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https://www.readbyqxmd.com/read/28320305/intermolecular-interactions-of-myosin-subfragment-1-induced-by-the-n-terminal-extension-of-essential-light-chain-1
#1
D S Logvinova, O P Nikolaeva, D I Levitsky
We applied dynamic light scattering (DLS) to compare aggregation properties of two isoforms of myosin subfragment 1 (S1) containing different "essential" (or "alkali") light chains, A1 or A2, which differ by the presence of an N-terminal extension in A1. Upon mild heating (up to 40°C), which was not accompanied by thermal denaturation of the protein, we observed a significant growth in the hydrodynamic radius of the particles for S1(A1), from ~18 to ~600-700 nm, whereas the radius of S1(A2) remained unchanged and equal to ~18 nm...
February 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/28306622/treatment-of-forearm-deformity-with-radial-head-dislocation-because-of-multiple-osteochondromas-a-series-of-three-cases-treated-by-simple-axis-correction-and-distraction-osteogenesis-of-the-ulna
#2
Kousuke Iba, Megumi Hanaka, Yasuhiro Ozasa, Nobuyuki Takahashi, Kohei Kanaya, Toshihiko Yamashita
Radial head dislocation in multiple osteochondroma leads to functional impairment and cosmetic problems, and surgical intervention has not been successful to date, with high rates of redislocation. Simple correction of the longitudinal axis and distraction oste8ogenesis of the ulna without corrective osteotomy of the radius were performed within 1 year of radial head dislocation. The mean age of the patients was 7.2 years and the postoperative follow-up duration was 63.6 months. In all cases, the dislocated radial head was repositioned without surgical invention involving the radius...
March 16, 2017: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/28302571/alpha-9-nicotinic-acetylcholine-receptors-mediate-hypothermic-responses-elicited-by-provocative-motion-in-mice
#3
Longlong Tu, Lauren Poppi, John Rudd, Ethan T Cresswell, Doug W Smith, Alan Brichta, Eugene Nalivaiko
Hypothermic responses accompany motion sickness in humans and can be elicited by provocative motion in rats. We aimed to determine the potential role in these responses of the efferent cholinergic vestibular innervation. To this end, we used knockout (KO) mice lacking α9 cholinoreceptor subunit predominantly expressed in the vestibular hair cells and CBA strain as a wild-type (WT) control. In WT mice, circular horizontal motion (1Hz, 4cm radius, 20min) caused rapid and dramatic falls in core body temperature and surface head temperature associated with a transient rise in the tail temperature; these responses were substantially attenuated in KO mice; changes were (WT vs...
March 14, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28297276/rounded-leaf-end-modeling-in-pinnacle-vmat-treatment-planning-for-fixed-jaw-linacs
#4
Lori A Young, Fei Yang, Ning Cao, Juergen Meyer
During volume-modulated arc therapies (VMAT), dosimetric errors are introduced by multiple open dynamic leaf gaps that are present in fixed diaphragm linear accelerators. The purpose of this work was to develop a methodology for adjusting the rounded leaf end modeling parameters to improve out-of-field dose agreement in SmartArc VMAT treatment plans delivered by fixed jaw linacs where leaf gap dose is not negligible. Leaf gap doses were measured for an Elekta beam modulator linac with 0.4 cm micro-multileaf collimators (MLC) using an A16 micro-ionization chamber, a MatriXX ion chamber detector array, and Kodak EDR2 film dosimetry in a solid water phantom...
November 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28279880/electrobioremediation-of-oil-spills
#5
REVIEW
Matteo Daghio, Federico Aulenta, Eleni Vaiopoulou, Andrea Franzetti, Jan B A Arends, Angela Sherry, Ana Suárez-Suárez, Ian M Head, Giuseppina Bestetti, Korneel Rabaey
Annually, thousands of oil spills occur across the globe. As a result, petroleum substances and petrochemical compounds are widespread contaminants causing concern due to their toxicity and recalcitrance. Many remediation strategies have been developed using both physicochemical and biological approaches. Biological strategies are most benign, aiming to enhance microbial metabolic activities by supplying limiting inorganic nutrients, electron acceptors or donors, thus stimulating oxidation or reduction of contaminants...
