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Pterostilbene

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https://www.readbyqxmd.com/read/29435127/%C3%AE-tocopherol-succinate-enhances-pterostilbene-anti-tumor-activity-in-human-breast-cancer-cells-in-vivo-and-in-vitro
#1
Ka-Wai Tam, Chi-Tang Ho, Shih-Hsin Tu, Wen-Jui Lee, Ching-Shui Huang, Ching-Shyang Chen, Chih-Hsiung Wu, Chia-Hwa Lee, Yuan-Soon Ho
Vitamin E (Vit. E) is considered an essential dietary nutrient for humans and animals. An enormous body of evidence indicates the biological and protective effects of Vit. E consumption. Tocopherol-associated protein (TAP) is a major tocopherol-binding protein affecting Vit. E stimulation and downstream signaling transduction. However, how Vit. E utilizes TAP as an anti-cancer mechanism remains unclear. Microarray analysis of signature gene profiles in breast cancer cells treated with α-tocopheryl succinate (α-TOS, a Vit...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29403551/pterostilbene-protects-against-acute-renal-ischemia-reperfusion-injury-and-inhibits-oxidative-stress-inducible-nitric-oxide-synthase-expression-and-inflammation-in-rats-via-the-toll-like-receptor-4-nuclear-factor-%C3%AE%C2%BAb-signaling-pathway
#2
Dan Gao, Sanhui Jing, Qian Zhang, Ge Wu
Previous studies have demonstrated that pterostilbene (Pter) prevents oxidative stress, suppresses cell growth and exhibits anti-fungal and anti-inflammatory effects. Pter is used to treat a number of clinical diseases, including Alzheimer's disease, various malignancies and hypercholesteremia. The aim of the present study was to investigate whether Pter protects against acute renal ischemia reperfusion injury (IRI) and inhibits oxidative stress, inducible nitric oxide synthase (iNOS) expression and inflammation in rats...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29393488/pterostilbene-increases-pten-expression-through-the-targeted-downregulation-of-microrna-19a-in-hepatocellular-carcinoma
#3
Yu-Yuan Qian, Zhi-Su Liu, Zidong Zhang, Anait S Levenson, Kun Li
Pterostilbene (Pter) is reported to exhibit an anticancer effect in hepatocellular carcinoma (HCC). In order to explore the anticancer mechanism in HCC cells, the present study aimed to investigate whether pterostilbene (Pter) may increase phosphatase and tensin homolog (PTEN) expression through targeted downregulation of microRNA (miRNA/miR)-19a in hepatocellular carcinoma (HCC). The proliferation, apoptosis and cell cycle was analyzed in the SMMC‑7721 HCC cell line by MTT assays and flow cytometry methods...
January 29, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29346311/apoptotic-and-nonapoptotic-activities-of-pterostilbene-against-cancer
#4
REVIEW
Rong-Jane Chen, Hsiao-Che Kuo, Li-Hsin Cheng, Yu-Hsuan Lee, Wen-Tsan Chang, Bour-Jr Wang, Ying-Jan Wang, Hung-Chi Cheng
Cancer is a major cause of death. The outcomes of current therapeutic strategies against cancer often ironically lead to even increased mortality due to the subsequent drug resistance and to metastatic recurrence. Alternative medicines are thus urgently needed. Cumulative evidence has pointed out that pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene, PS) has excellent pharmacological benefits for the prevention and treatment for various types of cancer in their different stages of progression by evoking apoptotic or nonapoptotic anti-cancer activities...
January 18, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29339386/pterostilbene-a-potential-mcr-1-inhibitor-that-enhances-the-efficacy-of-polymyxin-b
#5
Yonglin Zhou, Shui Liu, Tingting Wang, Hui Li, Shusheng Tang, Jianfeng Wang, Yang Wang, Xuming Deng
We characterized pterostilbene produced a synergistic effect with polymyxin B (FIC index=0.156 or 0.188) against MCR-producing Escherichia coli strains of both human and animal origin. The time-killing assays showed that either pterostilbene or polymyxin B failed to eradicate a mcr-1- and NDM-positive E. coli strain ZJ487, but the combination eliminated by 1-hour post-inoculation. The survival rate of mouse following the intraperitoneal infection significantly promoted from 0% to 60% in the group of combination therapy applied...
