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https://www.readbyqxmd.com/read/29775777/antidepressant-potential-of-novel-flavonoids-derivatives-from-sweet-violet-viola-odorata-l-pharmacological-biochemical-and-computational-evidences-for-possible-involvement-of-serotonergic-mechanism
#1
Nasiara Karim, Imran Khan, Abeer Abdelhalim, Ajmal Khan, Sobia Ahsan Halim
Plant-derived natural constituents are of great interest in modern drug discovery due to their natural diversity. Viola odorata L has been traditionally used for the treatment of neuropsychiatric disorders. The present study was undertaken to isolate phytoconstituents including three flavonoids 5,7-Dihydroxy-3,6-dimethoxyflavone[1] 5,7,4'-trihydroxy-3',5'dimethoxyflavone [2] and 5,7,4'-trihydroxy-3'-methoxyflavone [3] from the whole plant of Viola odorata L and to investigate the antidepressant-like effects of these compounds and their possible mechanism of action using antagonists of the serotonergic, dopaminergic and adrenergic system...
May 15, 2018: Fitoterapia
https://www.readbyqxmd.com/read/29775671/variable-ventilation-decreases-airway-responsiveness-and-improves-ventilation-efficiency-in-a-rat-model-of-asthma
#2
Fatemeh Ilka, Mohammad Javan, Mohammad Reza Raoufy
The optimal ventilation strategy in patients receiving mechanical ventilation for severe asthma remains unclear. The effect of conventional ventilation (with constant tidal volume and respiratory rate) and variable ventilation (with the same average but variable tidal volume and respiratory rate) on peak airway pressure and airway exacerbation induced by increasing doses of methacholine was compared in a rat model of asthma. The respiratory rate and tidal volume data were obtained from a spontaneously breathing intact rat during immobility using a whole-body plethysmograph...
May 15, 2018: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29774825/dietary-zinc-modulates-matrix-metalloproteinases-in-traumatic-brain-injury
#3
Angus Scrimgeour, Christopher Carrigan, Michelle Lynn Condlin, Maria L Urso, Roland M van den Berg, Herman P M van Helden, Scott J Montain, Marloes J A Joosen
Animal models of mild traumatic brain injury (mTBI) provide opportunity to examine the extent to which dietary interventions can be used to improve recovery after injury. Animal studies also suggest that matrix metalloproteinases (MMPs) play a role in tissue remodeling post-TBI. Because dietary zinc (Zn) improved recovery in non-blast mTBI models, and the MMPs are Zn-requiring enzymes, we evaluated the effects of low- and adequate Zn diets on MMP expression and behavioral responses, following exposure to a single blast...
May 18, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29772343/brain-stimulation-differentially-modulates-nociception-and-inflammation-in-aversive-and-non-aversive-behavioural-conditions
#4
G S Bassi, A Kanashiro, G J Rodrigues, F Q Cunha, N C Coimbra, L Ulloa
Inflammation and pain are major clinical burdens contributing to multiple disorders and limiting the quality of life of patients. We previously reported that brain electrical stimulation can attenuate joint inflammation in experimental arthritis. Here, we report that non-aversive electrical stimulation of the locus coeruleus (LC), the paraventricular hypothalamic nucleus (PVN) or the ventrolateral column of the periaqueductal grey matter (vlPAG) decreases thermal pain sensitivity, knee inflammation and synovial neutrophilic infiltration in ratswith intra-articular zymosan...
May 14, 2018: Neuroscience
https://www.readbyqxmd.com/read/29766828/protective-effects-of-crocetin-on-depression-like-behavior-induced-by-immobilization-in-rat
#5
Tahereh Farkhondeh, Saeed Samarghandian, Fariborz Samini, Ali Rajabpour Sanati
Crocetin, an active ingredient of saffron, has been recognized as a potent antioxidant. Plant extracts or their components may be useful in ameliorating the various diseases, including neurodegenerative disorders. This study investigated the effects of crocetin on oxidative damage induced by chronic restraint stress in the rat brain. For this reason, rats were kept in the restrainers for 1 hour every day, for 21 consecutive days. The animals were injected of crocetin (20, 40, 60 mg/kg) or vehicle daily for 21 days...
