keyword
MENU ▼
Read by QxMD icon Read
search

Pterostilbene

keyword
https://www.readbyqxmd.com/read/28815872/a-multimethod-computational-simulation-approach-for-investigating-mitochondrial-dynamics-and-dysfunction-in-degenerative-aging
#1
Timothy E Hoffman, Katherine J Barnett, Lyle Wallis, William H Hanneman
Research in biogerontology has largely focused on the complex relationship between mitochondrial dysfunction and biological aging. In particular, the mitochondrial free radical theory of aging (MFRTA) has been well accepted. However, this theory has been challenged by recent studies showing minimal increases in reactive oxygen species (ROS) as not entirely deleterious in nature, and even beneficial under the appropriate cellular circumstances. To assess these significant and nonintuitive observations in the context of a functional system, we have taken an in silico approach to expand the focus of the MFRTA by including other key mitochondrial stress response pathways, as they have been observed in the nematode Caenorhabditis elegans...
August 16, 2017: Aging Cell
https://www.readbyqxmd.com/read/28808300/pterostilbene-exerts-anticancer-activity-on-non-small-cell-lung-cancer-via-activating-endoplasmic-reticulum-stress
#2
Zhiqiang Ma, Yang Yang, Shouyin Di, Xiao Feng, Dong Liu, Shuai Jiang, Wei Hu, Zhigang Qin, Yue Li, Jianjun Lv, Chongxi Fan, Xiaolong Yan, Xiaofei Li
Pterostilbene (PT), the natural dimethylated analog of resveratrol (RSV), is a potent anticarcinogen for non-small-cell lung cancer (NSCLC), but its anti-NSCLC mechanisms remain unclear. In this study, we show that PT treatment time- and dose-dependently enhanced the endoplasmic reticulum stress (ERS) signaling (i.e., p-PERK, IRE1, ATF4, CHOP), thus decreasing the cell viability and inducing apoptosis in human PC9 and A549 NSCLC cell lines. Moreover, the decreased migratory and adhesive abilities, downregulation of intracellular glutathione (GSH) level, enhanced reactive oxygen species (ROS) generation, Caspase 3 activity and mitochondrial membrane depolarization were observed in NSCLC cells treated with PT...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28803136/anti-inflammatory-activity-of-natural-stilbenoids-a-review
#3
REVIEW
Marcela Dvorakova, Premysl Landa
Resveratrol and other natural stilbenoids, including piceatannol, pterostilbene, and gnetol, are well-known anti-inflammatory compounds with indisputable activity in vitro as well as in vivo. Their molecular targets include inducible nitric oxide synthase, cyclooxygenases, leukotrienes, nuclear factor kappa B, tumor necrosis factor α, interleukins and many more. This anti-inflammatory activity together with their antioxidant activity is believed to stand behind their other positive health effects against cancer, cardiovascular and neurodegenerative diseases or diabetes...
August 9, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28796247/p53-dependent-downregulation-of-htert-protein-expression-and-telomerase-activity-induces-senescence-in-lung-cancer-cells-as-a-result-of-pterostilbene-treatment
#4
Rong-Jane Chen, Pei-Hsuan Wu, Chi-Tang Ho, Tzong-Der Way, Min-Hsiung Pan, Hsiu-Min Chen, Yuan-Soon Ho, Ying-Jan Wang
Cellular senescence is characterized by permanent cell cycle arrest, triggered by a variety of stresses, such as telomerase inhibition, and it is recognized as a tumor-suppressor mechanism. In recent years, telomerase has become an important therapeutic target in several cancers; inhibition of telomerase can induce senescence via the DNA damage response (DDR). Pterostilbene (PT), a dimethyl ether analog of resveratrol, possesses a variety of biological functions, including anticancer effects; however, the molecular mechanisms underlying these effects are not fully understood...
August 10, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28703274/pterostilbene-reduces-oxidative-stress-prevents-hypertrophy-and-preserves-systolic-function-of-right-ventricle-in-cor-pulmonale-model
#5
Denise Dos Santos Lacerda, Patrick Türck, Bruna Gazzi de Lima-Seolin, Rafael Colombo, Vanessa Duarte Ortiz, Jéssica Hellen Poletto Bonetto, Cristina Campos-Carraro, Sara Elis Bianchi, Adriane Belló-Klein, Valquiria LinckBassani, Alex Sander da Rosa Araujo
BACKGROUND AND PURPOSE: In cor pulmonale, the increased afterload imposed on the right ventricle (RV) generates a maladaptive response, impairing the contractile cardiac function. Oxidative mechanisms play an important role in the pathophysiology and progression of this disease. The administration of pterostilbene (PTS), a phyto-phenol with antioxidant potential, may represent a therapeutic alternative. In the present study, the objective was to evaluate the effect of PTS complexed with hydroxypropyl-β-cyclodextrin (HPβCD) on hypertrophy, contractile function and oxidative parameters in the RV of rats with pulmonary hypertension induced by monocrotaline administration...
