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https://www.readbyqxmd.com/read/28431622/quantitative-biomechanical-assessment-of-trunk-control-in-huntington-s-disease-reveals-more-impairment-in-static-than-dynamic-tasks
#1
Deb A Kegelmeyer, Sandra K Kostyk, Nora E Fritz, Marianne M Fiumedora, Ajit Chaudhari, Marilly Palettas, Gregory Young, Anne D Kloos
Postural instability is common in individuals with Huntington's disease (HD), yet little is known about control of the trunk during static and dynamic activities. We compared the trunk motion of 41 individuals with HD and 36 controls at thoracic and pelvic levels during sitting, standing, and walking using wearable iPod sensors. We also examined the ability of individuals with HD to respond to an auditory cue to modify trunk position when the pelvis moved >8° in sagittal or frontal planes during sitting using custom software...
May 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28425497/single-dose-memantine-improves-cortical-oscillatory-response-dynamics-in-patients-with-schizophrenia
#2
Gregory A Light, Wen Zhang, Yash B Joshi, Savita Bhakta, Jo A Talledo, Neal R Swerdlow
Aberrant gamma band (30-80 Hz) oscillations may underlie cognitive deficits in schizophrenia (SZ). Gamma oscillations and their regulation by NMDA receptors can be studied via their evoked power (γEP) and phase locking (γPL) in response to auditory steady state stimulation; these Auditory Steady State Responses (ASSRs) may be biomarkers for target engagement and early therapeutic effects. We previously reported that memantine, an NMDA receptor antagonist, enhanced 2 biomarkers of early auditory information processing: prepulse inhibition (PPI) and mismatch negativity (MMN) in SZ patients and healthy subjects (HS)...
April 20, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28424605/white-matter-integrity-and-treatment-based-change-in-speech-performance-in-minimally-verbal-children-with-autism-spectrum-disorder
#3
Karen Chenausky, Julius Kernbach, Andrea Norton, Gottfried Schlaug
We investigated the relationship between imaging variables for two language/speech-motor tracts and speech fluency variables in 10 minimally verbal (MV) children with autism. Specifically, we tested whether measures of white matter integrity-fractional anisotropy (FA) of the arcuate fasciculus (AF) and frontal aslant tract (FAT)-were related to change in percent syllable-initial consonants correct, percent items responded to, and percent syllable insertion errors (from best baseline to post 25 treatment sessions)...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28420951/shared-neural-mechanisms-for-the-prediction-of-own-and-partner-musical-sequences-after-short-term-piano-duet-training
#4
Claudia Lappe, Sabine Bodeck, Markus Lappe, Christo Pantev
Predictive mechanisms in the human brain can be investigated using markers for prediction violations like the mismatch negativity (MMN). Short-term piano training increases the MMN for melodic and rhythmic deviations in the training material. This increase occurs only when the material is actually played, not when it is only perceived through listening, suggesting that learning predictions about upcoming musical events are derived from motor involvement. However, music is often performed in concert with others...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28419201/functional-imaging-of-audio-visual-selective-attention-in-monkeys-and-humans-how-do-lapses-in-monkey-performance-affect-cross-species-correspondences
#5
Teemu Rinne, Ross S Muers, Emma Salo, Heather Slater, Christopher I Petkov
The cross-species correspondences and differences in how attention modulates brain responses in humans and animal models are poorly understood. We trained 2 monkeys to perform an audio-visual selective attention task during functional magnetic resonance imaging (fMRI), rewarding them to attend to stimuli in one modality while ignoring those in the other. Monkey fMRI identified regions strongly modulated by auditory or visual attention. Surprisingly, auditory attention-related modulations were much more restricted in monkeys than humans performing the same tasks during fMRI...
April 13, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28418324/prosody-perception-and-production-in-children-with-hearing-loss-and-age-and-gender-matched-controls
#6
Rose Thomas Kalathottukaren, Suzanne C Purdy, Elaine Ballard
BACKGROUND: Auditory development in children with hearing loss, including the perception of prosody, depends on having adequate input from cochlear implants and/or hearing aids. Lack of adequate auditory stimulation can lead to delayed speech and language development. Nevertheless, prosody perception and production in people with hearing loss have received less attention than other aspects of language. The perception of auditory information conveyed through prosody using variations in the pitch, amplitude, and duration of speech is not usually evaluated clinically...
April 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/28417105/substitution-patterns-of-phoneme-errors-in-hearing-aid-and-cochlear-implant-users
#7
Woojae Han, Hyungi Chun, Gibbeum Kim, In-Ki Jin
BACKGROUND AND OBJECTIVES: It is acknowledged that speech perceptual errors are increased in listeners who have sensorineural hearing loss as noise increases. However, there is a lack of detailed information for their error pattern. The purpose of the present study was to analyze substitution patterns of phoneme errors in Korean hearing aid (HA) and cochlear implant (CI) users who are postlingually deafened adults. SUBJECTS AND METHODS: In quiet and under two noise conditions, the phoneme errors of twenty HA and fourteen CI users were measured by using monosyllabic words, and a substitution pattern was analyzed in terms of manner of articulation...
