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https://www.readbyqxmd.com/read/28087887/evaluation-of-a-standardized-ward-round-in-a-prenatal-inpatient-setting
#1
Katie Christensen, Sarah Janssens, Michael Beckmann
OBJECTIVE: To evaluate the impact of incorporating a standardized ward round (SWR) tool including checklists for communication, safety, and efficiency into ward rounds. METHODS: A prospective non-randomized, before-and-after observational study was conducted at a tertiary maternity hospital in Brisbane, Australia, between October 1, 2014, and October 1, 2015. Obstetric team members performing prenatal ward rounds used role-specific lanyards prompting the structure of each consultation...
December 10, 2016: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28068333/bdf1-bromodomains-are-essential-for-meiosis-and-the-expression-of-meiotic-specific-genes
#2
Encar García-Oliver, Claire Ramus, Jonathan Perot, Marie Arlotto, Morgane Champleboux, Flore Mietton, Christophe Battail, Anne Boland, Jean-François Deleuze, Myriam Ferro, Yohann Couté, Jérôme Govin
Bromodomain and Extra-terminal motif (BET) proteins play a central role in transcription regulation and chromatin signalling pathways. They are present in unicellular eukaryotes and in this study, the role of the BET protein Bdf1 has been explored in Saccharomyces cerevisiae. Mutation of Bdf1 bromodomains revealed defects on both the formation of spores and the meiotic progression, blocking cells at the exit from prophase, before the first meiotic division. This phenotype is associated with a massive deregulation of the transcription of meiotic genes and Bdf1 bromodomains are required for appropriate expression of the key meiotic transcription factor NDT80 and almost all the Ndt80-inducible genes, including APC complex components...
January 9, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28064308/-structural-studies-of-chromatin-remodeling-factors
#3
O I Volokh, N I Derkacheva, V M Studitsky, O S Sokolova
Changes of chromatin structure require participation of chromatin remodeling factors (CRFs), which are ATP-dependent multisubunit complexes that change the structure of the nucleosome without covalently modifying its components. CRFs act together with other protein factors to regulate the extent of chromatin condensation. Four CRF families are currently distinguished based on their structural and biochemical characteristics: SWI/SNF, ISWI, Mi-2/CHD, and SWR/INO80. X-ray diffraction analysis and electron microscopy are the main methods to obtain structural information about macromolecules...
November 2016: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/28044323/production-amplification-and-systemic-propagation-of-redox-messengers-in-plants-the-phloem-can-do-it-all
#4
Frank Gaupels, Jörg Durner, Karl-Heinz Kogel
Rapid long-distance signalling is an emerging topic in plant research, and is particularly associated with responses to biotic and abiotic stress. Systemic acquired resistance (SAR) to pathogen attack is dependent on nitric oxide (NO) and reactive oxygen species (ROS) such as hydrogen peroxide (H2 O2 ). By comparison, systemic wound responses (SWRs) and systemic acquired acclimation (SAA) to abiotic stress encounters are triggered by rapid waves of H2 O2 , calcium and electrical signalling. Efforts have been made to decipher the relationship between redox messengers, calcium and other known systemic defence signals...
January 3, 2017: New Phytologist
https://www.readbyqxmd.com/read/28041883/phase-locked-inhibition-but-not-excitation-underlies-hippocampal-ripple-oscillations-in-awake-mice-in%C3%A2-vivo
#5
Jian Gan, Shih-Ming Weng, Alejandro J Pernía-Andrade, Jozsef Csicsvari, Peter Jonas
Sharp wave-ripple (SWR) oscillations play a key role in memory consolidation during non-rapid eye movement sleep, immobility, and consummatory behavior. However, whether temporally modulated synaptic excitation or inhibition underlies the ripples is controversial. To address this question, we performed simultaneous recordings of excitatory and inhibitory postsynaptic currents (EPSCs and IPSCs) and local field potentials (LFPs) in the CA1 region of awake mice in vivo. During SWRs, inhibition dominated over excitation, with a peak conductance ratio of 4...
