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https://www.readbyqxmd.com/read/28916927/genetic-test-risk-prediction-and-counseling
#1
Maggie Haitian Wang, Haoyi Weng
Advancement in technology has nurtured the new era of genetic tests for personalized medicine. In this chapter, we will introduce the current development, challenges, and the outlook of genetic test, disease risk prediction, and genetic counseling. In the first section, we will present the success cases in the areas of molecular classification of tumors, pharmacogenomics, and Mendelian disorders, and the challenges of genetic tests implementations. In the second section, common methods for genetic risk prediction models and evaluation measures will be introduced, as well as challenges in feature reliability, risk model stability, and clinical utility...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28912065/taino-and-african-maternal-heritage-in-the-greater-antilles
#2
Areej Bukhari, Javier Rodriguez Luis, Miguel A Alfonso-Sanchez, Ralph Garcia-Bertrand, Rene J Herrera
Notwithstanding the general interest and the geopolitical importance of the island countries in the Greater Antilles, little is known about the specific ancestral Native American and African populations that settled them. In an effort to alleviate this lacuna of information on the genetic constituents of the Greater Antilles, we comprehensively compared the mtDNA compositions of Cuba, Dominican Republic, Haiti, Jamaica and Puerto Rico. To accomplish this, the mtDNA HVRI and HVRII regions, as well as coding diagnostic sites, were assessed in the Haitian general population and compared to data from reference populations...
September 11, 2017: Gene
https://www.readbyqxmd.com/read/28887975/synthesis-of-silk-fibroin-g-paa-composite-using-h2o2-hrp-and-characterization-of-the-in-situ-biomimetic-mineralization-behavior
#3
Buguang Zhou, Min He, Ping Wang, Haitian Fu, Yuanyuan Yu, Qiang Wang, Xuerong Fan
Silk fibroin (SF) as a bioactive protein can offer growth substrates for hydroxyapatite (HAp) deposition. In the current work, graft copolymerization of acrylic acid (AA) onto fibroin chains was carried out using hydrogen peroxide-horseradish peroxidase (H2O2-HRP) catalytic system, SF-g-polyacrylic acid (PAA) membranes was prepared subsequently, followed by in situ biomimetic mineralization in the Ca/P solutions, aiming at promoting the deposition of HAp and endowing the fibroin-based biocomposite with enhanced bioactivity...
December 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28883135/insights-into-the-draft-genome-sequence-of-a-haitian-variant-vibrio%C3%A2-cholerae-strain-isolated-from-a-clinical-setting-in-kerala-south-india
#4
Lekshmi Narendrakumar, Karthika Suryaletha, Dinesh Reghunathan, Manoj Prasannakumar, Sabu Thomas
We report here the draft genome sequence of a Haitian variant Vibrio cholerae strain, W4-13, isolated from Kerala, South India, possessing cholera toxin gene in chromosomes I and II. The sequence will be useful to achieve a profound understanding on its evolution, with emphasis on its pathogenesis and antibiotic resistance.
September 7, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28875866/in-haitian-women-and-preschool-children-iron-absorption-from-wheat-flour-based-meals-fortified-with-sodium-iron-edta-is-higher-than-that-from-meals-fortified-with-ferrous-fumarate-and-is-not-affected-by-helicobacter-pylori-infection-in-children
#5
RANDOMIZED CONTROLLED TRIAL
Isabelle Herter-Aeberli, Kerline Eliancy, Yanick Rathon, Cornelia U Loechl, Joseline Marhône Pierre, Michael B Zimmermann
Fe fortification of wheat flour was proposed in Haiti to combat Fe deficiency, but Fe bioavailability from fortificants has never been investigated in Haitian women or preschool children, two key target groups. We aimed to investigate the bioavailability of ferrous fumarate (FeFum), NaFeEDTA and their combination from fortified wheat flour. We recruited twenty-two healthy mother-child pairs in Port au Prince, Haiti, for an Fe-absorption study. We administered stable Fe isotopes as FeFum or NaFeEDTA individually in low-extraction wheat flour bread rolls consumed by all participants in a randomised, cross-over design...
