keyword
MENU ▼
Read by QxMD icon Read
search

Immunocompromised host

keyword
https://www.readbyqxmd.com/read/29140544/a-cryptosporidium-infection-in-a-patient-with-relapsed-t-lymphoblastic-lymphoma-undergoing-allogeneic-stem-cell-transplantation
#1
Joanna Schiller, Sebastian Klein, Marianne Engels, Reinhard Büttner, Jan Rybniker, Gerd Fätkenheuer, Christof Scheid, Christian Wybranski, Alexander Quaas, Hans Christian Reinhardt, Ruth Waßermann
Cryptosporidium infection is a rare cause of enterocolitis. In immunocompromised patients, cryptosporidiosis may lead to debilitating and life-threatening diarrhea and malabsorption, occasionally with multi organ involvement. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) requires long-term immunosuppressive therapy, while cellular immunity is usually compromised due to intensive conditioning chemotherapy. Diarrhea in patients who underwent allo-HSCT may be a sign of an infection, but can also be the result of intestinal graft-versus-host disease (GvHD)...
November 15, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/29140240/case-report-strongyloides-stercoralis-hyperinfection-in-a-patient-with-chronic-lymphocytic-leukemia
#2
Richelle Guerrero-Wooley, Ernesto Aranda-Aguirre, Wencheng Li, Aimee Wilkin, Elizabeth Palavecino
Strongyloides stercoralis is an intestinal nematode that can cause disseminated infection in an immunocompromised host. It is most commonly acquired in developing countries. It was previously a common infection in many parts of the United States, particularly in the Appalachian region, but is rarely identified currently. Here, we describe a patient born and raised in Appalachia, with no history of travel outside the United States, who presented with chronic lymphocytic leukemia and S. stercoralis hyperinfection characterized by acute respiratory failure, altered mental status, and extended-spectrum-beta-lactamase Klebsiella pneumoniae bacteremia...
November 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29140233/case-report-a-case-of-recurrent-strongyloides-stercoralis-colitis-in-a-patient-with-multiple-myeloma
#3
Keith Glenn, David A Lindholm, Gregory Meis, Luisa Watts, Nicholas Conger
Strongyloides stercoralis chronic infection is frequently subclinical and thus under-recognized, although its increasing prevalence in nonendemic regions has implications for immunocompromised hosts. We present a 75-year-old male with stage II multiple myeloma who presented with relapse of Strongyloides infection after initial treatment, negative surveillance testing, and subsequent resumption of chemotherapy for his multiple myeloma. The optimal regimen for secondary prophylaxis against recurrent infections is unknown...
November 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29136537/new-advances-in-understanding-the-host-immune-response-to-pneumocystis
#4
REVIEW
J Claire Hoving, Jay K Kolls
Pneumocystis jirovecii causes clinical pneumonia in immunocompromised hosts. Despite this, the inability to cultivate this organism in vitro has likely hindered the field in ascertaining the true impact of Pneumocystis in human infection. However the recent release of the genome as well as in advances in understanding host genetics, and other risk factors for infection and robust experimental models of disease have shed new light on the impact of this fungal pathogen as to better define populations at risk...
November 11, 2017: Current Opinion in Microbiology
https://www.readbyqxmd.com/read/29130815/aspergillus-infection-in-an-immunocompetent-host-with-supravalvular-aortic-stenosis
#5
Sedigheh Saedi, Zahra Khajali, Azin Alizadehasl
Supravalvular aortic stenosis is the rarest form of left ventricular outflow tract obstruction. Aspergillus endocarditis is also rare and generally reported in immunocompromised hosts. Here we present a case of an immunocompetent patient with supravalvular aortic stenosis complicated by aortic mycotic pseudoaneurysm due to invasive aspergillosis.
