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https://www.readbyqxmd.com/read/28524731/german-taxi-drivers-experience-and-expression-of-driving-anger-are-the-driving-anger-scale-and-the-driving-anger-expression-inventory-valid-measures
#1
Stefan Brandenburg, Michael Oehl, Kristin Seigies
OBJECTIVE: The objective of this paper was twofold: firstly, we wanted to examine whether the original Driving Anger Scale (DAS) and the original Driving Anger Expression Inventory (DAX) apply to German professional taxi drivers as these scales have previously been given to professional and particularly to non-professional drivers in different countries. Secondly, we wanted to examine possible differences in driving anger experience and expression between professional German taxi drivers and non-professional German drivers...
May 19, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28524365/revision-of-the-competency-standards-for-occupational-therapy-driver-assessors-an-overview-of-the-evidence-for-the-inclusion-of-cognitive-and-perceptual-assessments-within-fitness-to-drive-evaluations
#2
REVIEW
Sally M Fields, Carolyn A Unsworth
BACKGROUND/AIM: Determination of fitness-to-drive after illness or injury is a complex process typically requiring a comprehensive driving assessment, including off-road and on-road assessment components. The competency standards for occupational therapy driver assessors (Victoria, Australia) define the requirements for performance of a comprehensive driving assessment, and we are currently revising these. Assessment of cognitive and perceptual skills forms an important part of the off-road assessment...
May 19, 2017: Australian Occupational Therapy Journal
https://www.readbyqxmd.com/read/28520671/living-life-after-traumatic-brain-injury-phase-1-of-a-longitudinal-qualitative-study
#3
Kathryn McPherson, Joanna Fadyl, Alice Theadom, Alexis Channon, William Levack, Nicola Starkey, Laura Wilkinson-Meyers, Nicola Kayes
OBJECTIVE: To explore what helps and hinders recovery and adaptation after disabling traumatic brain injury (TBI) and make recommendations for improving service responsiveness. DESIGN: A longitudinal qualitative descriptive study across all TBI severities. SETTING: Community. PARTICIPANTS: Forty people with TBI, and 22 significant others, 6 to 9 months following a TBI. MAIN MEASURES: Semistructured interviews, analyzed using qualitative description, focused on (a) key areas of importance or concern and (b) strategies or actions that people found helpful or that hindered recovery...
May 17, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28515871/wolf-in-sheep-s-clothing-model-misspecification-undermines-tests-of-the-neutral-theory-for-life-histories
#4
Matthieu Authier, Lise M Aubry, Emmanuelle Cam
Understanding the processes behind change in reproductive state along life-history trajectories is a salient research program in evolutionary ecology. Two processes, state dependence and heterogeneity, can drive the dynamics of change among states. Both processes can operate simultaneously, begging the difficult question of how to tease them apart in practice. The Neutral Theory for Life Histories (NTLH) holds that the bulk of variations in life-history trajectories is due to state dependence and is hence neutral: Once previous (breeding) state is taken into account, variations are mostly random...
May 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28515419/new-insights-into-ocean-sunfish-mola-mola-abundance-and-seasonal-distribution-in-the-northeast-atlantic
#5
Patricia Breen, Ana Cañadas, Oliver Ó Cadhla, Mick Mackey, Meike Scheidat, Steve C V Geelhoed, Emer Rogan, Mark Jessopp
The ocean sunfish, Mola mola, is the largest teleost fish in the world. Despite being found in all oceans of the world, little is known about its abundance and factors driving its distribution. In this study we provide the first abundance estimates for sunfish in offshore waters in the northeast Atlantic and the first record of extensive sunfish presence in these waters year-round. Abundance estimates and predictive distributions for sunfish in approximately 300,000 km² of the northeast Atlantic were derived from large scale offshore aerial surveys in 2015-2016 using distance sampling techniques...
