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https://www.readbyqxmd.com/read/28091538/mircorna-145-promotes-activation-of-hepatic-stellate-cells-via-targeting-kr%C3%A3-ppel-like-factor-4
#1
Ruoting Men, Maoyao Wen, Mingyue Zhao, Xuelian Dan, Zongze Yang, Wenchao Wu, Maggie Haitian Wang, Xiaojing Liu, Li Yang
Krüppel-like Factor 4 (KLF4), a target gene of miR-145, can negatively regulate lung fibrosis. However, the potential role of KLF4 and miR-145 in hepatic stellate cells (HSCs) activation or in hepatic fibrosis keeps unclear. This study aims to characterize miR-145 and KLF4 in activated HSCs and liver cirrhotic, and the underlying molecular basis. miR-145 was significantly up-regulated, while KLF4 was dramatically down-regulated during the activation of rat primary HSCs and TGF-βtreated HSCs. Furthermore, miR-145 mimics induced and inhibition of miR-145 reduced α-SMA and COL-I expression in primary HSCs...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28086983/mailed-hpv-self-sampling-for-cervical-cancer-screening-among-underserved-minority-women-study-protocol-for-a-randomized-controlled-trial
#2
Erin Kobetz, Julia Seay, Anthony Amofah, Larry Pierre, Jordan Baeker Bispo, Dinah Trevil, Martha Gonzalez, Martine Poitevien, Tulay Koru-Sengul, Olveen Carrasquillo
BACKGROUND: Underserved ethnic minority women experience significant disparities in cervical cancer incidence and mortality, mainly due to lack of cervical cancer screening. Barriers to Pap smear screening include lack of knowledge, lack of health insurance and access, and cultural beliefs regarding disease prevention. In our previous SUCCESS trial, we demonstrated that HPV self-sampling delivered by a community health worker (CHW) is efficacious in circumventing these barriers. This approach increased screening uptake relative to navigation to Pap smear screening...
January 13, 2017: Trials
https://www.readbyqxmd.com/read/27987670/application-of-acellular-intima-from-porcine-thoracic-aorta-in-full-thickness-skin-wound-healing-in-a-rat-model
#3
Haitian Fu, Liping Teng, RuiZhen Bai, Chao Deng, Guozhong Lv, Jinghua Chen
The tunica intima of aorta is made up of one layer of smooth endothelium and basement membrane. The basement membrane is rich in extracellular matrix (ECM) molecules, including collagen, glycosaminoglycans (e.g., heparan sulfate), proteoglycans (e.g., perlecan), and glycoproteins. All or most of these components are involved in wound healing process. In this work, we determined whether the acellular intima from porcine thoracic aorta can be a new kind of xenograft to repair the skin-wound surface in a rat model...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27977644/assessing-change-in-avian-influenza-a-h7n9-virus-infections-during-the-fourth-epidemic-china-september-2015-august-2016
#4
Nijuan Xiang, Xiyan Li, Ruiqi Ren, Dayan Wang, Suizan Zhou, Carolyn M Greene, Ying Song, Lei Zhou, Lei Yang, C Todd Davis, Ye Zhang, Yali Wang, Jian Zhao, Xiaodan Li, A Danielle Iuliano, Fiona Havers, Sonja J Olsen, Timothy M Uyeki, Eduardo Azziz-Baumgartner, Susan Trock, Bo Liu, Haitian Sui, Xu Huang, Yanping Zhang, Daxin Ni, Zijian Feng, Yuelong Shu, Qun Li
Since human infections with avian influenza A(H7N9) virus were first reported by the Chinese Center for Disease Control and Prevention (China CDC) in March 2013 (1), mainland China has experienced four influenza A(H7N9) virus epidemics. Prior investigations demonstrated that age and sex distribution, clinical features, and exposure history of A(H7N9) virus human infections reported during the first three epidemics were similar (2). In this report, epidemiology and virology data from the most recent, fourth epidemic (September 2015-August 2016) were compared with those from the three earlier epidemics...
December 16, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27941464/end-of-life-in-a-haitian-american-faith-based-community-caring-for-family-and-communal-unity
#5
Susan Charlotte Ladd, Shirley C Gordon
This article presents two models resulting from a grounded theory study of the end-of-life decision-making process for Haitian Americans. Successful access to this vulnerable population was achieved through the faith-based community. The first model describes this faith-based community of Haitian Americans. The second model describes the process used by families in this community who must make end-of-life healthcare decisions. Implications for nursing practice and caring science include a need to improve the congruence between the nursing care provided at this vulnerable time and the cultural values of a population...
