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https://www.readbyqxmd.com/read/29437200/kunskap-om-levnadsvanor-v%C3%A3-rderas-olika-p%C3%A3-l%C3%A3-karutbildningarna-en-genomg%C3%A3-ng-av-124-skriftliga-examinationer
#1
Benno Krachler, Lars Jerdén, Christina Lindén
Substantial differences in valuation of lifestyle-related knowledge at Swedish medical schools Lifestyle factors are crucial for prevention and management of many non-communicable diseases such as hypertension, stroke, diabetes, coronary heart disease and chronic obstructive pulmonary disease. Lifestyle medicine is included in national learning outcomes for undergraduate medical education in Sweden. Since assessment drives learning, we reviewed questions from 124 written examinations from all 7 medical schools in Sweden, conducted between 2012 and 2015...
February 9, 2018: Läkartidningen
https://www.readbyqxmd.com/read/29436505/-drip-and-drive-shipping-the-neurointerventionalist-to-provide-mechanical-thrombectomy-in-primary-stroke-centers
#2
Caspar Brekenfeld, Einar Goebell, Holger Schmidt, Henning Henningsen, Christoffer Kraemer, Jörg Tebben, Fabian Flottmann, Götz Thomalla, Jens Fiehler
BACKGROUND: To satisfy the increasing demand of mechanical thrombectomy (MT) for acute ischemic stroke treatment, new organizational concepts for patient care are required. This study evaluates time intervals of acute stroke management in two stroke care models, including one based on transportation of the interventionalist from a comprehensive stroke center (CSC) to treat patients in two primary stroke centers (PSC). We hypothesized that time intervals were not inferior for the 'drip-and-drive' concept compared with the traditional 'drip-and-ship' concept...
February 7, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29432464/a-robust-technique-based-on-vlm-and-frangi-filter-for-retinal-vessel-extraction-and-denoising
#3
Khan Bahadar Khan, Amir A Khaliq, Abdul Jalil, Muhammad Shahid
The exploration of retinal vessel structure is colossally important on account of numerous diseases including stroke, Diabetic Retinopathy (DR) and coronary heart diseases, which can damage the retinal vessel structure. The retinal vascular network is very hard to be extracted due to its spreading and diminishing geometry and contrast variation in an image. The proposed technique consists of unique parallel processes for denoising and extraction of blood vessels in retinal images. In the preprocessing section, an adaptive histogram equalization enhances dissimilarity between the vessels and the background and morphological top-hat filters are employed to eliminate macula and optic disc, etc...
2018: PloS One
https://www.readbyqxmd.com/read/29416854/regulation-of-plasma-von-willebrand-factor
#4
REVIEW
Karl C Desch
Von Willebrand factor (VWF) is a multimeric plasma glycoprotein that plays a central role in the initiation of blood coagulation. Through interactions between its specific functional domains, the vascular wall, coagulation factor VIII, and platelet receptors, VWF maintains hemostasis by binding to platelets and delivering factor VIII to the sites of vascular injury. In the healthy human population, plasma VWF levels vary widely. The important role of VWF is illustrated by individuals at the extremes of the normal distribution of plasma VWF concentrations where individuals with low VWF levels are more likely to present with mucocutaneous bleeding...
2018: F1000Research
https://www.readbyqxmd.com/read/29416029/neuroglobin-boosts-axon-regeneration-during-ischemic-reperfusion-via-p38-binding-and-activation-depending-on-oxygen-signal
#5
Xin Xin Xiong, Feng Pan, Ruo Qiao Chen, Dian Xing Hu, Xin Yao Qiu, Chun Yang Li, Xiao Qiang Xie, Bo Tian, Xiao Qian Chen
Cerebral ischemia causes severe cell death or injury including axon breakdown or retraction in the brain. Axon regeneration is crucial for the functional recovery of injured neurons or brains after ischemia/reperfusion (I/R); however, this process has been proved extremely difficult in adult brains and there is still no effective therapy for it. Here we reported that neuroglobin (Ngb), a novel oxygen-binding or sensor protein existing predominantly in neurons or brains, functions as a driving factor for axon regeneration during I/R...
