keyword
https://read.qxmd.com/read/38540991/is-there-a-place-for-apheresis-in-the-management-of-idiopathic-membranous-nephropathy-a-report-of-three-cases-and-literature-review
#1
JOURNAL ARTICLE
Hamza Naciri Bennani, Augustin Twite Banza, Diane Giovannini, Lionel Motte, Johan Noble, Alexandra Corbu, Paolo Malvezzi, Thomas Jouve, Lionel Rostaing
Membranous nephropathy constitutes approximately 20% of adult nephrotic syndrome cases. In approximately 80% of cases, membranous nephropathy is primary, mediated by IgG autoantibodies primarily targeting podocyte antigens (PLA2R, THSD7A, etc.). The treatment involves a combination of corticosteroids and cyclophosphamide or anti-CD20-based therapies, e.g., rituximab. In the event of significant proteinuria and in order to avoid the urinary elimination of rituximab, therapeutic apheresis, in particular semi-specific immunoadsorption, may be an option allowing for a reduction in proteinuria and autoantibodies before initiating treatment with rituximab...
February 26, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38535536/supportive-treatment-of-a-dog-with-leishmaniosis-and-severe-glomerulopathy-with-immunoadsorption
#2
Florian Sänger, Michèle Bergmann, Katrin Hartmann, René Dörfelt
A three-year-old, intact female mix-breed dog, weighing 30 kg, was presented due to vomitus and diarrhea. At presentation, the patient had a slightly reduced general condition and moderately enlarged mandibular and popliteal lymph nodes. The initial blood work showed severe azotemia and hypoalbuminemia. In the urinalysis, marked proteinuria with a urine protein/creatinine ratio (UPC) of 4.69 was found. Further workup showed a high leishmania antibody titer. The dog was diagnosed with leishmaniosis and glomerulonephritis...
February 21, 2024: Pathogens
https://read.qxmd.com/read/38502222/therapeutic-apheresis-is-it-safe-in-children-with-kidney-disease
#3
JOURNAL ARTICLE
Muhammed Doğukan Kalenderoğlu, Elif Çomak, Gülşah Kaya Aksoy, Uğur Bilge, Osman Alphan Küpesiz, Mustafa Koyun, Sema Akman
BACKGROUND: Therapeutic apheresis (TA) is already used to treat various diseases in the field of nephrology. The aim of this study was to evaluate the frequency and types of complications that occur during TA in children with kidney disease. METHODS: Records of children (≤ 18 years) who underwent TA between 2007 and 2022 were retrospectively reviewed. Children with missing data and those with a diagnosis of nonnephrological disease were excluded...
March 19, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38473836/the-utility-of-miniaturized-adsorbers-in-exploring-the-cellular-and-molecular-effects-of-blood-purification-a-pilot-study-with-a-focus-on-immunoadsorption-in-multiple-sclerosis
#4
JOURNAL ARTICLE
Andreas Körtge, Anne Breitrück, Sandra Doß, Jacqueline Hofrichter, Sophie-Charlotte Nelz, Horst Krüsemann, Reinhold Wasserkort, Brit Fitzner, Michael Hecker, Steffen Mitzner, Uwe Klaus Zettl
Immunoadsorption (IA) has proven to be clinically effective in the treatment of steroid-refractory multiple sclerosis (MS) relapses, but its mechanism of action remains unclear. We used miniaturized adsorber devices with a tryptophan-immobilized polyvinyl alcohol (PVA) gel sorbent to mimic the IA treatment of patients with MS in vitro. The plasma was screened before and after adsorption with regard to disease-specific mediators, and the effect of the IA treatment on the migration of neutrophils and the integrity of the endothelial cell barrier was tested in cell-based models...
February 23, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38454468/ia-pacs-cfs-a-double-blinded-randomized-sham-controlled-exploratory-trial-of-immunoadsorption-in-patients-with-chronic-fatigue-syndrome-cfs-including-patients-with-post-acute-covid-19-cfs-pacs-cfs
#5
JOURNAL ARTICLE
Hannah Preßler, Marie-Luise Machule, Friederike Ufer, Isabel Bünger, Lucie Yuanting Li, Emilie Buchholz, Claudia Werner, Esther Beraha, Frank Wagner, Matthes Metz, Susen Burock, Lisa Bruckert, Christiana Franke, Nicola Wilck, Anne Krüger, Alexander Reshetnik, Kai-Uwe Eckardt, Matthias Endres, Harald Prüss
BACKGROUND: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severely debilitating condition which markedly restricts activity and function of affected people. Since the beginning of the COVID-19 pandemic ME/CFS related to post-acute COVID-19 syndrome (PACS) can be diagnosed in a subset of patients presenting with persistent fatigue 6 months after a mostly mild SARS-CoV-2 infection by fulfillment of the Canadian Consensus Criteria (CCC 2003). Induction of autoimmunity after viral infection is a mechanism under intensive investigation...