December 22, 2016: Neuron
https://www.readbyqxmd.com/read/28041797/sharp-wave-ripples-in-primates-are-enhanced-near-remembered-visual-objects
#6
Timothy K Leonard, Kari L Hoffman
The hippocampus plays an important role in memory for events that are distinct in space and time. One of the strongest, most synchronous neural signals produced by the hippocampus is the sharp-wave ripple (SWR), observed in a variety of mammalian species during offline behaviors, such as slow-wave sleep [1-3] and quiescent waking and pauses in exploration [4-8], leading to long-standing and widespread theories of its contribution to plasticity and memory during these inactive or immobile states [9-14]. Indeed, during sleep and waking inactivity, hippocampal SWRs in rodents appear to support spatial long-term and working memory [4, 15-23], but so far, they have not been linked to memory in primates...
December 21, 2016: Current Biology: CB
https://www.readbyqxmd.com/read/27993620/characterization-of-putative-virulence-factors-of-serratia-marcescens-strain-sen-for-pathogenesis-in-spodoptera-litura
#7
Chetana Aggarwal, Sangeeta Paul, Vishwas Tripathi, Bishwajeet Paul, Md Aslam Khan
Two Serratia marcescens strains, SEN and ICC-4, isolated from diseased insect cadavers were observed to differ considerably in their virulence towards Spodoptera litura. The present study was aimed to characterize the possible virulence factors present in the virulent Serratia marcescens strain SEN. Both the S. marcescens strains were evaluated for the presence of various lytic enzymes such as chitinase, lipase, protease and phospholipase. The virulent S. marcescens strain SEN was observed to possess considerably higher activity of chitinase and protease enzymes; activity of phospholipase enzyme was also higher...
December 18, 2016: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/27973741/clicking-the-brain-into-deep-sleep-commentary-on-weigenand-et%C3%A2-al-2016
#8
Maurice Göldi, Thomas Schreiner
Slow-wave sleep (SWS) has been ascribed to play a key role in memory consolidation processes (Rasch & Born, 2013). One of the most salient features of SWS is the elevated occurrence of slow oscillations (< 1 Hz). Slow oscillations (SOs) are generated in thalamic and neocortical circuits and comprise alterations between periods of increased excitability (up-states) and hyperpolarized neural silence (down-states) (Contreras & Steriade, 1995). This alternating neural activity spreads throughout the neocortex and also affects other brain regions amongst others the hippocampus (Contreras et al...
December 14, 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27941790/a-cortical-hippocampal-cortical-loop-of-information-processing-during-memory-consolidation
#9
Gideon Rothschild, Elad Eban, Loren M Frank
Hippocampal replay during sharp-wave ripple events (SWRs) is thought to drive memory consolidation in hippocampal and cortical circuits. Changes in neocortical activity can precede SWR events, but whether and how these changes influence the content of replay remains unknown. Here we show that during sleep there is a rapid cortical-hippocampal-cortical loop of information flow around the times of SWRs. We recorded neural activity in auditory cortex (AC) and hippocampus of rats as they learned a sound-guided task and during sleep...
December 12, 2016: Nature Neuroscience
https://www.readbyqxmd.com/read/27866796/interplay-between-hippocampal-sharp-wave-ripple-events-and-vicarious-trial-and-error-behaviors-in-decision-making
#10
Andrew E Papale, Mark C Zielinski, Loren M Frank, Shantanu P Jadhav, A David Redish
Current theories posit that memories encoded during experiences are subsequently consolidated into longer-term storage. Hippocampal sharp-wave-ripple (SWR) events have been linked to this consolidation process during sleep, but SWRs also occur during awake immobility, where their role remains unclear. We report that awake SWR rates at the reward site are inversely related to the prevalence of vicarious trial and error (VTE) behaviors, thought to be involved in deliberation processes. SWR rates were diminished immediately after VTE behaviors and an increase in the rate of SWR events at the reward site predicted a decrease in subsequent VTE behaviors at the choice point...
