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https://www.readbyqxmd.com/read/29315863/activatable-protein-nanoparticles-for-targeted-delivery-of-therapeutic-peptides
#1
Xi Yu, Xingchun Gou, Peng Wu, Liang Han, Daofeng Tian, Fengyi Du, Zeming Chen, Fuyao Liu, Gang Deng, Ann T Chen, Chao Ma, Jun Liu, Sara M Hashmi, Xing Guo, Xiaolong Wang, Haitian Zhao, Xinran Liu, Xudong Zhu, Kevin Sheth, Qianxue Chen, Louzhen Fan, Jiangbing Zhou
Clinical translation of therapeutic peptides, particularly those that require penetration of the cell membrane or are cytolytic, is a major challenge. A novel approach based on a complementary mechanism, which has been widely used for guided synthesis of DNA or RNA nanoparticles, for de novo design of activatable protein nanoparticles (APNPs) for targeted delivery of therapeutic peptides is described. APNPs are formed through self-assembly of three independent polypeptides based on pairwise coiled-coil dimerization...
January 8, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29310583/proteomics-reveals-changes-in-hepatic-proteins-during-chicken-embryonic-development-an-alternative-model-to-study-human-obesity
#2
Mengling Peng, Shengnan Li, Qianian He, Jinlong Zhao, Longlong Li, Haitian Ma
BACKGROUND: Chicken embryos are widely used as a model for studies of obesity; however, no detailed information is available about the dynamic changes of proteins during the regulation of adipose biology and metabolism. Thus, the present study used an isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomic approach to identify the changes in protein abundance at different stages of chicken embryonic development. RESULTS: In this study, the abundances of 293 hepatic proteins in 19-day old of chicken embryos compared with 14-day old and 160 hepatic proteins at hatching compared with 19-day old embryos were significantly changed...
January 8, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29274798/adapting-the-caesium-137-technique-to-document-soil-redistribution-rates-associated-with-traditional-cultivation-practices-in-haiti
#3
H Velasco, R Torres Astorga, D Joseph, J S Antoine, L Mabit, A Toloza, G Dercon, Des E Walling
Large-scale deforestation, intensive land use and unfavourable rainfall conditions are responsible for significant continuous degradation of the Haitian uplands. To develop soil conservation strategies, simple and cost-effective methods are needed to assess rates of soil loss from farmland in Haiti. The fallout radionuclide caesium-137 (137Cs) provides one such means of documenting medium-term soil redistribution rates. In this contribution, the authors report the first use in Haiti of 137Cs measurements to document soil redistribution rates and the associated pattern of erosion/sedimentation rates along typical hillslopes within a traditional upland Haitian farming area...
December 21, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/29274416/dectin-1-mediates-the-immunoenhancement-effect-of-the-polysaccharide-from-dictyophora-indusiata
#4
Chao Deng, Haitian Fu, Jingying Shang, Jinghua Chen, Xin Xu
The polysaccharides (DIP) extracted from Dictyophora indusiate has been found featuring great anti-cancer activity through enhancing organism immunity ability, and the DIP-induced macrophages activation might be mediated via TLR4/NF-κB signaling pathway. In this work, we make further investigation of the effect of DIP on macrophages and whether there was another pathway to regulate the immunoenhancement effect of DIP. The results showed that DIP could activate macrophages, causing the enhancement of its phagocyte activity, and then increase the secretion of IL-1β and TNF-α...
December 20, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29234496/persistent-diarrhoea-in-a-5-month-old-baby-carrying-vibrio-cholerae-nono1-nono139-producing-haitian-cholera-toxin
#5
P Kumar, S Karmakar, R Prasad, R Chopra, S Khandelwal, S Gupta, A C Dhariwal, P Yadav, P K Yadava
Cholera toxin (CT) is the principal virulence factor of Vibrio cholerae for fatal cholera diarrhoea. Serogroups O1 and O139 harbour CT and are known to be epidemic strains. The remaining serogroups (nonO1/nonO139) are non-toxigenic and may be associated with mild disease. O1 serogroup emerged with a variant of CT known as Haitian cholera toxin (HCT). The HCT strains are hypervirulent and have been associated with severe cholera outbreaks in India, Western Africa and Haiti. Here, we report the presence of HCT (ctxB7) in a nonO1/nonO139 isolate causing persistent diarrhoea...
