keyword
MENU ▼
Read by QxMD icon Read
search

Haitian

keyword
https://www.readbyqxmd.com/read/29784948/simultaneous-cell-disruption-and-semi-quantitative-activity-assays-for-high-throughput-screening-of-thermostable-l-asparaginases
#1
Xu Li, Xian Zhang, Shuqin Xu, Hengwei Zhang, Meijuan Xu, Taowei Yang, Li Wang, Haifeng Qian, Huiling Zhang, Haitian Fang, Tolbert Osire, Zhiming Rao, Shangtian Yang
L-asparaginase, which catalyses the hydrolysis of L-asparagine to L-aspartate, has attracted the attention of researchers due to its expanded applications in medicine and the food industry. In this study, a novel thermostable L-asparaginase from Pyrococcus yayanosii CH1 was cloned and over-expressed in Bacillus subtilis 168. To obtain thermostable L-asparaginase mutants with higher activity, a robust high-throughput screening process was developed specifically for thermophilic enzymes. In this process, cell disruption and enzyme activity assays are simultaneously performed in 96-deep well plates...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29771791/a-successful-model-of-expedited-antiretroviral-therapy-for-clinically-stable-patients-living-with-hiv-in-haiti
#2
Colette Guiteau Moise, Vanessa R Rivera, Kelly A Hennessey, Clovy Bellot, Chris Nicholas, Anna P Fang, Rose Irène Verdier, Patrice Severe, Alix Sainvil, Benedict Charles, Derothy Dorval, Juseline St Amour, Jean W Pape, Serena P Koenig
BACKGROUND: Recommendations for universal antiretroviral therapy (ART) have greatly increased the number of HIV-infected patients who qualify for treatment, particularly with early clinical disease. Less intensive models of care are needed for clinically stable patients. SETTING: A Rapid Pathway (RP) model of expedited outpatient care for clinically stable patients was implemented at the Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO) Center, Port-au-Prince, Haiti...
April 30, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29768401/near-real-time-forecasting-for-cholera-decision-making-in-haiti-after-hurricane-matthew
#3
Damiano Pasetto, Flavio Finger, Anton Camacho, Francesco Grandesso, Sandra Cohuet, Joseph C Lemaitre, Andrew S Azman, Francisco J Luquero, Enrico Bertuzzo, Andrea Rinaldo
Computational models of cholera transmission can provide objective insights into the course of an ongoing epidemic and aid decision making on allocation of health care resources. However, models are typically designed, calibrated and interpreted post-hoc. Here, we report the efforts of a team from academia, field research and humanitarian organizations to model in near real-time the Haitian cholera outbreak after Hurricane Matthew in October 2016, to assess risk and to quantitatively estimate the efficacy of a then ongoing vaccination campaign...
May 16, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29746539/a-new-american-subgroup-of-african-lineage-chikungunya-virus-detected-in-and-isolated-from-mosquitoes-collected-in-haiti-2016
#4
Sarah Keller White, Carla Mavian, Marco Salemi, John Glenn Morris, Maha A Elbadry, Bernard A Okech, John A Lednicky, James C Dunford
As part of on-going arboviral surveillance activity in a semi-rural region in Haiti, Chikungunya virus (CHIKV)-positive mosquito pools were identified in 2014 (the peak of the Caribbean Asian-clade epidemic), and again in 2016 by RT-PCR. In 2014, CHIKV was only identified in Aedes aegypti (11 positive pools/124 screened). In contrast, in sampling in 2016, CHIKV was not identified in Ae. aegypti, but, rather, in (a) a female Aedes albopictus pool, and (b) a female Culex quinquefasciatus pool. Genomic sequence analyses indicated that the CHIKV viruses in the 2016 mosquito pools were from the East-Central-South African (ECSA) lineage, rather than the Asian lineage...
2018: PloS One
https://www.readbyqxmd.com/read/29739879/chemical-synapses-without-synaptic-vesicles-purinergic-neurotransmission-through-a-calhm1-channel-mitochondrial-signaling-complex
#5
Roman A Romanov, Robert S Lasher, Brigit High, Logan E Savidge, Adam Lawson, Olga A Rogachevskaja, Haitian Zhao, Vadim V Rogachevsky, Marina F Bystrova, Gleb D Churbanov, Igor Adameyko, Tibor Harkany, Ruibiao Yang, Grahame J Kidd, Philippe Marambaud, John C Kinnamon, Stanislav S Kolesnikov, Thomas E Finger
Conventional chemical synapses in the nervous system involve a presynaptic accumulation of neurotransmitter-containing vesicles, which fuse with the plasma membrane to release neurotransmitters that activate postsynaptic receptors. In taste buds, type II receptor cells do not have conventional synaptic features but nonetheless show regulated release of their afferent neurotransmitter, ATP, through a large-pore, voltage-gated channel, CALHM1. Immunohistochemistry revealed that CALHM1 was localized to points of contact between the receptor cells and sensory nerve fibers...
