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https://www.readbyqxmd.com/read/29663923/selenium-and-iron-oxide-nanocomposites-for-magnetically-targeted-anti-cancer-applications
#1
Halla Laufey Hauksdóttir, Thomas J Webster
Iron oxide nanoparticles (IONP) are already well-established in the medical field due to their ability to improve contrast in magnetic resonance imaging (MRI) and for their external magnetic control in the body. Moreover, selenium has been shown to kill numerous cancer cells at lower concentrations that IONP (e.g., 1 μg/ml). Selenium is a trace mineral of growing interest in cancer treatment since it is an essential nutrient in the human body and can interfere with thiolcontaining proteins necessary for cancer cells to function...
March 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29546541/the-physiological-role-of-boron-on-health
#2
REVIEW
Haseeb Khaliq, Zhong Juming, Peng Ke-Mei
Boron is an essential mineral that plays an important role in several biological processes. Boron is required for growth of plants, animals, and humans. There are increasing evidences of this nutrient showing a variety of pleiotropic effects, ranging from anti-inflammatory and antioxidant effects to the modulation of different body systems. In the past few years, the trials showed disease-related polymorphisms of boron in different species, which has drawn attention of scientists to the significance of boron to health...
March 15, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29499131/dynamic-regulation-of-long-chain-fatty-acid-oxidation-by-a-noncanonical-interaction-between-the-mcl-1-bh3-helix-and-vlcad
#3
Silvia Escudero, Elma Zaganjor, Susan Lee, Christopher P Mill, Ann M Morgan, Emily B Crawford, Jiahao Chen, Thomas E Wales, Rida Mourtada, James Luccarelli, Gregory H Bird, Ulrich Steidl, John R Engen, Marcia C Haigis, Joseph T Opferman, Loren D Walensky
MCL-1 is a BCL-2 family protein implicated in the development and chemoresistance of human cancer. Unlike its anti-apoptotic homologs, Mcl-1 deletion has profound physiologic consequences, indicative of a broader role in homeostasis. We report that the BCL-2 homology 3 (BH3) α helix of MCL-1 can directly engage very long-chain acyl-CoA dehydrogenase (VLCAD), a key enzyme of the mitochondrial fatty acid β-oxidation (FAO) pathway. Proteomic analysis confirmed that the mitochondrial matrix isoform of MCL-1 (MCL-1Matrix ) interacts with VLCAD...
March 1, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29490888/the-dark-side-of-tumor-associated-endothelial-cells
#4
REVIEW
Francesco De Sanctis, Stefano Ugel, John Facciponte, Andrea Facciabene
Angiogenesis is a hallmark of cancer and a requisite that tumors must achieve to fulfill their metabolic needs of nutrients and oxygen. As a critical step in cancer progression, the 'angiogenic switch' allows tumor cells to survive and grow, and provides them access to vasculature resulting in metastatic progression and dissemination. Tumor-dependent triggering of the angiogenic switch has critical consequences on tumor progression which extends from an increased nutrient supply and relies instead on the ability of the tumor to hijack the host immune response for the generation of a local immunoprivileged microenvironment...
February 26, 2018: Seminars in Immunology
https://www.readbyqxmd.com/read/29475214/micro-environment-and-intracellular-metabolism-modulation-of-adipose-tissue-macrophage-polarization-in-relation-to-chronic-inflammatory-diseases
#5
REVIEW
Xiao Zhu, Yixuan Tu, Hainan Chen, Ampadu O Jackson, Vaibhav Patel, Kai Yin
BACKGROUND: The accumulation and pro-inflammatory polarization of immune cells, mainly macrophages, in adipose tissue (AT) are considered crucial factors for obesity-induced chronic inflammatory diseases. SCOPE OF REVIEW: In this review, we highlighted the role of adipose tissue macrophage (ATM) polarization on AT function in the obese state and the effect of the micro-environment and intracellular metabolism on the dynamic switch of ATMs into their pro-inflammatory or anti-inflammatory phenotypes, which may have distinct influences on obesity-related chronic inflammatory diseases...