August 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28864264/a-self-reported-needs-assessment-survey-of-pediatric-orthopaedic-education-in-haiti
#6
Rameez A Qudsi, Heather J Roberts, Abhiram R Bhashyam, Elena Losina, Donald S Bae, Francel Alexis, George S Dyer
OBJECTIVE: The burden of musculoskeletal disease remains high in low-income countries, with a high rate of pediatric disease. Efforts continue for orthopedic education, but there is little guidance on local needs and desires. Our aim was to determine the specific content and modalities that would be most useful for pediatric orthopedic educational programs abroad, and we demonstrate a practical method of identifying country-specific educational deficits through a self-reported needs survey in Haiti...
August 29, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28831447/presentation-treatment-and-outcomes-of-haitian-women-with-breast-cancer-in-miami-and-haiti-disparities-in-breast-cancer-a-retrospective-cohort-study
#7
Alexandra Gomez, Vincent DeGennaro, Sophia H L George, Isildinha M Reis, Estefania Santamaria, Gustavo Figueiredo Westin, Dieudina Gabriel, Judith Hurley
PURPOSE: We compared a cohort of Haitian immigrants with residents in Haiti with breast cancer (BC) to evaluate the effects of location on presentation, treatment, and outcomes. PATIENTS AND METHODS: Participants were Haitian women with BC living in Miami who presented to the University of Miami/Jackson Memorial Hospital and women with BC living in Haiti who presented to the Innovating Health International Women's Cancer Center. The primary outcome was the relationship between location, cancer characteristics, and survival...
August 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/28820711/molecular-epidemiology-of-cholera-outbreaks-during-the-rainy-season-in-mandalay-myanmar
#8
Amonrattana Roobthaisong, Kazuhisa Okada, Nilar Htun, Wah Wah Aung, Warawan Wongboot, Watcharaporn Kamjumphol, Aye Aye Han, Yi Yi, Shigeyuki Hamada
Cholera, caused by Vibrio cholerae, remains a global threat to public health. In Myanmar, the availability of published information on the occurrence of the disease is scarce. We report here that cholera incidence in Mandalay generally exhibited a single annual peak, with an annual average of 312 patients with severe dehydration over the past 5 years (since 2011) and was closely associated with the rainy season. We analyzed cholera outbreaks, characterized 67 isolates of V. cholerae serogroup O1 in 2015 from patients from Mandalay, and compared them with 22 V...
August 14, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28820704/the-price-of-peace-peacekeeping-with-impunity-harms-public-health-in-haiti
#9
Louise C Ivers, Yodeline Guillaume
In April, 2017, the United Nations (UN) announced that it will withdraw peacekeeping soldiers from Haiti after 13 years there.(1) Known by its French acronym MINUSTAH, the mission has been controversial in security terms, but in terms of public health, it is not controversial to state that peacekeepers will be leaving a heavy mark on the health of Haitians. The UN has acknowledged that peacekeeping soldiers were responsible for both the introduction of cholera (which sparked a nationwide epidemic) and the sexual abuse and exploitation of Haitians, including minors...
August 7, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28804986/effects-of-hydroxycitric-acid-on-lipid-droplet-accumulation-in-chicken-embryos
#10
Mengling Peng, Longlong Li, Lei Yu, Chongyang Ge, Haitian Ma
This study was conducted to determine the impact of (-)-hydroxycitric acid ((-)-HCA) on biochemical indices and lipid metabolism parameters in chicken embryos. Two hundred and forty fertilized eggs were divided into six groups and injected with (-)-HCA at concentrations of 0, 0.1, 0.5, 1.0, 10.0 and 50 mg/kg (n = 40). After 19 days of incubation, serum and liver were collected for analysis of biochemical indices and lipid metabolism parameters. Results showed no significant differences on serum biochemical indices: 1-50 mg/kg (-)-HCA significantly increased serum glucose and hepatic glycogen contents (P < 0...