May 15, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29766152/undesired-effect-of-excessive-betamethasone-administration-during-pregnancy-a-rare-case
#6
Alireza Mirzaei, Solmaz Piri, Kaveh Gharanizadeh, Mozhdeh Zabihiyeganeh
Background: Postpartum bilateral femoral neck fracture (BFNF) is a rare condition. We here report a case of BFNF due to excessive corticosteroid consumption, twin pregnancy, immobility, and vitamin D deficiency. Case: This is a report of a 32-yr-old woman with bilateral femoral insufficiency fracture five days after emergency cesarean section due to preterm labor, twin pregnancy, and the history of a previous cesarean section at 33 wk. Antenatal repeated courses of betamethasone injections for fetal lung maturity, daily oral use of prednisolone for the history of miscarriage, immobilization, and vitamin D deficiency were the important contributing factors in her past medical history and lab investigations...
March 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29761007/behavioral-changes-induced-through-adenosine-a2a-receptor-ligands-in-a-rat-depression-model-induced-by-olfactory-bulbectomy
#7
Karla Margarita Padilla, Andres Quintanar-Setephano, Fabian López-Vallejo, Laura Cristina Berumen, Ricardo Miledi, Guadalupe García-Alcocer
Background: Major depressive disorders are characterized by their severity and long-lasting symptoms, which make such disorders highly disabling illnesses. Unfortunately, 50% of major depressive patients experience relapses, perhaps partly because drug research has been performed only in animal models that screen for antidepressant drugs that appear to only ameliorate acute depression symptoms. The bilateral olfactory bulbectomy (OBX) animal model presents the advantage of mimicking the symptoms of chronic depression by means of brain surgery...
May 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29757463/depression-related-behavioural-and-neuroendocrine-changes-in-the-spontaneously-diabetic-torii-sdt-fatty-rat-an-animal-model-of-type-2-diabetes-mellitus
#8
Katsuya Sakimura, Tatsuya Maekawa, Kazuo Sasagawa, Yukihito Ishii, Shin-Ichi Kume, Takeshi Ohta
Depression is one of the most common psychiatric diseases and is commonly comorbid with type 1 or 2 diabetes mellitus (DM). However, the pathophysiology underlying the depressive state in DM remains poorly understood. Animal models are useful tools to investigate the association between depression and DM. In the present study we investigated whether the Spontaneously Diabetic Torii (SDT) fatty rat, a novel animal model of type 2 DM, shows depression-related features. We assessed depression-like behaviour, hyperactivation of the hypothalamic-pituitary-adrenal (HPA) axis, and neurotransmitter levels in the brain...
May 14, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29755551/antidepressant-like-effect-of-a-chalcone-compound-dhipc-and-its-possible-mechanism
#9
Dong-Hai Zhao, Yan-Chun Wang, Lian-Wen Zheng, Bing-Yu Liu, Li-Ping Guan
DHIPC (2,4-dichloro-2´-hydroxyl-4´,6´-diisoprenyloxychalcone) is a new chalcone compound. In this study, its antidepressant-like activity of compound DHIPC was evaluated by the forced swimming test and the tail suspension test in mice. The results showed that DHIPC significantly reduced the immobility time for 2 h after treatment through the oral administration at dose of 10, 20, and 30 mg/kg in the forced swimming test and the tail suspension test, indicating a significant antidepressant-like effect. The maximal effect was obtained at 30 mg/kg, which is similar to the positive control fluoxetine...
2018: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29754167/an-extract-of-synedrella-nodiflora-l-gaertn-exhibits-antidepressant-properties-through-monoaminergic-mechanisms
#10
Patrick Amoateng, Kennedy Kwami Edem Kukuia, Jeffrey Amoako Mensah, Dorcas Osei-Safo, Samuel Adjei, Audrey Akyea Eklemet, Emmanuel Atsu Vinyo, Thomas K Karikari
Synedrella nodiflora (SNE) has been used traditionally for many neurological conditions and some of these neuroactive effects have been scientifically substantiated. The usefulness of SNE in depression has however not been investigated despite the availability of data in other disease models indicating it may be useful. The present study therefore examined the effect of SNE in acute murine models of depression and the possible mechanisms mediating its activities in these models. Preliminary qualitative phytochemical and high performance liquid chromatography (HPLC) screening were conducted on SNE...