July 12, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28664898/anticancer-activity-of-pterostilbene-in-human-ovarian-cancer-cell-lines
#6
Hui-Lin Pei, Dan-Mei Mu, Bin Zhang
BACKGROUND Epithelial ovarian cancer is a major cause of mortality in women and one of the most common gynecologic disorders. Pterostilbene (PTS), a trans-3,5-dimethoxy-4'-hydroxystilbene, was chosen for this work due to its reported effectiveness as a chemotherapeutic agent in cancer studies. In this work, we studied underlying molecular mechanisms of PTS treatment in various ovarian cancer cell lines such as OVCAR8, OV1063, IGROV-1, and SKOV3. MATERIAL AND METHODS We used the cytometric bead array (CBA) method and real-time PCR analysis to analyze the secretion level of tumor necrosis factor alpha (TNF-α) and to measure the TNF-α mRNA expression...
June 30, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28662290/resveratrol-and-pterostilbene-as-a-microrna-mediated-chemopreventive-and-therapeutic-strategy-in-prostate-cancer
#7
REVIEW
Avinash Kumar, Agnes M Rimando, Anait S Levenson
Growing evidence indicates that deregulation of the epigenetic machinery comprising the microRNA (miRNA) network is a critical factor in the progression of various diseases, including cancer. Concurrently, dietary phytochemicals are being intensively studied for their miRNA-mediated health-beneficial properties, such as anti-inflammatory, cardioprotective, antioxidative, and anticancer properties. Available experimental data have suggested that dietary polyphenols may be effective miRNA-modulating chemopreventive and therapeutic agents...
June 29, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28659908/pterostilbene-a-methoxylated-resveratrol-derivative-efficiently-eradicates-planktonic-biofilm-and-intracellular-mrsa-by-topical-application
#8
Shih-Chun Yang, Chih-Hua Tseng, Pei-Wen Wang, Po-Liang Lu, Yi-Han Weng, Feng-Lin Yen, Jia-You Fang
Pterostilbene is a methoxylated derivative of resveratrol originated from natural sources. We investigated the antibacterial activity of pterostilbene against drug-resistant Staphylococcus aureus and the feasibility of using it to treat cutaneous bacteria. The antimicrobial effect was evaluated using an in vitro culture model and an in vivo mouse model of cutaneous infection. The minimum inhibitory concentration (MIC) assay demonstrated a superior biocidal activity of pterostilbene compared to resveratrol (8~16-fold) against methicillin-resistant S...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28653245/muscadinia-rotundifolia-noble-defense-response-to-plasmopara-viticola-inoculation-by-inducing-phytohormone-mediated-stilbene-accumulation
#9
Chaoxia Wang, Jiao Wu, Yali Zhang, Jiang Lu
Downy mildew (DM), one of the most devastating grape diseases worldwide, is caused by the biotrophic oomycete Plasmopara viticola (Pv). In general, grapevine responds to Pv infection with the accumulation of phytoalexins as part of the innate immune system, and diverse phytoalexins are induced on grapevines with different DM-resistance levels in response to Pv invasion. However, the regulation of phytoalexin biosynthesis during grapevine against Pv is still unclear. Herein, we detected stilbenes by UPLC-ESI-MS/MS and found that resveratrol was accumulated to higher level and earlier in the DM-immune Muscadinia rotundifolia 'Noble' than that in the DM-susceptible Vitis vinifera 'Thompson Seedless' after Pv inoculation...
June 26, 2017: Protoplasma
https://www.readbyqxmd.com/read/28652233/potent-inhibition-of-hiv-1-replication-in-resting-cd4-t-cells-by-resveratrol-and-pterostilbene
#10
Chi N Chan, Benjamin Trinité, David N Levy
HIV-1 infection of resting CD4 T cells plays a crucial and numerically dominant role during virus transmission at mucosal sites and during subsequent acute replication and T cell depletion. Resveratrol and pterostilbene are plant stilbenoids associated with several health promoting benefits. Resveratrol has been shown to inhibit replication of several viruses, including herpes simplex 1 and 2, papillomaviruses, SARS virus and influenza virus. Alone, resveratrol does not inhibit HIV-1 infection of activated T cells, but it does synergize with nucleoside reverse transcriptase inhibitors in these cells to inhibit reverse transcription...
