Neel H Mehta, Xiuyuan Wang, Samantha A Keil, Ke Xi, Liangdong Zhou, Kevin Lee, Wanbin Tan, Edward Spector, Amirhossein Goldan, James Kelly, Nicolas A Karakatsanis, P David Mozley, Sadek Nehmeh, J Levi Chazen, Simon Morin, John Babich, Jana Ivanidze, Silky Pahlajani, Emily B Tanzi, Leslie Saint-Louis, Tracy Butler, Kewei Chen, Henry Rusinek, Roxana O Carare, Yi Li, Gloria C Chiang, Mony J de Leon
BACKGROUND: Reduced clearance of cerebrospinal fluid (CSF) has been suggested as a pathological feature of Alzheimer's disease (AD). With extensive documentation in non-human mammals and contradictory human neuroimaging data it remains unknown whether the nasal mucosa is a CSF drainage site in humans. Here, we used dynamic PET with [1-11 C]-Butanol, a highly permeable radiotracer with no appreciable brain binding, to test the hypothesis that tracer drainage from the nasal pathway reflects CSF drainage from brain...
April 2, 2024: Fluids and Barriers of the CNS