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https://www.readbyqxmd.com/read/28319694/sexual-trauma-is-more-strongly-associated-with-tonic-immobility-than-other-types-of-trauma-a-population-based-study
#1
Juliana Kalaf, Evandro Silva Freire Coutinho, Liliane Maria Pereira Vilete, Mariana Pires Luz, William Berger, Mauro Mendlowicz, Eliane Volchan, Sergio Baxter Andreoli, Maria Inês Quintana, Jair de Jesus Mari, Ivan Figueira
BACKGROUND: Tonic immobility is an involuntary motor and vocal inhibition reaction, considered the last-ditch response of the defensive cascade model. It is elicited in context of inescapable threat and perception of entrapment. Our aim was to investigate the association between different traumatic events and peritraumatic tonic immobility (PTI) in a representative sample of the general population. METHODS: This is a cross-sectional study of general population from Rio de Janeiro and São Paulo with 3231 victims of traumatic events aged 15-75 years who completed the Tonic Immobility Scale (TIS)...
March 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28314958/unilateral-vocal-fold-immobility-a-tertiary-hospital-s-experience-over-5-years
#2
Vyas M N Prasad, Raja Fakhoury, Diane Helou, Georges Lawson, Marc Remacle
The objective of the study was to determine the etiology and subsequent management of patients with unilateral vocal fold immobility (UVFI) and compare our results with other such studies. This was a retrospective case series of all patients that were treated for UVFI at one single tertiary referral centre between 2010 and 2014. The medical records of 161 patients over a 5-year period diagnosed with UVFI were analyzed. We looked at the patient demographics, side of immobility, etiology, management and voice assessment...
March 17, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28314177/gintonin-attenuates-depressive-like-behaviors-associated-with-alcohol-withdrawal-in-mice
#3
Hyeon-Joong Kim, Sang-Deuk Park, Ra Mi Lee, Byung-Hwan Lee, Sun-Hye Choi, Sung-Hee Hwang, Hyewhon Rhim, Hyoung-Chun Kim, Seung-Yeol Nah
BACKGROUND: Panax ginseng Meyer extracts have been used to improve mood and alleviate symptoms of depression. However, little is known about the extracts' active ingredients and the molecular mechanisms underlying their reported anti-depressive effects. METHODS: Gintonin is an exogenous lysophosphatidic acid (LPA) receptor ligand isolated from P. ginseng. BON cells, an enterochromaffin cell line, and C57BL/6 mice were used to investigate whether gintonin stimulates serotonin release...
March 9, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28303202/effects-of-deep-brain-stimulation-on-vocal-fold-immobility-in-parkinson-s-disease
#4
Elsa V Arocho-Quinones, Michael J Hammer, Jonathan M Bock, Peter A Pahapill
BACKGROUND: Vocal fold (VF) immobility is a rare, potentially fatal complication of advanced Parkinson's disease (PD). Previous reports suggest that subthalamic nucleus deep brain stimulation (STN-DBS) may influence laryngeal function, yet the role of STN-DBS on VF immobility remains unexplored. CASE DESCRIPTION: We report a case of a patient with advanced PD and bilateral VF immobility ultimately requiring a tracheostomy. To assess the effects of STN-DBS on vocal cord function and to correlate these effects with peripheral motor symptoms at different stimulation settings, the patient was evaluated before and after initiation of bilateral STN-DBS...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28299299/effect-of-early-physical-activity-programs-on-motor-performance-and-neuromuscular-development-in-infants-born-preterm-a-randomized-clinical-trial
#5
Leila Valizadeh, Mahnaz Sanaeefar, Mohammad Bager Hosseini, Mohammad Asgari Jafarabadi, Aryan Shamili
Introduction: Although the survival rate of infants born preterm has increased, the prevalence of developmental problems and motor disorders among this population of infants remains the same. This study investigated the effect of physical activity programs in and out of water on motor performance and neuromuscular development of infants born preterm and had induced immobility by mechanical ventilation. Methods: This study was carried out in Al-Zahra hospital, Tabriz. 76 premature infants were randomly assigned into four groups...
