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Stroke AND driving

Danielle C Sutzko, Elizabeth A Andraska, Andrew A Gonzalez, Apurba K Chakrabarti, Nicholas H Osborne
BACKGROUND: There is a growing interest in providing high quality and low-cost care to Americans. A pursuit exists to measure not only how well hospitals are performing but also at what cost. We examined the variation in costs associated with carotid endarterectomy (CEA), to determine which components contribute to the variation and what drives increased payments. MATERIALS AND METHODS: Patients undergoing CEA between 2009 and 2012 were identified in the Medicare provider and analysis review database...
August 2018: Journal of Surgical Research
Aspasia Karageorge, Janine Vargas, Louise Ada, Patrick J Kelly, Annie McCluskey
BACKGROUND: Following hospital discharge, stroke survivors may experience a decline in mobility, outings, and community participation. The aim of this study was to examine the relationship between demographic and clinical measures, and the level of participation by community-dwelling stroke survivors. METHODS: A prospective, multicenter, observational study was conducted. Participants were 83 community-dwelling stroke survivors with participation goals who were undergoing post-inpatient rehabilitation in Australia...
June 14, 2018: Physiotherapy Theory and Practice
Fares Ould-Brahim, Sailendra Nath Sarma, Charvi Syal, Kevin Jiaqi Lu, Matthew Seegobin, Anthony Carter, Matthew S Jeffers, Carole Doré, William Stanford, Dale Corbett, Jing Wang
While transplantation of hiPSC-derived neural stem cells (hiPSC-NSCs) shows therapeutic potential in animal stroke models, major concerns for translating hiPSC therapy to the clinic are efficacy and safety. Therefore, there is a demand to develop an optimal strategy to enhance the engraftment and regenerative capacity of transplanted hiPSC-NSCs in order to produce fully differentiated neural cells to replace lost brain tissues. Metformin, an FDA approved drug, is an optimal neuroregenerative agent that not only promotes NSC proliferation but also drives NSC towards differentiation...
June 12, 2018: Stem Cells and Development
Svetlana Pundik, Aleka Scoco, Margaret Skelly, Jessica P McCabe, Janis J Daly
OBJECTIVE: Somatosensory function is critical to normal motor control. After stroke, dysfunction of the sensory systems prevents normal motor function and degrades quality of life. Structural neuroplasticity underpinnings of sensory recovery after stroke are not fully understood. The objective of this study was to identify changes in bilateral cortical thickness (CT) that may drive recovery of sensory acuity. METHODS: Chronic stroke survivors (n = 20) were treated with 12 weeks of rehabilitation...
June 1, 2018: Neurorehabilitation and Neural Repair
Eugene Lin, Victoria Calderon, Julie Goins-Whitmore, Vibhav Bansal, Osama Zaidat
Background and purpose: As the fourth mobile stroke unit (MSU) in the nation, and the first 24/7 unit worldwide, we review our initial experience with the Mercy Health MSU and institutional protocols implemented to facilitate rapid treatment of acute stroke patients and field triage for patients suffering other time-sensitive, acute neurologic emergencies in Lucas County, Ohio, and the greater Toledo metropolitan area. Methods: Data was prospectively collected for all patients transported and treated by the MSU during the first 6 months of service...
2018: Frontiers in Neurology
Somayyeh Hamzei Taj, Debbie Le Blon, Chloé Hoornaert, Jasmijn Daans, Alessandra Quarta, Jelle Praet, Annemie Van der Linden, Peter Ponsaerts, Mathias Hoehn
BACKGROUND: Subtle adjustment of the activation status of CNS resident microglia and peripheral macrophages, to promote their neuroprotective and neuroregenerative functions, may facilitate research towards curing neurodegenerative disorders. In the present study, we investigated whether targeted intracerebral delivery of the anti-inflammatory cytokine interleukin (IL)13, by means of transplanting IL13-expressing mesenchymal stem cells (IL13-MSCs), can promote a phenotypic switch in both microglia and macrophages during the pro-inflammatory phase in a mouse model of ischemic stroke...