January 2018: New Microbes and New Infections
https://www.readbyqxmd.com/read/29218035/characterization-of-two-cryptic-plasmids-isolated-in-haiti-from-clinical-vibrio-cholerae-non-o1-non-o139
#6
Daniela Ceccarelli, Geneviève Garriss, Seon Y Choi, Nur A Hasan, Ramunas Stepanauskas, Mihai Pop, Anwar Huq, Rita R Colwell
We report the complete sequence of two novel plasmids, pSDH-1 and pSDH-2, isolated from clinical Vibrio cholerae non-O1/non-O139 during the early phase of the 2010 Haitian cholera epidemic. Plasmids were revealed by employing single-cell genomics and their genome content suggests self-mobilization and, for pSDH-2, a toxin-antitoxin (TA) system for plasmid stabilization was identified. The putative origin of replication of pSDH-2 was mapped suggesting it replicates following the ColE1 model of plasmid replication...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29188126/the-united-nations-material-assistance-to-survivors-of-cholera-in-haiti-consulting-survivors-and-rebuilding-trust
#7
Phuong N Pham, Niamh Gibbons, Patrick Vinck
Introduction: In August 2016, the United Nations (U.N.) Secretary General acknowledged the U.N.'s role in the cholera epidemic that has beset Haiti since 2010. Two months later, the Secretary General issued a historic apology to the Haitian people before the U.N. General Assembly, for the organization's insufficient response to the cholera outbreak. These steps are part of the U.N.'s "new approach" to cholera in Haiti, which also includes launching a material assistance package for those most affected by cholera...
October 23, 2017: PLoS Currents
https://www.readbyqxmd.com/read/29167251/complete-genome-sequence-of-human-coronavirus-strain-229e-isolated-from-plasma-collected-from-a-haitian-child-in-2016
#8
Tania S Bonny, Kuttichantran Subramaniam, Thomas B Waltzek, Maha A Elbadry, Valery Madsen Beau De Rochars, Taina Telisma, Mohammed Rashid, J Glenn Morris, John A Lednicky
Human coronavirus strain 229E (HCoV-229E) and human alphaherpesvirus 1 were isolated from the plasma of a Haitian child in 2016 with suspected arbovirus diseases. To our knowledge, this is the first description of HCoV-229E in human plasma, which is the focus of this article.
November 22, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29153700/heparanase-expression-in-blood-is-sensitive-to-monitor-response-to-anticancer-treatment-in-pancreatic-cancer-a-pilot-study
#9
Wujun Wu, Lin Zhao, Yongtian Yu, Haitian Hu, Huaiping Shi, Qian'an Jia, Lixue Du
BACKGROUND: /Objectives: High heparanase level was shown in maliganant tumor; however, whether or not heparanase may serve as a sensitive marker to monitor response to anticancer treatment is still unknown. METHODS: In the pilot study, heparanase mRNA expression in peripheral blood mononuclear cell fraction (PBMC) and activity in plasma and urine were detected by quantitative real time RT-PCR and heparan-degrading enzyme assay in 31 pancreatic cancer patients. RESULTS: Heparanase mRNA and activity in samples from cancer patients were significantly higher than that in healthy donors...
November 13, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29152440/risperidone-induced-amenorrhea-in-floridly-psychotic-female
#10
Shanila Shagufta, Faiza Farooq, Ali M Khan, Kamil Dar, Abdul Mohit
Despite the high prevalence of hyperprolactinemia in patients receiving antipsychotic medications, its side effects are often neglected. In patients receiving risperidone, the incidence of menstrual abnormalities is relatively small. Our patient was a 44-year-old, Haitian female whose total course of hospitalization was nine months, during most of which she remained floridly psychotic with low cognitive function with waxing and waning symptoms. She developed hyperprolactinemia and amenorrhea on risperidone...