March 2017: Journal of Caring Sciences
https://www.readbyqxmd.com/read/28295547/practitioner-perceptions-of-the-anesthetic-needs-for-magnetic-resonance-imaging-in-pediatric-patients
#6
Glenn E Mann, Adam Canter, Singh Nair, Donna LaMonica, Madelyn Kahana, Jennifer Yoo, Ellise Delphin
There is currently an increasing use of magnetic resonance imaging (MRI) as a diagnostic tool in the pediatric population(1). MRI is often viewed as an ideal diagnostic modality because it does not require exposure to ionizing radiation, provides superior soft tissue image quality compared with computed tomography (CT) and is thus well-suited for neurological, musculoskeletal, cardiac, thoracic, and abdominal studies(2). However, MRIs require patient cooperation and extended time periods of immobility, as the studies are often long, loud, and may induce claustrophobia (2-7)...
March 12, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28294390/combined-xil-6r-and-urocortin-2-treatment-restores-mdx-diaphragm-muscle-force
#7
Jennifer Manning, Maria M Buckley, Ken D O'Halloran, Dervla O'Malley
Introduction Duchenne muscular dystrophy (DMD) is characterized by progressive muscle degeneration leading to immobility, respiratory failure and premature death. As chronic inflammation and stress are implicated in DMD pathology, the efficacy of an anti-inflammatory and anti-stress intervention strategy in ameliorating diaphragm dysfunction was investigated. Methods Diaphragm muscle contractile function was compared in wild-type and dystrophin-deficient mdx mice treated with saline, anti-IL-6R antibodies (xIL-6R), the corticotrophin-releasing factor receptor 2 (CRFR2) agonist, urocortin 2 or both xIL-6R and urocortin 2...
March 13, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28291777/adolescent-but-not-adult-ethanol-binge-drinking-modulates-cocaine-withdrawal-symptoms-in-mice
#8
Juan Carlos Ledesma, Maria A Aguilar, Pablo Giménez-Gómez, José Miñarro, Marta Rodríguez-Arias
BACKGROUND: Ethanol (EtOH) binge drinking is an increasingly common behavior among teenagers that induces long-lasting neurobehavioral alterations in adulthood. An early history of EtOH abuse during adolescence is highly correlated with cocaine addiction in adulthood. Abstinence of cocaine abuse can cause psychiatric symptoms, such as anxiety, psychosis, depression, and cognitive impairments. This study assessed the consequences of adolescent exposure to EtOH on the behavioral alterations promoted by cocaine withdrawal in adulthood...
2017: PloS One
https://www.readbyqxmd.com/read/28288856/environmental-enrichment-ameliorates-chronic-immobilisation-stress-induced-spatial-learning-deficits-and-restores-the-expression-of-bdnf-vegf-gfap-and-glucocorticoid-receptors
#9
B M Shilpa, V Bhagya, G Harish, M M Srinivas Bharath, B S Shankaranarayana Rao
Severe and prolonged stress is the main environmental factor that precipitates depression, anxiety and cognitive dysfunctions. On the other hand, exposure to environmental enrichment (EE) has been shown to induce progressive plasticity in the brain and improve learning and memory in various neurological and psychiatric disorders. It is not known whether exposure to enriched environment could ameliorate chronic immobilisation stress-induced cognitive deficits and altered molecular markers. Hence, in the present study we aimed to evaluate the effect of enriched environment on chronic immobilisation stress (CIS) associated changes in spatial learning and memory, behavioural measures of anxiety, depression and molecular markers as well as structural alterations...
March 10, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28287791/adolescent-chronic-restraint-stress-acrs-elicits-robust-depressive-like-behavior-in-freely-cycling-adult-female-rats-without-increasing-anxiety-like-behaviors
#10
Meghan Hibicke, Martha A Graham, Renée L Hayslett
Stress during times of rapid development is a risk factor for Major Depressive Disorder, a mood disorder that disproportionately affects women. We developed an adolescent chronic restraint stress (aCRS) protocol using female rats to address the impact of adolescent stress on female adult depressive-like behavior. Animals were divided into 4 treatment groups: not restrained:saline (NRSAL), not restrained:desipramine (NRDES), restrained:saline (RSAL), and restrained:desipramine (RDES). NRSAL and NRDES rats were housed in a separate colony room from RSAL and RDES rats...
