Oscar Fraile-Martinez, Diego De Leon-Oliva, Diego Liviu Boaru, Patricia De Castro-Martinez, Cielo Garcia-Montero, Silvestra Barrena-Blázquez, Joaquin García-García, Natalio García-Honduvilla, Melchor Alvarez-Mon, Laura Lopez-Gonzalez, Raul Diaz-Pedrero, Luis G Guijarro, Miguel A Ortega
Vascular diseases pose major health challenges, and understanding their underlying molecular mechanisms is essential to advance therapeutic interventions. Cellular senescence, a hallmark of aging, is a cellular state characterized by cell-cycle arrest, a senescence-associated secretory phenotype macromolecular damage, and metabolic dysregulation. Vascular senescence has been demonstrated to play a key role in different vascular diseases, such as atherosclerosis, peripheral arterial disease, hypertension, stroke, diabetes, chronic venous disease, and venous ulcers...
2024: Frontiers in Genetics