December 7, 2016: Neuron
https://www.readbyqxmd.com/read/27846828/the-potential-effectiveness-of-the-nutrition-improvement-program-on-infant-and-young-child-feeding-and-nutritional-status-in-the-northwest-and-southwest-regions-of-cameroon-central-africa
#11
Kate Reinsma, Godlove Nkuoh, Emmanuel Nshom
BACKGROUND: Despite the recent international focus on maternal and child nutrition, little attention is paid to nutrition capacity development. Although infant feeding counselling by health workers increases caregivers' knowledge, and improves breastfeeding, complementary feeding, and children's linear growth, most of the counselling in sub-Saharan Africa is primarily conducted by nurses or volunteers, and little is done to develop capacity for nutrition at the professional, organizational, or systemic levels...
November 15, 2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27832604/intra-and-inter-regional-cortical-interactions-related-to-sharp-wave-ripples-and-dentate-spikes
#12
Drew B Headley, Vasiliki Kanta, Denis Pare
The hippocampus generates population events termed sharp-wave ripples (SWRs) and dentate spikes (DSs). While little is known about DSs, SWR-related hippocampal discharges during sleep are thought to replay prior waking activity, reactivating the cortical networks that encoded the initial experience. During slow-wave sleep, such reactivations likely occur during up-states, when most cortical neurons are depolarized. However, most studies have examined the relationship between SWRs and up-states measured in single neocortical regions...
November 9, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/27804006/ramadan-fasting-effects-on-postural-control-in-the-elderly-a-comparison-between-fallers-and-non-fallers
#13
Rabeb Laatar, Rym Baccouch, Rihab Borji, Hiba Kachouri, Haithem Rebai, Sonia Sahli
Our purpose was to compare the effects of Ramadan fasting on postural control in elderly fallers and non-fallers. The protocol involved twenty-four healthy old volunteer males divided into two groups: fallers (mean age = 75.43 ± 5.26 years, weight = 67.25 ± 5.30 kg and height = 1.65 ± 0.02 m) and non-fallers (mean age = 72.3 ± 6.42 years, weight = 65.5 ± 6.15 kg and height = 1.64 ± 0.03 m). Participants performed a simple reaction time test (SRT) and a postural control protocol on four different occasions: one week before Ramadan (BR), during the second (SWR) and the fourth week (FWR) of Ramadan and three weeks after Ramadan (AR)...
November 1, 2016: Journal of Religion and Health
https://www.readbyqxmd.com/read/27760209/pristane-accelerated-autoimmune-disease-in-swr-x-nzb-f1-mice-leads-to-prominent-tubulointerstitial-inflammation-and-human-lupus-nephritis-like-fibrosis
#14
Agnes Gardet, Wei C Chou, Taylor L Reynolds, Diana B Velez, Kai Fu, Julia M Czerkowicz, Jeffrey Bajko, Ann M Ranger, Normand Allaire, Hannah M Kerns, Sarah Ryan, Holly M Legault, Robert W Dunstan, Robert Lafyatis, Matvey Lukashev, Joanne L Viney, Jeffrey L Browning, Dania Rabah
Mouse models lupus nephritis (LN) have provided important insights into disease pathogenesis, although none have been able to recapitulate all features of the human disease. Using comprehensive longitudinal analyses, we characterized a novel accelerated mouse model of lupus using pristane treatment in SNF1 (SWR X NZB F1) lupus prone mice (pristane-SNF1 mice). Pristane treatment in SNF1 mice accelerated the onset and progression of proteinuria, autoantibody production, immune complex deposition and development of renal lesions...
2016: PloS One
https://www.readbyqxmd.com/read/27760158/optogenetically-blocking-sharp-wave-ripple-events-in-sleep-does-not-interfere-with-the-formation-of-stable-spatial-representation-in-the-ca1-area-of-the-hippocampus
#15
Krisztián A Kovács, Joseph O'Neill, Philipp Schoenenberger, Markku Penttonen, Damaris K Ranguel Guerrero, Jozsef Csicsvari
During hippocampal sharp wave/ripple (SWR) events, previously occurring, sensory input-driven neuronal firing patterns are replayed. Such replay is thought to be important for plasticity-related processes and consolidation of memory traces. It has previously been shown that the electrical stimulation-induced disruption of SWR events interferes with learning in rodents in different experimental paradigms. On the other hand, the cognitive map theory posits that the plastic changes of the firing of hippocampal place cells constitute the electrophysiological counterpart of the spatial learning, observable at the behavioral level...