March 13, 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28283324/early-mobilization-why-what-for-and-how
#11
A R Miranda Rocha, B P Martinez, V Z Maldaner da Silva, L A Forgiarini Junior
Early mobilization strategies in the intensive care unit may result in the prevention and reduction of polyneuromyopathy in the critical patient, improved quality of life, shortened ICU and hospital stay, and lesser mortality during hospitalization. However, it is well known that factors such as the protocol used, the population included in the studies, the timing of the strategy, the severity of the patients and different barriers directly influence the outcomes. This study examines the main protocols described in the literature and their associated results...
March 7, 2017: Medicina Intensiva
https://www.readbyqxmd.com/read/28278253/reduced-bone-formation-markers-and-altered-trabecular-and-cortical-bone-mineral-densities-of-non-paretic-femurs-observed-in-rats-with-ischemic-stroke-a-randomized-controlled-pilot-study
#12
Karen N Borschmann, Sarah S Rewell, Sandra Iuliano, Ali Ghasem-Zadeh, Rachel A Davey, Heidi Ho, Peta N Skeers, Julie Bernhardt, David W Howells
BACKGROUND: Immobility and neural damage likely contribute to accelerated bone loss after stroke, and subsequent heightened fracture risk in humans. OBJECTIVE: To investigate the skeletal effect of middle cerebral artery occlusion (MCAo) stroke in rats and examine its utility as a model of human post-stroke bone loss. METHODS: Twenty 15-week old spontaneously hypertensive male rats were randomized to MCAo or sham surgery controls. Primary outcome: group differences in trabecular bone volume fraction (BV/TV) measured by Micro-CT (10...
2017: PloS One
https://www.readbyqxmd.com/read/28276805/the-protective-effects-of-social-bonding-on-behavioral-and-pituitary-adrenal-axis-reactivity-to-chronic-mild-stress-in-prairie-voles
#13
Neal McNeal, Katherine M Appleton, Alan Kim Johnson, Melissa-Ann L Scotti, Joshua Wardwell, Rachel Murphy, Christina Bishop, Alison Knecht, Angela J Grippo
Positive social interactions may protect against stress. This study investigated the beneficial effects of pairing with a social partner on behaviors and neuroendocrine function in response to chronic mild stress (CMS) in 13 prairie vole pairs. Following 5 days of social bonding, male and female prairie voles were exposed to 10 days of CMS (mild, unpredictable stressors of varying durations, for instance, strobe light, white noise, and damp bedding), housed with either the social partner (paired group) or individually (isolated group)...
March 5, 2017: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/28271539/endoscopic-anterior-posterior-cricoid-split-for-pediatric-bilateral-vocal-fold-paralysis
#14
Michael J Rutter, Catherine K Hart, Alessandro de Alarcon, Sam Daniel, Sanjay R Parikh, Karthik Balakrishnan, Derek Lam, Kaalan Johnson, Douglas R Sidell
OBJECTIVES/HYPOTHESIS: Children with bilateral true vocal fold immobility (BTVFI) may present with significant airway distress necessitating tracheostomy. The objective of this study was to review our preliminary experience with the anterior-posterior cricoid split (APCS), an endoscopic intervention used as an alternative to tracheostomy in children with BTVFI. STUDY DESIGN: Multicenter review. METHODS: A review of patients undergoing endoscopic APCS for BTVFI at four institutions was performed...