June 4, 2018: Journal of Neuroinflammation
Kiefer James Forseth, Cihan Mehmet Kadipasaoglu, Christopher Richard Conner, Gregory Hickok, Robert Thomas Knight, Nitin Tandon
Semantic memory underpins our understanding of objects, people, places, and ideas. Anomia, a disruption of semantic memory access, is the most common residual language disturbance and is seen in dementia and following injury to temporal cortex. While such anomia has been well characterized by lesion symptom mapping studies, its pathophysiology is not well understood. We hypothesize that inputs to the semantic memory system engage a specific heteromodal network hub that integrates lexical retrieval with the appropriate semantic content...
May 30, 2018: Brain: a Journal of Neurology
Paul D Wiemers, Lucy Marney, Nicole White, Georgina Bough, Alistair Hustig, Wei Tan, Ching-Siang Cheng, Dong Kang, Sumit Yadav, Robert Tam, John F Fraser
BACKGROUND: There is a paucity of data in regards to longer term morbidity outcomes in Indigenous Australian patients undergoing coronary artery bypass grafting (CABG). No comparative data on re-infarction, stroke or reintervention rates exist. Outcome data following percutaneous coronary intervention (PCI) is also extremely limited. Addressing this gap in knowledge forms the major aim of our study. METHODS: This was a single centre cohort study conducted at the Townsville Hospital, Australia which provides tertiary adult cardiac surgical services to the northern parts of the state of Queensland...
April 24, 2018: Heart, Lung & Circulation
Geng Yang, Jia Deng, Gaoyang Pang, Hao Zhang, Jiayi Li, Bin Deng, Zhibo Pang, Juan Xu, Mingzhe Jiang, Pasi Liljeberg, Haibo Xie, Huayong Yang
Surface electromyography signal plays an important role in hand function recovery training. In this paper, an IoT-enabled stroke rehabilitation system was introduced which was based on a smart wearable armband (SWA), machine learning (ML) algorithms, and a 3-D printed dexterous robot hand. User comfort is one of the key issues which should be addressed for wearable devices. The SWA was developed by integrating a low-power and tiny-sized IoT sensing device with textile electrodes, which can measure, pre-process, and wirelessly transmit bio-potential signals...
2018: IEEE Journal of Translational Engineering in Health and Medicine
Giuliano da Paz Oliveira, Giselle Truzzi, Fernando Cascio Barros Lima, Fernando Morgadinho Santos Coelho
Stroke is an example of neurological diseases that can commonly drives Excessive Daytime Sleepiness (EDS). Extensive strokes with brain edema can leave a brain herniation and coma. Other causes of EDS after stroke are strategic lesions at Thalamus and brainstein. A 56-year-old man, right handed, with hypertension and hypercholesterolemia was admitted at Emergency Room due to 5 days onset of EDS, memory impairment, and left-sided weakness. A brain magnetic resonance imaging showed paramedian thalamic hyperintensity with rostral midbrain hyperintensity extending along the pial surface of the interpeduncular fossa...
January 2018: Sleep Science
Boubker Zaaimi, Demetris S Soteropoulos, Karen M Fisher, C Nicholas Riddle, Stuart N Baker
The reticular formation is important in primate motor control, both in health and during recovery after brain damage. Little is known about the different neurons present in the reticular nuclei. Here we recorded extracellular spikes from the reticular formation in five healthy female awake behaving monkeys (193 cells), and in two female monkeys one year after recovery from a unilateral pyramidal tract lesion (125 cells). Analysis of spike shape, and four measures derived from the inter-spike interval distribution identified four clusters of neurons in control animals...
May 23, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Catriona J Cunningham, Elena Redondo-Castro, Stuart M Allan
Mesenchymal stem cells (MSCs) hold great potential as a regenerative therapy for stroke, leading to increased repair and functional recovery in animal models of cerebral ischaemia. While it was initially hypothesised that cell replacement was an important mechanism of action of MSCs, focus has shifted to their paracrine actions or the so called "bystander" effect. MSCs secrete a wide array of growth factors, chemokines, cytokines and extracellular vesicles, commonly referred to as the MSC secretome...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
Erin R Weeda, Nicole Bohm
Background The impact of cancer on outcomes was not assessed in major trials of systemic thrombolysis in acute ischemic stroke. Aims To evaluate the association between comorbid cancer and hospital outcomes among patients receiving systemic thrombolysis for the treatment of acute ischemic stroke. Methods The 2013 and 2014 United States National Inpatient Sample was used to identify adult patients hospitalized for acute ischemic stroke who received systemic thrombolysis. Identified admissions were stratified into two cohorts based on the presence or absence of comorbid cancer...