January 1, 2017: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/29127615/fungal-and-parasitic-cns-infections
#6
Pratibha Singhi, Arushi Gahlot Saini
Central nervous system fungal infections can be broadly divided into those that infect a healthy host such as Cryptococcus, Coccidioides, Histoplasma, Blastomyces, Sporothrix spp., and those that cause opportunistic infections in an immunocompromised host such as Candida, Aspergillus, Zygomycetes, Trichosporon spp. The clinical manifestations of central nervous system fungal infections commonly seen in children in clinical practice include a chronic meningitis or meningoencephalitis syndrome, brain abscess, rhino-cerebral syndrome and rarely, a fungal ventriculitis...
November 11, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29126804/clinical-significance-of-human-cytomegalovirus-viruria-and-the-effect-of-antiviral-therapy-in-hematopoietic-stem-cell-transplant-recipients
#7
Wei-Lu, Su-Jung Chen, Shiang-Fen Huang, Yu-Jiun Chan, Fu-Der Wang, Hsin-Pai Chen
BACKGROUND: Cytomegalovirus (CMV) causes life-threatening infections in immunocompromised host. The clinical significance of asymptomatic CMV viruria in patients receiving hematopoietic stem cell transplantation (HSCT) remains unclear. This study aims to clarify whether antiviral therapy is associated with a favorable clinical outcome. METHODS: HSCT recipients whose urine was culture-positive for CMV were retrospectively reviewed and followed. Viruria episodes were divided according to whether or not antiviral therapy was used...
September 23, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/29125649/milker-s-nodule-an-occupational-infection-and-threat-to-the-immunocompromised
#8
REVIEW
Nancy S Handler, M Z Handler, Andris Rubins, Silvestr Rubins, Marcis Septe, Camila K Janniger, Robert A Schwartz
Milker's nodule virus, also called paravaccinia virus is a DNA virus of the parapoxvirus genus transmitted from infected cows to humans. It results from contact with cattle, cattle byproducts, or fomites. Classified as an occupational disorder, those at risk of exposure include farmers, butchers, and agricultural tourists. The viral infection begins 5-15 days after inoculation as an erythematous-purple, round nodule with a clear depressed center, and a surrounding erythematous ring. While familiar to those in farming communities, the presence of the nodule may be concerning to others, particularly the immunosuppressed...
November 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29123966/pd-1-blockade-at-the-time-of-tumor-escape-potentiates-the-immune-mediated-antitumor-effects-of-a-melanoma-targeting-monoclonal-antibody
#9
Laetitia They, Henri-Alexandre Michaud, Ondine Becquart, Virginie Lafont, Bernard Guillot, Florence Boissière-Michot, Marta Jarlier, Caroline Mollevi, Jean-François Eliaou, Nathalie Bonnefoy, Laurent Gros
Tumor antigen-targeting monoclonal antibodies (TA-targeting mAbs) are used as therapeutics in many malignancies and their capacity to mobilize the host immunity puts them at the forefront of anti-cancer immunotherapies. Both innate and adaptive immune cells have been associated with the therapeutic activity of such antibodies, but tumor escape from mAb-induced tumor immune surveillance remains one of the main clinical issues. In this preclinical study, we grafted immunocompetent and immunocompromised mice with the B16F10 mouse melanoma cell line and treated them with the TA99 TA-targeting mAb to analyze the immune mechanisms associated with the tumor response and resistance to TA99 monotherapy...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/29110978/mumps-an-emergency-medicine-focused-update
#10
Chelsea Bockelman, Thomas C Frawley, Brit Long, Alex Koyfman
BACKGROUND: Mumps is a Paramyxoviridae virus. This disease was rampant prior to introduction of the measles, mumps, and rubella vaccine, resulting in decreased incidence. This disease has demonstrated several outbreaks. OBJECTIVE: This review provides a focused evaluation of mumps, an update on outbreaks, management recommendations, and ways to decrease transmission. DISCUSSION: Clusters of mumps outbreaks continue to occur. The virus is a paramyxovirus, a single-stranded RNA virus...