May 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28500779/beyond-nutrients-a-meta-analysis-of-the-diverse-effects-of-arbuscular-mycorrhizal-fungi-on-plants-and-soils
#6
Camille S Delavaux, Lauren M Smith-Ramesh, Sara E Kuebbing
Arbuscular mycorrhizal fungi (AMF) can increase plant fitness under certain environmental conditions. Among the mechanisms that may drive this mutualism, the most studied is provisioning of nutrients by AMF in exchange for carbon from plant hosts. However, AMF may also provide a suite of non-nutritional benefits to plants including improved water uptake, disease resistance, plant chemical defense, soil aggregation, and allelochemical transport and protection. Here, we use a meta-analysis of 93 studies to assess the relative effect of AMF on nutritional and non-nutritional factors that may influence plant fitness...
May 13, 2017: Ecology
https://www.readbyqxmd.com/read/28490584/a-naturally-occurring-recombinant-enterovirus-expresses-a-torovirus-deubiquitinase
#7
Pengcheng Shang, Saurav Misra, Ben Hause, Ying Fang
Enteroviruses are implicated in a wide range of diseases in human and animals. In this study, a novel enterovirus (species G; EVG 08/NC_USA/2015) was isolated from a diagnostic sample of neonatal pig diarrhea case and identified using metagenomics and complete genome sequencing. The viral genome shares 75.4% nucleotide identity with a prototypic EVG strain (PEV9 UKG/410/73). Remarkably, a 582 nucleotide insertion, flanked by 3C(pro) cleavage sites at 5' - and 3' - ends, was found in the 2C/3A junction region of the viral genome...
May 10, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28490286/loss-of-consciousness-collapse-and-associated-driving-restrictions-a-retrospective-case-note-review-an-important-reminder-regarding-driving-restrictions
#8
Adam Williamson, Scott Muir
Background and aims National guidelines outlining medical standards for fitness to drive are provided by The Driver and Vehicle Licensing Agency. We aimed to establish whether patients presenting with collapse or loss of consciousness received documented advice regarding driving restrictions, if appropriate for their working diagnosis. Methods and results A retrospective case note review was undertaken over a four-month period for emergency patients clinically coded as seizure/convulsion (R568) and collapse/syncope (R55X); 163 patients had a primary or working diagnosis on discharge that suggested driving status and restrictions could have been reviewed...
January 1, 2017: Scottish Medical Journal
https://www.readbyqxmd.com/read/28487387/different-determinants-of-ventilatory-inefficiency-at-different-stages-of-reduced-ejection-fraction-chronic-heart-failure-natural-history
#9
Alessandro Mezzani, Andrea Giordano, Klara Komici, Ugo Corrà
BACKGROUND: It is not known whether determinants of ventilation (VE)/volume of exhaled carbon dioxide (VCO2) slope during incremental exercise may differ at different stages of reduced ejection fraction chronic heart failure natural history. METHODS AND RESULTS: VE/VCO2 slope was fitted up to lowest VE/VCO2 ratio, that is, a proxy of the VE/perfusion ratio devoid of nonmetabolic stimuli to ventilatory drive. VE/VCO2 slope tertiles were generated from our database (<27...
May 9, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28485924/cooperative-interactions-in-the-hammerhead-ribozyme-drive-pka-shifting-of-g12-and-its-stacked-base-c17
#10
Erica A Frankel, Christopher A Strulson, Christine D Keating, Philip C Bevilacqua
General acid-base catalysis is a key mechanistic strategy in protein and RNA enzymes. Ribozymes use hydrated metal ions, nucleobases, and organic cofactors to carry this out. In most small ribozymes, a guanosine is positioned to participate in proton transfer with the nucleophilic 2'-OH. The unshifted pKa values for nucleobases and solvated metal ions are far from neutrality, however, and thus nonideal for general acid-base catalysis. Herein, evidence is provided for cooperative interaction in the hammerhead ribozyme among the guanine that interacts with the nucleophilic 2'-OH, G12, the -1 nucleobase C17, and Mg(2+) ions...