February 7, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29406186/current-concepts-of-fluid-management-in-enhanced-recovery-pathways
#6
REVIEW
R Makaryus, T E Miller, T J Gan
Perioperative fluid management impacts outcomes and plays a pivotal role in enhanced recovery pathways (ERPs). There have been major advances in understanding the effects of fluid therapy and administration during the perioperative period. Improving fluid management during this period leads to a decrease in complications, decrease in length of stay (LOS), and enhanced patient outcomes. It is important to consider preoperative and postoperative fluid management to be just as critical as intraoperative management given multiple associated benefits to the patients...
February 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29382633/prediction-of-incident-hypertension-within-the-next-year-prospective-study-using-statewide-electronic-health-records-and-machine-learning
#7
Chengyin Ye, Tianyun Fu, Shiying Hao, Yan Zhang, Oliver Wang, Bo Jin, Minjie Xia, Modi Liu, Xin Zhou, Qian Wu, Yanting Guo, Chunqing Zhu, Yu-Ming Li, Devore S Culver, Shaun T Alfreds, Frank Stearns, Karl G Sylvester, Eric Widen, Doff McElhinney, Xuefeng Ling
BACKGROUND: As a high-prevalence health condition, hypertension is clinically costly, difficult to manage, and often leads to severe and life-threatening diseases such as cardiovascular disease (CVD) and stroke. OBJECTIVE: The aim of this study was to develop and validate prospectively a risk prediction model of incident essential hypertension within the following year. METHODS: Data from individual patient electronic health records (EHRs) were extracted from the Maine Health Information Exchange network...
January 30, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29378582/a-novel-one-arm-motorized-walker-for-hemiplegic-stroke-survivors-a-feasibility-study
#8
Ki-Hun Cho, SeungHyeon Pyo, Gi-Su Shin, Sung-Duk Hong, Se-Han Lee, DongGeon Lee, SunHae Song, GyuChang Lee
BACKGROUND: A hemiplegic stroke survivor with a moderate to severe gait disturbance may have difficulty walking using a one-arm walker. This study aimed to test the safety and feasibility of a prototype one-arm motorized walker that uses a power-driven device to provide gait assistance to hemiplegic stroke survivors with moderate to severe gait disturbances. METHODS: A one-arm motorized walker with a power-driven device was developed and tested with respect to 10 distinct variables, including weight, degrees of freedom, handle, handle substitution function, two-sided use function, variable handle height, redirecting function, electric moving parts through the handle control, brake function using the handle control, folding chairs, and design stability...
January 30, 2018: Biomedical Engineering Online
https://www.readbyqxmd.com/read/29345035/pressure-and-pipes-from-neuroimaging-to-virtual-measurement
#9
Marialuisa Zedde, Rosario Pascarella
Leng et al. [1] described the practical application of a computational fluid dynamics (CFD) model based on Computed Tomography Angiography (CTA) in 85 patients with symptomatic atherosclerotic M1 middle cerebral artery (MCA) stenosis, to virtually measure arterial pressure (AP) across the stenotic segment, according to the theory that translesional pressure gradient (PG) drives arteriologenesis and leptomeningeal collaterals (LMC) development. This is a fundamental pathophysiological issue about the risk of recurrent stroke downstream an intracranial artery stenosis and both the degree of stenosis and the collateral circulation affect it; in WASID trial [2] patients with severe (> 70%) intracranial stenosis and efficient collaterals had a lower risk of recurrent stroke than patients with poor collaterals...
January 18, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29342483/-fitness-to-drive-after-stroke
#10
Peter Marx
In Germany, patient information and expert testimony on driving ability requires knowledge of the corresponding legislation and the Guideline for expertises on driver aptitude. The testimony should clearly identify handicaps with regard to driving, give estimates on the future risks of a sudden loss of control, and also consider personal attitudes such as inadequate behavior, lack of insight etc. Physical handicaps often can be compensated for by restrains or restrictions such as vehicle modifications, daylight driving only etc...
