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https://www.readbyqxmd.com/read/28454124/influence-of-the-rehabilitation-outcome-on-returning-to-drive-after-neurological-impairment
#1
Urša Š Čižman, Gaj Vidmar, Petra Drnovšek
In traumatic brain injury (TBI) and stroke rehabilitation, the question of reintegration of the driver into traffic is faced very often. Driving is an important domain and for some patients, return to driving represents a crucial event for community inclusion. The aim of our study was to examine the utility of Glasgow Coma Scale within the first 24 h of injury and the Functional Independence Measure (FIM) at rehabilitation admission for predicting the return to driving. We included 72 patients after TBI or stroke...
June 2017: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/28439750/hospital-heterogeneity-what-drives-the-quality-of-health-care
#2
Manhal Ali, Reza Salehnejad, Mohaimen Mansur
A major feature of health care systems is substantial variation in health care quality across hospitals. The quality of stroke care widely varies across NHS hospitals. We investigate factors that may explain variations in health care quality using measures of quality of stroke care. We combine NHS trust data from the National Sentinel Stroke Audit with other data sets from the Office for National Statistics, NHS and census data to capture hospitals' human and physical assets and organisational characteristics...
April 24, 2017: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/28436703/in-the-driver-s-seat-development-and-implementation-of-an-e-learning-module-on-return-to-driving-after-stroke
#3
Janet Frith, Isobel Hubbard, Carole James, Helen Warren-Forward
Gaps exist in the knowledge of return-to-driving guidelines, and education is needed for Australian health professionals working in the field of stroke. In this paper, authors evaluate the implementation of an e-learning module. A pre- and post-module knowledge test and survey were used to assess the e-module's success in achieving its learning objectives. Initially, 204 learners completed the module, with 68% of learners scoring 100% in the post-module knowledge test. Only 12 learners completed the survey...
April 24, 2017: Occupational Therapy in Health Care
https://www.readbyqxmd.com/read/28408965/phospholipase-c-related-catalytically-inactive-protein-can-regulate-obesity-a-state-of-peripheral-inflammation
#4
REVIEW
Yosuke Yamawaki, Kana Oue, Satomi Shirawachi, Satoshi Asano, Kae Harada, Takashi Kanematsu
Obesity is defined as abnormal or excessive fat accumulation. Chronic inflammation in fat influences the development of obesity-related diseases. Many reports state that obesity increases the risk of morbidity in many diseases, including hypertension, dyslipidemia, type 2 diabetes, coronary heart disease, stroke, sleep apnea, and breast, prostate and colon cancers, leading to increased mortality. Obesity is also associated with chronic neuropathologic conditions such as depression and Alzheimer's disease. However, there is strong evidence that weight loss reduces these risks, by limiting blood pressure and improving levels of serum triglycerides, total cholesterol, low-density lipoprotein (LDL)-cholesterol, and high-density lipoprotein (HDL)-cholesterol...
February 2017: Japanese Dental Science Review
https://www.readbyqxmd.com/read/28404729/wings-as-impellers-honey-bees-co-opt-flight-system-to-induce-nest-ventilation-and-disperse-pheromones
#5
Jacob M Peters, Nick Gravish, Stacey A Combes
Honey bees (Apis mellifera) are remarkable fliers that regularly carry heavy loads of nectar and pollen, supported by a flight system - the wings, thorax and flight muscles - that one might assume is optimized for aerial locomotion. However, honey bees also use this system to perform other crucial tasks that are unrelated to flight. When ventilating the nest, bees grip the surface of the comb or nest entrance and fan their wings to drive airflow through the nest, and a similar wing-fanning behavior is used to disperse volatile pheromones from the Nasonov gland...
April 12, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28396569/local-ancestry-and-clinical-cardiovascular-events-among-african-americans-from-the-atherosclerosis-risk-in-communities-study
#6
Aditi Shendre, Marguerite R Irvin, Howard Wiener, Degui Zhi, Nita A Limdi, Edgar T Overton, Sadeep Shrestha
BACKGROUND: Local ancestry in relation to clinical cardiovascular events (CVEs) among African Americans can provide insight into their genetic susceptibility to the disease. METHODS AND RESULTS: We examined local European ancestry (LEA) association with CVEs among 3000 African Americans from the Atherosclerosis Risk in Communities Study (ARIC). We estimated LEA using Local Ancestry Inference in adMixed Populations using Linkage Disequilibrium (LAMP-LD) and examined its association with myocardial infarction, stroke, coronary heart disease and its composite and cardiovascular disease composite using logistic regression...