August 14, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28804083/vaginal-infections-in-haitian-immigrant-women-living-in-miami-florida
#11
Julia Seay, Morgan Mandigo, Karina Hew, Erin Kobetz
OBJECTIVE: To characterize vulvovaginal candidiasis (VC), trichomonas vaginalis (TV), and bacterial vaginosis (BV) among Haitian women living in Miami to identify contributing factors to cervical cancer disparity in this population. METHODS: Using a CBPR framework, 246 Haitian women (ages 21-65) were recruited. Self-collected cervical cytology specimens were analyzed for VC, TV, and BV. RESULTS: The proportion of participants with VC, TV, and BV, were 7...
2017: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/28796056/examining-the-association-between-possessing-a-regular-source-of-healthcare-and-adherence-with-cancer-screenings-among-haitian-households-in-little-haiti-miami-dade-county-florida
#12
Hauchie Pang, Mariel Cataldi, Emmanuelle Allseits, Melissa Ward-Peterson, Pura Rodríguez de la Vega, Grettel Castro, Juan Manuel Acuña
Immigrant minorities regularly experience higher incidence and mortality rates of cancer. Frequently, a variety of social determinants create obstacles for those individuals to get the screenings they need. This is especially true for Haitian immigrants, a particularly vulnerable immigrant population in South Florida, who have been identified as having low cancer screening rates. While Haitian immigrants have some of the lowest cancer screening rates in the country, there is little existing literature that addresses barriers to cancer screenings among the population of Little Haiti in Miami-Dade County, Florida...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28777660/moral-adherence-hiv-treatment-undetectability-and-stigmatized-viral-loads-among-haitians-in-south-florida
#13
Chelsea Cormier McSwiggin
In the United States, HIV is rendered a chronic condition, and viral transmission is minimized through strict adherence to pharmaceutical treatment. Treatment reduces viral loads to untraceable levels in the blood, a status known as 'undetectable', as determined by laboratory testing. For Haitians living with HIV in South Florida, 'undetectable' has become more than a viral status; it is a means to know and govern themselves as moral actors and to survey and stigmatize others who remain 'detectable'. The ethnographic evidence I present here suggests that Haitians adopt novel forms of subjectivity based on undetectability, producing identities entangled in biotechnical categorizations and dominant narratives of responsibility, morality, and health...
August 4, 2017: Medical Anthropology
https://www.readbyqxmd.com/read/28767964/-international-migration-health-and-work-an-analysis-of-haitians-in-mato-grosso-state-brazil
#14
Luís Henrique da Costa Leão, Ana Paula Muraro, Cássia Carraco Palos, Maria Angela C Martins, Fabiano Tonaco Borges
This article addresses the relations between immigration, health, and work in Haitian immigrants in Cuiabá and Várzea Grande, Mato Grosso State, Brazil, emphasizing their work conditions. This was an exploratory study based on primary data collected through a survey of the Haitian population in Cuiabá in 2014-2015. A total of 452 Haitians were interviewed, living in Cuiabá and Várzea Grande (373 men and 79 women), and the findings point to the precarious social situation of Haitian immigrants in Mato Grosso State, marked by high unemployment...
July 27, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28755088/adjuvant-endocrine-monotherapy-for-postmenopausal-early-breast-cancer-patients-with-hormone-receptor-positive-a-systemic-review-and-network-meta-analysis
#15
REVIEW
Zhu Yu, Xiaojing Guo, Yicheng Jiang, Lei Teng, Jinwu Luo, Pengfei Wang, Yunsheng Liang, Haitian Zhang
BACKGROUND: In patients with hormone receptor-positive postmenopausal of early stage breast cancer, adjuvant endocrine monotherapies include letrozole, anastrozole, exemestane, toremifene and tamoxifen. But the optimum regimen remains controversial. METHODS: PubMed, Cochrane Database and ClinicalTrials.gov were systematically reviewed of abstract for randomized-controlled trials (RCTs) to assess the efficacy of tamoxifen, letrozole, exemestane, anastrozle and toremifene for postmenopausal patients with hormone-receptor positive (HR+), who have not received prior therapy for early stage breast cancer...