February 23, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29462928/omega-3-pufa-loaded-in-resveratrol-based-solid-lipid-nanoparticles-physicochemical-properties-and-antineoplastic-activities-in-human-colorectal-cancer-cells-in-vitro
#6
Simona Serini, Roberta Cassano, Paola Antonia Corsetto, Angela Maria Rizzo, Gabriella Calviello, Sonia Trombino
New strategies are being investigated to ameliorate the efficacy and reduce the toxicity of the drugs currently used in colorectal cancer (CRC), one of the most common malignancies in the Western world. Data have been accumulated demonstrating that the antineoplastic therapies with either conventional or single-targeted drugs could take advantage from a combined treatment with omega-3 polyunsaturated fatty acids (omega-3 PUFA). These nutrients, shown to be safe at the dosage generally used in human trials, are able to modulate molecules involved in colon cancer cell growth and survival...
February 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29461625/beyond-symptomatic-relief-for-chemotherapy-induced-peripheral-neuropathy-targeting-the-source
#7
REVIEW
Jiacheng Ma, Annemieke Kavelaars, Patrick M Dougherty, Cobi J Heijnen
Chemotherapy-induced peripheral neuropathy (CIPN) is a serious adverse side effect of many chemotherapeutic agents, affecting >60% of patients with cancer. Moreover, CIPN persists long into survivorship in approximately 20% to 30% of these patients. To the authors' knowledge, no drugs have been approved to date by the US Food and Drug Administration to effectively manage chemotherapy-induced neuropathic pain. The majority of the drugs tested for the management of CIPN aim at symptom relief, including pain and paresthesia, yet are not very efficacious...
February 20, 2018: Cancer
https://www.readbyqxmd.com/read/29444163/the-effect-of-nutramiltm-complex-food-for-special-medical-purpose-on-breast-and-prostate-carcinoma-cells
#8
Aneta A Koronowicz, Mariola Drozdowska, Barbara Wielgos, Ewelina Piasna-Słupecka, Dominik Domagała, Joanna Dulińska-Litewka, Teresa Leszczyńska
NutramilTM Complex is a multicomponent food product that meets the requirements of a food for special medical purpose. As a complete, high-energy diet it consists of properly balanced nutrients, vitamins and minerals. The aim of this study was to assess the effect of NutramilTM Complex on breast and prostate carcinoma cells. Our results showed that NutramilTM Complex reduced the viability and proliferation of breast and prostate cancer cells and that this process was associated with the induction of apoptosis via activation of caspase signalling...
2018: PloS One
https://www.readbyqxmd.com/read/29438676/stress-induced-cellular-responses-in-immunogenic-cell-death-implications-for-cancer-immunotherapy
#9
REVIEW
Flavia Radogna, Marc Diederich
Cancer is evading the host's defense mechanisms leading to avoidance of immune destruction. During tumor progression, immune-evading cancer cells arise due to selective pressure from the hypoxic and nutrient-deprived microenvironment. Thus, therapies aiming at re-establishing immune destruction of pathological cells constitute innovating anti-cancer strategies. Accumulating evidence suggests that selected conventional chemotherapeutic drugs increase the immunogenicity of stressed and dying cancer cells by triggering a form of cell death called immunogenic cell death (ICD), which is characterized by the release of danger-associated molecular patterns (DAMPs)...
February 10, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29435127/%C3%AE-tocopherol-succinate-enhances-pterostilbene-anti-tumor-activity-in-human-breast-cancer-cells-in-vivo-and-in-vitro
#10
Ka-Wai Tam, Chi-Tang Ho, Shih-Hsin Tu, Wen-Jui Lee, Ching-Shui Huang, Ching-Shyang Chen, Chih-Hsiung Wu, Chia-Hwa Lee, Yuan-Soon Ho
Vitamin E (Vit. E) is considered an essential dietary nutrient for humans and animals. An enormous body of evidence indicates the biological and protective effects of Vit. E consumption. Tocopherol-associated protein (TAP) is a major tocopherol-binding protein affecting Vit. E stimulation and downstream signaling transduction. However, how Vit. E utilizes TAP as an anti-cancer mechanism remains unclear. Microarray analysis of signature gene profiles in breast cancer cells treated with α-tocopheryl succinate (α-TOS, a Vit...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29381475/the-role-of-nutrition-in-influencing-mechanisms-involved-in-environmentally-mediated-diseases
#11
REVIEW
Bernhard Hennig, Michael C Petriello, Mary V Gamble, Young-Joon Surh, Laura A Kresty, Norbert Frank, Nuchanart Rangkadilok, Mathuros Ruchirawat, William A Suk
Human exposure to environmental contaminants such as persistent chlorinated organics, heavy metals, pesticides, phthalates, flame retardants, electronic waste and airborne pollutants around the world, and especially in Southeast Asian regions, are significant and require urgent attention. Given this widespread contamination and abundance of such toxins as persistent organic pollutants (POPs) in the ecosystem, it is unlikely that remediation alone will be sufficient to address the health impacts associated with this exposure...