April 10, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28395980/long-term-outcome-and-risk-assessment-in-premature-acute-myocardial-infarction-a-10-year-follow-up-study
#7
Max-Paul Winter, Hermann Blessberger, Arman Alimohammadi, Noemi Pavo, Kurt Huber, Johann Wojta, Irene M Lang, Franz Wiesbauer, Georg Goliasch
BACKGROUND: Premature acute myocardial infarction (AMI) is a rare disease carrying significant morbidity and mortality. Existing data on outcome in these patients is based on retrospective analysis of angiographic reports or refer to time periods with incomparable treatment regimes, making them unusable for risk assessment in times of widespread use of reperfusion therapy. Aim of this study was to assess the outcome of premature AMI in a prospectively recruited study population enrolled in the times of modern reperfusion therapy...
April 2, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28385306/detection-of-atherosclerotic-inflammation-by-68-ga-dotatate-pet-compared-to-18-f-fdg-pet-imaging
#8
Jason M Tarkin, Francis R Joshi, Nicholas R Evans, Mohammed M Chowdhury, Nichola L Figg, Aarti V Shah, Lakshi T Starks, Abel Martin-Garrido, Roido Manavaki, Emma Yu, Rhoda E Kuc, Luigi Grassi, Roman Kreuzhuber, Myrto A Kostadima, Mattia Frontini, Peter J Kirkpatrick, Patrick A Coughlin, Deepa Gopalan, Tim D Fryer, John R Buscombe, Ashley M Groves, Willem H Ouwehand, Martin R Bennett, Elizabeth A Warburton, Anthony P Davenport, James H F Rudd
BACKGROUND: Inflammation drives atherosclerotic plaque rupture. Although inflammation can be measured using fluorine-18-labeled fluorodeoxyglucose positron emission tomography ([(18)F]FDG PET), [(18)F]FDG lacks cell specificity, and coronary imaging is unreliable because of myocardial spillover. OBJECTIVES: This study tested the efficacy of gallium-68-labeled DOTATATE ((68)Ga-DOTATATE), a somatostatin receptor subtype-2 (SST2)-binding PET tracer, for imaging atherosclerotic inflammation...
April 11, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28384147/trends-in-new-zealand-stroke-thrombolysis-treatment-rates
#9
Qiliang Liu, Annemarei Anna Ranta, Ginny Abernethy, P Alan Barber
AIMS: To describe trends in treatment delays and short-term outcome over the first 18 months of the New Zealand stroke thrombolysis register. METHODS: The National Stroke Network introduced a central register of all ischaemic stroke patients treated with intravenous alteplase on January 1, 2015. The aim was to increase thrombolysis treatment rates and drive improvements in safety. RESULTS: From January 1, 2015 to June 30, 2016, alteplase was given to 623 patients [344 men, mean (range) age 70 (22-98) years] out of a total of 8,857 ischaemic and unspecified stroke patients, giving a thrombolysis rate of 7...
April 7, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28382159/a-crucial-role-of-cxcl14-for-promoting-regulatory-t-cells-activation-in-stroke
#10
Hsu-Tung Lee, Shih-Ping Liu, Chen-Huan Lin, Sophie Wei Lee, Chung Y Hsu, Huey-Kang Sytwu, Chia-Hung Hsieh, Woei-Cherng Shyu
Inflammatory processes have a detrimental role in the pathophysiology of ischemic stroke. However, little is known about the endogenous anti-inflammatory mechanisms in ischemic brain. Here, we identify CXCL14 as a critical mediator of these mechanisms. CXCL14 levels were upregulated in the ischemic brains of humans and rodents. Moreover, hypoxia inducible factor-1α (HIF-1α) drives hypoxia- or cerebral ischemia (CI)-dependent CXCL14 expression via directly binding to the CXCL14 promoter. Depletion of CXCL14 inhibited the accumulation of immature dendritic cells (iDC) or regulatory T cells (Treg) and increased the infarct volume, whereas the supplementation of CXCL14 had the opposite effects...