January 2017: Journal of Christian Nursing: a Quarterly Publication of Nurses Christian Fellowship
https://www.readbyqxmd.com/read/27924972/protective-mechanisms-of-purified-polyphenols-from-pinecones-of-pinus-koraiensis-on-spleen-tissues-in-tumor-bearing-s180-mice-in-vivo
#6
Juanjuan Yi, Cuilin Cheng, Xiaoyu Li, Haitian Zhao, Hang Qu, Zhenyu Wang, Lu Wang
The previous study evaluated the antitumor activity and the underlying mechanism of the purified polyphenols from pinecones of Pinus koraiensis (PPP-40) using a tumor-bearing S180 mice model. This study was designed to evaluate the protective effects of PPP-40 on spleen tissues of S180 mice in vivo. Pretreatment with PPP-40 (150 mg per kg BW per D) could significantly inhibit tumor growth, enhance spleen index and prevent the decline of haematological parameters of S180 mice induced by the tumor microenvironment...
December 7, 2016: Food & Function
https://www.readbyqxmd.com/read/27919757/dietary-administration-of-bacillus-subtilis-hainup40-enhances-growth-digestive-enzyme-activities-innate-immune-responses-and-disease-resistance-of-tilapia-oreochromis-niloticus
#7
Haitian Liu, Shifeng Wang, Yan Cai, Xiaohui Guo, Zhenjie Cao, Yongzheng Zhang, Shubin Liu, Wei Yuan, Weiwei Zhu, Yu Zheng, Zhenyu Xie, Weiliang Guo, Yongcan Zhou
The probiotic properties of Bacillus subtilis HAINUP40 isolated from the aquatic environment, and the effects of dietary administration of B. subtilis HAINUP40 on the growth performance, intestinal probiotic recovery, digestive enzyme activities, innate immunity and disease resistance of tilapia (Oreochromis niloticus) were evaluated. The probiotic properties investigated include tolerance to simulated gastrointestinal stress, auto-aggregation, cell surface hydrophobicity and extracellular enzyme production...
December 2, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27906806/awareness-of-cervical-cancer-causes-and-predeterminants-of-likelihood-to-screen-among-women-in-haiti
#8
Schatzi H McCarthy, Kathy A Walmer, Joel C Boggan, Margaret W Gichane, William A Calo, Harry A Beauvais, Noel T Brewer
OBJECTIVES: Cervical cancer is the leading cause of cancer deaths among women in Haiti. Given this high disease burden, we sought to better understand women's knowledge of its causes and the sociodemographic and health correlates of cervical cancer screening. MATERIALS AND METHODS: Participants were 410 adult women presenting at clinics in Léogâne and Port-au-Prince, Haiti. We used bivariate and multivariate logic regression to identify correlates of Pap smear receipt...
January 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/27900387/a-modification-specific-peptide-based-immunization-approach-using-crm197-carrier-protein-development-of-a-selective-vaccine-against-pyroglutamate-a%C3%AE-peptides
#9
Valérie Vingtdeux, Haitian Zhao, Pallavi Chandakkar, Christopher M Acker, Peter Davies, Philippe Marambaud
Strategies aimed at reducing cerebral accumulation of the amyloid-β (Aβ) peptides have therapeutic potential in Alzheimer's disease (AD). Aβ immunization has proven to be effective at promoting Aβ clearance in animal models but adverse effects have hampered its clinical evaluation. The first anti-Aβ immunization clinical trial, which assessed a full-length Aβ1-42 vaccine, increased the risk of encephalitis most likely because of autoimmune pro-inflammatory T helper 1 (Th1) response against all forms of Aβ...