March 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28270754/interaction-effect-of-social-isolation-and-high-dose-corticosteroid-on-neurogenesis-and-emotional-behavior
#15
Jackie N-M Chan, Jada C-D Lee, Sylvia S P Lee, Katy K Y Hui, Alan H L Chan, Timothy K-H Fung, Dalinda I Sánchez-Vidaña, Benson W-M Lau, Shirley P-C Ngai
Hypercortisolemia is one of the clinical features found in depressed patients. This clinical feature has been mimicked in animal studies via application of exogenous corticosterone (CORT). Previous studies suggested that CORT can induce behavioral disturbance in anxious-depressive like behavior, which is associated with suppressed neurogenesis. Hippocampal neurogenesis plays an important role in adult cognitive and behavioral regulation. Its suppression may thus lead to neuropsychiatric disorders. Similar to the effects of CORT on the animals' depression-like behaviors and neurogenesis, social deprivation has been regarded as one factor that predicts poor prognosis in depression...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28269444/muscle-fiber-excitation-system
#16
Bertram N Ezenwa, Thomas Kernozek
Persons unable to exercise due to old age, immobility or medical condition may develop low bone density, decline in muscle contraction, blood pooling or clot. Due to musculoskeletal fragility caution is required in bone and muscle strengthening. Similarly, caution is required to use anticoagulant drug to prevent blood clot due to side effect, and compression devices are not as effective as drug. This paper presents a transcutaneous muscle fiber excitation system adaptable for use in seated, walking or lying position...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267680/pressure-ulcer-prevalence-and-care-in-indonesian-hospitals-a-multicenter-cross-sectional-evaluation-using-an-extended-donabedian-model
#17
Yufitriana Amir, Frans E S Tan, Ruud Halfens, Christa Lohrmann, Jos Schols
Although the number of studies on pressure ulcer (PU) occurrence continues to grow, research regarding the quality of PU care and its effect on outcomes is limited. Using an extended Donabedian model, a 1-day, multicenter, cross-sectional evaluation of the quality of PU care was conducted in a convenience sample of Indonesian hospitals among patients ≥18 years of age in the medical, surgical, and intensive care units. Structure (ie, hospital attributes), process (recommended PU preventive measures), and outcome indicators (nosocomial PU prevalence excluding nonblanchable erythema), along with patient characteristics (age, gender, ethnicity, admission days, diseases [per ICD-10], recent surgery, PU categorization [4 categories according to National Pressure Ulcer Advisory Panel-European Pressure Ulcer Advisory Panel guidelines], PU history, care dependency, and Braden score) were examined...
February 2017: Ostomy/wound Management
https://www.readbyqxmd.com/read/28263826/borneol-enhances-the-antidepressant-effects-of-asiaticoside-by-promoting-its-distribution-into-the-brain
#18
Tianheng Hou, Xiaobo Li, Chongsheng Peng
Asiaticoside (AS) has antidepressant effects, with poor druggability characterized with inaccessibility into the brain. Here, we assessed AS distribution in the asiaticoside-borneol formula (FAB), with AS administrated orally. High performance liquid chromatography (HPLC) was applied for AS detection. The antidepressant effects of both FAB and AS were evaluated. Rats were subjected to behavioral despair paradigms and chronic unpredictable stress model (CUS) after acute and chronic drug administration, respectively...
March 3, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28259097/mammalian-target-of-rapamycin-mtor-nitric-oxide-system-possibly-modulate-antidepressant-like-effect-of-17%C3%AE-ethinyl-estradiol-in-ovariectomized-mice
#19
Seyed Soheil Saeedi Saravi, Alireza Arefidoust, Seyed Sobhan Saeedi Saravi, Rahele Yaftian, Mahdi Bayati, Milad Salehi, Ahmad Reza Dehpour
Due to a close association between depressive disorders and altered estrogen levels, this study was conducted to examine the hypothesis that antidepressant-like effect of ethinyl estradiol (EE2) in ovariectomized mice is modulated by mammalian target of rapamycin (mTOR)/nitric oxide pathways. Female mice were undergone bilateral ovariectomy and different doses of EE2 were intraperitoenally injected alone and combined with specific mTOR inhibitor, rapamycin, non-specific NOS inhibitor, L-NAME, nNOS inhibitor, 7-NI, NO precursor, l-arginine, and selective PDE5I, sildenafil...
March 1, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28255313/effect-of-concomitant-administration-of-three-different-antidepressants-with-vitamin-b6-on-depression-and-obsessive-compulsive-disorder-in-mice-models
#20
Azadeh Mesripour, Valiollah Hajhashemi, Athar Kuchak
Vitamin B6 is a cofactor of various enzymes influencing numerous neurotransmitters in the brain such as norepinephrin, and serotonin. Since these neurotransmitters influence mood, the aim the present work to evaluate the effect of vitamin B6 on depression and obsessive compulsive behavior when coadministred with clomipramine, fluoxetine, or venlafaxine. Male mice weighing 25-30 g were used. The immobility time and latency to immobility was measured in the forced swimming test as a model of despair and the number of marbles buried (MB) in an open field was used as the model of obsessive compulsive behavior in mice...
February 2017: Research in Pharmaceutical Sciences
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