2017: Theranostics
https://www.readbyqxmd.com/read/28377155/level-of-need-divertibility-and-outcomes-of-newly-admitted-nursing-home-residents
#11
Peter Tanuseputro, Amy Hsu, Kerry Kuluski, Mathieu Chalifoux, Melissa Donskov, Sarah Beach, Peter Walker
OBJECTIVES: To describe the level of need and divertibility of newly admitted nursing home residents, describe the factors that drive need, and describe the outcomes of residents across different levels of need. DESIGN: Retrospective cohort study. SETTING: A total of 640 publicly funded nursing homes (also known as long-term care facilities) in Ontario, Canada. PARTICIPANTS: All newly admitted residents between January 1, 2010 and March 1, 2012...
April 1, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28367109/low-latency-estimation-of-motor-intentions-to-assist-reaching-movements-along-multiple-sessions-in-chronic-stroke-patients-a-feasibility-study
#12
Jaime Ibáñez, Esther Monge-Pereira, Francisco Molina-Rueda, J I Serrano, Maria D Del Castillo, Alicia Cuesta-Gómez, María Carratalá-Tejada, Roberto Cano-de-la-Cuerda, Isabel M Alguacil-Diego, Juan C Miangolarra-Page, Jose L Pons
Background: The association between motor-related cortical activity and peripheral stimulation with temporal precision has been proposed as a possible intervention to facilitate cortico-muscular pathways and thereby improve motor rehabilitation after stroke. Previous studies with patients have provided evidence of the possibility to implement brain-machine interface platforms able to decode motor intentions and use this information to trigger afferent stimulation and movement assistance. This study tests the use a low-latency movement intention detector to drive functional electrical stimulation assisting upper-limb reaching movements of patients with stroke...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28339828/single-session-of-functional-electrical-stimulation-assisted-walking-produces-corticomotor-symmetry-changes-related-to-changes-in-poststroke-walking-mechanics
#13
Jacqueline A Palmer, HaoYuan Hsiao, Tamara Wright, Stuart A Binder-Macleod
Background: Recent research demonstrated that symmetry of corticomotor drive to paretic and nonparetic plantarflexor muscles are related to the biomechanical ankle moment strategy that individuals with chronic stroke used to achieve their greatest walking speeds. Rehabilitation strategies that promote corticomotor balance could potentially improve post-stroke walking mechanics and enhance functional ambulation. Objective: To 1) test the effectiveness of a single session of gait training using functional electrical stimulation (FES) to improve plantarflexor corticomotor symmetry and plantarflexion ankle moment symmetry and 2) determine if changes in corticomotor symmetry relate to changes in ankle moment symmetry within the session...
February 23, 2017: Physical Therapy
https://www.readbyqxmd.com/read/28338788/hypertension-and-atrial-fibrillation-an-intimate-association-of-epidemiology-pathophysiology-and-outcomes
#14
Mikhail S Dzeshka, Farhan Shahid, Alena Shantsila, Gregory Y H Lip
Atrial fibrillation (AF) is the most prevalent sustained arrhythmia found in clinical practice. AF rarely exists as a single entity but rather as part of a diverse clinical spectrum of cardiovascular diseases, related to structural and electrical remodeling within the left atrium, leading to AF onset, perpetuation, and progression. Due to the high overall prevalence within the AF population arterial hypertension plays a significant role in the pathogenesis of AF and its complications. Fibroblast proliferation, apoptosis of cardiomyocytes, gap junction remodeling, accumulation of collagen both in atrial and ventricular myocardium all accompany ageing-related structural remodeling with impact on electrical activity...
February 18, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28337932/stroke-lesions-in-a-large-upper-limb-rehabilitation-trial-cohort-rarely-match-lesions-in-common-preclinical-models
#15
Matthew A Edwardson, Ximing Wang, Brent Liu, Li Ding, Christianne J Lane, Caron Park, Monica A Nelsen, Theresa A Jones, Steven L Wolf, Carolee J Winstein, Alexander W Dromerick
BACKGROUND: Stroke patients with mild-moderate upper extremity motor impairments and minimal sensory and cognitive deficits provide a useful model to study recovery and improve rehabilitation. Laboratory-based investigators use lesioning techniques for similar goals. OBJECTIVE: To determine whether stroke lesions in an upper extremity rehabilitation trial cohort match lesions from the preclinical stroke recovery models used to drive translational research. METHODS: Clinical neuroimages from 297 participants enrolled in the Interdisciplinary Comprehensive Arm Rehabilitation Evaluation (ICARE) study were reviewed...