March 7, 2024: Trials
https://read.qxmd.com/read/38310704/chimeric-aqp4-based-immunosorbent-for-highly-specific-removal-of-aqp4-igg-from-blood
#6
JOURNAL ARTICLE
Xiaofei Wang, Fangling Ji, Lingyun Jia
Anti-aquaporin-4 autoantibodies (AQP4-IgG) are implicated in the pathogenesis of neuromyelitis optica spectrum disorders (NMOSD), and their removal from the blood circulation is considered to be an effective method for acute treatment. An ideal extracorporeal AQP4-IgG removal system should have high specificity, which means that it can selectively remove AQP4-IgG without affecting normal immunoglobulins. However, the conventional tryptophan immobilized column lacks sufficient specificity and cannot achieve this goal...
February 22, 2024: Journal of Chromatography. A
https://read.qxmd.com/read/38200764/successful-emergency-management-of-a-dog-with-ventilator-dependent-acquired-myasthenia-gravis-with-immunoadsorption
#7
Florian Sänger, Stefanie Dörfelt, Bettina Giani, Gesine Buhmann, Andrea Fischer, René Dörfelt
A one-year-old, female intact Samoyed, 12.5 kg, was presented with coughing for 2 weeks, progressive appendicular and axial muscle weakness, megaesophagus and labored breathing for 5 days. There was no improvement with standard treatment. Acquired myasthenia gravis was suspected and the dog was referred with increasing dyspnea. At presentation, the dog showed a severely reduced general condition, was non-ambulatory and showed abdominal and severely labored breathing. A marked hypercapnia (PvCO2 = 90.1 mmHg) was present in venous blood gas analysis...
December 21, 2023: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38174665/development-of-novel-treatment-for-pemphigus-and-confirmation-of-its-efficacy-a-randomized-controlled-trial-of-protein-a-immunoadsorption-therapy
#8
EDITORIAL
Takashi Hashimoto, Jun Yamagami
No abstract text is available yet for this article.
January 4, 2024: British Journal of Dermatology
https://read.qxmd.com/read/38152089/guideline-for-the-management-of-myasthenic-syndromes
#9
REVIEW
Heinz Wiendl, Angela Abicht, Andrew Chan, Adela Della Marina, Tim Hagenacker, Khosro Hekmat, Sarah Hoffmann, Hans-Stefan Hoffmann, Sebastian Jander, Christian Keller, Alexander Marx, Arthur Melms, Nico Melzer, Wolfgang Müller-Felber, Marc Pawlitzki, Jens-Carsten Rückert, Christiane Schneider-Gold, Benedikt Schoser, Bettina Schreiner, Michael Schroeter, Bettina Schubert, Jörn-Peter Sieb, Fritz Zimprich, Andreas Meisel
Myasthenia gravis (MG), Lambert-Eaton myasthenic syndrome (LEMS), and congenital myasthenic syndromes (CMS) represent an etiologically heterogeneous group of (very) rare chronic diseases. MG and LEMS have an autoimmune-mediated etiology, while CMS are genetic disorders. A (strain dependent) muscle weakness due to neuromuscular transmission disorder is a common feature. Generalized MG requires increasingly differentiated therapeutic strategies that consider the enormous therapeutic developments of recent years...
2023: Therapeutic Advances in Neurological Disorders
https://read.qxmd.com/read/38136038/-multisystem-inflammatory-syndrome-in-children-like-disease-after-covid-19-vaccination-mis-v-with-potential-significance-of-functional-active-autoantibodies-targeting-g-protein-coupled-receptors-gpcr-faab-for-pathophysiology-and-therapy
#10
Marius Schmidt, Steven Hébert, Gerd Wallukat, Rolf Ponader, Tobias Krickau, Matthias Galiano, Heiko Reutter, Joachim Woelfle, Abbas Agaimy, Christian Mardin, André Hoerning, Bettina Hohberger
BACKGROUND: An infection with SARS-CoV-2 can trigger a systemic disorder by pathological autoimmune processes. A certain type of this dysregulation is known as Multisystemic inflammatory syndrome in children (MIS-C). However, similar symptoms may occur and have been described as Multisystemic inflammatory syndrome after SARS-CoV-2 Vaccination (MIS-V) following vaccination against SARS-CoV-2. We report the case of a 12-year-old boy who was identified with MIS-C symptoms without previous SARS-CoV-2 infection after receiving two doses of the Pfizer-BioNTech COVID-19 vaccine approximately one month prior to the onset of symptoms...