June 26, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28629731/pterostilbene-ameliorates-insulin-sensitivity-glycemic-control-and-oxidative-stress-in-fructose-fed-diabetic-rats
#11
COMPARATIVE STUDY
Ramoji Kosuru, Sanjay Singh
AIMS: The present investigation was designed to explore the effectiveness of pterostilbene (PT) on insulin resistance, metabolic syndrome and oxidative stress in fructose-fed insulin resistant rats. MAIN METHODS: Age-matched, male Sprague-Dawley rats (330±30g body weight) were allocated into five groups (n=10). Control (C) group received 65% cornstarch, and the diabetic (D) group received 65% fructose for eight weeks. The third group (D+PT20) received 65% fructose and PT 20mg/kg/day for eight weeks...
August 1, 2017: Life Sciences
https://www.readbyqxmd.com/read/28627722/pterostilbene-inhibits-lipogenic-activity-similar-to-resveratrol-or-caffeine-but-differently-modulates-lipolysis-in-adipocytes
#12
Saioa Gomez-Zorita, Chloé Belles, Anaïs Briot, Alfredo Fernández-Quintela, Maria P Portillo, Christian Carpéné
The anti-obesity effects of resveratrol shown in rodents are not transposed into an efficient therapy of human obesity. Consequently, the search for molecules mimicking or surpassing resveratrol actions is ongoing. The natural phenolic compound pterostilbene exhibits beneficial health effects and has the capacity to limit fat mass in animal models. In this study, we tested whether pterostilbene modulates triacylglycerol accumulation/breakdown. Prolonged exposure to pterostilbene or resveratrol inhibited adipocyte differentiation in 3T3-F442A preadipocytes...
August 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28607633/pterostilbene-4-%C3%AE-glucoside-protects-against-dss-induced-colitis-via-induction-of-tristetraprolin
#13
Yingqing Chen, Jeongmin Park, Yeonsoo Joe, Hyeok-Jun Park, Seung-Joo Jekal, Daisuke Sato, Hiroki Hamada, Hun Taeg Chung
Pterostilbene, a dimethyl ester analog of resveratrol, has anti-inflammatory and antioxidative effects and alters cell proliferation. Tristetraprolin (TTP) promotes the degradation of proinflammatory mediators via binding to adenosine and uridine- (AU-) rich elements (ARE) located in the 3'-untranslated regions of mRNAs. Here, we utilized pterostilbene 4'-β-glucoside (4-PG), a compound derived from pterostilbene, to investigate whether it has anti-inflammatory effects on dextran sulfate sodium- (DSS-) induced colitis via TTP enhancement...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28595835/the-effect-of-resveratrol-its-naturally-occurring-derivatives-and-tannic-acid-on-the-induction-of-cell-cycle-arrest-and-apoptosis-in-rat-c6-and-human-t98g-glioma-cell-lines
#14
Małgorzata Zielińska-Przyjemska, Mariusz Kaczmarek, Violetta Krajka-Kuźniak, Michał Łuczak, Wanda Baer-Dubowska
Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a potent chemopreventive and potentially cancer therapeutic agent. Since rapid metabolism limits resveratrol bioavailability, derivatives less prone to metabolic transformation are being sought and tested. We evaluated the effect of resveratrol, and its analogs (pterostilbene and 3,5,4'-trimethoxystilbene) along with tannic acid, on cell cycle and apoptosis in rat C6 and human T98G glioma cells. At concentration ranges both lower and higher than IC50 calculated based on MTT assay, all these polyphenols affected the cell cycle distribution...
June 6, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28570053/correlative-analysis-of-fluorescent-phytoalexins-by-mass-spectrometry-imaging-and-fluorescence-microscopy-in-grapevine-leaves
#15
Loïc Becker, Sébastien Bellow, Vincent Carré, Gwendal Latouche, Anne Poutaraud, Didier Merdinoglu, Spencer C Brown, Zoran G Cerovic, Patrick Chaimbault
Plant response to their environment stresses is a complex mechanism involving secondary metabolites. Stilbene phytoalexins, namely resveratrol, pterostilbene, piceids and viniferins play a key role in grapevine (Vitis vinifera) leaf defense. Despite their well-established qualities, conventional analyses such as HPLC-DAD or LC-MS lose valuable information on metabolite localization during the extraction process. To overcome this issue, a correlative analysis combining mass spectroscopy imaging (MSI) and fluorescence imaging was developed to localize in situ stilbenes on the same stressed grapevine leaves...