2016: PloS One
https://www.readbyqxmd.com/read/27741109/patient-safety-walkaround-a-communication-tool-for-the-reallocation-of-health-service-resources-an-italian-experience-of-safety-healthcare-implementation
#16
Davide Ferorelli, Fiorenza Zotti, Silvio Tafuri, Angela Pezzolla, Alessandro Dell'Erba
The study aims to evaluate the use of Patient Safety Walkaround (SWR) execution model in an Italian Hospital, through the adoption of parametric indices, survey tools, and process indicators.In the 1st meeting an interview was conducted to verify the knowledge of concepts of clinical risk management (process indicators). One month after, the questions provided by Frankel (survey tool) were administered.Each month after, an SWR has been carried trying to assist the healthcare professionals and collecting suggestions and solutions...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27669180/reliability-and-accuracy-of-a-standardized-shallow-water-running-test-to-determine-cardiorespiratory-fitness
#17
Elizabeth F Nagle, Mary E Sanders, Bethany B Gibbs, Barry A Franklin, Jacquelyn A Nagle, Philip J Prins, Caleb D Johnson, Robert J Robertson
A standardized fitness assessment is critical for the development of an individualized exercise prescription. Although the benefits of aquatic exercise have been well established, there remains the need for a standardized non-swimming protocol to accurately assess cardiorespiratory fitness (CRF) in shallow water. The present investigation was designed to assess: 1) reliability of a standardized Shallow Water Run (SWR) test of CRF; and 2) accuracy of a standardized SWR compared with a land-based treadmill test (LTM)...
September 16, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27633034/heat-stress-and-inadequate-sanitary-facilities-at-workplaces-an-occupational-health-concern-for-women
#18
Vidhya Venugopal, Shanmugam Rekha, Krishnamoorthy Manikandan, Perumal Kamalakkannan Latha, Viswanathan Vennila, Nalini Ganesan, Perumal Kumaravel, Stephen Jeremiah Chinnadurai
BACKGROUND: Health concerns unique to women are growing with the large number of women venturing into different trades that expose them to hot working environments and inadequate sanitation facilities, common in many Indian workplaces. OBJECTIVE: The study was carried out to investigate the health implications of exposures to hot work environments and inadequate sanitation facilities at their workplaces for women workers. DESIGN: A cross-sectional study was conducted with 312 women workers in three occupational sectors in 2014-2015...
2016: Global Health Action
https://www.readbyqxmd.com/read/27568518/reverse-replay-of-hippocampal-place-cells-is-uniquely-modulated-by-changing-reward
#19
R Ellen Ambrose, Brad E Pfeiffer, David J Foster
Hippocampal replays are episodes of sequential place cell activity during sharp-wave ripple oscillations (SWRs). Conflicting hypotheses implicate awake replay in learning from reward and in memory retrieval for decision making. Further, awake replays can be forward, in the same order as experienced, or reverse, in the opposite order. However, while the presence or absence of reward has been reported to modulate SWR rate, the effect of reward changes on replay, and on replay direction in particular, has not been examined...
September 7, 2016: Neuron
https://www.readbyqxmd.com/read/27535369/rapid-classification-of-hippocampal-replay-content-for-real-time-applications
#20
Xinyi Deng, Daniel F Liu, Mattias P Karlsson, Loren M Frank, Uri T Eden
Sharp-wave ripple (SWR) events in the hippocampus replay millisecond-timescale patterns of place cell activity related to the past experience of an animal. Interrupting SWR events leads to learning and memory impairments, but how the specific patterns of place cell spiking seen during SWRs contribute to learning and memory remains unclear. A deeper understanding of this issue will require the ability to manipulate SWR events based on their content. Accurate real-time decoding of SWR replay events requires new algorithms that are able to estimate replay content and the associated uncertainty, along with software and hardware that can execute these algorithms for biological interventions on a millisecond timescale...
November 1, 2016: Journal of Neurophysiology
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