January 2018: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/29342151/cd8-signaling-in-microglia-macrophage-m1-polarization-in-a-rat-model-of-cerebral-ischemia
#11
Jan Boddaert, Kenny Bielen, Bart 's Jongers, Ekta Manocha, Laetitia Yperzeele, Patrick Cras, Daniel Pirici, Samir Kumar-Singh
Classical or M1 activity of microglia/macrophages has been described in several neurodegenerative and brain inflammatory conditions and has also been linked to expansion of ischemic injury in post-stroke brain. While different pathways of M1 polarization have been suggested to occur in the post-stroke brain, the precise underlying mechanisms remain undefined. Using a transient middle cerebral artery occlusion (MCAO) rat model, we showed a progressive M2 to M1 polarization in the perilesional brain region with M1 cells becoming one of the dominant subsets by day 4 post-stroke...
2018: PloS One
https://www.readbyqxmd.com/read/29337235/frequency-specific-effective-connectivity-in-subjects-with-cerebral-infarction-as-revealed-by-nirs-method
#12
Qianying Liu, Bitian Wang, Ying Liu, Zeping Lv, Wenhao Li, Zengyong Li, Yubo Fan
A connectivity-based approach can highlight the network reorganization in the chronic phases after stroke and contributes to the development of therapeutic interventions. Using dynamic Bayesian inference, this study aimed to assess the effective connectivity(EC)in various frequency bands through the near-infrared spectroscopy(NIRS) method in subjects with cerebral infarction(CI). A phase-coupling model was established based on phase information extracted using the wavelet transform of NIRS signals. Coupling strength and the main coupling direction were estimated using dynamic Bayesian inference...
January 11, 2018: Neuroscience
https://www.readbyqxmd.com/read/29330604/driving-forces-of-translocation-through-bacterial-translocon-secyeg
#13
Denis G Knyazev, Roland Kuttner, Mirjam Zimmermann, Ekaterina Sobakinskaya, Peter Pohl
This review focusses on the energetics of protein translocation via the Sec translocation machinery. First we complement structural data about SecYEG's conformational rearrangements by insight obtained from functional assays. These include measurements of SecYEG permeability that allow assessment of channel gating by ligand binding and membrane voltage. Second we will discuss the power stroke and Brownian ratcheting models of substrate translocation and the role that the two models assign to the putative driving forces: (i) ATP (SecA) and GTP (ribosome) hydrolysis, (ii) interaction with accessory proteins, (iii) membrane partitioning and folding, (iv) proton motive force (PMF), and (v) entropic contributions...
January 12, 2018: Journal of Membrane Biology
https://www.readbyqxmd.com/read/29322861/community-mobility-after-stroke-a-systematic-review
#14
Steven Wesselhoff, Timothy A Hanke, Christian C Evans
Background Stroke is the leading cause of severe disability and many survivors report long-term physical or cognitive impairments that may impact their ability to achieve community mobility (CM). PURPOSE: To determine the extent to which people with chronic stroke achieve CM compared to age-matched norms or non-neurologically impaired controls. Methods The StrokEDGE outcome measures were searched to identify validated tools that included >25% of items addressing CM. MEDLINE, CINAHL, Google Scholar, PubMed, PEDro and the Cochrane databases were searched from 2001 to 2015 with the identified outcome measures cross-referenced against search terms related to stroke and CM...
January 11, 2018: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/29299953/general-self-efficacy-as-a-driving-factor-of-post-stroke-depression-a-longitudinal-study
#15
Matthias Volz, Manuel C Voelkle, Katja Werheid
Post-stroke depression (PSD) is the most common psychiatric condition after stroke, affecting one third of survivors. Despite identification of meaningful predictors, knowledge about the interplay between these factors remains fragmentary. General self-efficacy (GSE) is closely linked to PSD, yet direction and magnitude of this relationship remains unclear. The authors assessed the relationship between GSE and depression during the first two years post-stroke while controlling for stable inter-individual differences using continuous time (CT) structural equation modelling (SEM)...