July 5, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28560392/the-blueberry-component-pterostilbene-has-potent-anti-myeloma-activity-in-bortezomib-resistant-cells
#16
Gege Chen, Zhijian Xu, Gaomei Chang, Jun Hou, Liangning Hu, Yiwen Zhang, Dandan Yu, Bo Li, Shuaikang Chang, Yongsheng Xie, Yong Zhang, Rong Wei, Huiqun Wu, Wenqin Xiao, Xi Sun, Yi Tao, Lu Gao, Bojie Dai, Jumei Shi, Weiliang Zhu
Multiple myeloma (MM) is an incurable hematologic malignancy because of its drug resistance. Pterostilbene (Pter) is found mainly in blueberries and grapes. The effects of Pter and its exact pharmacologic mechanisms on chemoresistant myeloma are not known. Herein, we investigated the anti-myeloma activity of Pter in bortezomib-resistant cell line H929R and explored the related mechanism of action for the first time. We found that Pter inhibited proliferation of H929R cells and promoted apoptosis of the cells through a caspase-dependent pathway, loss of mitochondrial membrane potential, and activation of Akt and p38 mitogen-activated protein kinase (MAPK) signaling pathways...
May 30, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28552912/pterostilbene-suppresses-human-endometrial-cancer-cells-in-vitro-by-down-regulating-mir-663b
#17
Ya-Ling Wang, Yuan Shen, Jian-Ping Xu, Kun Han, Yan Zhou, Su Yang, Jun-Yi Yin, Da-Liu Min, Hai-Yan Hu
Resveratrol has long been known as an antioxidant and a chemopreventive agent. Similar to resveratrol, pterostilbene (PT) is also a phenolic compound extracted from the Vitis species. However, there are few studies on the antitumor effect of PT. Thus, we investigated the effects of PT on the endometrial cancer (EC) cells in vitro and the related molecular mechanisms. Treatment of EC cell lines HTB-111 and Ishikawa with PT (25-100 μmol/L) dose-dependently suppressed the cell viability and induced apoptosis...
May 29, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28550734/pterostilbene-alleviates-polymicrobial-sepsis-induced-liver-injury-possible-role-of-sirt1-signaling
#18
Xiaojing Liu, Xueliang Yang, Lingna Han, Feng Ye, Min Liu, Wanhu Fan, Kai Zhang, Ying Kong, Jian Zhang, Lei Shi, Yunru Chen, Xi Zhang, Shumei Lin
Liver injury occurs frequently during sepsis. Pterostilbene (Pte), a natural dimethylated analog of resveratrol from blueberries, exerts anti-inflammatory and anti-apoptotic effects in various diseases. However, the role of Pte in sepsis-induced liver injury and its underlying mechanisms remain unknown. The current study aimed to evaluate the protective effects of Pte on sepsis-induced liver injury and its potential mechanisms. Sepsis was induced using cecal ligation and puncture (CLP) in C57BL/6 mice. Mice were administered Pte (5, 10, 15mg/kg, i...
August 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28532341/pterostilbene-protects-against-uvb-induced-photo-damage-through-a-phosphatidylinositol-3-kinase-dependent-nrf2-are-pathway-in-human-keratinocytes
#19
Huaping Li, Na Jiang, Bihua Liang, Qing Liu, Erting Zhang, Liqian Peng, Huiyan Deng, Runxiang Li, Zhenjie Li, Huilan Zhu
OBJECTIVE: Ultraviolet B (UVB) irradiation is the initial etiological factor for various skin disorders, including erythema, sunburn, photoaging, and photocarcinogenesis. Pterostilbene (Pter) displayed remarkable antioxidant, anti-inflammatory, and anticarcinogenic activities. This study aimed to investigate the effective mechanism of Pter against UVB-induced photodamage in immortalized human keratinocytes. METHODS: Human keratinocytes were pretreated with Pter (5 and 10 μM) for 24 h prior to UVB irradiation (300 mJ/cm(2))...
May 22, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28433778/novel-lipid-mimetic-prodrugs-delivering-active-compounds-to-adipose-tissue
#20
Andrea Mattarei, Andrea Rossa, Veronica Bombardelli, Michele Azzolini, Martina La Spina, Cristina Paradisi, Mario Zoratti, Lucia Biasutto
Obesity and associated pathologies are a dramatically growing problem. New therapies to prevent and/or cure them are strongly needed. Adipose tissue is a logical target for pharmacological intervention, since it is now recognized to exert an important endocrine function, secreting a variety of adipokines affecting, for example, adiposity and insulin resistance. This proof of principle work focuses on the development of novel lipid-mimetic prodrugs reaching fat deposits by the same lymphatic absorption route followed by dietary triglycerides...
April 13, 2017: European Journal of Medicinal Chemistry
keyword
keyword
79772
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"