May 12, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29753049/antidepressant-effects-of-creatine-on-amyloid-%C3%AE-1-40-treated-mice-the-role-of-gsk-3%C3%AE-nrf-2-pathway
#11
Julia M Rosa, Francis L Pazini, Mauricio P Cunha, André R S Colla, Luana M Manosso, Gianni Mancini, Ana Cristina G Souza, Andreza F de Bem, Rui Daniel Prediger, Ana Lúcia S Rodrigues
Alzheimer's disease (AD) is characterized by progressive synaptic dysfunction and neuronal lost in specific brain areas including hippocampus, resulting in memory/learning deficits and cognitive impairments. In addition, non-cognitive symptoms are reported in AD patients, such as anxiety, apathy and depressed mood. The current antidepressant drugs present reduced efficacy to improve depressive symptoms in AD patients. Here, we investigated the ability of creatine, a compound with neuroprotective and antidepressant properties, to counteract amyloid β1-40 peptide-induced depressive-like behavior in mice...
May 9, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29752382/a-neural-pathway-controlling-motivation-to-exert-effort
#12
Christophe D Proulx, Sage Aronson, Djordje Milivojevic, Cris Molina, Alan Loi, Bradley Monk, Steven J Shabel, Roberto Malinow
The neural mechanisms conferring reduced motivation, as observed in depressed individuals, is poorly understood. Here, we examine in rodents if reduced motivation to exert effort is controlled by transmission from the lateral habenula (LHb), a nucleus overactive in depressed-like states, to the rostromedial tegmental nucleus (RMTg), a nucleus that inhibits dopaminergic neurons. In an aversive test wherein immobility indicates loss of effort, LHb→RMTg transmission increased during transitions into immobility, driving LHb→RMTg increased immobility, and inhibiting LHb→RMTg produced the opposite effects...
May 11, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29747562/early-ambulation-in-patients-with-external-ventricular-drains-results-of-a-quality-improvement-project
#13
Syed Omar Shah, Jacqueline Kraft, Nethra Ankam, Paula Bu, Kristen Stout, Sara Melnyk, Fred Rincon, M Kamran Athar
INTRODUCTION: Prolonged immobility in patients in the intensive care unit (ICU) can lead to muscle wasting and weakness, longer hospital stays, increased number of days in restraints, and hospital-acquired infections. Increasing evidence demonstrates the safety and feasibility of early mobilization in the ICU. However, there is a lack of evidence in the safety and feasibility of mobilizing patients with external ventricular drains (EVDs). The purpose of this study was to determine the safety and feasibility of early mobility in this patient population...
June 2018: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/29744362/antioxidant-hepatoprotective-and-antidepression-effects-of-rumex-tingitanus-extracts-and-identification-of-a-novel-bioactive-compound
#14
Dhekra Mhalla, Karama Zouari Bouassida, Rachid Chawech, Amira Bouaziz, Samar Makni, Lobna Jlaiel, Slim Tounsi, Raoudha Mezghani Jarraya, Mohamed Trigui
Over the last few decades, Rumex species have been recognized as a promising source of new compounds with numerous pharmacological activities. Therefore, the antioxidant activity of Rumex tingitanus (R. tingitanus) leaves extracts was evaluated in vitro and then confirmed in vivo as well as the antidepressant-like and toxicological effects of the extracts. The ethyl acetate fraction (Rt EtOAcF) followed by hydroalcoholic extract (Rt EtOH-H2 O) showed a remarkable in vitro antioxidant activity. The hydroalcoholic extract (Rt EtOH-H2 O) showed significant hepatoprotective activity against carbon tetrachloride- (CCl4 -) induced liver toxicity which is seen from inhibition of the malondialdehyde (MDA) accumulation and enhancement of the liver antioxidant enzymes activities...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29739458/anti-stress-effects-of-human-placenta-extract-possible-involvement-of-the-oxidative-stress-system-in-rats
#15
Hyun-Jung Park, Hyun Soo Shim, Sunyoung Lee, Dae Hyun Hahm, Hyejung Lee, Chang Taek Oh, Hae Jung Han, Hyi Jeong Ji, Insop Shim
BACKGROUND: Human placenta hydrolysate (hPH) has been utilized to improve menopausal, fatigue, liver function. Its high concentration of bioactive substances is known to produce including antioxidant, anti-inflammatory and anti-nociceptive activities. However, its mechanisms of stress-induced depression remain unknown. METHODS: The present study examined the effect of hPH on stress-induced depressive behaviors and biochemical parameters in rats. hPH (0.02 ml, 0...