February 20, 2017: Water Research
https://www.readbyqxmd.com/read/28259283/impact-of-distal-ulnar-fracture-malunion-on-distal-radioulnar-joint-instability-a-biomechanical-study-of-the-distal-interosseous-membrane-using-a-cadaver-model
#6
Satoshi Miyamura, Atsuo Shigi, Jirachart Kraisarin, Shohei Omokawa, Tsuyoshi Murase, Hideki Yoshikawa, Hisao Moritomo
PURPOSE: Certain distal ulna fractures may contribute to distal radioulnar joint (DRUJ) instability. We hypothesized that residual distal ulna translation could affect DRUJ stability by slackening the distal interosseous membrane (DIOM). We aimed to test this hypothesis in a cadaver model. METHODS: We created an ulnar translated distal ulna fracture model in 6 cadavers. Dorsal and palmar displacements of the ulna relative to the radius were measured and DRUJ instability was staged under the following conditions: (1) 0-, 2-, and 4-mm ulnar translation of the distal ulna with an intact triangular fibrocartilage complex (TFCC) and DIOM; (2) 0-, 2-, and 4-mm translations with TFCC divided and an intact DIOM; and (3) a 0-mm translation with TFCC and DIOM divided...
March 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28258886/cross-calibrated-dual-energy-x-ray-absorptiometry-scanners-demonstrate-systematic-bias-in-pediatric-and-young-adult-females
#7
Jodi N Dowthwaite, Kristen A Dunsmore, Dongliang Wang, Paula F Rosenbaum, Tamara A Scerpella
Consistency of dual-energy X-ray absorptiometry (DXA) scan results is critical for data integrity. For pediatric subjects, the extent to which cross-calibration of DXA scanners alleviates model-to-model scanner differences is unclear. In the current study, DXA bone outcomes were compared for same-day measurements performed using different scanners, cross-calibrated to alleviate discrepancies (Hologic; Discovery A [DISCO] and QDR 4500W [QDR]). Interscanner differences were evaluated in approximately 130 females aged 8-24 yr...
February 28, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28249791/an-evaluation-of-forearm-deformities-in-hereditary-multiple-exostoses-factors-associated-with-radial-head-dislocation-and-comprehensive-classification
#8
Ah Reum Jo, Sung Taek Jung, Myung Sun Kim, Chang Seon Oh, Byung Ju Min
PURPOSE: This study attempted to evaluate a series of patients with hereditary multiple exostoses (HME) who could not be categorized according to the widely accepted Masada classification and to identify radiographic variables such as radial bowing, ulnar shortening, ulnar variance, radial articular angle, and carpal slip predictive of deformity. METHODS: We retrospectively reviewed data on 102 upper limbs of 53 pediatric patients with HME. Demographics, site of forearm involvement, and radiographic parameters were documented...
February 27, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28238092/radial-shortening-osteotomy-reduces-radiocapitellar-contact-pressures-while-preserving-valgus-stability-of-the-elbow
#9
Michael Hackl, Kilian Wegmann, Stephanie L Kahmann, Nicolai Heinze, Manfred Staat, Wolfram F Neiss, Martin Scaal, Lars P Müller
PURPOSE: Shortening osteotomy of the proximal radius might represent a potential salvage procedure in symptomatic radiocapitellar osteoarthritis, which could decrease radiocapitellar load while preserving the native radial head. In an in-vitro biomechanical investigation, we sought to determine whether shortening osteotomy of the proximal radius (1) decreases the radiocapitellar joint pressure upon axial loading and (2) retains valgus stability of the elbow. In addition, the anatomic configuration of the lesser sigmoid notch was evaluated to assess possible contraindications...
