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Pterostilbene

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https://www.readbyqxmd.com/read/27882602/the-resveratrol-derivatives-trans-3-5-dimethoxy-4-fluoro-4-hydroxystilbene-and-trans-2-4-5-trihydroxystilbene-decrease-oxidative-stress-and-prolong-lifespan-in-caenorhabditis-elegans
#1
Nadine Fischer, Christian Büchter, Karoline Koch, Sabrina Albert, René Csuk, Wim Wätjen
OBJECTIVES: Resveratrol (trans-3,4',5-trihydroxystilbene (1)) was previously shown to extend the lifespan of different model organisms. However, its pharmacological efficiency is controversially discussed. Therefore, the bioactivity of four newly synthesized stilbenes (trans-3,5-dimethoxy-4-fluoro-4'-hydroxystilbene (3), trans-4'-hydroxy-3,4,5-trifluorostilbene (4), trans-2,5-dimethoxy-4'-hydroxystilbene (5), trans-2,4',5-trihydroxystilbene (6)) was compared to (1) and pterostilbene (trans-3,5-dimethoxy-4'-hydroxystilbene (2)) in the established model organism Caenorhabditis elegans...
November 23, 2016: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/27869675/pterostilbene-inhibits-human-multiple-myeloma-cells-via-erk1-2-and-jnk-pathway-in-vitro-and-in-vivo
#2
Bingqian Xie, Zhijian Xu, Liangning Hu, Gege Chen, Rong Wei, Guang Yang, Bo Li, Gaomei Chang, Xi Sun, Huiqun Wu, Yong Zhang, Bojie Dai, Yi Tao, Jumei Shi, Weiliang Zhu
Multiple myeloma (MM) is the second most common malignancy in the hematologic system, which is characterized by accumulation of plasma cells in bone marrow. Pterostilbene (PTE) is a natural dimethylated analog of resveratrol, which has anti-oxidant, anti-inflammatory and anti-tumor properties. In the present study, we examined the anti-tumor effect of PTE on MM cell lines both in vitro and in vivo using the cell counting kit (CCK)-8, apoptosis assays, cell cycle analysis, reactive oxygen species (ROS) generation, JC-1 mitochondrial membrane potential assay, Western blotting and tumor xenograft models...
November 17, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27869173/pterostilbene-induces-apoptosis-and-cell-cycle-arrest-in-diffuse-large-b-cell-lymphoma-cells
#3
Yuanyuan Kong, Gege Chen, Zhijian Xu, Guang Yang, Bo Li, Xiaosong Wu, Wenqin Xiao, Bingqian Xie, Liangning Hu, Xi Sun, Gaomei Chang, Minjie Gao, Lu Gao, Bojie Dai, Yi Tao, Weiliang Zhu, Jumei Shi
Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma (NHL). Pterostilbene, a natural dimethylated analog of resveratrol, has been shown to possess diverse pharmacological activities, including anti-inflammatory, antioxidant and anticancer properties. However, to the best of our knowledge, there has been no study of the effects of pterostilbene upon hematological malignancies. Herein, we report the antitumor activity and mechanism of pterostilbene against DLBCL cells both in vitro and in vivo...
November 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27836749/enhanced-chemoprevention-by-the-combined-treatment-of-pterostilbene-and-lupeol-in-b-a-p-induced-mouse-skin-tumorigenesis
#4
Payal Singh, Deepika Arora, Yogeshwer Shukla
The present study is aimed to evaluate the inhibitory effect of the combination of two phytochemicals; pterostilbeneand lupeol (generally obtained from blue berries, grapes, white cabbage, green pepper, olive and mangoes) on mouse skin tumorigenesis. We hypothesized that the concomitant topical treatment of selected phytochemicals would lead to improved impediment of skin cancer. Swiss albino mice (n = 25) received a topical dose of Benzo[a]pyrene (B[a]P, 5 μg/animal) with pre/post application of pterostilbene (16 μM/0...
November 8, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27833117/engineering-yeast-for-high-level-production-of-stilbenoid-antioxidants
#5
Mingji Li, Konstantin Schneider, Mette Kristensen, Irina Borodina, Jens Nielsen
Stilbenoids, including resveratrol and its methylated derivatives, are natural potent antioxidants, produced by some plants in trace amounts as defense compounds. Extraction of stilbenoids from natural sources is costly due to their low abundance and often limited availability of the plant. Here we engineered the yeast Saccharomyces cerevisiae for production of stilbenoids on a simple mineral medium typically used for industrial production. We applied a pull-push-block strain engineering strategy that included overexpression of the resveratrol biosynthesis pathway, optimization of the electron transfer to the cytochrome P450 monooxygenase, increase of the precursors supply, and decrease of the pathway intermediates degradation...