November 22, 2023: Children
https://read.qxmd.com/read/38133541/efficacy-and-safety-of-adjuvant-immunoadsorption-in-pemphigus-vulgaris-and-pemphigus-foliaceus-ia-pem-study-a-multicentre-randomised-controlled-trial
#11
JOURNAL ARTICLE
Nina van Beek, Rüdiger Eming, Alexander Reuss, Detlef Zillikens, Miklós Sárdy, Claudia Günther, Dimitra Kiritsi, Sandrine Benoit, Stefan Beissert, Regine Gläser, Harald Gollnick, Orsolya N Horváth, Christiane Pfeiffer, Martin Röcken, Franziska Schauer, Stephan Schreml, Kerstin Steinbrink, Alexander Zink, Carmen Schade-Brittinger, Michael Hertl, Enno Schmidt
BACKGROUND: Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are potentially life-threatening autoimmune blistering diseases. Treatment is based on long term immunosuppression with high doses of glucocorticosteroids in combination with potentially corticosteroid-sparing agents and/or rituximab. Immunoadsorption (IA) has emerged as fast acting adjuvant treatment option. OBJECTIVES: To assess the clinical efficacy of IA in addition to best medical treatment. METHODS: Multicentre (26 centres from Germany and Austria) randomised controlled trial in 72 patients with newly diagnosed, relapsed or chronic active PV or PF (34 females, 38 males, aged 42-72 years) comparing best medical treatment (BMT) (prednisolone 1...
December 22, 2023: British Journal of Dermatology
https://read.qxmd.com/read/38125878/retracted-effects-of-dna-immunoadsorption-combined-with-medication-on-immune-function-and-renal-function-in-patients-with-systemic-lupus-erythematosus
#12
Journal Of Environmental And Public Health
[This retracts the article DOI: 10.1155/2023/2843979.].
2023: Journal of Environmental and Public Health
https://read.qxmd.com/read/38068526/de-novo-donor-specific-antibodies-after-heart-transplantation-a-comprehensive-guide-for-clinicians
#13
REVIEW
Irene Marco, Juan Carlos López-Azor García, Javier González Martín, Andrea Severo Sánchez, María Dolores García-Cosío Carmena, Esther Mancebo Sierra, Javier de Juan Bagudá, Javier Castrodeza Calvo, Francisco José Hernández Pérez, Juan Francisco Delgado
Antibodies directed against donor-specific human leukocyte antigens (HLAs) can be detected de novo after heart transplantation and play a key role in long-term survival. De novo donor-specific antibodies (dnDSAs) have been associated with cardiac allograft vasculopathy, antibody-mediated rejection, and mortality. Advances in detection methods and international guideline recommendations have encouraged the adoption of screening protocols among heart transplant units. However, there is still a lack of consensus about the correct course of action after dnDSA detection...
December 2, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/38063248/recurrent-hypoglycemia-induced-by-clopidogrel-a-case-report-and-mini-review
#14
REVIEW
Weiguan Du, Haining Wang, Ye Liu, Tianpei Hong
This report describes a patient who developed recurrent hypoglycemia episodes after 23 days of antiplatelet therapy with clopidogrel for left subclavian artery stent implantation. The patient suffered from palpitation, profuse sweating and weakness on the 23rd day of clopidogrel treatment. The minimum plasma glucose was 2.2 mmol/L, and the hypoglycemia was associated with significantly elevated levels of insulin. A diagnosis of insulin autoimmune syndrome (IAS) was made with the presence of insulin autoantibody and a comprehensive differential diagnosis of other conditions related with hypoglycemia...
December 8, 2023: Journal of Diabetes Investigation
https://read.qxmd.com/read/38042838/top-100-cited-articles-in-the-thromboangiitis-obliterans-a-bibliometric-analysis-and-visualized-study
#15
JOURNAL ARTICLE
Zhenxing Liu, Weiwei Ning, Jinlong Liang, Tao Zhang, Qingxu Yang, Jie Zhang, Ming Xie
OBJECTIVE: Thromboangiitis obliterans (TAO) is one of the most common types of peripheral arterial disease (PAD). This study aimed to explore the characteristics of the top 100 most cited articles in the TAO. METHODS: A bibliometric analysis based on the Web of Science (WOS) database was performed. Literature was retrieved and ranked by the citations. Listed below are the top 100 citations, including original articles, reviews, full-length proceeding papers, and case reports that were included for analysis...