February 25, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28225285/multiscale-modeling-of-the-effects-of-salt-and-perfume-raw-materials-on-the-rheological-properties-of-commercial-threadlike-micellar-solutions
#10
Xueming Tang, Weizhong Zou, Peter H Koenig, Shawn D McConaughy, Mike R Weaver, David M Eike, Michael J Schmidt, Ronald G Larson
We link micellar structures to their rheological properties for two surfactant body-wash formulations at various concentrations of salts and perfume raw materials (PRMs) using molecular simulations and micellar-scale modeling, as well as traditional surfactant packing arguments. The two body washes, namely, BW-1EO and BW-3EO, are composed of sodium lauryl ethylene glycol ether sulfate (SLEnS, where n is the average number of ethylene glycol repeat units), cocamidopropyl betaine (CAPB), ACCORD (which is a mixture of six PRMs), and NaCl salt...
March 13, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28164054/a-very-rare-presentation-of-type-1-monteggia-equivalent-fracture-with-ipsilateral-fracture-of-distal-forearm-approach-with-outcome-case-report
#11
Dhananjay Singh, Bhanu Awasthi, Vikas Padha, Sanjay Thakur
INTRODUCTION: We report a case of Type 1 Monteggia equivalent injury with intact radio-capitellar congruity, associated with epiphyseal fracture of distal radius and distal ulna shaft in an 11-year-old boy. There are only a few cases of Monteggia or Monteggia equivalent injury with ipsilateral forearm fractures in children, and injury pattern being reported by us is not only rare but also the only case reported thus far to the best of our knowledge, Sood et al. described Type 1 equivalent with epiphyseal injuries of both radius and ulna Osada et al...
September 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28153481/percutaneous-reduction-of-proximal-radius-fracture-in-adults-a-12-case-series
#12
Antoine Peyronnet, Clément Marc, Romain Lancigu, Louis Rony, Patrick Cronier, Laurent Hubert
INTRODUCTION: Fractures of the head or neck of the radius account for 5% of elbow fractures in adults. Treatment varies between authors. MATERIAL AND METHODS: We report a retrospective series of 12 cases of percutaneous reduction of Mason II radial head fracture, without internal fixation. RESULTS: All fractures consolidated, without secondary displacement. There were no postoperative complications. Mean ranges of motion were 136° flexion-extension and 175° pronation-supination...
January 30, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28114022/kinesthetic-feedback-during-2dof-wrist-movements-via-a-novel-mr-compatible-robot
#13
Andrew Erwin, Marcia O'Malley, David Ress, Fabrizio Sergi
We demonstrate the interaction control capabilities of the MR-SoftWrist, a novel MR-compatible robot capable of applying accurate kinesthetic feedback to wrist pointing movements executed during fMRI. The MR-SoftWrist, based on a novel design that combines parallel piezoelectric actuation with compliant force feedback, is capable of delivering 1.5 N·m of torque to the wrist of an interacting subject about the flexion/extension and radial/ulnar axes. The robot workspace, defined by admissible wrist rotation angles, fully includes a circle with a 20 deg radius...
December 1, 2016: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28088646/bone-microarchitecture-in-adolescent-boys-with-autism-spectrum-disorder
#14
Ann M Neumeyer, Natalia Cano Sokoloff, Erin McDonnell, Eric A Macklin, Christopher J McDougle, Madhusmita Misra
BACKGROUND: Boys with autism spectrum disorder (ASD) have lower areal bone mineral density (aBMD) than typically developing controls (TDC). Studies of volumetric BMD (vBMD) and bone microarchitecture provide information about fracture risk beyond that provided by aBMD but are currently lacking in ASD. OBJECTIVES: To assess ultradistal radius and distal tibia vBMD, bone microarchitecture and strength estimates in adolescent boys with ASD compared to TDC. DESIGN/METHODS: Cross-sectional study of 34 boys (16 ASD, 18 TDC) that assessed (i) aBMD at the whole body (WB), WB less head (WBLH), hip and spine using dual X-ray absorptiometry (DXA), (ii) vBMD and bone microarchitecture at the ultradistal radius and distal tibia using high-resolution peripheral quantitative CT (HRpQCT), and (iii) bone strength estimates (stiffness and failure load) using micro-finite element analysis (FEA)...