January 4, 2018: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/29273581/mortality-differences-associated-with-treatment-responses-in-cantos-and-fourier-insights-and-implications
#16
Paul M Ridker
Similarities and differences in two contemporary post-randomization on-treatment analyses from the FOURIER and CANTOS trials may provide insight into what factors drive reductions in cardiovascular mortality and all-cause mortality among atherosclerosis patients already treated with high intensity statins. In the first paper, the FOURIER investigators elegantly demonstrate that lower is better for low-density lipoprotein cholesterol (LDLC) after adjunctive therapy with the PCSK9 inhibitor evolocumab1 For the FOURIER primary endpoint (a composite of myocardial infarction, stroke, coronary revascularization, unstable angina, or cardiovascular death), there was a highly significant monotonic relationship between sequentially lower achieved LDLC concentrations and lower cardiovascular risk, extending even to those with on-treatment LDLC below 20 mg/dL...
December 22, 2017: Circulation
https://www.readbyqxmd.com/read/29247485/an-eeg-index-of-sensorimotor-interhemispheric-coupling-after-unilateral-stroke-clinical-and-neurophysiological-study
#17
Floriana Pichiorri, Manuela Petti, Stefano Caschera, Laura Astolfi, Febo Cincotti, Donatella Mattia
Brain connectivity has been employed to investigate on post-stroke recovery mechanisms and assess the effect of specific rehabilitation interventions. Changes in interhemispheric coupling after stroke have been related to the extent of damage in the corticospinal tract (CST) and thus, to motor impairment. In this study, we aimed at defining an index of interhemispheric connectivity derived from electroencephalography (EEG), correlated with CST integrity and clinical impairment. Thirty sub-acute stroke patients underwent clinical and neurophysiological evaluation: CST integrity was assessed by Transcranial Magnetic Stimulation and high-density EEG was recorded at rest...
January 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29230011/pairing-sound-with-vagus-nerve-stimulation-modulates-cortical-synchrony-and-phase-coherence-in-tinnitus-an-exploratory-retrospective-study
#18
Sven Vanneste, Jeffrey Martin, Robert L Rennaker, Michael P Kilgard
Recent research has shown that vagus nerve stimulation (VNS) paired with tones or with rehabilitative training can help patients to achieve reductions in tinnitus perception or to expedite motor rehabilitation after suffering an ischemic stroke. The rationale behind this treatment is that VNS paired with experience can drive neural plasticity in a controlled and therapeutic direction. Since previous studies observed that gamma activity in the auditory cortex is correlated with tinnitus loudness, we assessed resting-state source-localized EEG before and after one to three months of VNS-tone pairing in chronic tinnitus patients...
December 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29223708/comparison-of-neuroplastic-responses-to-cathodal-transcranial-direct-current-stimulation-and-continuous-theta-burst-stimulation-in-subacute-stroke
#19
Pierre Nicolo, Cécile Magnin, Elena Pedrazzini, Gijs Plomp, Anaïs Mottaz, Armin Schnider, Adrian G Guggisberg
OBJECTIVE: To investigate the effects of cathodal transcranial direct current stimulation (tDCS) and continuous theta burst stimulation (cTBS) on neural network connectivity and motor recovery in individuals with subacute stroke. DESIGN: Double-blinded, randomized, placebo-controlled study. SETTING: Stroke subjects recruited through a university hospital rehabilitation program. PARTICIPANTS: Stroke inpatients (N=41; mean age 65y, range 28-85; mean weeks poststroke 5, range 2-10) with resultant paresis in the upper extremity (mean Fugl-Meyer score 14, range 3-48)...
December 6, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29223103/bilateral-early-activity-in-the-hip-flexors-associated-with-falls-in-stroke-survivors-preliminary-evidence-from-laboratory-induced-falls
#20
Dmitrijs Celinskis, Mark D Grabiner, Claire F Honeycutt
OBJECTIVE: Falls are the most common and expensive medical complication following stroke. Hypermetric reflexes have been suggested to impact post-stroke balance but no study has evaluated reflex amplitudes under real conditions of falls in this population. Our objective was to quantify the early reflexive responses during falls induced in the laboratory. METHODS: Sixteen stroke survivors were exposed to posteriorly directed treadmill perturbations that required a forward step to maintain a balance...
November 21, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
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