January 16, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29328494/pterostilbene-inhibits-reactive-oxygen-species-production-and-apoptosis-in-primary-spinal-cord-neurons-by-activating-autophagy-via-the-mechanistic-target-of-rapamycin-signaling-pathway
#6
Jing-Lan He, Xiao-Hui Dong, Zong-Hu Li, Xiao-Ying Wang, Zhi-An Fu, Na Shen
Autophagy is an important self-adaptive mechanism that is involved in inhibiting reactive oxygen species (ROS) in spinal cord neurons. Pterostilbene, a natural plant extract, has been demonstrated to possess antioxidant effects; however, it has not yet been investigated whether pterostilbene could activate autophagy and protect spinal cord neurons from oxidative stress. In the present study, primary spinal cord neurons of Sprague Dawley rats were cultured. Cell counting kit‑8 analysis was used to detect cytotoxicity of pterostilbene...
January 9, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29322567/oral-delivery-system-enhanced-the-bioavailability-of-stilbenes-resveratrol-and-pterostilbene
#7
REVIEW
Ru-Min Peng, Guan-Ru Lin, Yuwen Ting, Jing-Yu Hu
Stilbenes are a large group of compounds with the C 6 C 2 C 6 skeleton, in which two aromatic rings are connected by an ethylene bridge. Resveratrol and its structural analog, pterostilbene, are by far the two most widely researched stilbenes in terms of their beneficial bioactivities. However, the bioefficacy of these compounds is greatly reduced when consumed orally due to their poor aqueous solubility, which leads to poor bioavailability. To overcome the limitation, strategies improving their solubility, absorption, and systemic concentration were applied when designing a suitable edible delivery system...
January 2018: BioFactors
https://www.readbyqxmd.com/read/29315906/antiobesity-molecular-mechanisms-of-action-resveratrol-and-pterostilbene
#8
REVIEW
Min-Hsiung Pan, Jia-Ching Wu, Chi-Tang Ho, Ching-Shu Lai
Obesity is a current global epidemic that has led to a marked increase in metabolic diseases. However, its treatment remains a challenge. Obesity is a multifactorial disease, which involves the dysfunction of neuropeptides, hormones, and inflammatory adipokines from the brain, gut, and adipose tissue. An understanding of the mechanisms and signal interactions in the crosstalk between organs and tissue in the coordination of whole-body energy metabolism would be helpful to provide therapeutic and putative approaches to the treatment and prevention of obesity and related complications...
January 5, 2018: BioFactors
https://www.readbyqxmd.com/read/29315886/metabolism-and-pharmacokinetics-of-resveratrol-and-pterostilbene
#9
REVIEW
Pei Wang, Shengmin Sang
Beneficial properties of resveratrol and pterostilbene, a dimethyl ether analog of resveratrol, have attracted increasing interest in recent years. Resveratrol and pterostilbene exhibit many pharmacological similarities and both of them are generally considered to be safe for human consumption. Beyond the structural and general bioactivity similarities between them, large amounts of data are now available to reveal the metabolic fate and pharmacological differences between them. Pterostilbene was found to be more metabolically stable and usually exhibited stronger pharmacological activities than that of resveratrol...
January 8, 2018: BioFactors
https://www.readbyqxmd.com/read/29285084/pterostilbene-attenuates-myocardial-ischemia-reperfusion-injury-via-the-phosphatidylinositol-3-kinase-protein-kinase-b-signaling-pathway
#10
Lei Hu, Na Cai, Hui Jia
The current study aimed to evaluate the cardioprotective effects of pterostilbene (PTB) on myocardial ischemia-reperfusion (I/R) injury in rats and identify its possible underlying mechanisms of action. A rat I/R model was established by ligating the left anterior descending coronary artery for 30 min and releasing the ligature to induce reperfusion for 120 min. Serum creatine kinase-MB (CK-MB) and lactate dehydrogenase (LDH) levels were measured using CK-MB and LDH assay kits and myeloperoxidase (MPO) activity in the myocardium was evaluated using an MPO assay kit...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29220106/chemoprevention-by-resveratrol-and-pterostilbene-targeting-on-epigenetic-regulation
#11
REVIEW
Pei-Sheng Lee, Yi-Shiou Chiou, Chi-Tang Ho, Min-Hsiung Pan
Epigenetic mechanisms are essential in regulating normal cellular functions and play an important role during the disease developmental stages. However, aberrant epigenetic mechanisms may lead to pathological consequences such as cancer, neurological disorders, bone and skeletal diseases, cardiovascular dysfunction, and metabolic syndrome. The molecular mechanisms of epigenetic modification include DNA methylation, histone modification (acetylation, methylation and phosphorylation), and microRNAs (miRNAs). Unlike genetic modifications, epigenetic states of genes are reversible and can be altered by certain intrinsic and extrinsic factors...