May 8, 2018: Science Signaling
https://www.readbyqxmd.com/read/29727703/statistical-methods-for-genome-wide-association-studies
#6
REVIEW
Maggie Haitian Wang, Heather J Cordell, Kristel Van Steen
Genome-wide association studies (GWAS) detect common genetic variants associated with complex disorders. With their comprehensive coverage of common single nucleotide polymorphisms and comparatively low cost, GWAS are an attractive tool in the clinical and commercial genetic testing. This review introduces the pipeline of statistical methods used in GWAS analysis, from data quality control, association tests, population structure control, interaction effects and results visualization, through to post-GWAS validation methods and related issues...
May 1, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/29726121/meeting-the-urgent-need-for-rabies-education-in-haiti
#7
M O V Osinubi, N Fenelon, J L Dyer, R Franka, M Etheart, A Ali, M Birhane, N Phaimyr Jn Charles, A Destine, N Saleme, C Newman, K Crowdis, C Lutfy, C E Rupprecht, R M Wallace, V R Johnson
The highest rate of human rabies deaths reported in the Americas is in Haiti, and most of these deaths result from rabies virus infections that occur after individuals are bitten by infected dogs and do not receive rabies post-exposure prophylaxis. One barrier to rabies prevention in Haiti is a lack of knowledge about this disease among healthcare professionals and community members. During the past 4 years, The US Centers for Disease Control and Prevention has collaborated with public health officials and partners to develop, test and refine educational materials aimed at filling this need for rabies education...
May 3, 2018: Zoonoses and Public Health
https://www.readbyqxmd.com/read/29706835/the-undead-in-culture-and-science
#8
Connie Nugent, Gilbert Berdine, Kenneth Nugent
The undead have a significant role in mythology, religion, folklore, and literature. In the 1800s, the word zombie was used to describe reanimated corpses in the Caribbean who often worked on plantations doing long, arduous field work. The movie White Zombie was released in 1932 and exploited this folklore, but it ignored the fact that zombies represent one outcome in Vodou religious beliefs regarding death and the migration of spirits following death. The interest in zombies eventually led to sociological and medical investigations into zombification...
April 2018: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/29700918/high-rates-of-ocular-complications-in-a-cohort-of-haitian-children-and-adolescents-with-diabetes
#9
Marie-Ève Robinson, Ketly Altenor, Christopher Carpenter, Ric Bonnell, Eddy Jean-Baptiste, Julia von Oettingen
BACKGROUND: Ophthalmic complications of pediatric diabetes are rare, and rates are unknown in Haitian youth. OBJECTIVES: Determine the prevalence and predictors of diabetic retinopathy (DR) and cataracts in a cohort of Haitian youth with insulin-treated diabetes. METHODS: We performed a cross-sectional retrospective review of pediatric patients with diabetes from a pediatric chronic disease center in Haiti, from Dec 1, 2012 to Nov 1, 2016...
April 26, 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/29697553/socioeconomic-vulnerability-and-sexually-transmitted-infection-among-pregnant-haitian-women
#10
Joy D Scheidell, Valery Madsen Beau De Rochars, Marie Nancy Séraphin, Marcia M Hobbs, J Glenn Morris, Joseph Pierre Célestin, Linda B Cottler, Maria R Khan
BACKGROUND: Despite evidence that education and poverty act through distinct pathways to influence sexually transmitted infection (STI), few studies have examined the unique, independent associations of these socioeconomic vulnerabilities on sexual risk behaviors and STI among women. METHODS: From August-October 2013, women at an antenatal clinic in Gressier, Haiti, were interviewed and tested for Chlamydial infection, gonorrhea, and trichomoniasis (N=200). We measured low educational attainment as <9 years of schooling and currently living in poverty based on crowding, defined as >2 people sleeping in one room...
