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Ryan C Jacobs, Shawn Groth, Farhood Farjah, Mark A Wilson, Laura A Petersen, Nader N Massarweh
OBJECTIVE: To quantify the number of US hospitals that would meet "Take the Volume Pledge" (TVP) volume thresholds and compare outcomes at hospitals meeting and not meeting TVP thresholds. SUMMARY BACKGROUND DATA: TVP aims to regionalize complex cancer resections to hospitals meeting established annual average volume thresholds. There is little data describing the potential impact on patient access if this initiative were broadly implemented or the relationship between these volume thresholds and quality of oncologic care...
April 24, 2018: Annals of Surgery
Long Wu, Huan Zhang, Yixing Jiang, Robert C Gallo, Hua Cheng
Dendritic cell (DC)-based cancer immunotherapy has achieved modest clinical benefits, but several technical hurdles in DC preparation, activation, and cancer/testis antigen (CTA) delivery limit its broad applications. Here, we report the development of immortalized and constitutively activated human primary blood dendritic cell lines (ihv-DCs). The ihv-DCs are a subset of CD11c+ /CD205+ DCs that constitutively display costimulatory molecules. The ihv-DCs can be genetically modified to express human telomerase reverse transcriptase (hTERT) or the testis antigen MAGEA3 in generating CTA-specific cytotoxic T lymphocytes (CTLs)...
April 19, 2018: Proceedings of the National Academy of Sciences of the United States of America
K Hallén, P Jildenstål, O Stenqvist, J Oras, S-E Ricksten, S Lindgren
BACKGROUND: Isocapnic hyperventilation (IHV) shortens recovery time after inhalation anaesthesia by increasing ventilation while maintaining a normal airway carbon dioxide (CO2 )-level. One way of performing IHV is to infuse CO2 to the inspiratory limb of a breathing circuit during mechanical hyperventilation (HV). In a prospective randomized study, we compared this IHV technique to a standard emergence procedure (control). METHODS: Thirty-one adult ASA I-III patients undergoing long-duration (>3 hours) sevoflurane anaesthesia for major head and neck surgery were included and randomized to IHV-treatment (n = 16) or control (n = 15)...
April 19, 2018: Acta Anaesthesiologica Scandinavica
Jaehun Jung, Sung-Jun Ko, Hong Sang Oh, Song Mi Moon, Jin-Won Song, Kyungmin Huh
As there is no effective treatment against hemorrhagic fever with renal syndrome (HFRS), the development of effective vaccine is important. An inactivated hantavirus vaccine (IHV) has been used in Korea, but there has been controversy regarding its effectiveness. We conducted a case-control study to evaluate the vaccine effectiveness (VE) of IHV against HFRS in the Korean military. Unadjusted and adjusted VEs of IHV were 59.1% and 58.9%, respectively. VE was higher in divisions with high incidence of HFRS (unadjusted VE, 71...
April 11, 2018: Journal of Infectious Diseases
K Hallén, P Jildenstål, O Stenqvist, S-E Ricksten, S Lindgren
BACKGROUND: Isocapnic hyperventilation (IHV) is a method that shortens time to extubation after inhalation anaesthesia using hyperventilation (HV) without lowering airway CO2 . In a clinical trial on patients undergoing long-duration sevoflurane anaesthesia for major ear-nose-throat (ENT) surgery, we evaluated the utility of a technique for CO2 delivery (DCO2 ) to the inspiratory limb of a closed breathing circuit, during HV, to achieve isocapnia. METHODS: Fifteen adult ASA 1-3 patients were included...
February 2018: Acta Anaesthesiologica Scandinavica
(no author information available yet)
Health visitors are in a good position to spot the signs that someone is living as a domestic slave, according to the Institute of Health Visiting (IHV).
April 26, 2017: Nursing Standard
Sara Khalid Memon
OBJECTIVE: To evaluate the ultrasound abdomen findings in patients having viral chronic liver disease (CLD) and build correlation of these findings with the duration of disease. STUDY DESIGN: Cross-sectional analytical study. PLACE AND DURATION OF STUDY: Department of Medicine, Liaquat University Hospital, Hyderabad and Jamshoro, Pakistan, from February to July 2016. METHODOLOGY: Known cases of CLD were inducted. Data was collected using a standardized form which included details of patients, duration of disease and their ultrasound abdomen findings, like liver size, echo pattern and echogenicity, nodularity, intrahepatic vessel (IHV) obliteration, ascites and splenomegaly...