November 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27756183/synthesis-oxygen-radical-absorbance-capacity-and-tyrosinase-inhibitory-activity-of-glycosides-of-resveratrol-pterostilbene-and-pinostilbene
#6
Daisuke Uesugi, Hiroki Hamada, Kei Shimoda, Naoji Kubota, Shin-Ichi Ozaki, Naoki Nagatani
The stilbene compound resveratrol was glycosylated to give its 4'-O-β-D-glucoside as the major product in addition to its 3-O-β-D-glucoside by a plant glucosyltransferase from Phytolacca americana expressed in recombinant Escherichia coli. This enzyme transformed pterostilbene to its 4'-O-β-D-glucoside, and converted pinostilbene to its 4'-O-β-D-glucoside as a major product and its 3-O-β-D-glucoside as a minor product. An analysis of antioxidant capacity showed that the above stilbene glycosides had lower oxygen radical absorbance capacity (ORAC) values than those of the corresponding stilbene aglycones...
October 19, 2016: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/27748853/pterostilbene-inhibits-hepatocellular-carcinoma-through-p53-sod2-ros-mediated-mitochondrial-apoptosis
#7
Liying Guo, Kai Tan, Hao Wang, Xuan Zhang
Hepatocellular carcinoma (HCC) is one of the most common malignancies and the second cause of cancer-related deaths around the world. Pterostilbene (PTE), is a natural analog of resveratrol, possessing diverse pharmacological activities. In the present study, we aimed to examine the effect of PTE on tumor growth in mouse models of HCC and to elucidate the possible molecular mechanism in vivo and in vitro. We showed that PTE dose-dependently suppressed tumor growth in mice induced by diethylnitrosamine plus carbon tetrachloride, as evidenced by a decrease in the number of tumors and in the maximum size of the tumors...
October 5, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27739192/the-resveratrol-analogue-trimethoxystilbene-inhibits-cancer-cell-growth-by-inducing-multipolar-cell-mitosis
#8
Gianandrea Traversi, Mario Fiore, Zulema Percario, Francesca Degrassi, Renata Cozzi
Natural compounds are extensively studied for their potential use in traditional and non-traditional medicine. Several natural and synthetic Resveratrol analogues have shown interesting biological activities in the field of cancer chemoprevention. In the present study, we have focused on the ability of Resveratrol and two methoxylated derivatives (Trimethoxystilbene and Pterostilbene) to inhibit human cancer cell growth particularly analyzing their ability to interfere with tubulin dynamics at mitosis. We show that Trimethoxystilbene, differently from Resveratrol and Pterostilbene, alters microtubule polymerization dynamics in HeLa cells specifically inducing multipolar spindles and mitotic arrest coupled to a reduction of cell growth and an increase in apoptotic death by mitotic catastrophe...
October 14, 2016: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/27689322/case-specific-potentiation-of-glioblastoma-drugs-by-pterostilbene
#9
Linnéa Schmidt, Sathishkumar Baskaran, Patrik Johansson, Narendra Padhan, Damian Matuszewski, Lydia C Green, Ludmila Elfineh, Shimei Wee, Maria Häggblad, Ulf Martens, Bengt Westermark, Karin Forsberg-Nilsson, Lene Uhrbom, Lena Claesson-Welsh, Michael Andäng, Ida-Maria Sintorn, Bo Lundgren, Ingrid Lönnstedt, Cecilia Krona, Sven Nelander
Glioblastoma multiforme (GBM, astrocytoma grade IV) is the most common malignant primary brain tumor in adults. Addressing the shortage of effective treatment options for this cancer, we explored repurposing of existing drugs into combinations with potent activity against GBM cells. We report that the phytoalexin pterostilbene is a potentiator of two drugs with previously reported anti-GBM activity, the EGFR inhibitor gefitinib and the antidepressant sertraline. Combinations of either of these two compounds with pterostilbene suppress cell growth, viability, sphere formation and inhibit migration in tumor GBM cell (GC) cultures...