January 1, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
James L Martin, Robert Ishmukhametov, David Spetzler, Tassilo Hornung, Wayne D Frasch
The angular velocity profile of the 120° F1 -ATPase power stroke was resolved as a function of temperature from 16.3 to 44.6 °C using a ΔμATP = -31.25 k B T at a time resolution of 10 μs. Angular velocities during the first 60° of the power stroke (phase 1) varied inversely with temperature, resulting in negative activation energies with a parabolic dependence. This is direct evidence that phase 1 rotation derives from elastic energy (spring constant, κ = 50 k B T ·rad-2 ). Phase 2 of the power stroke had an enthalpic component indicating that additional energy input occurred to enable the γ-subunit to overcome energy stored by the spring after rotating beyond its 34° equilibrium position...
May 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
Shidong Zhu, Lin Luo, Bibo Yang, Kai Ni, Qian Zhou, Xinghui Li, Xiaohao Wang
BACKGROUND: A novel intra-ventricular assist device (iVAD) was established as a new pulsatile assist device to address various disadvantages, such as bulky configuration and reduced arterial pulsatility, observed in conventional ventricular assist devices. OBJECTIVE: Analyzed the native left ventricular stroke volume (SV) after iVAD support in vitro. METHODS: The SV of iVAD was examined in a home-designed mock circulatory system (MCS) at different heart rates and drive pressures and the SV of a failure ventricle was examined with iVAD at 75, 90, 120 bpm and 120-180 mmHg drive pressure after iVAD support...
May 4, 2018: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
Prabhakara R Nagareddy, Sunil K Noothi, Michelle Christine Flynn, Andrew Murphy
Platelets play a critical role in both the initiation and progression of atherosclerosis, and even more so in the ensuing atherothrombotic complications. Low-dose aspirin remains the mainstay of antiplatelet therapy in high-risk patients by reducing the risk of myocardial ischemia (MI), stroke, or death due to cardiovascular disease (CVD). However, antiplatelet therapies lose their efficacy in people with diabetes mellitus (DM), increasing the risk of future atherothrombotic events. The molecular mechanisms that promote platelet hyperactivity remain unclear but could be due to glycation-induced conformational changes of platelet membranes resulting in impaired aspirin entry, or less-efficient acetylation/compensatory increase in COX-2 expression in newborn platelets...
May 2, 2018: Journal of Endocrinology
Shujin Deng, Aurélia Chenu, Pengpeng Diao, Fang Li, Shi Yu, Ivan Coulamy, Adolfo Del Campo, Haibin Wu
Optimal performance of thermal machines is reached by suppressing friction. Friction in quantum thermodynamics results from fast driving schemes that generate nonadiabatic excitations. The far-from-equilibrium dynamics of quantum devices can be tailored by shortcuts to adiabaticity to suppress quantum friction. We experimentally demonstrate friction-free superadiabatic strokes with a trapped unitary Fermi gas as a working substance and establish the equivalence between the superadiabatic work and its adiabatic value...
April 2018: Science Advances
Debanjan Mukherjee, Neel D Jani, Jared Narvid, Shawn C Shadden
We describe a patient-specific simulation based investigation on the role of Circle of Willis anatomy in cardioembolic stroke. Our simulation framework consists of medical image-driven modeling of patient anatomy including the Circle, 3D blood flow simulation through patient vasculature, embolus transport modeling using a discrete particle dynamics technique, and a sampling based approach to incorporate parametric variations. A total of 24 (four patients and six Circle anatomies including the complete Circle) models were considered, with cardiogenic emboli of varying sizes and compositions released virtually and tracked to compute distribution to the brain...
April 24, 2018: Annals of Biomedical Engineering
Jacob G McPherson, Laura M McPherson, Christopher K Thompson, Michael D Ellis, Charles J Heckman, Julius P A Dewald
Exaggerated stretch-sensitive reflexes are a common finding in elbow flexors of the contralesional arm in chronic hemiparetic stroke, particularly when muscles are not voluntarily activated prior to stretch. Previous investigations have suggested that this exaggeration could arise either from an abnormal tonic ionotropic drive to motoneuron pools innervating the paretic limbs, which could bring additional motor units near firing threshold, or from an increased influence of descending monoaminergic neuromodulatory pathways, which could depolarize motoneurons and amplify their responses to synaptic inputs...
2018: Frontiers in Human Neuroscience
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