April 24, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29689178/gender-differences-in-psychosocial-and-physical-outcomes-in-haitian-amputees
#11
Pey-Shan Wen, Marilys G Randolph, Leonard Elbaum, Mario De la Rosa
OBJECTIVE: The purpose of this study was to investigate the gender differences in psychosocial and physical outcomes in users of lower-extremity prostheses who became amputees after the 2010 earthquake in Haiti. METHOD: We enrolled 140 unilateral amputees in this cross-sectional study in Port-au-Prince, Haiti. Trained staff administered the assessments by reading the questions aloud to participants. Participants completed the Trinity Amputation and Prosthesis Experience Scales and Locomotor Capabilities Index about 2 yr after the earthquake...
May 2018: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/29664018/increased-vessel-perfusion-predicts-the-efficacy-of-immune-checkpoint-blockade
#12
Xichen Zheng, Zhaoxu Fang, Xiaomei Liu, Shengming Deng, Pei Zhou, Xuexiang Wang, Chenglin Zhang, Rongping Yin, Haitian Hu, Xiaolan Chen, Yijie Han, Yun Zhao, Steven H Lin, Songbing Qin, Xiaohua Wang, Betty Ys Kim, Penghui Zhou, Wen Jiang, Qingyu Wu, Yuhui Huang
Immune checkpoint blockade (ICB) has demonstrated curative potential in several types of cancer, but only for a small number of patients. Thus, the identification of reliable and noninvasive biomarkers for predicting ICB responsiveness is an urgent unmet need. Here, we show that ICB increased tumor vessel perfusion in treatment-sensitive EO771 and MMTV-PyVT breast tumor as well as CT26 and MCA38 colon tumor models, but not in treatment-resistant MCaP0008 and 4T1 breast tumor models. In the sensitive tumor models, the ability of anti-cytotoxic T lymphocyte-associated protein 4 or anti-programmed cell death 1 therapy to increase vessel perfusion strongly correlated with its antitumor efficacy...
April 16, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29656419/oral-health-knowledge-attitudes-and-practices-kap-in-rural-haiti-a-40-year-follow-up-study
#13
Ralph V Katz, Samuel E Prophete, Christina Lafontant, Bette Gebrian, Louis C Bourdeau, Jr Ernst Joseph, Gladys J Lafontant, H Ludwig St Jean, Paul E Rundberg
This paper reports the changed findings over a 40-year period on oral health knowledge, attitudes, and practices (KAP) of a very remote and rural population living the Jeremie region of Haiti. The far-sighted investigators of that original 1970 survey stated in their published 1972 paper that our "…findings are descriptive, but have to be accepted tentatively rather than definitively because time was short, transportation was difficult, and the small sample that had to be used could not random." They further insightfully stated their hopes that their "…results may be regarded as an anthropological cultural baseline from which to review further findings concerning Haitian dental beliefs...
April 14, 2018: Journal of Public Health Dentistry
https://www.readbyqxmd.com/read/29653203/approximate-bayesian-algorithm-to-estimate-the-basic-reproduction-number-in-an-influenza-pandemic-using-arrival-times-of-imported-cases
#14
Ka Chun Chong, Benny Chung Ying Zee, Maggie Haitian Wang
BACKGROUND: In an influenza pandemic, arrival times of cases are a proxy of the epidemic size and disease transmissibility. Because of intense surveillance of travelers from infected countries, detection is more rapid and complete than on local surveillance. Travel information can provide a more reliable estimation of transmission parameters. METHOD: We developed an Approximate Bayesian Computation algorithm to estimate the basic reproduction number (R0 ) in addition to the reporting rate and unobserved epidemic start time, utilizing travel, and routine surveillance data in an influenza pandemic...
April 10, 2018: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29626265/addressing-the-immediate-need-for-emergency-providers-in-resource-limited-settings-the-model-of-a-six-month-emergency-medicine-curriculum-in-haiti
#15
Shada A Rouhani, Kerling Israel, Fernet Leandre, Sosthène Pierre, Brennan Bollman, Regan H Marsh
BACKGROUND: In many resource-limited settings, emergency medicine (EM) is underdeveloped and formal EM training limited. Residencies and fellowships are an ideal long-term solution but cannot meet immediate needs for emergency providers, while short-term programs are often too limited in content. We describe a third method successfully implemented in Haiti: a medium-duration certificate program to meet the immediate need for emergency specialists. METHODS: In conjunction with the Haitian Ministry of Health and National Medical School, we developed and implemented a novel, 6-month EM certificate program to build human resources for health and emergency care capacity...