December 8, 2017: BioFactors
https://www.readbyqxmd.com/read/29216713/poly-2-oxazoline-pterostilbene-block-copolymer-nanoparticles-for-dual-anticancer-drug-delivery
#12
Matteo Romio, Giulia Morgese, Lucca Trachsel, Samuel Babity, Cristina Paradisi, Davide Brambilla, Edmondo Maria Benetti
Functional block-copolymers based on poly(2-oxazoline)s are versatile building blocks for the fabrication of dual-drug delivery nanoparticles (NPs) that show promising properties for the development of a anticancer chemotherapy. Core-shell NPs are fabricated from diblock-copolymers featuring a long and hydrophilic poly(2-methyl-2-oxazoline) (PMOXA) block, coupled to a relatively short and functionalizable poly(2-methylsuccinate-2-oxazoline) (PMestOXA) segment. The PMOXA block stabilizes the NP dispersions, whereas the PMestOXA segment is used to conjugate pterostilbene (PTS), a natural bioactive phenolic compound that is used as lipophilic model-drug and constitutes the hydrophobic core of the designed NPs...
December 7, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29210129/effect-of-resveratrol-and-pterostilbene-on-aging-and-longevity
#13
REVIEW
Yi-Rong Li, Shiming Li, Chi-Chien Lin
Over the past years, several studies have found that foods rich in polyphenols protect against age-related disease, such as atherosclerosis, cardiovascular disease, cancer, arthritis, cataracts, osteoporosis, type 2 diabetes (T2D), hypertension and Alzheimer's disease. Resveratrol and pterostilbene, the polyphenol found in grape and blueberries, have beneficial effects as anti-aging compounds through modulating the hallmarks of aging, including oxidative damage, inflammation, telomere attrition and cell senescence...
December 6, 2017: BioFactors
https://www.readbyqxmd.com/read/29205560/targeting-cancer-stem-cells-and-signaling-pathways-by-resveratrol-and-pterostilbene
#14
REVIEW
Lingling Zhang, Xiang Wen, Mengmeng Li, Shiming Li, Hui Zhao
In past decades, increasing evidence regarding cancer stem cells (CSCs) may account for carcinogenesis, tumor drug-resistant, and metastasis. CSCs are even considered as the root causes of tumor recurrence and metastases. Targeting CSCs may provide a new clue to cure cancer. Epidemiological and clinical studies have suggested that intake of dietary natural products may bring health benefits including lowering risk of cancer incidence. In this review, we have particularly focused on targeting signaling pathways of CSCs by natural resveratrol and its dimethylated derivative pterostilbene...
December 4, 2017: BioFactors
https://www.readbyqxmd.com/read/29184669/repeat-dose-nrpt-nicotinamide-riboside-and-pterostilbene-increases-nad-levels-in-humans-safely-and-sustainably-a-randomized-double-blind-placebo-controlled-study
#15
Ryan W Dellinger, Santiago Roel Santos, Mark Morris, Mal Evans, Dan Alminana, Leonard Guarente, Eric Marcotulli
NRPT is a combination of nicotinamide riboside (NR), a nicotinamide adenine dinucleotide (NAD+)precursor vitamin found in milk, and pterostilbene (PT), a polyphenol found in blueberries. Here, we report this first-in-humans clinical trial designed to assess the safety and efficacy of a repeat dose of NRPT (commercially known as Basis). NRPT was evaluated in a randomized, double-blind, and placebo-controlled study in a population of 120 healthy adults between the ages of 60 and 80 years. The study consisted of three treatment arms: placebo, recommended dose of NRPT (NRPT 1X), and double dose of NRPT (NRPT 2X)...