November 28, 2016: Molecular Medicine
https://www.readbyqxmd.com/read/27874028/a-mouse-model-of-hereditary-hemorrhagic-telangiectasia-generated-by-transmammary-delivered-immunoblocking-of-bmp9-and-bmp10
#10
Santiago Ruiz, Haitian Zhao, Pallavi Chandakkar, Prodyot K Chatterjee, Julien Papoin, Lionel Blanc, Christine N Metz, Fabien Campagne, Philippe Marambaud
Hereditary hemorrhagic telangiectasia (HHT) is a potentially life-threatening genetic vascular disorder caused by loss-of-function mutations in the genes encoding activin receptor-like kinase 1 (ALK1), endoglin, Smad4, and bone morphogenetic protein 9 (BMP9). Injections of mouse neonates with BMP9/10 blocking antibodies lead to HHT-like vascular defects in the postnatal retinal angiogenesis model. Mothers and their newborns share the same immunity through the transfer of maternal antibodies during lactation...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27829646/october-surprises
#11
(no author information available yet)
Ushered in with the rampage of Hurricane Matthew, later days brightened in this month that has often been harbinger of both good and bad news for Cuba and the world. Hurricane Matthew ripped through Eastern Cuba, devastating the historic town of Baracoa (Cuba's first capital, founded in 1511) and the village of Maisí, where the morning sun first rises over Cuban territory. Wind and flood leveled hundreds of homes, brought down the power grid and destroyed crops. Yet there was no loss of human life, unlike in neighboring Haiti and other countries in Matthew's path, and unlike in Cuba in 1963, when Hurricane Flora caused more than 1200 deaths...
October 2016: MEDICC Review
https://www.readbyqxmd.com/read/27821884/measuring-haitian-children-s-exposure-to-chikungunya-dengue-and-malaria
#12
Mathieu Jp Poirier, Delynn M Moss, Karla R Feeser, Thomas G Streit, Gwong-Jen J Chang, Matthew Whitney, Brandy J Russell, Barbara W Johnson, Alison J Basile, Christin H Goodman, Amanda K Barry, Patrick J Lammie
OBJECTIVE: To differentiate exposure to the newly introduced chikungunya virus from exposure to endemic dengue virus and other pathogens in Haiti. METHODS: We used a multiplex bead assay to detect immunoglobulin G (IgG) responses to a recombinant chikungunya virus antigen, two dengue virus-like particles and three recombinant Plasmodium falciparum antigens. Most (217) of the blood samples investigated were collected longitudinally, from each of 61 children, between 2011 and 2014 but another 127 were collected from a cross-sectional sample of children in 2014...
November 1, 2016: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/27818656/antimicrobial-susceptibility-of-autochthonous-aquatic-vibrio-cholerae-in-haiti
#13
Sandrine Baron, Jean Lesne, Eric Jouy, Emeline Larvor, Isabelle Kempf, Jacques Boncy, Stanilas Rebaudet, Renaud Piarroux
We investigated the antimicrobial susceptibility of 50 environmental isolates of Vibrio cholerae non-O1/non-O139 collected in surface waters in Haiti in July 2012, during an active cholera outbreak. A panel of 16 antibiotics was tested on the isolates using the disk diffusion method and PCR detection of seven resistance-associated genes (strA/B, sul1/2, ermA/B, and mefA). All isolates were susceptible to amoxicillin-clavulanic acid, cefotaxime, imipenem, ciprofloxacin, norfloxacin, amikacin, and gentamicin...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27810628/community-health-needs-assessment-and-action-planning-in-seven-dominican-bateyes
#14
Sarah V Suiter
Haitians and persons of Haitian descent living in the Dominican Republic are often relegated to living in deeply impoverished communities called bateyes. Despite obvious needs and some NGO presence in the bateyes, little assessment has been done to identify specific needs as understood and experienced by community members themselves. This article describes a community health needs assessment and action planning process developed and implemented by university researchers, NGO staff, and community members to identify needed areas for community-based health intervention in seven Dominican bateyes...
February 2017: Evaluation and Program Planning
https://www.readbyqxmd.com/read/27799635/isolation-of-coronavirus-nl63-from-blood-from-children-in-rural-haiti-phylogenetic-similarities-with-recent-isolates-from-malaysia
#15
Valery Madsen Beau De Rochars, John Lednicky, Sarah White, Julia Loeb, Maha A Elbadry, Taina Telisma, Sonese Chavannes, Marie Gina Anilis, Eleonora Cella, Massimo Ciccozzi, Bernard A Okech, Marco Salemi, J Glenn Morris
Human coronavirus (HCoV) NL63 is recognized as a common cause of upper respiratory infections and influenza-like illness. In screening children with acute undifferentiated febrile illness in a school cohort in rural Haiti, we identified HCoV-NL63 in blood samples from four children. Cases clustered over an 11-day period; children did not have respiratory symptoms, but two had gastrointestinal complaints. On phylogenetic analysis, the Haitian HCoV-NL63 strains cluster together in a highly supported monophyletic clade linked most closely with recently reported strains from Malaysia; two respiratory HCoV-NL63 strains identified in north Florida in the same general period form a separate clade, albeit again with close linkages with the Malaysian strains...