July 28, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/28752949/haitian-people-s-expectations-regarding-post-disaster-humanitarian-aid-teams-actions
#16
Lonzozou Kpanake, Ronald Jean-Jacques, Paul Clay Sorum, Etienne Mullet
The way people at the receiving end of humanitarian assistance perceive this intervention may provide invaluable bottom-up feedback to improve the quality of the intervention. We analyzed and mapped Haitians' views regarding international humanitarian aid in cases of natural disaster. Two hundred fifty participants-137 women and 113 men aged 18-67-who had suffered from the consequences of the earthquake in 2010 were presented with a series of vignettes depicting a humanitarian team's action and were asked to what extent these actions corresponded to what ought to be expected from an international aid mission...
July 28, 2017: Developing World Bioethics
https://www.readbyqxmd.com/read/28742880/same-day-hiv-testing-with-initiation-of-antiretroviral-therapy-versus-standard-care-for-persons-living-with-hiv-a-randomized-unblinded-trial
#17
RANDOMIZED CONTROLLED TRIAL
Serena P Koenig, Nancy Dorvil, Jessy G Dévieux, Bethany L Hedt-Gauthier, Cynthia Riviere, Mikerlyne Faustin, Kerlyne Lavoile, Christian Perodin, Alexandra Apollon, Limathe Duverger, Margaret L McNairy, Kelly A Hennessey, Ariadne Souroutzidis, Pierre-Yves Cremieux, Patrice Severe, Jean W Pape
BACKGROUND: Attrition during the period from HIV testing to antiretroviral therapy (ART) initiation is high worldwide. We assessed whether same-day HIV testing and ART initiation improves retention and virologic suppression. METHODS AND FINDINGS: We conducted an unblinded, randomized trial of standard ART initiation versus same-day HIV testing and ART initiation among eligible adults ≥18 years old with World Health Organization Stage 1 or 2 disease and CD4 count ≤500 cells/mm3...
July 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28737079/menstrual-education-and-personal-hygiene-supplies-to-empower-young-women-in-haiti
#18
Patricia Coker-Bolt, Annika Jansson, Sherridan Bigg, Elizabeth Hammond, Harmony Hudson, Sarah Hunkler, Jana Kitch, Heather Richardson, Erica Tiedemann, Janet O'Flynn, Marie Dominque Laurent
Recent studies report that Haitian women are concerned about unmet women's health issues. The Days for Girls (DfG) International program features women's health education and personal hygiene kits to ensure women understand the process of menstruation and sanitary hygiene practices. The aim was to train Haitian seamstresses to produce the DfG kits during an in-country workshop and investigate the perceived benefit of the DfG program in young women who used the DfG kits. Posttest only design was used to measure the effectiveness of DfG workshop and postsurvey to study perception of women using DfG kits...
July 1, 2017: OTJR: Occupation, Participation and Health
https://www.readbyqxmd.com/read/28734541/response-to-mortality-length-of-stay-bloodstream-and-respiratory-viral-infections-in-a-pediatric-intensivecare-unit-comment-on-data-sparsity
#19
Kam Lun Hon, Maggie Haitian Wang
No abstract text is available yet for this article.
July 9, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28729127/variation-in-safe-sleep-and-breastfeeding-practices-among-non-hispanic-black-mothers-in-the-us-according-to-birth-country
#20
Margaret G K Parker, Eve R Colson, Lauren Provini, Denis V Rybin, Stephen M Kerr, Timothy Heeren, Michael J Corwin
OBJECTIVE: To examine variation in safe sleep and breastfeeding practices among US non-Hispanic black (NHB) mothers according to birth country METHODS: We analyzed NHB mothers that were surveyed regarding safe sleep and breastfeeding practices when their infants were 2-6 months of age in 2011-14, as part of a larger national study. We examined prevalences of safe sleep and breastfeeding practices according to birth country and examined odds of adherence to American Academy of Pediatrics recommended safe sleep and breastfeeding practices in foreign born NHBs, compared to US born NHBs...
July 17, 2017: Academic Pediatrics
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