September 28, 2016: Oncotarget
https://www.readbyqxmd.com/read/27686467/stilbene-accumulation-and-expression-of-stilbene-biosynthesis-pathway-genes-in-wild-grapevine-vitis-amurensis-rupr
#10
Konstantin V Kiselev, Olga A Aleynova, Valeria P Grigorchuk, Alexandra S Dubrovina
We detected and quantified six stilbenes ( cis -piceid, t -piceid, t -ε-viniferin, cis -ε-viniferin, t -resveratrol, and t -δ-viniferin) in the leaves, petioles, berry skins, and seeds of wild-growing Vitis amurensis . The highest content of stilbenes and expression of stilbene biosynthesis genes were in the probes collected in the autumn and after ultraviolet elicitation. Stilbenes, including the best-studied stilbene resveratrol, are known to display valuable bioactivities and protect plants against various pathogens...
September 29, 2016: Planta
https://www.readbyqxmd.com/read/27665283/pterostilbene-attenuates-early-brain-injury-following-subarachnoid-hemorrhage-via-inhibition-of-the-nlrp3-inflammasome-and-nox2-related-oxidative-stress
#11
Haixiao Liu, Lei Zhao, Liang Yue, Bodong Wang, Xia Li, Hao Guo, Yihui Ma, Chen Yao, Li Gao, Jianping Deng, Lihong Li, Dayun Feng, Yan Qu
Pterostilbene (PTE), one of the polyphenols present in plants such as blueberries and grapes, has been suggested to have various effects, such as anti-oxidation, anti-apoptosis, and anti-cancer effects. Subarachnoid hemorrhage (SAH) is a severe neurological event known for its high morbidity and mortality. Recently, early brain injury (EBI) has been reported to play a significant role in the prognosis of patients with SAH. The present study aimed to investigate whether PTE could attenuate EBI after SAH was induced in C57BL/6 J mice...
September 24, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27623505/arbuscular-mycorrhizal-symbiosis-stimulates-key-genes-of-the-phenylpropanoid-biosynthesis-and-stilbenoid-production-in-grapevine-leaves-in-response-to-downy-mildew-and-grey-mould-infection
#12
Sébastien Bruisson, Pascale Maillot, Paul Schellenbaum, Bernard Walter, Katia Gindro, Laurence Deglène-Benbrahim
Grapevine (Vitis spp) is susceptible to serious fungal diseases usually controlled by chemical treatments. Arbuscular mycorrhizal fungi (AMF) are obligate plant symbionts which can stimulate plant defences. We investigated the effect of mycorrhization on grapevine stilbenoid defences. Vitis vinifera cvs Chasselas, Pinot noir and the interspecific hybrid Divico, on the rootstock 41B, were mycorrhized with Rhizophagus irregularis before leaf infection by Plasmopara viticola or Botrytis cinerea. Gene expression analysis showed an up-regulation of PAL, STS, and ROMT, involved in the stilbenoid biosynthesis pathway, in plant leaves, 48 h after pathogen inoculation...
November 2016: Phytochemistry
https://www.readbyqxmd.com/read/27613388/synergistic-combinatorial-antihyperlipidemic-study-of-selected-natural-antioxidants-modulatory-effects-on-lipid-profile-and-endogenous-antioxidants
#13
Peer Abdul Hannan, Jamshaid Ali Khan, Irfan Ullah, Safi Ullah
BACKGROUND: Hyperlipidemia, a major pathological condition associated with disrupted lipid levels and physiological redox homeostasis. The excessive release of reactive oxygen species (ROS) leads to enhanced lipid peroxidation, aggravated atherosclerosis and oxidative stress. Integration of natural antioxidant blends in alone or with conventional treatments can alleviate these issues synergistically contributing least side effects. Published literature reported the efficacy of natural antioxidants as individual and in combinations in various conditions but less data is available on their evaluation in low dose ratio blends particularly in hypercholesterolemic diet...
2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27612029/atm-chk-p53-pathway-dependent-chemopreventive-and-therapeutic-activity-on-lung-cancer-by-pterostilbene
#14
Hani Lee, Yonghwan Kim, Ji Hye Jeong, Jae-Ha Ryu, Woo-Young Kim
Among the many stilbenoids found in a variety of berries, resveratrol and pterostilbene are of particular interest given their potential for use in cancer therapeutics and prevention. We purified four stilbenoids from R. undulatum and found that pterostilbene inhibits cancer cell proliferation more efficiently than rhapontigenin, piceatannol and resveratrol. To investigate the underlying mechanism of this superior action of pterostilbene on cancer cells, we utilized a reverse-phase protein array followed by bioinformatic analysis and found that the ATM/CHK pathway is modified by pterostilbene in a lung cancer cell line...