May 8, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29738849/5-ht-1a-receptor-stimulation-in-the-medial-prefrontal-cortex-mediates-the-antidepressant-effects-of-mglu2-3-receptor-antagonist-in-mice
#16
Kenichi Fukumoto, Michihiko Iijima, Takeo Funakoshi, Shigeyuki Chaki
We previously reported that serotonergic transmission is involved in the antidepressant effects of metabotropic glutamate 2/3 (mGlu2/3) receptor antagonists. However, the detailed underlying mechanisms had not yet been explored. In the present study, we investigated the role of the 5-HT1A receptor and its signaling cascade in the medial prefrontal cortex (mPFC) in the antidepressant effects of LY341495, an mGlu2/3 receptor antagonist. LY341495 significantly reduced the immobility time in the forced swimming test which sustained for 24 h after administration...
May 5, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29738811/hypobaric-hypoxia-exposure-in-rats-differentially-alters-antidepressant-efficacy-of-the-selective-serotonin-reuptake-inhibitors-fluoxetine-paroxetine-escitalopram-and-sertraline
#17
Shami Kanekar, Chandni S Sheth, Hendrik J Ombach, Paul R Olson, Olena V Bogdanova, Matthew Petersen, Chloe E Renshaw, Young-Hoon Sung, Kristen E D'Anci, Perry F Renshaw
Treatment-resistant depression, a chronic condition that affects 30% of depressed patients on antidepressants, is highly linked to suicidal behavior. Chronic hypoxia exposure via living at altitude (hypobaric hypoxia) or with chronic hypoxic diseases is demographically linked to increased risk for depression and suicide. We previously demonstrated that housing rats at altitude for a week incrementally increases depression-like behavior in the forced swim test (FST) in females, but not males. In animal models, high altitude exposure reduces brain serotonin, and selective serotonin reuptake inhibitors (SSRIs) can lose efficacy when brain serotonin levels are low...
May 5, 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29736913/effects-of-caffeine-on-behavioural-and-cognitive-deficits-in-rats
#18
Melissa S Assis, Aluízio C Soares, Dircilei N de Sousa, João Eudes-Filho, Lilian Rosana F Faro, Fabiana P Carneiro, Mônica V da Silva, Andrea B Motoyama, Greice Maria R de Souza, Stéphanie Marchiori, Nadyelle T de Lima, Raphael Boëchat-Barros, Vania M Ferreira
There are many studies that have sought to find drug therapies to prevent harm arising from sepsis. Such studies have represented a progress in the support to septic patients and also in the development of new pharmacological alternatives. Our interest was to investigate the caffeine effect on sepsis behavioural and memory impairments. Male rats were anaesthetized and the surgery was made to allow exposure of the cecum, which was then squeezed to extrude a small amount of faeces from the perforation site, which was later placed back into the peritoneal cavity...
May 7, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29732909/treatment-of-patients-with-benign-paroxysmal-positional-vertigo-and-severe-immobility-using-the-particle-repositioning-chair-a-retrospective-cohort-study
#19
Alexander L Luryi, Juliana Lawrence, Michael LaRouere, Seilesh Babu, Dennis I Bojrab, John Zappia, Eric W Sargent, Christopher A Schutt
OBJECTIVE: To report treatment of benign paroxysmal positional vertigo (BPPV) in patients unable to undergo traditional canalith repositioning maneuvers (CRMs) using a particle repositioning chair (PRC). METHODS: A retrospective chart review was conducted at a single high-volume otology practice of patients diagnosed with BPPV from 2007 to 2017 with immobility prohibiting use of traditional CRMs. Patients were diagnosed and treated using a PRC, and outcome measures including resolution, recurrence, and number of treatment visits were recorded...
May 1, 2018: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29731709/spike-timing-of-orbitofrontal-neurons-is-synchronized-with-breathing
#20
Áron Kőszeghy, Bálint Lasztóczi, Thomas Forro, Thomas Klausberger
The orbitofrontal cortex (OFC) has been implicated in a multiplicity of complex brain functions, including representations of expected outcome properties, post-decision confidence, momentary food-reward values, complex flavors and odors. As breathing rhythm has an influence on odor processing at primary olfactory areas, we tested the hypothesis that it may also influence neuronal activity in the OFC, a prefrontal area involved also in higher order processing of odors. We recorded spike timing of orbitofrontal neurons as well as local field potentials (LFPs) in awake, head-fixed mice, together with the breathing rhythm...
2018: Frontiers in Cellular Neuroscience
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