October 31, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27786291/non-toxigenic-environmental-vibrio-cholerae-o1-strain-from-haiti-provides-evidence-of-pre-pandemic-cholera-in-hispaniola
#16
Taj Azarian, Afsar Ali, Judith A Johnson, Mohammad Jubair, Eleonora Cella, Massimo Ciccozzi, David J Nolan, William Farmerie, Mohammad H Rashid, Shrestha Sinha-Ray, Meer T Alam, J Glenn Morris, Marco Salemi
Vibrio cholerae is ubiquitous in aquatic environments, with environmental toxigenic V. cholerae O1 strains serving as a source for recurrent cholera epidemics and pandemic disease. However, a number of questions remain about long-term survival and evolution of V. cholerae strains within these aquatic environmental reservoirs. Through monitoring of the Haitian aquatic environment following the 2010 cholera epidemic, we isolated two novel non-toxigenic (ctxA/B-negative) Vibrio cholerae O1. These two isolates underwent whole-genome sequencing and were investigated through comparative genomics and Bayesian coalescent analysis...
October 27, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27774794/intravaginal-practices-are-associated-with-greater-odds-of-high-risk-hpv-infection-in-haitian-women
#17
Julia S Seay, Morgan Mandigo, Jonathan Kish, Janelle Menard, Sarah Marsh, Erin Kobetz
OBJECTIVE: Haitian women have the highest incidence of cervical cancer within the Western hemisphere. Intravaginal hygiene practices have been linked with human papilloma virus (HPV) infection and cervical dysplasia. These practices, known as 'twalet deba' in Haitian Creole, are common among Haitian women and are performed with various natural and synthetic agents. As part of a community-based participatory research initiative aimed at reducing cervical cancer disparities in rural Haiti, we explored the use of intravaginal agents and their associations with high-risk HPV infection...
October 24, 2016: Ethnicity & Health
https://www.readbyqxmd.com/read/27768855/population-survey-of-iodine-deficiency-and-environmental-disruptors-of-thyroid-function-in-young-children-in-haiti
#18
Julia Elisabeth von Oettingen, Tesha Dawn Brathwaite, Christopher Carpenter, Ric Bonnell, Xuemei He, Lewis E Braverman, Elizabeth N Pearce, Philippe Larco, Nancy Charles Larco, Eddy Jean-Baptiste, Rosalind S Brown
CONTEXT: Iodine deficiency is the leading cause of preventable neurodevelopmental delay in children worldwide. It is a possible public health concern in Haiti. OBJECTIVE: To perform a population iodine survey in Haitian young children, and its influence by environmental factors. DESIGN: Cross-sectional study, March-June 2015. SETTING: Community churches in 3 geographical regions in Haiti. PARTICIPANTS: 299 healthy Haitian children aged 9 months to 6 years; 100 enrolled in coastal (C) and mountainous (M) regions, and 99 in an urban region (U)...
October 21, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27764716/mobile-clinics-in-haiti-part-2-lessons-learned-through-service
#19
Janice M Haley, Pamela H Cone
Learning from experience is a positive approach when preparing for mobile clinic service in a developing country. Mobile clinics provide healthcare services to people in hard to reach areas around the world, but preparation for their use needs to be done in collaboration with local leaders and healthcare providers. For over 16 years, Azusa Pacific University School of Nursing has sponsored mobile clinics to rural northern Haiti with the aim to provide culturally sensitive healthcare in collaboration with Haitian leaders...
November 2016: Nurse Education in Practice
https://www.readbyqxmd.com/read/27760535/the-haiti-medical-education-project-development-and-analysis-of-a-competency-based-continuing-medical-education-course-in-haiti-through-distance-learning
#20
EDITORIAL
Robert Battat, Marc Jhonson, Lorne Wiseblatt, Cruff Renard, Laura Habib, Manouchka Normil, Brian Remillard, Timothy F Brewer, Galit Sacajiu
BACKGROUND: Recent calls for reform in healthcare training emphasize using competency-based curricula and information technology-empowered learning. Continuing Medical Education programs are essential in maintaining physician accreditation. Haitian physicians have expressed a lack access to these activities. The Haiti Medical Education Project works in alliance with Haitian medical leadership, faculty and students to support the Country's medical education system. We present the creation, delivery and evaluation of a competency-based continuing medical education curriculum for physicians in rural Haiti...
October 19, 2016: BMC Medical Education
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