October 27, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29110133/recurrent-pulmonary-alveolar-proteinosis-in-an-immunocompromised-host
#11
Amrit K Kamboj, Patrick Hoversten, Thomas G Cotter, Subir Bhatia, Kannan Ramar
No abstract text is available yet for this article.
November 6, 2017: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29109476/the-major-targets-of-acute-norovirus-infection-are-immune-cells-in-the-gut-associated-lymphoid-tissue
#12
Katrina R Grau, Alexa N Roth, Shu Zhu, Abel Hernandez, Natacha Colliou, Bayli B DiVita, Drake T Philip, Cara Riffe, Benoit Giasson, Shannon M Wallet, Mansour Mohamadzadeh, Stephanie M Karst
Noroviruses are the leading cause of food-borne gastroenteritis outbreaks and childhood diarrhoea globally, estimated to be responsible for 200,000 deaths in children each year (1-4) . Thus, reducing norovirus-associated disease is a critical priority. Development of vaccines and therapeutics has been hindered by the limited understanding of basic norovirus pathogenesis and cell tropism. While macrophages, dendritic cells, B cells and stem-cell-derived enteroids can all support infection of certain noroviruses in vitro (5-7) , efforts to define in vivo norovirus cell tropism have generated conflicting results...
November 6, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/29104652/plain-and-contrast-enhanced-chest-computed-tomography-scan-findings-of-pulmonary-cryptococcosis-in-immunocompetent-patients
#13
Rongshui Yang, Yan Yan, Yuhuan Wang, Xiaohuan Liu, Xinhui Su
Pulmonary cryptococcosis is most commonly reported in immunocompromised patients, whereas immunocompetent hosts are rarely affected and may be asymptomatic, resulting in reduced diagnostic performance of computed tomography (CT) imaging. Thus, the aim of the present study was to review the plain and contrast-enhanced chest CT scan findings of primary pulmonary cryptococcosis in immunocompetent patients, with the aim of improving the diagnosis of this type of pulmonary disease. In the present study, a total of 27 immunocompetent patients of clinically confirmed pulmonary cryptococcosis were analyzed retrospectively...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29099868/evaluation-of-a-multiplex-panel-for-the-diagnosis-of-acute-infectious-diarrhea-in-immunocompromised-hematologic-patients
#14
Izaskun Alejo-Cancho, Francesc Fernández Avilés, Alicia Capón, Cristina Rodríguez, Josep Barrachina, Pilar Salvador, Mª Eugenia Valls, Miriam J Álvarez-Martínez, Yuliya Zboromyrska, Jordi Vila, Mª Ángeles Marcos
INTRODUCTION: Diarrhea is a frequent complication in hematologic patients, being an infectious cause frequently suspected. Rapid and accurate detection of gastrointestinal pathogens is vital in immunocompromised hosts. The aim of this study was to compare routine diagnostic methods versus a multiplex polymerase chain reaction (PCR) assay for the diagnosis of infectious diarrhea in immunocompromised hematologic patients. MATERIAL AND METHODS: We conducted a prospective observational study from March 2015 to January 2016 to compare conventional methods for the diagnosis of infectious diarrhea with FIlmArray GI Panel (BioFire-bioMérieux, France)...
2017: PloS One
https://www.readbyqxmd.com/read/29096346/intraabdominal-abscess-caused-by-stenotrophomonas-maltophilia-a-case-report
#15
Toyomitsu Sawai, Sumako Yoshioka, Nobuko Matsuo, Naofumi Suyama, Hiroshi Mukae
INTRODUCTION: Stenotrophomonas maltophilia usually causes nosocomial infections, but intraabdominal abscesses or organ/space surgical site infection (SSI) secondary to this organism has been rarely reported. Here, we reported a rare case of SSI that presented as intraabdominal abscess caused by S. maltophilia. PRESENTATION OF CASE: A 68-year-old woman presented to our hospital with transverse colon cancer. Further work up with abdominal computed tomography (CT) revealed left renal cell carcinoma...