2017: NPJ Aging and Mechanisms of Disease
https://www.readbyqxmd.com/read/29179999/phytochemicals-as-inhibitors-of-nf-%C3%AE%C2%BAb-for-treatment-of-alzheimer-s-disease
#16
REVIEW
Ean-Jeong Seo, Nicolas Fischer, Thomas Efferth
Alzheimer's disease (AD) is the most prevalent form of dementia. The exact pathophysiology of this disease remains incompletely understood and safe and effective therapies are required. AD is highly correlated with neuroinflammation and oxidative stress in brain causing neuronal loss. Nuclear factor of activated B-cells (NF-κB) is involved in physiological inflammatory processes and thus representing a promising target for inflammation-based AD therapy. Phytochemicals are able to interfere with the NF-κB pathway...
November 24, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29168580/resveratrol-pterostilbene-and-dementia
#17
REVIEW
Klaus W Lange, Shiming Li
Resveratrol is a natural phytoestrogen with neuroprotective properties. Polyphenolic compounds including resveratrol exert in vitro antioxidant, anti-inflammatory, and antiamyloid effects. Resveratrol and its derivative pterostilbene are able to cross the blood-brain barrier and to influence brain activity. The present short review summarizes the available evidence regarding the effects of these polyphenols on pathology and cognition in animal models and human subjects with dementia. Numerous investigations in cellular and mammalian models have associated resveratrol and pterostilbene with protection against dementia syndromes such as Alzheimer's disease (AD) and vascular dementia...
November 23, 2017: BioFactors
https://www.readbyqxmd.com/read/29164887/pterostilbene-enhances-trail-induced-apoptosis-through-the-induction-of-death-receptors-and-downregulation-of-cell-survival-proteins-in-trail-resistance-triple-negative-breast-cancer-cells
#18
Chao-Ming Hung, Liang-Chih Liu, Chi-Tang Ho, Ying-Chao Lin, Tzong-Der Way
Tumor necrosis factor-related apoptosis-induced ligand (TRAIL) is nontoxic to normal cells and preferentially cytotoxic to cancer cells. However, recent data suggest that malignant breast cancer cells tend to be resistant to TRAIL. Pterostilbene (PTER), a natural dimethylated analog of resveratrol, is known to have diverse pharmacologic activities, including anticancer properties. In the present study, we investigated whether PTER affects TRAIL-induced apoptosis and its mechanism in TRAIL-resistant triple negative breast cancer (TNBC) cells...
November 22, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29125889/pterostilbene-down-regulates-htert-at-physiological-concentrations-in-breast-cancer-cells-potentially-through-the-inhibition-of-cmyc
#19
Michael Daniel, Trygve O Tollefsbol
Human telomerase reverse transcriptase (hTERT) encodes the catalytic subunit of telomerase, which has been shown to be upregulated in many cancers. Pterostilbene is a naturally occurring stilbenoid and phytoalexin found primarily in blueberries that exhibits antioxidant activity and inhibits the growth of various cancer cell types. Therefore, the aim of this study was to determine whether treatment with pterostilbene, at physiologically achievable concentrations, can inhibit the proliferation of breast cancer cells and down-regulate the expression of hTERT...
November 10, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29094331/pterostilbene-protects-against-uraemia-serum-induced-endothelial-cell-damage-via-activation-of-keap1-nrf2-ho-1-signaling
#20
Zhi-Wei Chen, Hai-Feng Miu, Hui-Ping Wang, Zhi-Niu Wu, Wen-Juan Wang, Yu-Jing Ling, Xiao-Hui Xu, Hai-Jian Sun, Xia Jiang
Chronic kidney disease causes uremia-related endothelial cell dysfunction associated with high risk for cardiovascular diseases. The vascular endothelium is permanently exposed to uraemic toxins including indoxyl sulfate, which provokes endothelial damage in subjects with end-stage renal disease. Pterostilbene (PT) is identified to be homologous derivative of resveratrol and exerts antioxidant and anti-inflammatory actions. However, the effects of PT on uraemic serum-induced endothelial cell damage have not been elucidated...
November 1, 2017: International Urology and Nephrology
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