September 13, 2017: Curēus
https://www.readbyqxmd.com/read/29150186/articular-scaling-and-body-mass-estimation-in-platyrrhines-and-catarrhines-modern-variation-and-application-to-fossil-anthropoids
#11
Jonathan M G Perry, Siobhán B Cooke, Jacqueline A Runestad Connour, M Loring Burgess, Christopher B Ruff
Body mass is an important component of any paleobiological reconstruction. Reliable skeletal dimensions for making estimates are desirable but extant primate reference samples with known body masses are rare. We estimated body mass in a sample of extinct platyrrhines and Fayum anthropoids based on four measurements of the articular surfaces of the humerus and femur. Estimates were based on a large extant reference sample of wild-collected individuals with associated body masses, including previously published and new data from extant platyrrhines, cercopithecoids, and hominoids...
November 14, 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/29142787/sleep-apnea-symptoms-and-cardiovascular-disease-risks-among-haitian-medical-students
#12
Diana M Rosenthal, Donaldson F Conserve, Dodley Severe, Michaele A Gedeon, Ferdinand Zizi, Georges Casimir, Samy I McFarlane, Girardin Jean Louis
Sleep apnea is a prevalent sleep disorder that disproportionately affects blacks and has been previously studied among Caribbean-born blacks in Brooklyn, New York, but there has been negligible research in the Caribbean, specifically Haiti, and developing countries on this pressing health issue. A total of 373 medical students (mean age=20.6 years ± 2.3 years) from a medical school in Haiti participated in this study. Participants were administered a questionnaire assessing their sleep health and cardiovascular outcomes...
April 2017: Journal of Sleep Disorders & Therapy
https://www.readbyqxmd.com/read/29138650/evaluation-of-antibiotic-self-medication-among-outpatients-of-the-state-university-hospital-of-port-au-prince-haiti-a-cross-sectional-study
#13
Kenny Moise, Joseph Junior Bernard, Jean Hugues Henrys
In Haiti, where all drugs are available over the counter, self-medication with antibiotics appears as a common practice. Inappropriate use of beta-lactams and macrolides is likely to contribute to the development of antimicrobial resistance. This study aimed to (i) assess the extent of self-medication with antibiotics, (ii) explore the contributing factors (age, gender and educational background) and (iii) identify specific antibiotic drug classes used among patients attending the outpatient clinic of the State University Hospital of Port-au-Prince...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29112856/the-experience-of-violence-against-children-in-domestic-servitude-in-haiti-results-from-the-violence-against-children-survey-haiti-2012
#14
Leah Gilbert, Avid Reza, James Mercy, Veronica Lea, Juliette Lee, Likang Xu, Louis Herns Marcelin, Marisa Hast, John Vertefeuille, Jean Wysler Domercant
BACKGROUND: There have been estimates that over 150,000 Haitian children are living in servitude. Child domestic servants who perform unpaid labor are referred to as "restavèks." Restavèks are often stigmatized, prohibited from attending school, and isolated from family placing them at higher risk for experiencing violence. In the absence of national data on the experiences of restavèks in Haiti, the study objective was to describe the sociodemographic characteristics of restavèks in Haiti and to assess their experiences of violence in childhood...
November 4, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29082817/prevalence-and-factors-associated-with-ptsd-anxiety-and-depression-symptoms-in-haitian-migrants-in-southern-brazil
#15
Alice E Brunnet, Laura T Bolaséll, João LA Weber, Christian H Kristensen
BACKGROUND: Prevalence rates of mental health disorders in migrants are controversial. The socio-historical and economic background of the host country may play an important role in the mental health status of migrants. As studies are mostly conducted in developed countries, researching migration in developing countries may add important information to scientific literature. AIMS: This study aims to investigate the prevalence and factors associated with posttraumatic stress disorder (PTSD), anxiety and depression symptoms in Haitian migrants in southern Brazil...
October 1, 2017: International Journal of Social Psychiatry
https://www.readbyqxmd.com/read/29077499/human-immunodeficiency-virus-negative-associated-lymphangioma-like-kaposi-s-sarcoma-with-variable-clinical-presentationsa-case-report
#16
Georgios Kotzias, Modupe Agunbiade, Leon Isaac, Morteza Khaladj
Lymphangioma-like Kaposi's sarcoma (LLKS) is a rare histologic variant of KS. Kaposi's sarcoma is also known as human herpesvirus type 8. The clinical presentation of the LLKS lesion is highly unusual and similar to that of classic KS but with multinodular vascular tumors and lymphedema. We present a 63-year-old native Haitian man with multiple slowly progressive exophytic ulcerated lesions covering more than 60% of his left lower extremity with no systemic involvement. Much confusion surrounded the clinical presentation of these wounds, and we postulated several differential diagnoses...