May 9, 2017: Biochemistry
https://www.readbyqxmd.com/read/28481347/membrane-curvature-regulates-ligand-specific-membrane-sorting-of-gpcrs-in-living-cells
#11
Kadla R Rosholm, Natascha Leijnse, Anna Mantsiou, Vadym Tkach, Søren L Pedersen, Volker F Wirth, Lene B Oddershede, Knud J Jensen, Karen L Martinez, Nikos S Hatzakis, Poul Martin Bendix, Andrew Callan-Jones, Dimitrios Stamou
The targeted spatial organization (sorting) of Gprotein-coupled receptors (GPCRs) is essential for their biological function and often takes place in highly curved membrane compartments such as filopodia, endocytic pits, trafficking vesicles or endosome tubules. However, the influence of geometrical membrane curvature on GPCR sorting remains unknown. Here we used fluorescence imaging to establish a quantitative correlation between membrane curvature and sorting of three prototypic class A GPCRs (the neuropeptide Y receptor Y2, the β1 adrenergic receptor and the β2 adrenergic receptor) in living cells...
May 8, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28480017/the-evolution-of-different-maternal-investment-strategies-in-two-closely-related-desert-vertebrates
#12
Joshua R Ennen, Jeffrey E Lovich, Roy C Averill-Murray, Charles B Yackulic, Mickey Agha, Caleb Loughran, Laura Tennant, Barry Sinervo
We compared egg size phenotypes and tested several predictions from the optimal egg size (OES) and bet-hedging theories in two North American desert-dwelling sister tortoise taxa, Gopherus agassizii and G. morafkai, that inhabit different climate spaces: relatively unpredictable and more predictable climate spaces, respectively. Observed patterns in both species differed from the predictions of OES in several ways. Mean egg size increased with maternal body size in both species. Mean egg size was inversely related to clutch order in G...
May 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28474463/entropy-drives-the-formation-of-salt-bridges-in-protein-gb3
#13
Lishan Yao, Ning Zhang, Yefei Wang, Liaoyuan An, Qingshan Huang, Zhijun Liu
Salt bridges are very common in proteins. But what drives the formation of protein salt bridges is not that clear. In this work, we determined the strength of four salt bridges in protein GB3 by measuring dpKa values of the basic residues that constitute the salt bridges with a highly accurate NMR titration method at different temperatures. The results show that the dpKas increase with temperature, indicating that the salt bridges are stronger at higher temperature. Fitting of dpKas to the van't Hoff equation yields positive dH and dS, indicating that entropy drives the salt bridge formation...
May 4, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28472031/estimating-the-effect-of-multiple-environmental-stressors-on-coral-bleaching-and-mortality
#14
Paul D Welle, Mitchell J Small, Scott C Doney, Inês L Azevedo
Coral cover has been declining in recent decades due to increased temperatures and environmental stressors. However, the extent to which different stressors contribute both individually and in concert to bleaching and mortality is still very uncertain. We develop and use a novel regression approach, using non-linear parametric models that control for unobserved time invariant effects to estimate the effects on coral bleaching and mortality due to temperature, solar radiation, depth, hurricanes and anthropogenic stressors using historical data from a large bleaching event in 2005 across the Caribbean...
2017: PloS One
https://www.readbyqxmd.com/read/28462775/feasibility-of-a-novel-combination-of-influenza-vaccinations-and-child-passenger-safety-seat-fittings-in-a-drive-through-clinic-setting
#15
Ngoc Le, Rachel L Charney, James Gerard
OBJECTIVE: Public health preparedness is an ever-evolving area of medicine with the purpose of helping the masses quickly and efficiently. The drive-through clinic (DTC) model allows the distribution of supplies or services while participants remain in their cars. Influenza vaccination is the most common form of DTC and has been utilized successfully in metropolitan areas. METHODS: We hypothesized that combining influenza vaccinations and child passenger seat fittings in a DTC format would be both feasible and desired by the community...