March 28, 2018: Reviews on Environmental Health
https://www.readbyqxmd.com/read/29378235/translational-models-of-tumor-angiogenesis-a-nexus-of-in-silico-and-in-vitro-models
#12
REVIEW
Shirin Soleimani, Milad Shamsi, Mehran Akbarpour Ghazani, Hassan Pezeshgi Modarres, Karolina Papera Valente, Mohsen Saghafian, Mehdi Mohammadi Ashani, Mohsen Akbari, Amir Sanati-Nezhad
Emerging evidence shows that endothelial cells are not only the building blocks of vascular networks that enable oxygen and nutrient delivery throughout a tissue but also serve as a rich resource of angiocrine factors. Endothelial cells play key roles in determining cancer progression and response to anti-cancer drugs. Furthermore, the endothelium-specific deposition of extracellular matrix is a key modulator of the availability of angiocrine factors to both stromal and cancer cells. Considering tumor vascular network as a decisive factor in cancer pathogenesis and treatment response, these networks need to be an inseparable component of cancer models...
January 25, 2018: Biotechnology Advances
https://www.readbyqxmd.com/read/29358225/association-between-post-cancer-diagnosis-dietary-inflammatory-potential-and-mortality-among-invasive-breast-cancer-survivors-in-the-women-s-health-initiative
#13
Jiali Zheng, Fred K Tabung, Jiajia Zhang, Angela D Liese, Nitin Shivappa, Judith K Ockene, Bette Caan, Candyce H Kroenke, James R Hébert, Susan E Steck
Background: Inflammation is important in chronic disease and can be modulated by dietary exposures. Our aim was to examine whether the inflammatory potential of diet after cancer diagnosis, assessed using the dietary inflammatory index (DII), is associated with all-cause and cause-specific mortality among women diagnosed with invasive breast cancer in the Women's Health Initiative (WHI). Methods: Our analytic cohort included 2,150 postmenopausal women, ages 50 to 79 years at baseline, who developed invasive breast cancer during follow-up and completed a food frequency questionnaire (FFQ) on average 1...
April 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29305107/five-threads-how-u-shaped-thinking-weaves-together-dogs-men-selenium-and-prostate-cancer-risk
#14
REVIEW
David J Waters, Emily C Chiang
Prostate cancer is one of the leading causes of cancer-related mortality among men living in developed countries, making the development of safe, practical approaches to prostate cancer risk reduction a high research priority. The relationship between prostate cancer risk and selenium, an essential nutrient required for a number of metabolically important enzymes including glutathione peroxidases, has been investigated, but a satisfactory integration of results has proven elusive. Dogs, like men, naturally develop prostate cancer during aging, providing an appropriate context to study the effects of selenium supplementation on the dysregulation of homeostasis that drives cancer development within the aging prostate...
January 2, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29296175/organotypic-three-dimensional-cancer-cell-cultures-mirror-drug-responses-in-vivo-lessons-learned-from-the-inhibition-of-egfr-signaling
#15
Nico Jacobi, Rita Seeboeck, Elisabeth Hofmann, Helmut Schweiger, Veronika Smolinska, Thomas Mohr, Alexandra Boyer, Wolfgang Sommergruber, Peter Lechner, Corina Pichler-Huebschmann, Kamil Önder, Harald Hundsberger, Christoph Wiesner, Andreas Eger
Complex three-dimensional (3D) in vitro models that recapitulate human tumor biology are essential to understand the pathophysiology of the disease and to aid in the discovery of novel anti-cancer therapies. 3D organotypic cultures exhibit intercellular communication, nutrient and oxygen gradients, and cell polarity that is lacking in two-dimensional (2D) monolayer cultures. In the present study, we demonstrate that 2D and 3D cancer models exhibit different drug sensitivities towards both targeted inhibitors of EGFR signaling and broad acting cytotoxic agents...