April 2017: Journal of Audiology & Otology
https://www.readbyqxmd.com/read/28408871/focused-and-sustained-attention-is-modified-by-a-goal-based-rehabilitation-in-parkinsonian-patients
#8
Davide Ferrazzoli, Paola Ortelli, Roberto Maestri, Rossana Bera, Roberto Gargantini, Grazia Palamara, Marianna Zarucchi, Nir Giladi, Giuseppe Frazzitta
Rehabilitation for patients with Parkinson's disease (PD) is based on cognitive strategies that exploit attention. Parkinsonians exhibit impairments in divided attention and interference control. Nevertheless, the effectiveness of specific rehabilitation treatments based on attention suggests that other attentional functions are preserved. Data about attention are conflicting in PD, and it is not clear whether rehabilitative treatments that entail attentional strategies affect attention itself. Reaction times (RTs) represent an instrument to explore attention and investigate whether changes in attentional performances parallel rehabilitation induced-gains...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28408414/posterior-parietal-cortex-guides-visual-decisions-in-rats
#9
Angela M Licata, Matthew T Kaufman, David Raposo, Michael B Ryan, John P Sheppard, Anne K Churchland
Neurons in putative decision-making structures can reflect both sensory and decision signals, making their causal role in decisions unclear. Here, we tested whether rat posterior parietal cortex (PPC) is causal for processing visual sensory signals or instead for accumulating evidence for decision alternatives. We optogenetically disrupted PPC activity during decision-making and compared effects on decisions guided by auditory vs. visual evidence. Deficits were largely restricted to visual decisions. To further test for visual dominance in PPC, we evaluated electrophysiological responses following individual sensory events and observed much larger response modulation following visual stimuli than auditory stimuli...
April 13, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28400103/common-marmoset-callithrix-jacchus-as-a-primate-model-for-behavioral-neuroscience-studies
#10
Noeline W Prins, Eric Pohlmeyer, Shubham Debnath, Ramanamurthy Mylavarapu, Shijia Geng, Justin C Sanchez, Daniel Rothen, Abhishek Prasad
BACKGROUND: The common marmoset (Callithrix jacchus) has been proposed as a suitable bridge between rodents and larger primates. They have been used in several types of research including auditory, vocal, visual, pharmacological and genetics studies. However, marmosets have not been used as much for behavioral studies. NEW METHOD: Here we present data from training 12 adult marmosets for behavioral neuroscience studies. We discuss the husbandry, food preferences, handling, acclimation to laboratory environments and neurosurgical techniques...
April 8, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28396142/atypical-binding-at-dopamine-and-serotonin-transporters-contribute-to-the-discriminative-stimulus-effects-of-mephedrone
#11
Alyssa F DeLarge, Laura L Erwin, Peter J Winsauer
Mephedrone (4-methylmethcathinone), a constituent of the recreational substances known as "bath salts", is a synthetic cathinone that can produce auditory and visual hallucinations, as well as problematic cardiovascular effects. This study compared the discriminative stimulus effects of mephedrone (0.32-10 mg/kg) with other prototypical drugs of abuse: cocaine (0.56-32 mg/kg), d-amphetamine (0.18-3.2 mg/kg), ketamine (1.8-18 mg/kg), phencyclidine (PCP, 1-5.6 mg/kg), heroin (1-10 mg/kg), 2,5-dimethoxy-4-iodoamphetamine (R-DOI, 0...
April 7, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28394938/words-from-spontaneous-conversational-speech-can-be-recognized-with-human-like-accuracy-by-an-error-driven-learning-algorithm-that-discriminates-between-meanings-straight-from-smart-acoustic-features-bypassing-the-phoneme-as-recognition-unit
#12
Denis Arnold, Fabian Tomaschek, Konstantin Sering, Florence Lopez, R Harald Baayen
Sound units play a pivotal role in cognitive models of auditory comprehension. The general consensus is that during perception listeners break down speech into auditory words and subsequently phones. Indeed, cognitive speech recognition is typically taken to be computationally intractable without phones. Here we present a computational model trained on 20 hours of conversational speech that recognizes word meanings within the range of human performance (model 25%, native speakers 20-44%), without making use of phone or word form representations...
2017: PloS One
https://www.readbyqxmd.com/read/28391488/selective-auditory-grouping-by-zebra-finches-testing-the-iambic-trochaic-law
#13
Michelle Spierings, Jeroen Hubert, Carel Ten Cate
Humans have a strong tendency to spontaneously group visual or auditory stimuli together in larger patterns. One of these perceptual grouping biases is formulated as the iambic/trochaic law, where humans group successive tones alternating in pitch and intensity as trochees (high-low and loud-soft) and alternating in duration as iambs (short-long). The grouping of alternations in pitch and intensity into trochees is a human universal and is also present in one non-human animal species, rats. The perceptual grouping of sounds alternating in duration seems to be affected by native language in humans and has so far not been found among animals...