April 6, 2018: International Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29594933/hpv-self-sampling-for-cervical-cancer-screening-among-ethnic-minority-women-in-south-florida-a-randomized-trial
#16
Olveen Carrasquillo, Julia Seay, Anthony Amofah, Larry Pierre, Yisel Alonzo, Shelia McCann, Martha Gonzalez, Dinah Trevil, Tulay Koru-Sengul, Erin Kobetz
BACKGROUND: Ethnic minority women are at increased risk of cervical cancer. Self-sampling for high-risk human papillomavirus (HPV) is a promising approach to increase cervical screening among hard-to-reach populations. OBJECTIVE: To compare a community health worker (CHW)-led HPV self-sampling intervention with standard cervical cancer screening approaches. DESIGN: A 26-week single-blind randomized pragmatic clinical trial. PARTICIPANTS: From October 6, 2011 to July 7, 2014, a total of 601 Black, Haitian, and Hispanic women aged 30-65 years in need of cervical cancer screening were recruited, 479 of whom completed study follow-up...
March 28, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29580642/impact-of-community-delivered-sms-alerts-on-dog-owner-participation-during-a-mass-rabies-vaccination-campaign-haiti-2017
#17
Julie M Cleaton, Ryan M Wallace, Kelly Crowdis, Andy Gibson, Benjamin Monroe, Fleurinord Ludder, Melissa D Etheart, Marco Antonio Natal Vigilato, Alasdair King
Haiti has historically vaccinated between 100,000 and 300,000 dogs annually against rabies, however national authorities have not been able to reach and maintain the 70% coverage required to eliminate the canine rabies virus variant. Haiti conducts massive dog vaccination campaigns on an annual basis and utilizes both central point and door-to-door methods. These methods require that dog owners are aware of the dates and locations of the campaign. To improve this awareness among dog owners, 600,000 text messages were sent to phones in two Haitian communes (Gonaives and Saint-Marc) to remind dog owners to attend the campaign...
April 19, 2018: Vaccine
https://www.readbyqxmd.com/read/29571766/dehydroepiandrosterone-reduces-accumulation-of-lipid-droplets-in-primary-chicken-hepatocytes-by-biotransformation-mediated-via-the-camp-pka-erk1-2-signaling-pathway
#18
Longlong Li, Chongyang Ge, Dian Wang, Lei Yu, Jinlong Zhao, Haitian Ma
Dehydroepiandrosterone (DHEA) is commonly used as a nutritional supplement to control fat deposition, but the mechanism of this action is poorly understood. In this study, we demonstrated that DHEA increased phosphorylation of AMP-activated protein kinase (p-AMPK). Elevated p-AMPK levels resulted in reduced expression of sterol regulatory element binding protein-1c, acetyl CoA carboxylase, fatty acid synthase and enhanced expression of peroxisome proliferators-activated receptor α and carnitine palmitoyl transferase-I, ultimately leading to the reduction of lipid droplet accumulation in primary chicken hepatocytes...
March 20, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29558413/influence-of-feeding-practices-on-malnutrition-in-haitian-infants-and-young-children
#19
Belén Irarrázaval, Salesa Barja, Edson Bustos, Romel Doirsaint, Gloria Senethmm, María Paz Guzmán, Ricardo Uauy
Infant malnutrition remains an important cause of death and disability, and Haiti has the highest prevalence in the Americas. Therefore, preventive strategies are needed. Our aims were (1) To assess the prevalence of malnutrition among young children seen at a health center in Haiti; (2) Examine adherence to infant feeding practices recommended by the World Health Organization (WHO) and the association to nutritional status. This cross-sectional study recruited children from the Saint Espri Health Center in Port Au Prince in 2014...
March 20, 2018: Nutrients
https://www.readbyqxmd.com/read/29521449/dehydroepiandrosterone-rehabilitate-brl-3a-cells-oxidative-stress-damage-induced-by-hydrogen-peroxide
#20
Longlong Li, Jinlong Zhao, Chongyang Ge, Lei Yu, Haitian Ma
This study aimed to investigate the molecular mechanism of dehydroepiandrosterone (DHEA) rehabilitated BRL-3A cells oxidative stress damage induced by hydrogen peroxide (H2 O2 ). Results showed that DHEA reversed the decrease of cell viability and ameliorated nuclear chromatin damage in H2 O2 -induced BRL-3A cells. DHEA increased the activities of superoxide dismutase, catalase, peroxidase, and glutathione peroxidase, and decreased the reactive oxygen species (ROS) production in H2 O2 -induced BRL-3A cells...
August 2018: Journal of Cellular Physiology
keyword
keyword
7978
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"