-of-multiple-real-time-quantitative-pcr-assays
#16
Elham Salehi, Mohammad T Hedayati, Jan Zoll, Haleh Rafati, Maryam Ghasemi, Atosa Doroudinia, Mahdi Abastabar, Ali Tolooe, Eveline Snelders, Henrich A van der Lee, Antonius J M M Rijs, Paul E Verweij, Seyedmojtaba Seyedmousavi, Willem J G Melchers
In a retrospective multicenter study, 102 formalin-fixed paraffin-embedded (FFPE) tissue specimens with histopathology results were tested. Two 4- to 5-μm FFPE tissue sections from each specimen were digested with proteinase K, followed by automated nucleic acid extraction. Multiple real-time quantitative PCR (qPCR) assays targeting the internal transcribed spacer 2 (ITS2) region of ribosomal DNA, using fluorescently labeled primers, was performed to identify clinically important genera and species of Aspergillus, Fusarium, Scedosporium, and the Mucormycetes The molecular identification was correlated with results from histological examination...
November 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27503915/molecular-and-pathological-characterization-of-fusarium-solani-species-complex-infection-in-the-head-and-lateral-line-system-of-sphyrna-lewini
#17
Nopadon Pirarat, Komsil Sahatrakul, Sitthichok Lacharoje, Eric Lombardini, Nantarika Chansue, Somporn Techangamsuwan
A severe fungal infection affecting the head and lateral line system was diagnosed in 7 captive scalloped hammerhead sharks Sphyrna lewini in an aquarium in Thailand. Extensive and severe necrotizing cellulitis was consistently observed microscopically along the cephalic and lateral line canals in conjunction with positive fungal cultures for Fusarium sp. Molecular phylogenetic analysis was performed from 3 isolates based on the nucleotide sequences containing internally transcribed spacer (ITS) and a portion of 5...
August 9, 2016: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/27470138/radiologic-findings-of-fusarium-pneumonia-in-neutropenic-patients
#18
Claudia Sassi, Marta Stanzani, Russell E Lewis, Nicola Vianelli, Andrea Tarsi, Antonio Poerio, Michele Cavo, Giuseppe Battista
In neutropenic patients, lungs are involved in 50%-80% of cases of fusariosis, but imaging of pulmonary fusariosis has been previously described as indistinguishable from other invasive mould diseases. Our attempt was to identify a radiological pattern that may distinguish pulmonary fusariosis from other mould diseases. We examined the CT findings of nine neutropenic haematology patients with invasive fusariosis. As control group for comparison, we examined 14 invasive mould diseases (11 aspergillosis, 3 mucormycosis) in haematology patients with similar underlying disease and timing of CT imaging...
February 2017: Mycoses
https://www.readbyqxmd.com/read/27447804/favorable-outcomes-of-filamentous-fungal-endophthalmitis-following-aggressive-management
#19
Diem K Bui, Petros E Carvounis
PURPOSE: To evaluate the visual outcomes following aggressive management of filamentous fungal endophthalmitis with prompt surgical intervention and oral and intravitreal voriconazole. METHODS: Retrospective chart review study of consecutive patients with culture- or biopsy-proven filamentous fungal endophthalmitis treated at an academic referral center. Clinical characteristics, treatment regimens, and visual outcomes were analyzed. RESULTS: Included were 5 patients, 1 with endogenous endophthalmitis due to systemic fusariosis and 4 due to exogenous endophthalmitis (1 with Fusarium, 2 with Scedosporium apiospermum, and 1 with Glomerella spp...
July 22, 2016: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27357655/in-vitro-synergistic-combinations-of-pentamidine-polymyxin-b-tigecycline-and-tobramycin-with-antifungal-agents-against-fusarium-spp
#20
Tarcieli Pozzebon Venturini, Luana Rossato, Francieli Chassot, Jéssica Tairine Keller, Fernanda Baldissera Piasentin, Janio Morais Santurio, Sydney Hartz Alves
The genus Fusarium is characterized by hyaline filamentous fungi that cause infections predominantly in immunocompromised patients. The remarkable primary resistance to antifungal agents of this genus requires a search for new therapeutic possibilities. This study assessed the in vitro susceptibility of 25 clinical isolates of Fusarium against antifungal agents (amphotericin B, caspofungin, itraconazole and voriconazole) and antimicrobials (pentamidine, polymyxin B, tigecycline and tobramycin) according to the broth microdilution method (M38-A2)...
August 2016: Journal of Medical Microbiology
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