December 2, 2023: European Journal of Medical Research
https://read.qxmd.com/read/38022864/blood-group-specific-apheresis-in-combination-with-daratumumab-as-a-rescue-therapy-of-acute-antibody-mediated-rejection-in-a-case-of-abo-and-human-leukocyte-antigen-incompatible-kidney-transplantation
#16
Can C Süsal, Leonie Kraft, Andrea Ender, Caner Süsal, Amelie Schwenger, Kerstin Amann, Georg A Böhmig, Vedat Schwenger
We report a case of antibody-mediated rejection treated with the human CD38 monoclonal antibody daratumumab in a 58-year-old female patient with end-stage kidney disease due to autosomal dominant polycystic kidney disease who received an ABO- and human leukocyte antigen antibody-incompatible living donor kidney transplant. The patient experienced an episode of severe antibody-mediated rejection within the first week of transplantation. Blood-group-antibody selective immunoadsorption in combination with administration of four doses of daratumumab (each 1800 mg s...
2023: SAGE Open Medical Case Reports
https://read.qxmd.com/read/38008686/therapeutic-apheresis-in-renal-transplantation-an-update
#17
REVIEW
Christina Melexopoulou, Vassilis Filiopoulos, Smaragdi Marinaki
Therapeutic apheresis (TA) plays a significant role in various aspects of renal transplantation. It has been a necessary preconditioning component in ABO incompatible kidney transplants and an important modality in the removal of anti-human leukocyte antigen (HLA) antibodies both in the context of desensitization protocols that have been developed to allow highly sensitized kidney transplant candidates to be successfully transplanted and as treatment of antibody mediated rejection episodes post transplantation...
November 17, 2023: Transfusion and Apheresis Science
https://read.qxmd.com/read/37978039/therapeutic-apheresis-in-renal-transplantation-an-update
#18
REVIEW
Christina Melexopoulou, Vassilis Filiopoulos, Smaragdi Marinaki
Therapeutic apheresis (TA) plays a significant role in various aspects of renal transplantation. It has been a necessary preconditioning component in ABO incompatible kidney transplants and an important modality in the removal of anti-human leukocyte antigen (HLA) antibodies both in the context of desensitization protocols that have been developed to allow highly sensitized kidney transplant candidates to be successfully transplanted and as treatment of antibody mediated rejection episodes post transplantation...
November 3, 2023: Transfusion and Apheresis Science
https://read.qxmd.com/read/37923937/weaning-and-extubation-failure-in-myasthenic-crisis-a-multicenter-analysis
#19
JOURNAL ARTICLE
Bernhard Neumann, Klemens Angstwurm, Christian Dohmen, Philipp Mergenthaler, Siegfried Kohler, Silvia Schönenberger, De-Hyung Lee, Stefan T Gerner, Hagen B Huttner, Andrea Thieme, Andreas Steinbrecher, Juliane Dunkel, Christian Roth, Hauke Schneider, Heinz Reichmann, Hannah Fuhrer, Ingo Kleiter, Christiane Schneider-Gold, Anke Alberty, Jan Zinke, Michael Schroeter, Ralf Linker, Andreas Meisel, Julian Bösel, Henning R Stetefeld
Myasthenic crisis (MC) requiring mechanical ventilation is a serious complication of myasthenia gravis (MG). Here we analyze the frequency and risk factors of weaning- and extubation failure as well as its impact on the clinical course in a large cohort. We performed a retrospective chart review on patients treated for MC in 12 German neurological departments between 2006 and 2015. Weaning failure (WF) was defined as negative spontaneous breathing trial, primary tracheostomy, or extubation failure (EF) (reintubation or death)...
November 3, 2023: Journal of Neurology
https://read.qxmd.com/read/37853934/clinical-application-of-blood-purification-in-polymyositis-dermatomyositis
#20
JOURNAL ARTICLE
Jieting Jia, Defang Meng, Xuexiang Zhang, Nalin Lai, Beibei Zhou, Hua Wei, Xiaocong Li
INTRODUCTION: We investigated the clinical efficacy and safety of blood purification technology in patients with polymyositis/dermatomyositis. METHODS: In a study of 22 patients, 10 cases received blood purification treatment (5 cases received plasma exchange, 5 cases received plasma HA280 immunoadsorption), and 12 cases served as the control group. A 3-month follow-up was conducted to compare the clinical manifestations and laboratory examination. RESULTS: Symptoms and signs of patients in treatment group were significantly improved, and the hormone usage was lower than the control group...
February 2024: Therapeutic Apheresis and Dialysis
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