March 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Stefan Hindel, Anika Söhner, Marc Maaß, Wolfgang Sauerwein, Dorothe Möllmann, Hideo Andreas Baba, Martin Kramer, Lutz Lüdemann
The purpose of this study was to assess the accuracy of fractional blood volume (vb) estimates in low-perfused and low-vascularized tissue using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). The results of different MRI methods were compared with histology to evaluate the accuracy of these methods under clinical conditions. vb was estimated by DCE-MRI using a 3D gradient echo sequence with k-space undersampling in five muscle groups in the hind leg of 9 female pigs. Two gadolinium-based contrast agents (CA) were used: a rapidly extravasating, extracellular, gadolinium-based, low-molecular-weight contrast agent (LMCA, gadoterate meglumine) and an extracellular, gadolinium-based, albumin-binding, slowly extravasating blood pool contrast agent (BPCA, gadofosveset trisodium)...
2017: PloS One
K Hallén, O Stenqvist, S-E Ricksten, S Lindgren
BACKGROUND: Isocapnic hyperventilation (IHV) is a method that fastens weaning from inhalation anaesthesia by increasing airway concentration of carbon dioxide (CO2 ) during hyperventilation (HV). In an animal model, we evaluated a technique of adding CO2 directly to the breathing circuit of a standard anaesthesia apparatus. METHODS: Eight anaesthetised pigs weighing 28 ± 2 kg were intubated and mechanically ventilated. From a baseline ventilation of 5 l/min, HV was achieved by doubling minute volume and fresh gas flow...
October 2016: Acta Anaesthesiologica Scandinavica
K Hallén, O Stenqvist, S-E Ricksten, S Lindgren
BACKGROUND: Isocapnic hyperventilation (IHV) has the potential to increase the elimination rate of anaesthetic gases and has been shown to shorten time to wake-up and post-operative recovery time after inhalation anaesthesia. In this bench test, we describe a technique to achieve isocapnia during hyperventilation (HV) by adding carbon dioxide (CO2) directly to the breathing circuit of a standard anaesthesia apparatus with standard monitoring equipment. METHODS: Into a mechanical lung model, carbon dioxide was added to simulate a CO2 production (V(CO2)) of 175, 200 and 225 ml/min...
May 2016: Acta Anaesthesiologica Scandinavica
Elaine McInnes
Many new qualified health visitors may find the transition from being a student to an accountable individual practitioner a daunting prospect. Although competent and knowledgeable, they may feel the need for support and guidance of more experienced professional colleagues as they find their feet in professional practice. The same may apply to those who have returned to practice after a break of five years or more. It may also apply to those who move registerable qualification, for example a registered nurse who subsequently qualifies as a health visitor...
October 2015: Community Practitioner: the Journal of the Community Practitioners' & Health Visitors' Association
T S Musaeva, A P Berdnikov, S I Goncharenko, E A Denisova
We performed a retrospective study in 68 patients (144 procedures) with severe sepsis and intracranial hypertension measured by the pressure in the central retinal vein. The patients underwent high-volume hemofiltration (HV-HF) for extrarenal indications. Increased pressure in the central retinal vein was accompanied by critical points of cerebral perfusion pressure and the growth of neurological deficit with inhibition level of consciousness to coma 1. In this case, IHV-HF may be associated with the formation of the critical points of cerebral perfihsion and severe disorders of microcirculation and the lack of resolution of tissue hypoperfusion...
November 2014: Anesteziologiia i Reanimatologiia
Mahua Dey, Agnieszka Stadnik, Fady Riad, Lingjiao Zhang, Nichol McBee, Carlos Kase, J Ricardo Carhuapoma, Malathi Ram, Karen Lane, Noeleen Ostapkovich, Francois Aldrich, Charlene Aldrich, Jack Jallo, Ken Butcher, Ryan Snider, Daniel Hanley, Wendy Ziai, Issam A Awad
BACKGROUND: Retrospective series report varied rates of bleeding and infection with external ventricular drainage (EVD). There have been no prospective studies of these risks with systematic surveillance, threshold definitions, or independent adjudication. OBJECTIVE: To analyze the rate of complications in the ongoing Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase III (CLEAR III) trial, providing a comparison with a systematic review of complications of EVD in the literature...
March 2015: Neurosurgery
Petra Kendall-Raynor
The Institute of Health Visiting (iHV) fellows programme is sponsored by the Department of Health. It acknowledges 150 health visitors invited to participate in a leadership programme.