April 8, 2017: Animal Cognition
https://www.readbyqxmd.com/read/28388865/audiological-management-of-adults-with-hearing-impairment-in-malaysia
#14
Akmaliza Ali, Louise Hickson, Carly Meyer
OBJECTIVE: This study explored the nature of audiological services for adults with hearing impairment in Malaysia, with an emphasis on whether current services address clients' overall functioning as described by the World Health Organisation's International Classification of Functioning, Disability, and Health (ICF) framework. DESIGN: An online survey exploring current practice, skills and confidence of audiologists, and the infrastructure and facilities available in their workplaces, was distributed to audiologists in Malaysia via professional associations and social media...
April 7, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28387692/the-role-of-sensory-augmentation-for-people-with-vestibular-deficits-real-time-balance-aid-and-or-rehabilitation-device
#15
K H Sienko, S L Whitney, W J Carender, C Wall
This narrative review highlights findings from the sensory augmentation field for people with vestibular deficits and addresses the outstanding questions that are critical to the translation of this technology into clinical and/or personal use. Prior research has demonstrated that the real-time use of visual, vibrotactile, auditory, and multimodal sensory augmentation technologies can improve balance during static and dynamic stance tasks within a laboratory setting. However, its application in improving gait requires additional investigation, as does its efficacy as a rehabilitation device for people with vestibular deficits...
2017: Journal of Vestibular Research: Equilibrium & Orientation
https://www.readbyqxmd.com/read/28387687/vibro-tactile-and-auditory-balance-biofeedback-changes-muscle-activity-patterns-possible-implications-for-vestibular%C3%A2-implants
#16
John H J Allum, Flurin Honegger
BACKGROUND: The two different types of balance prostheses being developed, implants and vibro-tactile/auditory feedback prostheses, rely on different measures to prove efficacy (those based on vestibular ocular reflexes versus balance control, respectively). Here we provide evidence that examining muscle activity might provide a useful alternative for both. METHODS: The muscle activity of 6 bilateral vestibular loss (BVL) and 7 age-matched healthy controls (HC) was examined while standing eyes closed on a foam support surface...
2017: Journal of Vestibular Research: Equilibrium & Orientation
https://www.readbyqxmd.com/read/28386211/on-the-auditory-proprioception-substitution-hypothesis-movement-sonification-in-two-deafferented-subjects-learning-to-write-new-characters
#17
Jérémy Danna, Jean-Luc Velay
The aim of this study was to evaluate the compensatory effects of real-time auditory feedback on two proprioceptively deafferented subjects. The real-time auditory feedback was based on a movement sonification approach, consisting of translating some movement variables into synthetic sounds to make them audible. The two deafferented subjects and 16 age-matched control participants were asked to learn four new characters. The characters were learned under two different conditions, one without sonification and one with sonification, respecting a within-subject protocol...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28385053/using-real-time-fmri-neurofeedback-to-restore-right-occipital-cortex-activity-in-patients-with-left-visuo-spatial-neglect-proof-of-principle-and-preliminary-results
#18
Fabien Robineau, Arnaud Saj, Rémi Neveu, Dimitri Van De Ville, Frank Scharnowski, Patrik Vuilleumier
Hemineglect is common after right parietal stroke, characterised by impaired awareness for stimuli in left visual space, with suppressed neural activity in the right visual cortex due to losses in top-down attention signals. Here we sought to assess whether hemineglect patients are able to up-regulate their right visual cortex activity using auditory real-time functional magnetic resonance imaging (rt-fMRI) neurofeedback. We also examined any effect of this training procedure on neglect severity. Two different neurofeedback methods were used...
April 6, 2017: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/28384509/brain-responses-to-biological-motion-predict-treatment-outcome-in-young-adults-with-autism-receiving-virtual-reality-social-cognition-training-preliminary-findings
#19
Y J Daniel Yang, Tandra Allen, Sebiha M Abdullahi, Kevin A Pelphrey, Fred R Volkmar, Sandra B Chapman
Autism Spectrum Disorder (ASD) is characterized by remarkable heterogeneity in social, communication, and behavioral deficits, creating a major barrier in identifying effective treatments for a given individual with ASD. To facilitate precision medicine in ASD, we utilized a well-validated biological motion neuroimaging task to identify pretreatment biomarkers that can accurately forecast the response to an evidence-based behavioral treatment, Virtual Reality-Social Cognition Training (VR-SCT). In a preliminary sample of 17 young adults with high-functioning ASD, we identified neural predictors of change in emotion recognition after VR-SCT...
March 29, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28384124/single-channel-in-ear-eeg-detects-the-focus-of-auditory-attention-to-concurrent-tone-streams-and-mixed-speech
#20
Lorenz Fiedler, Malte Wöstmann, Carina Graversen, Alex Brandmeyer, Thomas Lunner, Jonas Obleser
OBJECTIVE: Conventional, multi-channel scalp electroencephalography (EEG) allows the identification of the attended speaker in concurrent-listening ('cocktail party') scenarios. This implies that EEG might provide valuable information to complement hearing aids with some form of EEG and to install a level of neuro-feedback. APPROACH: To investigate whether a listener's attentional focus can be detected from single-channel hearing-aid-compatible EEG configurations, we recorded EEG from three electrodes inside the ear canal ('in-Ear-EEG') and additionally from 64 electrodes on the scalp...
April 6, 2017: Journal of Neural Engineering
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