October 27, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29093083/dynamics-of-sendai-virus-spread-clearance-and-immunotherapeutic-efficacy-after-hematopoietic-cell-transplant-imaged-non-invasively-in-mice
#16
Heba H Mostafa, Peter Vogel, Ashok Srinivasan, Charles J Russell
There are no approved vaccines or virus-specific treatments for human parainfluenza viruses (PIVs), which have recently been reclassified into species human respirovirus 1 and 3 and human rubulavirus 2 and 4 These viruses cause morbidity and mortality in immunocompromised patients including those undergoing hematopoietic cell transplant (HCT). No small-animal models exist for non-invasive imaging of respiratory viral infection in the HCT host despite the utility such a system would offer to monitor prolonged infection, its clearance, and treatment options...
November 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29090840/patatin-like-phospholipases-in-microbial-infections-with-emerging-roles-in-fatty-acid-metabolism-and-immune-regulation-by-apicomplexa
#17
REVIEW
Sarah K Wilson, Laura J Knoll
Emerging lipidomic technologies have enabled researchers to dissect the complex roles of phospholipases in lipid metabolism, cellular signaling, and immune regulation. Host phospholipase products are involved in stimulating and resolving the inflammatory response to pathogens. While many pathogen-derived phospholipases also manipulate the immune response, they have recently been shown to be involved in lipid remodeling and scavenging during replication. Animal and plant hosts as well as many pathogens contain a family of patatin-like phospholipases, which have been shown to have phospholipase A2 activity...
November 1, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/29075960/a-case-of-fungus-ball-type-maxillary-sinusitis-due-to-penicillium-roqueforti
#18
T Radulesco, A Varoquaux, S Ranque, P Dessi, J Michel, C Cassagne
The Penicillium genera, encompassing about 225 different species of fungi, are naturally present in the environment. These genera are poorly linked to human disease, except for Penicillium marneffei causing septicemia in immunocompromised hosts. Thus, Penicillium species recovered from respiratory tract samples are often considered as inhaled contaminants in the clinical laboratory. However, we report here a case of fungal maxillary sinusitis due to Penicillium roqueforti diagnosed in a 40-year-old female, a teacher, complaining of moderate pain for months in the maxillary sinus and chronic posterior rhinorrhea...
October 26, 2017: Mycopathologia
https://www.readbyqxmd.com/read/29075259/virus-specific-t-cells-for-the-immunocompromised-patient
#19
REVIEW
Amy Houghtelin, Catherine M Bollard
While progress has been made in the treatment of both hematologic cancers and solid tumors, chemorefractory or relapsed disease often portends a dismal prognosis, and salvage chemotherapy or radiation expose patients to intolerable toxicities and may not be effective. Hematopoietic stem cell transplant offers the promise of cure for many patients, and while mismatched, unrelated or haploidentical donors are increasingly available, the recipients are at higher risk of severe immunosuppression and immune dysregulation due to graft versus host disease...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29075257/the-p2x7-receptor-mediates-toxoplasma-gondii-control-in-macrophages-through-canonical-nlrp3-inflammasome-activation-and-reactive-oxygen-species-production
#20
Aline Cristina Abreu Moreira-Souza, Cássio Luiz Coutinho Almeida-da-Silva, Thuany Prado Rangel, Gabrielle da Costa Rocha, Maria Bellio, Dario Simões Zamboni, Rossiane Claudia Vommaro, Robson Coutinho-Silva
Toxoplasma gondii (T. gondii) is the protozoan parasite that causes toxoplasmosis, a potentially fatal disease to immunocompromised patients, and which affects approximately 30% of the world's population. Previously, we showed that purinergic signaling via the P2X7 receptor contributes to T. gondii elimination in macrophages, through reactive oxygen species (ROS) production and lysosome fusion with the parasitophorous vacuole. Moreover, we demonstrated that P2X7 receptor activation promotes the production of anti-parasitic pro-inflammatory cytokines during early T...
2017: Frontiers in Immunology
keyword
keyword
79787
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"