January 1, 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/28323679/the-day-that-went-missing-a-first-person-account-of-transient-global-amnesia
#16
Trip Gabriel
In this vivid first-person case history, political reporter Trip Gabriel describes experiencing a classic episode of transient global amnesia. He was near the average target age of 61. Although no cause has been established for the syndrome, as with many other patients his episode appears to have been triggered by contact with water: He was racing a sailboat. While remaining alert and handling complex sailing maneuvers, he suddenly developed amnesia that left him with no recollection of finishing two races, returning to shore, drinking a beer with his friends, needing help finding his car, and not knowing where he was or where he lived...
March 2017: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
https://www.readbyqxmd.com/read/28320217/patient-centered-mobility-outcome-preferences-according-to-individuals-with-stroke-and-caregivers-a-qualitative-analysis
#17
Shilpa Krishnan, Monique R Pappadis, Susan C Weller, Steve R Fisher, Catherine C Hay, Timothy A Reistetter
PURPOSE: To explore the mobility-related preferences among stroke survivors and caregivers following post-acute rehabilitation at inpatient or skilled nursing facilities. METHODS: In this cross-sectional study; semi-structured, qualitative interviews of stroke survivors (n = 24) and informal caregivers (n = 15) were conducted. The participants were recruited from the community. RESULTS: Comparative content analysis was used to identify themes by two independent coders...
March 21, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28314519/after-effects-of-peripheral-neurostimulation-on-brain-plasticity-and-ankle-function-in-chronic-stroke-the-role-of-afferents-recruited
#18
Louis-David Beaulieu, Hugo Massé-Alarie, Samuel Camiré-Bernier, Édith Ribot-Ciscar, Cyril Schneider
AIMS OF THE STUDY: This study tested the after-effects of neuromuscular electrical stimulation (NMES), repetitive peripheral magnetic stimulation (rPMS) and muscle tendon vibration (VIB) on brain plasticity and sensorimotor impairments in chronic stroke to investigate whether different results could depend on the nature of afferents recruited by each technique. MATERIALS AND METHODS: Fifteen people with chronic stroke participated in five sessions (one per week)...
March 14, 2017: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/28291535/the-health-burden-and-economic-costs-averted-by-ambient-pm2-5-pollution-reductions-in-nagpur-india
#19
Tunde O Etchie, Saravanadevi Sivanesan, Gregory O Adewuyi, Kannan Krishnamurthi, Padma S Rao, Ayotunde T Etchie, Ajay Pillarisetti, Narendra K Arora, Kirk R Smith
National estimates of the health and economic burdens of exposure to ambient fine particulate matter (PM2.5) in India reveal substantial impacts. This information, often lacking at the local level, can justify and drive mitigation interventions. Here, we assess the health and economic gains resulting from attainment of WHO guidelines for PM2.5 concentrations - including interim target 2 (IT-2), interim target 3 (IT-3), and the WHO air quality guideline (AQG) - in Nagpur district to inform policy decision making for mitigation...
March 10, 2017: Environment International
https://www.readbyqxmd.com/read/28288898/oral-administration-of-corticosterone-at-stress-like-levels-drives-microglial-but-not-vascular-disturbances-post-stroke
#20
Katarzyna Zalewska, Lin Kooi Ong, Sarah J Johnson, Michael Nilsson, Frederick R Walker
Exposure to chronic stress following stroke has been shown, both clinically and pre-clinically, to impact negatively on the recovery process. While this phenomenon is well established, the specific mechanisms involved have remained largely unexplored. One obvious signaling pathway through which chronic stress may impact on the recovery process is via corticosterone, and its effects on microglial activity and vascular remodeling. In the current study, we were interested in examining how orally delivered corticosterone at a stress-like concentration impacted on microglial activity and vascular remodeling after stroke...
March 11, 2017: Neuroscience
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