May 2, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28462584/gpx4-lipid-peroxidation-and-cell-death-discoveries-rediscoveries-and-open-issues
#16
Matilde Maiorino, Marcus Conrad, Fulvio Ursini
SIGNIFICANCE: Iron-dependent lipid peroxidation is a complex oxidative process where phospholipid hydroperoxides (PLOOH) are produced in membranes and finally transformed into a series of decomposition products, some of which endowed with biological activity. It is specifically prevented by GPx4, the selenoenzyme that reduces PLOOH by glutathione (GSH). PLOOH is both a product and the major initiator of peroxidative chain reactions, as well as an activator of lipoxygenases. -Tocopherol both specifically breaks peroxidative chain propagation and inhibits lipoxygenases...
May 2, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28460660/adaptive-tuning-of-mutation-rates-allows-fast-response-to-lethal-stress-in-escherichia-coli
#17
Toon Swings, Bram Van den Bergh, Sander Wuyts, Eline Oeyen, Karin Voordeckers, Kevin J Verstrepen, Maarten Fauvart, Natalie Verstraeten, Jan Michiels
While specific mutations allow organisms to adapt to stressful environments, most changes in an organism's DNA negatively impact fitness. The mutation rate is therefore strictly regulated and often considered a slowly-evolving parameter. In contrast, we demonstrate an unexpected flexibility in cellular mutation rates as a response to changes in selective pressure. We show that hypermutation independently evolves when different Escherichia coli cultures adapt to high ethanol stress. Furthermore, hypermutator states are transitory and repeatedly alternate with decreases in mutation rate...
May 2, 2017: ELife
https://www.readbyqxmd.com/read/28455506/genome-wide-fitness-analyses-of-the-foodborne-pathogen-campylobacter-jejuni-in-in-vitro-and-in-vivo-models
#18
Stefan P W de Vries, Srishti Gupta, Abiyad Baig, Elli Wright, Amy Wedley, Annette Nygaard Jensen, Lizeth LaCharme Lora, Suzanne Humphrey, Henrik Skovgård, Kareen Macleod, Elsa Pont, Dominika P Wolanska, Joanna L'Heureux, Fredrick M Mobegi, David G E Smith, Paul Everest, Aldert Zomer, Nicola Williams, Paul Wigley, Thomas Humphrey, Duncan J Maskell, Andrew J Grant
Campylobacter is the most common cause of foodborne bacterial illness worldwide. Faecal contamination of meat, especially chicken, during processing represents a key route of transmission to humans. There is a lack of insight into the mechanisms driving C. jejuni growth and survival within hosts and the environment. Here, we report a detailed analysis of C. jejuni fitness across models reflecting stages in its life cycle. Transposon (Tn) gene-inactivation libraries were generated in three C. jejuni strains and the impact on fitness during chicken colonisation, survival in houseflies and under nutrient-rich and -poor conditions at 4 °C and infection of human gut epithelial cells was assessed by Tn-insertion site sequencing (Tn-seq)...
April 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28449902/validation-of-the-epworth-sleepiness-scale-for-children-and-adolescents-using-rasch-analysis
#19
Kitty C Janssen, Sivanes Phillipson, Justen O'Connor, Murray W Johns
OBJECTIVE: A validated measure of daytime sleepiness for adolescents is needed to better explore emerging relationships between sleepiness and the mental and physical health of adolescents. The Epworth Sleepiness Scale (ESS) is a widely used scale for daytime sleepiness in adults but contains references to alcohol and driving. The Epworth Sleepiness Scale for Children and Adolescents (ESS-CHAD) has been proposed as the official modified version of the ESS for children and adolescents...
May 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28441324/designing-fit-for-purpose-health-and-social-services-for-ageing-populations
#20
Jean Woo
Population ageing is occurring in all countries, regardless of the level of economic development. While the rising burden of chronic diseases and disabilities as a consequence of this demographic transition is well recognized, the increasing prevalence of geriatric syndromes as a public health issue is not as well recognized. Recently the World Health Organization's World Health and Ageing Report emphasized functional ability as an important outcome for aging populations, highlighting the concept of raising intrinsic capacity throughout the life course...
April 25, 2017: International Journal of Environmental Research and Public Health
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