December 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/29291009/mir-93-5p-enhances-growth-and-angiogenesis-capacity-of-huvecs-by-down-regulating-eplin
#16
Liang Liang, Lei Zhao, Ying Zan, Qing Zhu, Juan Ren, Xinhan Zhao
Tumor angiogenesis is essential in delivering oxygen and nutrients to growing tumors, and therefore considered as a hallmark of cancer. MicroRNAs (miRNAs) have been shown to play important roles in regulating tumor angiogenesis. MicroRNA-93-5p (miR-93-5p) has been identified as an oncogenic miRNA in a variety of human malignancies and involved in tumor angiogenesis in astrocytoma. However, the direct effect(s) of miR-93-5p on the biological behaviors of endothelial cells have not been investigated. Thus, in the present study we investigated the role(s) of miR-93-5p in regulating the functions of human umbilical vein endothelial cells (HUVECs)...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29282684/disrupting-tumor-angiogenesis-and-the-hunger-games-for-breast-cancer
#17
Ziwei Zhou, Herui Yao, Hai Hu
Angiogenesis, one of the hallmarks of cancers, has become an attractive target for cancer therapy since decades ago. It is broadly thought that upregulation of angiogenesis is involved in tumor progression and metastasis. Though tumor vessels are tortuous, disorganized, and leaky, they deliver oxygen and nutrients for tumor development. Based on this knowledge, many kinds of drugs targeting angiogenesis pathways have been developed, such as bevacizumab. However, the clinical outcomes of anti-angiogenesis therapies are moderate in metastatic breast cancer as well as in metastatic colorectal cancer and non-small cell lung cancer, even combined with traditional chemotherapy...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29279319/survival-of-cancer-stem-like-cells-under-metabolic-stress-via-camk2%C3%AE-mediated-upregulation-of-sarco-endoplasmic-reticulum-calcium-atpase-expression
#18
Ki Cheong Park, Seung Won Kim, Jeong Yong Jeon, A Ra Jo, Hye Ji Choi, Jungmin Kim, Hyun Gyu Lee, Yonjung Kim, Gordon B Mills, Sung Hoon Noh, Min Goo Lee, Eun Sung Park, Jae-Ho Cheong
Purpose: Cancer cells grow in an unfavorable metabolic milieu in the tumor microenvironment and are constantly exposed to metabolic stress such as chronic nutrient depletion. Cancer stem-like cells (CSC) are intrinsically resistant to metabolic stress, thereby surviving nutrient insufficiency and driving more malignant tumor progression. In this study, we aimed to demonstrate the potential mechanisms by which CSCs avoid Ca2+ -dependent apoptosis during glucose deprivation. Experimental Design: We investigated cell viability and apoptosis under glucose deprivation, performed genome-wide transcriptional profiling of paired CSCs and parental cells, studied the effect of calcium/calmodulin-dependent protein kinase 2 alpha ( CaMK2α ) gene knockdown, and investigated the role of nuclear factor kappa B (NFκB) in CSCs during time-dependent Ca2+ -mediated and glucose deprivation-induced apoptosis...
December 26, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29251334/niclosamide-acts-as-a-new-inhibitor-of-vasculogenic-mimicry-in-oral-cancer-through-upregulation-of-mir-124-and-downregulation-of-stat3
#19
Xiaoxu Li, Zhicheng Yang, Zewen Han, Yanhui Wen, Zeyun Ma, Yixiang Wang
Tumors require nutrients and oxygen for growth and metastasis. Vasculogenic mimicry (VM) has been found as a new manner of blood supply, which is characterized as the formation of tumor cell-lined vessels instead of endothelial vessels. This is why angiogenesis agents targeted to endothelial cells show a limited efficacy. Up to this point, there is no effective drug reported for inhibiting VM formation. Niclosamide is an oral anti-helminthic drug used to treat human tapeworms. Recent studies have indicated that niclosamide has broad applications for cancer and other diseases...
February 2018: Oncology Reports
https://www.readbyqxmd.com/read/29216269/compensatory-role-of-neuroglobin-in-nervous-and-non-nervous-cancer-cells-in-response-to-the-nutrient-deprivation
#20
Marco Fiocchetti, Manuela Cipolletti, Maria Marino
Environmental factors or adverse growth conditions that may reduce cell function or viability are considered stress. The cell ability to sense and respond to environmental stresses determine its function and survival destiny. We recently defined Neuroglobin (NGB), a heme-protein, as a compensatory protein in the 17β-Estradiol (E2) anti-apoptotic activity and as a sensor of oxidative stress in both neurons and breast cancer cells. Here, the possibility that NGB levels could represent a pivotal regulator of integrated response of cancer cells to stress has been evaluated...
2017: PloS One
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