September 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/29064361/strengthening-national-disease-surveillance-and-response-haiti-2010-2015
#17
Stanley Juin, Nicolas Schaad, Donald Lafontant, Gerard A Joseph, Ezra Barzilay, Jacques Boncy, Robert Barrais, Frantz Jean Louis, Nadia Lapierre Jean Charles, Salomon Corvil, Nickolsno Barthelemy, Amber Dismer, Jean Samuel Pierre, Roodly W Archer, Mayer Antoine, Barbara Marston, Mark Katz, Patrick Dely, Paul Adrien, David L Fitter, David Lowrance, Roopal Patel
Haiti's health system has faced many challenges over the years, with competing health priorities in the context of chronic financial and human resource limitations. As a result, the existing notifiable disease surveillance system was unable to provide the most basic epidemiologic data for public health decision-making and action. In the wake of the January 2010 earthquake, the Haitian Ministry of Public Health and Population collaborated with the U.S. Centers for Disease Control and Prevention, the Pan American Health Organization, and other local and international partners to implement a functional national surveillance system...
October 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29064356/expansion-of-vaccination-services-and-strengthening-vaccine-preventable-diseases-surveillance-in-haiti-2010-2016
#18
Rania A Tohme, Jeannot Francois, Kathleen F Cavallaro, Gilson Paluku, Idrissa Yalcouye, Ernsley Jackson, Tracie Wright, Paul Adrien, Mark A Katz, Terri B Hyde, Pape Faye, Francine Kimanuka, Vance Dietz, John Vertefeuille, David Lowrance, Benjamin Dahl, Roopal Patel
Following the 2010 earthquake, Haiti was at heightened risk for vaccine-preventable diseases (VPDs) outbreaks due to the exacerbation of long-standing gaps in the vaccination program and subsequent risk of VPD importation from other countries. Therefore, partners supported the Haitian Ministry of Health and Population to improve vaccination services and VPD surveillance. During 2010-2016, three polio, measles, and rubella vaccination campaigns were implemented, achieving a coverage > 90% among children and maintaining Haiti free of those VPDs...
October 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29064354/building-and-rebuilding-the-national-public-health-laboratory-systems-and-services-before-and-after-the-earthquake-and-cholera-epidemic-haiti-2009-2015
#19
Frantz Jean Louis, Josiane Buteau, Jacques Boncy, Renette Anselme, Magalie Stanislas, Mary C Nagel, Stanley Juin, Macarthur Charles, Robert Burris, Eva Antoine, Chunfu Yang, Mireille Kalou, John Vertefeuille, Barbara J Marston, David W Lowrance, Varough Deyde
Before the 2010 devastating earthquake and cholera outbreak, Haiti's public health laboratory systems were weak and services were limited. There was no national laboratory strategic plan and only minimal coordination across the laboratory network. Laboratory capacity was further weakened by the destruction of over 25 laboratories and testing sites at the departmental and peripheral levels and the loss of life among the laboratory health-care workers. However, since 2010, tremendous progress has been made in building stronger laboratory infrastructure and training a qualified public health laboratory workforce across the country, allowing for decentralization of access to quality-assured services...
October 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29061521/effect-of-heparan-sulfate-mimetics-from-escherichia-coli-k5-polysaccharide-on-sdf-1-cxcl12-induced-endothelial-progenitor-cells-in-vitro
#20
Haitian Fu, Chao Deng, Liping Teng, Zhi Cai, Jinghua Chen, Guozhong Lu
In tumorigenesis, CXCL12 level increases sharply because of tumor tissue hypoxia. As CXCR4 cells, endothelial progenitor cells (EPCs) are mobilized to tumor bed through the CXCL12/CXCR4 axis and are involved in tumor angiogenesis. In this process, either glycosaminoglycan (GAG) or heparan sulfate (HS) carried by membrane proteoglycans is implicated. Exogenous soluble HS mimetics can act as a competitive inhibitor of membranous HS, thereby preventing the formation of a normal signal axis. In this work, the effect of HS mimetics on the CXCL12-induced EPCs in vitro was investigated...
October 20, 2017: International Journal of Biological Macromolecules
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