January 11, 2017: Bone
https://www.readbyqxmd.com/read/28070676/-upper-extremity-fractures-in-the-elderly
#15
Roland Biber, S Grüninger, H J Bail
Upper extremity fractures in the elderly are very frequent and second only to hip fractures in the group of fragility fractures. Their impact on mobility and functional decline seems to be underestimated especially when they occur in combination with lower extremity fractures. Fractures of the proximal humerus and the distal radius can often be treated conservatively; however, the indications for operative treatment must not be based on fracture morphology alone and due consideration should be given to all concomitant circumstances affecting functional aspects of patients...
January 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/28066887/the-effect-of-beam-purity-and-scanner-complexity-on-proton-ct-accuracy
#16
P Piersimoni, J Ramos-Méndez, T Geoghegan, V A Bashkirov, R W Schulte, B A Faddegon
PURPOSE: To determine the dependence of the accuracy in reconstruction of relative stopping power (RSP) with proton computerized tomography (pCT) scans on the purity of the proton beam and the technological complexity of the pCT scanner using standard phantoms and a digital representation of a pediatric patient. METHODS: The Monte Carlo method was applied to simulate the pCT scanner, using both a pure proton beam (uniform 200 MeV mono-energetic, parallel beam) and the Northwestern Medicine Chicago Proton Center (NMCPC) clinical beam in uniform scanning mode...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28064003/a-semi-automated-quantitative-ct-method-for-measuring-rotator-cuff-muscle-degeneration-in-shoulders-with-primary-osteoarthritis
#17
Alexandre Terrier, Julien Ston, Antoine Dewarrat, Fabio Becce, Alain Farron
BACKGROUND: Rotator cuff muscle degeneration is an important parameter to consider when planning shoulder arthroplasty. HYPOTHESIS: We hypothesized that rotator cuff muscle degeneration is correlated with scapulohumeral subluxation in patients planned for anatomical total shoulder arthroplasty (TSA). MATERIALS AND METHODS: We developed a semi-automated quantitative CT method to measure rotator cuff muscle degeneration, and retrospectively analyzed 107 preoperative shoulder CT scans of patients with primary osteoarthritis...
January 4, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28048763/su-g-brc-10-feasibility-of-a-web-based-monte-carlo-simulation-tool-for-dynamic-electron-arc-radiotherapy-dear
#18
A Rodrigues, D Sawkey, Q Wu
PURPOSE: DEAR is a radiation therapy technique utilizing synchronized motion of gantry and couch during delivery to optimize dose distribution homogeneity and penumbra for treatment of superficial disease. Dose calculation for DEAR is not yet supported by commercial TPSs. The purpose of this study is to demonstrate the feasibility of using a web-based Monte Carlo (MC) simulation tool (VirtuaLinac) to calculate dose distributions for a DEAR delivery. METHODS: MC simulations were run through VirtuaLinac, which is based on the GEANT4 platform...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048001/su-f-t-66-characteristics-of-electron-beams-from-varian-trubeam
#19
A Dimofte, C Kennedy, T Zhu
PURPOSE: The purpose of this study was to compare the electron beam data between Truebeam and 2300ix Varian accelerators for percent depth dose for broad beam and small circular cutouts, cone factors, head scatter factor as a function of cone size and SSD, phantom scatter factor, blocking factor, distance factor and virtual source position. METHODS: Measurements were performed for Truebeam and 2300ix Varian accelerators. The main energies used were: 6, 9, 12, 16 and 20 MeV...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047762/su-f-t-496-an-investigation-of-two-novel-devices-for-testing-linac-clearance-during-ct-simulation
#20
A Morrow, B Massingill
PURPOSE: This work's objective is to determine the efficacy of two newly patented devices termed the Mor-O rings, Mark1 and Mark2, developed to predict collisions between the patient and a linac at the time of CT simulation. METHODS: Mark1: A ring with an inner radius equal to the distance between the isocenter and the nearest portion of a linac head(diso) was made. This is mounted to a stand that allows vertical repositioning. The ring is placed around the patient on the CT table and aligned with isocenter...
June 2016: Medical Physics
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