2016: PloS One
https://www.readbyqxmd.com/read/27609747/targeting-cancer-stem-cells-and-signaling-pathways-by-phytochemicals-novel-approach-for-breast-cancer-therapy
#15
Prasad R Dandawate, Dharmalingam Subramaniam, Roy A Jensen, Shrikant Anant
Breast cancer is the most common form of cancer diagnosed in women worldwide and the second leading cause of cancer-related deaths in the USA. Despite the development of newer diagnostic methods, selective as well as targeted chemotherapies and their combinations, surgery, hormonal therapy, radiotherapy, breast cancer recurrence, metastasis and drug resistance are still the major problems for breast cancer. Emerging evidence suggest the existence of cancer stem cells (CSCs), a population of cells with the capacity to self-renew, differentiate and be capable of initiating and sustaining tumor growth...
October 2016: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/27576146/neuroprotective-actions-of-pterostilbene-on-hypoxic-ischemic-brain-damage-in-neonatal-rats-through-upregulation-of-heme-oxygenase-1
#16
Dan Li, Tingting Song, Lin Yang, Xueying Wang, Changhong Yang, Yongsheng Jiang
Neonatal hypoxic-ischemic (HI) brain damage causes acute mortality and morbidity in newborns and long-term neurological disorders in the survivors. Pterostilbene (PTE) is a natural compound possessing various biological and pharmacological activities. In the present study, we aimed to investigate the effect of PTE on neonatal HI brain damagein P7 rat model and to explore the possible mechanisms. Neonatal HI brain damage was induced in rat pups (P7). Prior to the induction of HI injury, PTE was injected with or without zinc protoporphyrin IX (ZnPP), an inhibitor of heme oxygenase-1 (HO-1)...
November 2016: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/27544549/modulatory-role-of-pterocarpus-santalinus-against-alcohol-induced-liver-oxidative-nitrosative-damage-in-rats
#17
Saradamma Bulle, Vaddi Damodara Reddy, Pannuru Padmavathi, Paramahamsa Maturu, Varadacharyulu N Ch
Pterocarpus santalinus, a traditional medicinal plant has shown protective mechanisms against various complications. The aim of the present study is to evaluate therapeutic efficacy of P. santalinus heartwood methanolic extract (PSE) against alcohol-induced oxidative/nitrosative stress leading to hepatotoxicity. In-vitro studies revealed that PSE possess strong DPPH (1,1-diphenyl-2-picryl hydrazyl) and nitric oxide radical scavenging activity. For in vivo studies male albino Wistar rats were treated with 20% alcohol (5g/kg b...
August 18, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27525946/pterostilbene-as-treatment-for-severe-acute-pancreatitis
#18
Y J Lin, Y Ding, J Wu, B T Ning
Acute pancreatitis (AP) has a fast onset and progression, which lead to an unfavorable prognosis. Therefore, the development of novel drugs for its treatment is critical. As a homologous derivative of resveratrol, pterostilbene exerts a variety of effects including anti-inflammatory, antioxidant, and antitumor effects. This study investigated the potential of pterostilbene for treatment of severe AP (SAP) and related mechanisms. Effects of pterostilbene were evaluated in a Wistar rat model of AP. Serum levels of amylase (AMY), creatinine (Cr), and alanine aminotransferase (ALT) were quantified...
2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27508025/effects-of-pterostilbene-on-treating-hyperprolactinemia-and-related-mechanisms
#19
Haoru Zhang, Changhua Wang, Xiaokun Li, Yong Zhang
Hyperprolactinemia (HPRL) frequently causes primary menopause and reproductive disorders. Pterostilbene is known to have anti-inflammation and modulation on cell apoptosis. However, its role in treating HPRL and potential mechanisms remain unclear yet. Healthy female virgin SD rats were randomly assigned into control, HPRL model group, bromocriptine treatment group, and low (20 mg/kg) and high (40 mg/kg) pterostilbene treatment groups. All groups except control ones received metoclopramide hydrochloride injection for generating HPRL model...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27475678/promising-therapeutic-potential-of-pterostilbene-and-its-mechanistic-insight-based-on-preclinical-evidence
#20
REVIEW
Ramoji Kosuru, Uddipak Rai, Swati Prakash, Abhishank Singh, Sanjay Singh
Pterostilbene (PS) is a well-recognized antioxidant that primarily exists in blueberries, grapevines and heartwood of red sandalwood. Interest in this compound has been renewed in recent years, and studies have found that PS possesses an array of pharmacological properties, including chemopreventive, antiinflammatory, antidiabetic, antidyslipidemic, antiatherosclerotic and neuroprotective effects. However, the greater in vivo bioavailability of PS, as compared to resveratrol, is an added advantage for its efficacy...
October 15, 2016: European Journal of Pharmacology
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