November 18, 2014: Nursing Standard
C Schabel, M Bongers, M Sedlmair, A Korn, U Grosse, S Mangold, C D Claussen, C Thomas
PURPOSE: To evaluate a novel monoenergetic post-processing algorithm (MEI+) in patients with poor intrahepatic contrast enhancement. MATERIALS AND METHODS: 25 patients were retrospectively included in this study. Late-phase imaging of the upper abdomen, which was acquired in dual-energy mode (100/140 kV), was used as a model for poor intrahepatic contrast enhancement. Traditional monoenergetic images (MEI), linearly weighted mixed images with different mixing ratios (MI), sole 100 and 140 kV and MEI+ images were calculated...
June 2014: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
Shahin Minouchehr, Arnold Radtke, Georgios C Sotiropoulos, Ernesto P Molmenti, Felix Braun, Milo Hindennach, Human Honarpisheh, Vito R Cicinnati, Massimo Malagó, Dieter C Broering, Tobias Schroeder
BACKGROUND/AIMS: Inadequate knowledge of the right (RHV) and accessory (IHV) hepatic 'venous drainage' territories can lead to severe postoperative venous congestion after right graft live donor liver transplantation. The purpose of our study was to define the anatomical-functional RHV and IHV drainage territories. METHODOLOGY: One hundred and forty consecutive live liver donor candidates were evaluated by means of 3-D CT reconstructions and 3-D virtual hepatectomies...
September 2011: Hepato-gastroenterology
Katarzyna Kosinska-Kaczynska, Robert Bartkowiak, Bartosz Kaczynski, Iwona Szymusik, Miroslaw Wielgos
The aim of the study was to determine whether human fetuses show ACTH response to stress stimuli, to define the gestational age from which these reactions may be present and to analyze the relationship between hormone concentrations and their changes, both in fetuses and in pregnant women. The study included 81 intrauterine transfusions carried out in 19 pregnant women. 52 procedures were performed directly into the umbilical vein, which is not innervated, so neutral for the fetus (the PCI group) and 29 transfusions into the intrahepatic vein -which puncture is stressful for the fetus (the IHV group)...
April 2012: Early Human Development
C Sabbagh, F Dumont, B Robert, R Badaoui, P Verhaeghe, J-M Regimbeau
INTRODUCTION: The surgical treatment of large incisional hernias with loss of domain (LIHLD) carries the risk of fascia closure under tension and, thus, abdominal compartment syndrome. We investigated volume measurements as a predictive factor for tension-free fascia closure. PATIENTS AND METHODS: From September 2004 to July 2008, we prospectively included 17 patients with LIHLD. The operation was prepared by a progressive preoperative pneumoperitoneum (PPP) technique known as the Goni Moreno procedure...
October 2011: Hernia: the Journal of Hernias and Abdominal Wall Surgery
P N Adama van Scheltema, S A Pasman, R Wolterbeek, J A Deprest, D Oepkes, F De Buck, M Van de Velde, F P H A Vandenbussche
OBJECTIVE: To document fetal stress hormone and Doppler changes after intrauterine transfusions (IUTs) in either the intrahepatic portion of the umbilical vein (IHV) or the placental cord insertion (PCI). METHOD: Pregnant women scheduled for IUT for fetal anemia (N = 25) were included prospectively. Cortisol, β-endorphin and noradrenalin concentrations in fetal plasma and middle cerebral artery pulsatility index before and after transfusion were compared. Transfusions were performed through the (IHV), thus puncturing the fetus, or at the PCI...
June 2011: Prenatal Diagnosis
Takahisa Kaneko, Takeshi Tomiyama, Hajime Kiyuna, Tadashi Machida, Hiromitsu Hayashi, Shin-Ichiro Kumita
BACKGROUND: Couinaud's segmentation is widely used for clinical segmentation of the liver. Recently, a new method of liver segmentation was described by Ryu. In this method, the right posterior sector in Couinaud's segmentation is regarded as 1 segment, and the right anterior sector is subdivided into the antero-ventral segment (AVS) and the antero-dorsal segment (ADS), which are demarcated by the anterior fissure vein (AFV). We used data from multi-detector row computed tomography (MDCT) to identify the portal and hepatic veins that are used as anatomical landmarks in both Couinaud's segmentation and Ryu's segmentation...
October 2010: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
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